International Journal of Drug Development and Research最新文献

{"title":"Abordagens terapeuticas na osteomielite crônica bacteriana: uma revisão integrativa de literatura","authors":"","doi":"10.37118/ijdr.26933.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26933.07.2023","url":null,"abstract":"Objetivo: Revisar de forma integrativaas principais formas de tratamento e diagnóstico de acordo com as bactérias mais encontradas nas infecções da Osteomielite crônica. Métodos: Foram utilizadas as bases de dados BVS-Lilacs, PubMed, SciElo e Cochrane Library através dos descritores “osteomyelitis”, “chronic” e “treatment” entre o período de 2016 a 2021. Resultados e Discussão: 13 artigos foram selecionados, a partir dos critérios de inclusão, reunindo informações acerca da Osteomielite Crônica. A Osteomielite Crônica ocorre geralmente nas infecções agudas tratadas de forma incorreta ou após procedimento cirúrgico. Os patógenos podem fazer parte da microbióta hospitalar, como a Pseudomonas aeruginosa eStaphylococcus aureus ou podem ser de origem polibacteriana. Os três principais locais de infecção são fêmur, tibiofibular e articulação do quadril e tratamento costuma ser cirúrgico associado a antibióticos locais e orais. A reincidência geralmente ocorre pelas bactérias MRSA (Staphilococcus aureus Resistentes a Metilcilina) e leva a substituição de antibióticos β-lactâmicos (penicillinas, cefalosporinas, carbapenem e subfamílias monobactam) pelos de 5ª geração como a daptomicina associada a rifampicina, vancomicina, fluoroquinolonas ou sulfametoxazol-trimetoprima (TMP-SMX). Conclusão: O presente estudo revelou a importância de revisar os mecanismos terapêuticos sobre a osteomielite aguda, visto que é considerada uma doença com elevado risco de reincidência e evoluir para o quadro crônico através de contaminações por microorganismos multirresistentes ao esquema terapêutico das drogas usuais.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88055208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inbound marketing and e-commerce on user experience in Algeria","authors":"","doi":"10.37118/ijdr.26963.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26963.07.2023","url":null,"abstract":"In today's digital age, businesses have undergone a profound transformation with the advent of digital technologies and marketing strategies. Digital transformation encompasses the integration of digital tools and technologies across all areas of a business, leading to fundamental changes in its operations, value delivery, and customer engagement. Simultaneously, digital marketing involves utilizing online platforms, including websites, social media, and online advertising, to promote products or services and expand the reach to a broader audience. The synergy between digital transformation and digital marketing enables businesses to adapt to the ever-evolving digital landscape, enhance customer experiences, streamline processes, and gain a competitive edge in a digitally interconnected world. This article aims to explore the significance of inbound marketing and e-commerce in shaping the user experience in the digital age. Through quantitative research involving a questionnaire, the study identifies key elements of inbound marketing, such as personalized content, targeted advertising, and user segmentation. These elements have a substantial impact on user experience satisfaction, engagement, and loyalty within the e-commerce context, particularly among Algerian consumers.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76666629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving hots literacy using the pjbl model with learner worksheets-based guided inquiry on reaction rate materials","authors":"","doi":"10.37118/ijdr.26961.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26961.07.2023","url":null,"abstract":"The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87265500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buddha and nature as depicted in Aśvaghoṣa’s buddhacarita","authors":"","doi":"10.37118/ijdr.26906.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26906.07.2023","url":null,"abstract":"This paper emphasizes the deep interdependence of nature and the Buddha as depicted in Buddhacarita of Aśvaghoṣa Bodhisattva. The text contends that the Buddha was inextricably linked with the natural world throughout his life. Nature is the Buddha's ally in the path to enlightenment, cultivating a deep regard for nature's extraordinary beauty and diversity. The accounts of the Buddha's life in Buddhacarita are difficult to divide between stories, facts, and myths. Many plants, flowers, animals, and trees are linked to Buddha's life story. Animals affected the Buddha's yearning for Nibbāna; observing the suffering of both mankind and animals motivated him to seek enlightenment. Furthermore, the Buddha's relationship with natural events is portrayed as one of the Buddha's vast and amazing traits. This paper employs the literary analysis method on three well-known English translations. The first is The Buddhacarita, or Acts of the Buddha, which E.H. Johnson translated from Sanskrit and augmented with the Tibetan version. The second is E.B. Cowell's translation from Sanskrit titled The Buddhacarita of Aśvaghoṣa. The last is Samuel Beal's translation from Chinese of The Fo-Sho-Hing-Tsan-King. According to the findings, Buddha's life is a remarkable example of the close relationship between humans and nature. It serves as a reminder that human and nonhuman ecosystems are intrinsically linked and intertwined.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89047000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the evolutionary relationships and impact of metacaspase proteins in harmful algal blooms in the uae waters","authors":"","doi":"10.37118/ijdr.26971.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26971.07.2023","url":null,"abstract":"Harmful algal blooms (HABs) pose significant threats to aquatic ecosystems, human health, and coastal economies worldwide. The causative agents of HABs are primarily dinoflagellates Marglefidiniumpolykrikoides and Prorocentrum minimum), and diatoms (Chaetocerostenuissimus, Fragilaria radians, Phaeodactylumtricornutum, and Skeletonemamarinoi), which produce various toxins that exacerbate the harmful effects. Metacaspase, a toxin-producing protein, has emerged as a critical component in the pathogenesis of HABs. This study aims to investigate the evolutionary relationships among diatoms and dinoflagellates based on the metacaspase protein. The analysis based on sequence clustering, indicates that the dinoflagellates anddiatoms share common ancestors where Marglefidiniumpolykrikoides and Prorocentrum minimum are evolutionarily closer to diatom Skeletonemamarinoi. This study prepares the base to further explore their involvement in HABs, elucidate the production of metacaspase by specific diatom and dinoflagellate species, and investigate the role of metacaspase in the toxicity of HABs.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88530836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of body weight on peak expiratory flow rate (pefr) among the adolescent rural school children, an observational study","authors":"","doi":"10.37118/ijdr.26872.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26872.07.2023","url":null,"abstract":"Background: The increasing prevalence of childhood obesity in developing countries is a growing public health concern. Obesity has been linked to pulmonary dysfunction, including reduced peak expiratory flow rate (PEFR). This study aimed to investigate the effect of body weight on PEFR among rural adolescent school children. Methods: A cross-sectional observational study was conducted in schools located in and around Nagamangala Taluk, with a study duration of 18 months. The sample size was determined using a formula based on the prevalence of obesity in school-going children. Anthropometric measurements, including height, weight, waist circumference (WC), and waist-to-height ratio (WHtR), were recorded. PEFR was measured using a peak flow meter. Statistical analysis, including correlation coefficient, t-test, and linear regression analysis, was performed using SPSS version 26. Results: The study included 573 rural adolescent school children, with a majority aged between 13 and 15 years and a higher proportion of female participants. The prevalence of overweight based on WHtR was 29.7%. There was no significant difference in mean age between overweight and normal WHtR groups. However, a higher prevalence of overweight was observed among boys compared to girls. Higher consumption of sweets, soft drinks, and fast food was significantly associated with overweight, while a higher frequency of exercise showed an inverse association. Longer duration of TV viewing was also associated with overweight. Overweight children had a significantly higher mean BMI and lower mean PEFR compared to children with a normal WHtR. There was a significant inverse correlation between PEFR and both BMI and WHtR. Conclusion: The present study observed a significant inverse correlation between PEFR and both BMI and WHtR. The study findings support the negative impact of excess body weight on lung function, as evidenced by reduced PEFR among overweight rural adolescent school children. The results emphasize the need for interventions to address childhood obesity and promote healthy lifestyle behaviors. Awareness among healthcare professionals, parents, and educators is crucial for early detection and management of pulmonary dysfunction associated with excess body weight in children.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"s3-29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90819250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correspondence between emptiness, dependent origination, and Nirvāna in early Buddhist Literature","authors":"","doi":"10.37118/ijdr.26960.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26960.07.2023","url":null,"abstract":"The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74035247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution des filets sociaux à l'amélioration des conditions de vie des ménages dans la province du zondoma","authors":"","doi":"10.37118/ijdr.26921.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26921.07.2023","url":null,"abstract":"The aim of this research was to measure the contribution of the social safety net project to the improvement of household living conditions and the development of early childhood in the province of Zondoma from 2015 to 2019. The methodological approach used is is based on field surveys with a dynamic and interactive approach that involved beneficiaries, resource persons and project managers. The results show that the Social Safety Nets project has positive effects on the economic and social level within the beneficiary community and more particularly on the beneficiary families, despite some difficulties observed in its implementation. For better consideration of early childhood in Burkinabe households with a view to breaking the intergenerational transmission of poverty, advocacy should be developed to increase funding for social protection, in order to reach all poor and vulnerable households ; set up a unified social register highlighting poor and vulnerables households with young children; coordinate the different approaches to social protection; strengthen support for beneficiaries despite degraded security conditions; and sustain the achievements through the provision of community relays after the closure of the project.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86934801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A licensing plan for coupling nuclear–renewable hybrid energy systems","authors":"","doi":"10.37118/ijdr.26914.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26914.07.2023","url":null,"abstract":"South Africa committed to reducing greenhouse gas emissions by 34% below \"Business As Usual\" levels by 2020 and 42% by 2025 at the Copenhagen climate change conference. However, global energy demand was projected to rise due to population and industrial growth, with energy usage expected to increase by 13% through 2040. In South Africa, a steady increase in electricity demand prompted the government to implement a new growth path (NGP), which prioritized job creation in all economic policies, including energy. To address the growing energy demand, an alternative energy source for combined heat and power was necessary, particularly for synthetic fuel production. The coupling of a high temperature reactor (HTR) with a chemical process plant could improve carbon and thermal efficiency, as seen in international organizations like the ARCHER (Advanced High-Temperature Reactors for Cogeneration of Heat and Electricity R&D) project. HTRs are still in their conceptual stages andaresuitable candidate forcouplingto an energy-intensiveindustrythat require process heat with sufficiently hightemperatures,with potential uses for NRHES (Nuclear-Renewable Hybrid Energy Systems). The South African team aimed to model the SASOL process, assess its financial viability, and develop a licensing plan.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"38 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90214186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and coping strategies in the Covid-19 pandemic: Comparison analysis between middle-aged and eldery people","authors":"","doi":"10.37118/ijdr.26908.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26908.07.2023","url":null,"abstract":"The emergence of the coronavirus disease (COVID-19) has triggered a global public health crisis and posed an unprecedented threat to mental health worldwide. The aim of this study was to compare quality of life variables and coping strategies during the COVID-19 pandemic between two different age groups: middle-aged people and elderly people. Descriptive and comparative studies were carried out. The study has a quantitative, correlational and cross-sectional design. The sample was for convenience and not probabilistic. 311 people aged over 40 years were interviewed. The following evaluation instruments were used: socio-demographic data, EUROHIS- QOL and the Coping Strategies Inventory. For the comparative study of means, the Mann-Whitney U test was used, with a significance level ≤. 0.05. For the statistical study, IBM-SPSS, v. 28.0. A statistically significant relationship (p<0.001) was identified with respect to the variable satisfaction with personal relationships during the pandemic, being higher among the group of elderly people. Coping strategies were more used by the middle-aged group (p=0.050). Coping strategies: thought that the situation happened because of others (p=0.031), complained or vented to someone (p<0.001), showed hostility (p=0.018), drank and ate excessively to compensate or to forget what was happening (p<0.001), shouting and swearing (p<0.001) were more used by middle-aged people. The strategy trusted in God or in some higher being or force was more used by elderly participants (p=0.012). The expression of negative emotions was more used by the middle-aged group (p<0.001) and the inhibition of emotions as well (p=0.002). The results highlight the resilience of older adults during the COVID-19 pandemic and provide additional insight into the influence of pandemic-related stressors on age-related psychosocial functioning.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75746992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}