CaSR Gen Polimorfizmin Kroner Arter Hastaların Patogenezinde Rolünün Araştırılması

Abstract

Objective: Coronary artery disease is one of the most commonly seen heart diseases worldwide. Given high prevalence in developing countries, it is considered as most frequent causes of death worldwide. Disorders of calcium homeostasis such as primary hyperparathyroidism can increase mortality risk due to cardiovascular causes. In this study, we aimed to investigate role of rs1048213 and rs9883099 polymorphisms in CaSR gene in the pathogenesis of coronary artery disease and to determine whether they are associated to all-causes death and mortality. Material and Method: Data from patients with 135 coronary artery disease and 139 healthy volunteer without heart disease were compared in this study. rs1048213 and rs9883099 polymorphisms were screened by using real-time PCR in blood samples obtained from patients. Results: Significant differences were detected in biochemical parameters, BMI, hypertension, diabetes mellitus, smoking, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol when compared to controls (p<0.05). No significant difference was detected in rs1048312 polymorphism between patients with coronary artery disease and healthy controls while significant differences were detected in rs0993099 polymorphism and A allele (p<0.05). Conclusion: This study showed that there is a significant relationship between rs9883099 polymorphism, A allele and coronary artery disease.