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International journal of biochemistry and molecular biology最新文献

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in vitro screening the antibacterial activity of four whole body eusocial insects extracted by polar solvents 对极性溶剂提取的四种全社会性昆虫体外抗菌活性进行了筛选
International journal of biochemistry and molecular biology Pub Date : 2021-01-01 DOI: 10.33545/26646501.2021.v3.i1a.21
A. Mekhlif
{"title":"in vitro screening the antibacterial activity of four whole body eusocial insects extracted by polar solvents","authors":"A. Mekhlif","doi":"10.33545/26646501.2021.v3.i1a.21","DOIUrl":"https://doi.org/10.33545/26646501.2021.v3.i1a.21","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83103690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel antibody against TMX2 and its effects on breast cancer cells. 新的抗TMX2抗体及其对乳腺癌细胞的影响。
International journal of biochemistry and molecular biology Pub Date : 2020-02-15 eCollection Date: 2020-01-01
Eleana Hatzidaki, Dimitrios A Ntanovasilis, Ioannis Papasotiriou
{"title":"Novel antibody against TMX2 and its effects on breast cancer cells.","authors":"Eleana Hatzidaki,&nbsp;Dimitrios A Ntanovasilis,&nbsp;Ioannis Papasotiriou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although monoclonal antibodies are promising, a truly fully human antibody is yet to be produced. Current human antibodies have the human sequence, but are produced in either transgenic animals or in phages. The aim of this paper was to produce a truly human antibody directed against an epitope of our choice, secreted by human plasma cells. The target protein was TMX2 one of the least studied disulfide isomerases. IgG and anti-TMX2 antibody were determined by both Elisa and western blot. TMX2 KD was evaluated by Surface Plasmon Resonance. TMX2 localization was determined by flow cytometry in MCF-7 cells. Efficiency was evaluated by MTT. Gene expression was evaluated by PCR. We have managed to produce two fully human antibodies directed against TMX2 protein. TMX2 protein was found both in the cytoplasm and cell membrane of breast cancer cells. RGCC TMX2 antibody recognizing an extracellular epitope increased cell proliferation. RGCC TMX2 antibody recognizing an intracellular epitope decreased cell proliferation and gene expression related to cancer survival, differentiation and metastasis. These findings suggest this platform is very promising for novel personalized therapies. TMX2 could be a novel target for cancer treatment.</p>","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"11 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076318/pdf/ijbmb0011-0001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37771148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ABO and WCM biotypology: The secret of the holobiont ABO和WCM生物类型学:全息生物的秘密
International journal of biochemistry and molecular biology Pub Date : 2020-01-01 DOI: 10.33545/26646501.2020.v2.i1a.17
M. Menapace
{"title":"ABO and WCM biotypology: The secret of the holobiont","authors":"M. Menapace","doi":"10.33545/26646501.2020.v2.i1a.17","DOIUrl":"https://doi.org/10.33545/26646501.2020.v2.i1a.17","url":null,"abstract":"It has always been thought that we are just plain old human beings being composed of mere human eukaryotic cells and occasionally attacked by viruses and bacteria. But this vision is plainly wrong. We now know that we are a coherent mix of all kinds of life, running from unicellular microorganisms to pluricellular organisms, which form part and parcel of what can be called human being. We are “holobionts” and as such the multiplicity of cells and viruses belonging to all kingdoms of life collaborate in an equilibrium that if perturbed can cause disease. The ancient medicines (including Western Constitutional Medicine [WCM]) adopted this way of thinking and the ancient observers sagely imprinted their medicinal systems with this holistic view of life for which disease has to be contrasted with a return to equilibrium. And the ancient medicines used as primary tool the correction of the diet seen as the restoration of the equilibrium between the energies (microorganisms) in the body. More recently a new medicinal system the ABO groups has taken a stronger stand in the scientific arena through the experimental confirmation of its main mechanism of action by glycosciences (especially glycobiology). Necessarily, bacteria, fungi and other unicellular organisms can feed off on glycans which are both produced and absorbed by the human body (diet) and the suitable balance of diet will interfere in this cycle. It is now the time to capture all these advances in ancient and modern medicine and fuse them into a new medicinal system, the ABO-WCM biotypology, to better explain the reality of the holobiont and to completely transform modern science into a truly personalized approach.","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78891625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of N-benzyl-9-(2-tetrahydropyranyl) and indole-3-acetic acid in vitro culture of Butea buteiformis Voigt n -苄基-9-(2-四氢吡喃基)和吲哚-3-乙酸对丁茶离体培养的影响
International journal of biochemistry and molecular biology Pub Date : 2020-01-01 DOI: 10.33545/26646501.2020.v2.i1a.16
Belai Meeta Suwal Singh
{"title":"Effects of N-benzyl-9-(2-tetrahydropyranyl) and indole-3-acetic acid in vitro culture of Butea buteiformis Voigt","authors":"Belai Meeta Suwal Singh","doi":"10.33545/26646501.2020.v2.i1a.16","DOIUrl":"https://doi.org/10.33545/26646501.2020.v2.i1a.16","url":null,"abstract":"Butea buteiformis is a valuable tree with large trifoliate leaves with beautiful flower (Fig.1). It is distributed in tropical and subtropical region of Nepal. The seeds are bitter in taste and used for an anthelmintic. The plant possesses importance in agroforestry due to their nitrogen fixing capability. Plants are used for reforestration mostly on slope areas. The seeds were surface sterilized and cultured on half strength Murashige and Skoog (1962) (MS) medium. Nodal explants obtained from cultured were subcultured on different concentrations of N-Benzyl-9-(2-tetrahydropyranyl) (BPA) and Indole-3-acetic acid (IAA). The best proliferation of nodes and shoots were observed on the MS medium supplemented with 0.5 μM BPA and 0.5 μM IAA. After 8 weeks of culture the propagated plants were acclimatized and transferred to the sand box containing 1:1 soil and sand. Well rooted plants were then established in the field. All the data collected were worked out statistically with SPSS, a system of analytical procedure.","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86675864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies of heavy metal content in dates, grapes, pineapple, rambutan, apple, banana and mango as fruit pollutant 红枣、葡萄、菠萝、红毛丹、苹果、香蕉、芒果等水果污染物重金属含量的研究
International journal of biochemistry and molecular biology Pub Date : 2020-01-01 DOI: 10.33545/26646501.2020.v2.i1a.14
A. Hossain
{"title":"Studies of heavy metal content in dates, grapes, pineapple, rambutan, apple, banana and mango as fruit pollutant","authors":"A. Hossain","doi":"10.33545/26646501.2020.v2.i1a.14","DOIUrl":"https://doi.org/10.33545/26646501.2020.v2.i1a.14","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88848856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Root, shoot and callus cell proliferation from broccoli root tip, shoot tip and leaf cutting in vitro 西兰花根尖、茎尖和离体切叶的根、茎和愈伤组织细胞增殖
International journal of biochemistry and molecular biology Pub Date : 2020-01-01 DOI: 10.33545/26646501.2020.v2.i1a.13
A. Hossain, M. M. Uddin
{"title":"Root, shoot and callus cell proliferation from broccoli root tip, shoot tip and leaf cutting in vitro","authors":"A. Hossain, M. M. Uddin","doi":"10.33545/26646501.2020.v2.i1a.13","DOIUrl":"https://doi.org/10.33545/26646501.2020.v2.i1a.13","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87471306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefits of camellia sinensis 山茶的好处
International journal of biochemistry and molecular biology Pub Date : 2019-07-01 DOI: 10.33545/26646501.2019.v1.i2a.11
Ashikujaman Syed
{"title":"Benefits of camellia sinensis","authors":"Ashikujaman Syed","doi":"10.33545/26646501.2019.v1.i2a.11","DOIUrl":"https://doi.org/10.33545/26646501.2019.v1.i2a.11","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78051313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
in vitro callus induction of safflower (Carthimus tinctorius L.) 红花离体愈伤组织诱导的研究
International journal of biochemistry and molecular biology Pub Date : 2019-07-01 DOI: 10.33545/26646501.2019.v1.i2a.8
NS Pawar, B. Rathod, P. K. Majhi, VE Gotamwad
{"title":"in vitro callus induction of safflower (Carthimus tinctorius L.)","authors":"NS Pawar, B. Rathod, P. K. Majhi, VE Gotamwad","doi":"10.33545/26646501.2019.v1.i2a.8","DOIUrl":"https://doi.org/10.33545/26646501.2019.v1.i2a.8","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79585188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitory effect of leaf and root bark of Calotropis procera and Parquetina nigrescens on larval midgut enzyme activities of Callosobruchus maculatus 牛角参叶、根皮和黑皮对斑点胼胝体幼虫中肠酶活性的抑制作用
International journal of biochemistry and molecular biology Pub Date : 2019-07-01 DOI: 10.33545/26646501.2019.v1.i2a.5
Alamuoye Nathaniel Olu
{"title":"Inhibitory effect of leaf and root bark of Calotropis procera and Parquetina nigrescens on larval midgut enzyme activities of Callosobruchus maculatus","authors":"Alamuoye Nathaniel Olu","doi":"10.33545/26646501.2019.v1.i2a.5","DOIUrl":"https://doi.org/10.33545/26646501.2019.v1.i2a.5","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74213545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization of hormones as cell signaling component, its mechanism and regulated protein and gene expression 激素作为细胞信号传导成分的利用及其机制及调控的蛋白和基因表达
International journal of biochemistry and molecular biology Pub Date : 2019-07-01 DOI: 10.33545/26646501.2019.v1.i2a.7
A. Hossain, M. M. Uddin
{"title":"Utilization of hormones as cell signaling component, its mechanism and regulated protein and gene expression","authors":"A. Hossain, M. M. Uddin","doi":"10.33545/26646501.2019.v1.i2a.7","DOIUrl":"https://doi.org/10.33545/26646501.2019.v1.i2a.7","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74485502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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