International Journal of Chemical Kinetics最新文献

{"title":"Solvent-Induced Modulation of Protease Catalysis: Kinetic and Thermodynamic Correlations With Polarity, Dielectric Constant and Solvatochromic Parameters","authors":"Yonca Duman,&nbsp;Altan Erarslan","doi":"10.1002/kin.70050","DOIUrl":"https://doi.org/10.1002/kin.70050","url":null,"abstract":"<div>\u0000 \u0000 <p>We report a systematic investigation of solvent-induced modulation of <i>Bacillus clausii</i> protease catalysis, focusing on correlations between kinetic and thermodynamic parameters and solvent descriptors (log <i>P</i>, dielectric constant, π*, β, ETN). Our findings demonstrate that the effect of DMSO on protease catalysis exhibited a dual behavior, with activity enhancement observed at lower solvent concentrations (up to 20% v/v), as revealed by activity measurements, while kinetic analyses performed at higher DMSO concentrations (≥30% v/v) indicated simple uncompetitive inhibition, as evidenced by Lineweaver–Burk and secondary plot analyses. Activation free energies (ΔG^#) and catalytic efficiencies were quantitatively correlated with solvatochromic scales, identifying π* as the most relevant descriptor under activating conditions. These results advance molecular-level understanding of enzyme behavior in nonconventional media and provide practical guidelines for solvent selection in chemo-enzymatic catalysis. Solvent polarity, assessed via log <i>P</i> values, revealed a direct correlation with enzyme activity, where solvents with log <i>P</i> between 1.5 and 3.0 favored higher catalytic efficiency. Dielectric constants influenced electrostatic interactions, with optimal enzyme performance observed in solvents possessing dielectric constants around 20. Solvatochromic parameters further illustrated how hydrogen-bond donor and acceptor properties modulate the enzyme's active site configuration, thereby affecting catalytic outcomes. These findings suggest that solvent environments play a critical role in shaping both kinetic and thermodynamic profiles of <i>Bacillus clausii</i> protease, offering insights for optimizing biocatalytic processes in nonaqueous media.</p>\u0000 <p>To our knowledge, this is the first study to systematically correlate kinetic and thermodynamic parameters with these solvent descriptors in protease catalysis. The findings provide fundamental insights for biotechnological applications involving enzyme-solvent interactions, paving the way for rational solvent selection in industrial biocatalysis.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"383-395"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148085857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atmospheric Chemistry of CFH2CH2CH2CFH2: Kinetics and Mechanism of Reactions With Cl Atoms and OH Radicals","authors":"Ellen R. Kjaergaard,&nbsp;Elena Jiménez,&nbsp;Connor Blair,&nbsp;Ole J. Nielsen,&nbsp;Mads P. Sulbaek Andersen","doi":"10.1002/kin.70052","DOIUrl":"https://doi.org/10.1002/kin.70052","url":null,"abstract":"<p>The atmospheric chemistry of 1,4-difluorobutane (CFH₂CH₂CH₂CFH₂) was investigated through a kinetic and mechanistic study of the reaction with chlorine (Cl) atoms and hydroxyl (OH) radicals. Using Fourier transform infrared (FTIR) spectroscopy and relative rate methods, the rate constants (<i>k</i>) for the reactions were determined at 298  ±  2 K as <i>k</i>(Cl + CFH₂CH₂CH₂CFH₂) = (2.96 ± 0.31) × 10⁻¹¹ cm³ molecule⁻¹ s⁻¹ and <i>k</i>(OH + CFH₂CH₂CH₂CFH₂) = (8.23 ± 0.77) × 10⁻¹³ cm³ molecule⁻¹ s⁻¹. The major product formed in both reactions was HC(O)F. Additional primary and secondary products were observed, and a proposed degradation mechanism is presented. The atmospheric lifetime of 1,4-difluorobutane with respect to reaction with OH radicals was determined to be 29 days. The IR spectrum of 1,4-difluorobutane was obtained using FTIR at Copenhagen Center for Atmospheric Research (CCAR) and at University of Castilla–La Mancha (UCLM). From these measurements, the radiative efficiency of CFH₂CH₂CH₂CFH₂ was calculated resulting in a lifetime-adjusted effective radiative efficiency of 0.015 W m⁻² ppb⁻¹. The Global Warming Potential (GWP) values for CFH₂CH₂CH₂CFH₂ were determined to 3.1, 0.9, and 0.3 for time horizons of 20, 100, and 500 years, respectively.</p>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"396-406"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/kin.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148090539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Nitric Acid From Liquid Effluent by the Solvent Extraction Method: Effect of Different Operating Parameters, Kinetic and Thermodynamic Study","authors":"Naima Habache,&nbsp;Ouahiba Bechiri","doi":"10.1002/kin.70047","DOIUrl":"https://doi.org/10.1002/kin.70047","url":null,"abstract":"<div>\u0000 \u0000 <p>This investigation focuses on the liquid-liquid extraction of nitric acid utilizing various organic solvents, specifically dichloroethane, dichloromethane, and trichloroethylene. The study comprehensively evaluated the impact of several operational parameters, such as solvent concentration, contact time, nitric acid concentration, settling time, the ratio of the organic to aqueous phase (V_O/V_a), stirring speed, and temperature on the extraction efficiency. Additionally, thermodynamic and kinetic studies were conducted to gain a deeper insight into the processes involved. The thermodynamic results indicate static system stability, characterized by low, negative ΔS values, suggesting that the organic phase system has achieved equilibrium. Kinetic findings reveal that the extraction rate is predominantly controlled by diffusion through the liquid film.</p>\u0000 <p>(ΔS° ranging from approximately −12 to −45 J.mol¹⁻.K ¹⁻depending on the solvent)</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"323-333"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148070157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Low-Concentration Methylene Blue From Water by Lignite-Loaded Humic Acid-Coated Nano Ferric Oxide","authors":"Lizhuang Dai,&nbsp;Yaodong Liang,&nbsp;Yongjun He","doi":"10.1002/kin.70056","DOIUrl":"https://doi.org/10.1002/kin.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>The composite material prepared in this study effectively removes low-concentration methylene blue (MB) from dye wastewater through immobilization of humic acid (HA)-coated Fe₃O₄ nanoparticles onto lignite substrates. Under controlled experimental conditions, systematic investigation was conducted to examine the adsorption behavior of this composite material toward low-concentration MB solutions. Under the optimized experimental conditions (MB concentration of 20 mg L⁻¹, pH = 7, and temperature of 298K), the maximum adsorption capacity reached 23.58 mg g⁻¹. The materials were comprehensively characterized using infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). The experimental data fitted well with the pseudo-second-order kinetic model and the Freundlich isothermal model. Thermodynamic analysis confirmed the spontaneity and endothermic nature of the adsorption process, with chemical adsorption being identified as the main mechanism. The study found that the adsorption process is regulated by cooperative effects, including electrostatic attraction, metal complexation, hydrogen bonds, and π-π stacking. After five consecutive regeneration cycles were completed, the initial adsorption efficiency stayed at 85.97%, which indicated that the material had excellent regeneration capability and significant potential for practical applications in wastewater treatment.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"432-443"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of Diethyl Oxalate Hydrogenation Over Cu/SiO2 Catalyst: Influence of Nickel as a Promoter","authors":"Nikhil K. Gor,&nbsp;Unnikrishnan P.,&nbsp;Praveen Kumar Chinthala,&nbsp;Asit Das,&nbsp;Prakash D. Vaidya","doi":"10.1002/kin.70054","DOIUrl":"https://doi.org/10.1002/kin.70054","url":null,"abstract":"<div>\u0000 \u0000 <p>The hydrogenation of diethyl oxalate (DEO) to monoethylene glycol (MEG) is an essential step toward developing an alternative MEG synthesis process that enables flexible utilization of carbon resources. Copper-based catalysts have been extensively studied for dimethyl oxalate (DMO) hydrogenation. However, their long-term stability remains a critical limitation, restricting their potential for industrial-scale application. The current study investigates nickel-promoted Cu/SiO₂ catalysts with optimized nickel content. The catalyst was prepared using the urea gel method and characterized by BET SA, XRD, TEM, and XPS to analyze its surface and chemical properties. At the optimal reaction conditions of 513 K, 2.5 MPa pressure, LHSV of 1 h⁻¹, and H₂/DEO ratio of 25 mol/mol, the time-on-stream study demonstrated 50 h of stable catalytic performance. Furthermore, the reaction kinetics were modeled using the power law and the Langmuir-Hinshelwood mechanism. Based on different conditions, 18 kinetic models were developed, and model discrimination and parameters were estimated. The results indicate that the reaction proceeds via the dissociative adsorption of DEO and H₂ on two different sites, with the surface reaction being the rate-controlling step.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"417-431"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role Metals of Second and 12th Group in the Oxidation of Ethylbenzene","authors":"Nikolai V. Ulitin,&nbsp;Ildar N. Zalyaliev,&nbsp;Nikolai A. Novikov,&nbsp;Yana L. Lyulinskaya,&nbsp;Konstantin A. Tereshchenko,&nbsp;Daria A. Shiyan,&nbsp;Natalia M. Nurullina,&nbsp;Svetlana N. Tuntseva,&nbsp;Tatyana L. Puchkova,&nbsp;Viktoriya I. Anisimova,&nbsp;Galina G. Elimanova,&nbsp;Kharlampii E. Kharlampidi","doi":"10.1002/kin.70049","DOIUrl":"https://doi.org/10.1002/kin.70049","url":null,"abstract":"<div>\u0000 \u0000 <p>A kinetic model of ethylbenzene oxidation by air oxygen in the presence of 2-ethylhexanoates of metals of the second and 12th groups (Mg, Ca, Sr, Ba, Zn, and Cd) as catalysts was constructed and parameterized using experimental data. Using the model, it is shown that: (1) in the range of 1–100 mmol/L, there exist initial concentrations of catalysts below which an increase in the initial catalyst concentration leads to an increase in the rate of ethylbenzene hydroperoxide formation in the oxidation of ethylbenzene (428 K, 1 atm, volume flow rate of air supply to the reactor of 0.018 m³/h, initial ethylbenzene concentration of 8.17 mol/L, initial concentrations of other species are 0), and above which it leads to a decrease (2-ethylhexanoates of Mg, Ca, and Zn) or a plateau (2-ethylhexanoates of Sr, Ba, and Cd); this is because the catalysts simultaneously accelerate the reactions of both formation and decomposition of ethylbenzene hydroperoxide, and starting from a certain initial catalyst concentration, the decomposition of ethylbenzene hydroperoxide begins to prevail over its formation; (2) the key reaction for the formation of ethylbenzene hydroperoxide and for ethylbenzene conversion in catalytic ethylbenzene oxidation, as in the non-catalytic process, is the reaction between ethylbenzene and the peroxyl radical of ethylbenzene; the key reactions governing selectivity are the formation of methylphenylcarbinol and acetophenone from oxyl and peroxyl radicals of ethylbenzene; the role of the catalyst is to increase the concentrations of these radicals through the decomposition reactions of the intermediate adduct “ethylbenzene hydroperoxide + catalyst”; (3) Mg, Ca, Sr, Cd 2-ethylhexanoates deactivate within 1 h of the ethylbenzene oxidation process, while Ba and Zn 2-ethylhexanoates deactivate within 4 h (428 K, 1 atm, volume flow rate of air supply to the reactor of 0.018 m³/h, initial ethylbenzene, ethylbenzene hydroperoxide, and catalyst concentrations of 8.163, 0.022, and 5 mmol/L, respectively, initial concentrations of other species are 0); therefore, these catalysts should not affect the subsequent transformations of ethylbenzene hydroperoxide during propylene epoxidation in the Halcon process.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"344-362"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148072691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Outer-Sphere Electron Transfer in Cobalt(III) Metallo-Surfactants Using Ionic Liquids and Lipid Vesicles","authors":"Karuppiah Nagaraj,&nbsp;Gunasekaran Velmurugan,&nbsp;Sivaranjani Paramasivam,&nbsp;Kamel Hessini,&nbsp;Mumtaj Shah","doi":"10.1002/kin.70039","DOIUrl":"https://doi.org/10.1002/kin.70039","url":null,"abstract":"<div>\u0000 \u0000 <p>This research examines the impact of the ionic liquid 1-butyl-3-methylimidazolium bromide ([Bmim]Br) and DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) vesicles on the kinetics of outer-sphere electron transfer (OSET) inside cobalt(III) metallo-surfactant systems. The systems studied were 1 <i>cis</i>-[Co(A1)₂(A)₂](ClO₄)₃, 2 <i>cis</i>-[Co(A2)₂(A)₂](ClO₄)₃, and 3 <i>cis</i>-[Co(A3)₂(A)₂](ClO₄)₃, (where A1 = imidazo[4,5-f][1,10]phenanthroline, A2 = dipyrido[3,2-d:2′-3′-f]quinoxaline, A3 = dipyrido[3,2-a:2′,4′-c]phenazine, and A = Dodecylamine) alongside [Fe(CN)₆]⁴⁻ ions. Kinetic data conducted across various concentrations of DPPC and [Bmim]Br, as well as different temperatures, validate a second-order OSET mechanism. The electron-transfer rate constants rise in direct correlation with [Bmim]Br concentration, indicating the influence of ionic liquid-induced microenvironmental effects. Conversely, DPPC vesicles impede the reaction below their phase transition temperature due to limited reactant mobility, whereas they accelerate the rate beyond the transition due to enhanced membrane fluidity and advantageous reactant arrangement. Activation parameters obtained from OSET theory indicate negative ΔS^‡ values, signifying a more ordered transition state. The results illustrate how ionic liquids (ILs) and lipid assemblies can affect electron-transfer kinetics via regulated self-aggregation, hydrophobic interactions, and reactant placement. The results provide insights for the rational design of metallo-surfactant systems in catalysis, biomimetic redox processes, and soft-matter electrochemistry, supporting SDG goals through advances in sustainable electron-transfer control.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 7","pages":"363-370"},"PeriodicalIF":1.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148076791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148095258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Green and QbD-Optimized Rp-Hplc Method for Simultaneous Estimation of Linagliptin and Dapagliflozin","authors":"Sourabh Satapathy,&nbsp;Kuladip barman,&nbsp;Shivam Kumar,&nbsp;Neha Singh,&nbsp;Balak Das Kurmi,&nbsp;Preeti Patel","doi":"10.1002/kin.70032","DOIUrl":"https://doi.org/10.1002/kin.70032","url":null,"abstract":"<div>\u0000 \u0000 <p>The present study focuses on the development and optimization of a robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of linagliptin and dapagliflozin in bulk and tablet dosage forms. A Quality by Design (QbD) approach was employed using the Box-Behnken design to systematically optimize critical chromatographic parameters, ensuring efficient separation with high sensitivity and reproducibility. The optimized conditions utilized a mobile phase of methanol: acetonitrile: buffer: triethylamine (80:10:10:0.1 v/v/v/v), with a pH adjusted to 5.0 using orthophosphoric acid and a flow rate of 1.0 mL/min. The method demonstrated excellent linearity (r² &gt; 0.998), precision (%RSD &lt; 2), and accuracy (98.9%–100.5%), complying with ICH guidelines. Additionally, a greenness evaluation was conducted using the AGREE analytical greenness metric tool, giving a score of 0.68, indicating an environmentally sustainable analytical approach. The developed method is rapid, reliable, and suitable for routine quality control analysis of linagliptin and dapagliflozin in pharmaceutical formulations.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 5","pages":"179-190"},"PeriodicalIF":1.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic Study of the Effect of C6H5-COONa as Corrosion Inhibitor on Concrete Properties","authors":"Latefa Sail,&nbsp;Bachir Boudjema","doi":"10.1002/kin.70037","DOIUrl":"https://doi.org/10.1002/kin.70037","url":null,"abstract":"<div>\u0000 \u0000 <p>This study tends to examine the use of sodium benzoate “C₆H₅-COONa” as a corrosion inhibitor added to the mixing water of concrete contaminated by chlorides, and test the mechanical performances of five types of concrete samples over several time periods, 7, 28, 56, and 90 days, in the absence and in the presence of limestone fillers and superplasticizing. Hence, the results confirm that the addition of “C₆H₅-COONa” increases the compressive resistance by 11.75%, 0.42%, 14.66%, and 20.63% comparing with the reference sample for the cited time periods, respectively. Also, the integration of limestone and superplasticizing significantly improves this resistance by 31.64%, 12.06%, 22.92%, and 21.88% respectively for 7, 28, 56, and 90 days. Tests were carried out on cement paste after the addition of sodium benzoate, results show that the start and the end setting time of cement shift out by 15.15% and 9.67% compared with reference cement. More than, after the addition of sodium benzoate and limestone fillers, the results indicate an increase in these parameters by 8.25% and 6.39% compared with reference cement, which indicates that sodium benzoate delays the start and end setting time of cement. In addition, Abrams cone slump tests were performed on fresh concrete for the different compositions in the absence and presence of superplasticizing “ORAFLOW THM 17200”. These results confirm that the addition of sodium benzoate to concrete does not negatively affect its properties in fresh or hard state, and then it can be used as a corrosion inhibitor for its reinforcements.</p>\u0000 </div>","PeriodicalId":13894,"journal":{"name":"International Journal of Chemical Kinetics","volume":"58 5","pages":"219-229"},"PeriodicalIF":1.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}