International Journal of Advances in Medicine最新文献_第4页

Study of age, sex and body mass index wise variation in C-peptide level among urban population of Northern part of Bihar 比哈尔邦北部城市人口 C 肽水平的年龄、性别和体重指数变化研究

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233885

Rajeev Kumar, Indu Priyadarshini, Alka Goyal, Swarnim Swarn, Sude Kumar Singh

{"title":"Study of age, sex and body mass index wise variation in C-peptide level among urban population of Northern part of Bihar","authors":"Rajeev Kumar, Indu Priyadarshini, Alka Goyal, Swarnim Swarn, Sude Kumar Singh","doi":"10.18203/2349-3933.ijam20233885","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233885","url":null,"abstract":"Background: Different factors regulate the insulin level in blood. Earlier C-peptide was considered as by product of insulin biosynthesis and its role in body seems to be negligible. C-peptide at low physiological concentrations mimics the effects of insulin. However, in the presence of elevated level of insulin concentrations concomitant raised level of C-peptide may blunt peripheral effects of insulin age. This study was carried out to verify the age, sex, and BMI wise variation in level of C-peptide among apparently healthy individual and its contribution in fine-tuning of the tissue’s metabolism under different physiological conditions. Methods: This is a prospective cross-sectional observational study. Estimation of serum c-peptide level was done by solid phase direct sandwich enzyme linked immunosorbent assay (ELISA) kit method. Glucose is estimated by Glucose oxidase peroxidase (GOD-POD) end point colorimetric method and HbA1C was estimated by ion exchange resin method (kit method). Result: Serum C-peptide level is significantly high in advance age and males in compared to younger age and females respectively. The mean level of serum C-peptide is higher in higher body mass index (BMI) group compared to lower, but this difference is statistically insignificant. Conclusions: In normal subjects, the level of C-peptide shows positive correlation with age and BMI. Males have higher level of C-peptide in comparison to females. Apart from these variation C-peptide contributes to different biological effects.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"134 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theruptor Novo, a novel wound dressing in the management of infected diabetic foot ulcer: two case reports 治疗感染性糖尿病足溃疡的新型伤口敷料 Theruptor Novo：两份病例报告

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233888

Subhash M. Kale

引用次数: 0

Good and rapid health promotion by curing diseases of various organs, using digital homeopathy 利用数字顺势疗法治疗各种器官的疾病，快速、良好地促进健康

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233889

Abhijit Biswas, Krishnan Ramasubramanian

{"title":"Good and rapid health promotion by curing diseases of various organs, using digital homeopathy","authors":"Abhijit Biswas, Krishnan Ramasubramanian","doi":"10.18203/2349-3933.ijam20233889","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233889","url":null,"abstract":"Health promotion methodology of evolved homeopathy is very useful to achieve near zero disease-levels in the various organs of a person’s body, only for those persons, who are health-conscious and want to continue sincerely with the preventive medicines of evolved homeopathy and digital homeopathy, and occasional GDV (Gas discharge visualization) check-up, as may be necessary. The methodology of evolved homeopathy utilizes medicines of digital homeopathy and evolved homeopathy for prevention and cure, according to the first fundamental-principle of cure (“Prevention is better than cure”). True “nipping in the bud” of any disease from a patient’s body is possible only when the treatment starts based not on a patient’s perception of symptom(s) but on a whole-body diagnostic chart generated by a sophisticated device like the GDV scanner. Based on the experience of the persons who are utilizing the side-effect free preventive and curative medicines of evolved-homeopathy and digital homeopathy for preventing and curing problems of various organs to achieve near zero disease-level, it is clear that the methodology of evolved-homeopathy and digital homeopathy for health promotion, is very effective. It seems evident that for the sincere followers of the three fundamental-principles of cure as detailed below, health promotion methodology of evolved homeopathy and digital homeopathy, is very beneficial. When the condition of near zero disease-levels in the various organs of a person’s body, is achieved, about 20 years age-reduction is felt along with improvement of physical and mental stamina.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-life depression: assessment of validity and performance of depression scales in patients attending outpatient clinic at the institute of mental health 晚年抑郁症：心理健康研究所门诊患者抑郁量表有效性和表现评估

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233883

S. Malini, C. Jayakrishnaveni, Saravanakumar Palaniappan

{"title":"Late-life depression: assessment of validity and performance of depression scales in patients attending outpatient clinic at the institute of mental health","authors":"S. Malini, C. Jayakrishnaveni, Saravanakumar Palaniappan","doi":"10.18203/2349-3933.ijam20233883","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233883","url":null,"abstract":"Background: Ageing and depression often coexist, with older individuals experiencing increased depressive symptoms. Factors include substance use, diabetes, cardiovascular disease, and rural elderly populations. This study aimed to assess the validity and performance of depression scales for late-life depression among patients attending the outpatient clinic at the Institute of Mental Health, Chennai. Methods: This prospective study was conducted on 358 patients aged >50 years who reported to the OPD and were diagnosed with depression at the institute of mental health, Chennai. Baseline assessments were done at the time of recruitment into the study, and assessments were done (visit 1) for depression as in assessment tools. Scheduled visits were performed every six months for two years (visits 2-5). Adverse events were monitored and recorded periodically. Results: The study found a significant positive correlation between CSDD, MADRS, and PHQ9 scores with HAMD, MADRS, and GDS. The HAMD had a higher correlation with all depression scales except the Geriatric Depression Scale (GDS). The GDS had a distinct dimensionality and varied items, while MADRS showed a good correlation with all depression scales except GDS. The PHQ9 and MADRS are more valid and accurate among the participants, with higher accuracy, sensitivity, and specificity values. After these two scales, the HAMD was better with higher values than all the other scales. Conclusions: Various depression scales were found to have a strong correlation with each other in measuring late-life depression at a tertiary care psychiatric institution.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between glycated hemoglobin and blood glucose levels in fasting and two hours after 75 g oral glucose in gestational diabetes mellitus 妊娠糖尿病患者空腹和口服 75 克葡萄糖两小时后糖化血红蛋白与血糖水平的关系

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233884

A. Jadhao, S. G. Vengurlekar, M. P. Shah, S. S. Pathare

{"title":"Relationship between glycated hemoglobin and blood glucose levels in fasting and two hours after 75 g oral glucose in gestational diabetes mellitus","authors":"A. Jadhao, S. G. Vengurlekar, M. P. Shah, S. S. Pathare","doi":"10.18203/2349-3933.ijam20233884","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233884","url":null,"abstract":"Background: Oral glucose tolerance test (OGTT) performed at 24-28 weeks gestation is the current recommended method to the diagnosis of gestational diabetes mellitus (GDM). Many recent studies investigating glycated hemoglobin (HbA1c) in detecting GDM yield different results. There are no published data on HbA1c in the diagnosis of GDM in India. Methods: A cross-sectional study was carried out at T.N.M.C. Mumbai during the period from January to June 2021 to assess the reliability of HbA1c in the diagnosis of GDM. Results: We included 397 pregnant females. The age range of the patients was 18 to 35 years, with a mean of 24.57±11.10 years. The mean fasting blood glucose level was 129.73 mg/dl and the mean 2 hours after 75 g oral glucose level was 188.21 mg/dl. The difference between the two was statistically significant. The Spearman's correlation coefficient (r) between fasting blood glucose and HbA1c was 0.610 (p<0.05) and between postprandial blood glucose and HbA1c was 0.683 (p<0.05). Scatter plots of FBG and 2 hours after 75 g oral glucose with HbA1C shows a positive correlation. Conclusions: This study showed that 2 hours after 75 g oral glucose had a better correlation with HbA1c than fasting blood glucose level. In the absence of HbA1c facility or unreliable HbA1c report, postprandial blood glucose can be a surrogate marker of HbA1c for management and monitoring of gestational diabetes mellitus, but a larger study is needed to confirm this finding.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"48 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnostic value of systemic inflammatory response markers as predictors of epithelial ovarian cancer 预测上皮性卵巢癌的全身炎症反应标记物的诊断价值

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233882

J. Alegbeleye, T. Kasso

{"title":"The diagnostic value of systemic inflammatory response markers as predictors of epithelial ovarian cancer","authors":"J. Alegbeleye, T. Kasso","doi":"10.18203/2349-3933.ijam20233882","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233882","url":null,"abstract":"Background: Early detection of ovarian neoplasms confers a better outcome and prognosis for patients. Although newer diagnostic modalities have been recently developed, the availability and accessibility of complete blood count parameters make it a convenient and cost-effective marker for malignancy. Objectives were to evaluate the diagnostic accuracy of pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with late-stage epithelial ovarian malignancy at the University of Port Harcourt Teaching Hospital. Methods: A prospective analysis of fifty-seven women with histologic diagnosis of epithelial ovarian cancer who were managed at the University of Port Harcourt Teaching Hospital between January 1, 2018, and December 31, 2022, was conducted. A data collection form was used to obtain socio-demographic and clinico-pathological characteristics from the patients after informed consent was obtained. Pretreatment levels of NLR and PLR were determined from complete blood count. The Receiver Operating Characteristic (ROC) curve analysis was used to assess the predictive accuracy of the haematological parameters for late-stage epithelial ovarian cancer. Results: Higher values of NLR and PLR were significantly associated with the stage of ovarian cancer (p=0.001). The optimal cut-off points based on ROC curve analyses for NLR and PLR were found to be 2.6 (AUC=0.61, p>0.05), and 155.8 (AUC=0.62, p>0.05) respectively. However, none of the haematological parameters could be used as predictive markers for advanced-stage ovarian cancer in this study. Conclusions: Pretreatment NLR and PLR cannot be used as a stand-alone predictor of advanced ovarian cancer, and should be correlated with other clinical, laboratory and radiologic parameters.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and performance of cognitive scales in elderly patients with depression in a tertiary care hospital in Chennai 钦奈一家三级医院老年抑郁症患者认知量表的有效性和性能

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233886

S. Malini, C. Jayakrishnaveni, Saravanakumar Palaniappan

{"title":"Validity and performance of cognitive scales in elderly patients with depression in a tertiary care hospital in Chennai","authors":"S. Malini, C. Jayakrishnaveni, Saravanakumar Palaniappan","doi":"10.18203/2349-3933.ijam20233886","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233886","url":null,"abstract":"Background: Late-life depression in older adults can cause reversible cognitive impairment, often resulting in pseudo-dementia. Cognitive impairment can lead to executive dysfunction, reduced flexibility, and difficulty thinking and decision-making. This study aimed to assess the validity and performance of cognitive scales in late-life depression among patients attending the outpatient department of the institute of mental health, Chennai. Methods: This prospective study included 360 patients aged >50 years who were diagnosed with depression and attended the OPD at the institute of mental health, Chennai. Baseline assessments were performed at the time of recruitment into the study (visit 1), and scheduled visits were performed every six months for two years (visits 2 to 5). Unscheduled visits were done every month, and adverse events were monitored and recorded periodically Results: Among 59 patients, 53.1% were female, 32.2% were diabetic, and 93.9% were experiencing subjective working difficulties. The Montreal cognitive assessment scale classified 51.4% as moderate, while the ADAS-cog and ACE scales classified 86% and 99.7%, respectively, as having abnormal mental status. However, a significant correlation and discrepancy between scores were observed for scales such as ACE, ADAS-cog, standardised mini-mental status examination, and Montreal cognitive assessment scale. A strong correlation was found between ACE, MMSE, MoCA, and ACE; however, FAST showed a significant negative correlation. The MoCA was strongly correlated with the MMSE, ACE, ADAS-cog, and Mini-Cog, indicating good alignment with the FAST. Conclusions: Cognitive scales strongly correlate with late-life depression in patients, suggesting an improvement in assessment, evaluation, and treatment to address cognitive deficits.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"261 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid storm in an uncontrolled graves’ disease with multiple complications: a case report 甲状腺风暴与多种并发症并存的未控制巴塞杜氏病：病例报告

International Journal of Advances in Medicine Pub Date : 2023-12-22 DOI: 10.18203/2349-3933.ijam20233887

I. K. O. Widiana, Dewi Catur Wulandari

{"title":"Thyroid storm in an uncontrolled graves’ disease with multiple complications: a case report","authors":"I. K. O. Widiana, Dewi Catur Wulandari","doi":"10.18203/2349-3933.ijam20233887","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233887","url":null,"abstract":"Thyroid storm is an acute and life-threatening condition. Graves’ disease is the most common cause of thyroid storm. In this case, reported an uncontrolled Graves’ disease patient with multiple complications progressing to thyroid storm. A 33-years-old woman was admitted to the emergency department with agitation. Patient had a history of uncontrolled hyperthyroidism four years ago. From physical examination found exophthalmos, bibasilar rales in both lungs, shifting dullness on stomach, swollen feet, and cold extremities. The ECG showed an atrial fibrillation with rapid ventricular response. Thyroid stimulating hormone (TSH) was found very low with 0.02 mIU/L and very high free thyroxine (FT4) with 5.04 ng/dL. The neck USG showed thyroiditis and bilateral neck lymphadenopathy. The patient was hospitalized for 9 days (4 days in ICCU and 5 days in the general ward). A very high thyroid hormone receptor antibody (TRab) of 35.9 signified a diagnosis of Graves’ disease. The patient had a total Burch-Wartofsky point scale (BWPS) score of 80 and highly suggestive of a thyroid storm. Multiple complications of Graves’ disease are cardiac failure, atrial fibrillation, seizures, vomiting, abdominal cramps, diarrhea, elevated liver enzymes, coma, jaundice, and thromboembolism while in this case the patient had cardiac failure, atrial fibrillation, and elevated liver enzymes. Thyroid storm is diagnosed with clinical features not on laboratory results. It is important to evaluate multiple complications of Graves’ disease as an early warning to reduce the mortality of thyroid storm.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"93 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case: evaluation of chronic hypoklemia in patient with Gitelman syndrome 罕见病例：评估吉特曼综合征患者的慢性低血钾症

International Journal of Advances in Medicine Pub Date : 2023-11-24 DOI: 10.18203/2349-3933.ijam20233569

I. G. S. A. J. Kusumadewi, Putu Nindya Ayu Ningrum Subadra, K. Suryana

引用次数: 0

Aetiological sub-classification of thyrotoxicosis and relevance of TT3/TT4 ratio in sub-classification of patients with thyrotoxicosis: an Indian cross-sectional study 甲亢的病因亚分类以及 TT3/TT4 比值在甲亢患者亚分类中的相关性：一项印度横断面研究

International Journal of Advances in Medicine Pub Date : 2023-11-24 DOI: 10.18203/2349-3933.ijam20233566

S. Singh, Rina Singh, S. K. Singh, M. Iquebal, S. Jaiswal, P. K. Rai

{"title":"Aetiological sub-classification of thyrotoxicosis and relevance of TT3/TT4 ratio in sub-classification of patients with thyrotoxicosis: an Indian cross-sectional study","authors":"S. Singh, Rina Singh, S. K. Singh, M. Iquebal, S. Jaiswal, P. K. Rai","doi":"10.18203/2349-3933.ijam20233566","DOIUrl":"https://doi.org/10.18203/2349-3933.ijam20233566","url":null,"abstract":"Background: Thyrotoxicosis is a common endocrine problem. Sub-classification and rapid diagnosis of disease is crucial in the management. Methods: In this prospective cross-sectional study from India, newly diagnosed thyrotoxicosis patients were enrolled. All patients were sub classified into Graves’ disease, (GD), sub-acute thyroiditis (SAT) and toxic nodular goiter (TNG) based on diagnostic criteria. Clinical features were noted and TT3, TT4 and TSH level were measured. A thyroid scan was also done. Results: TNG, respectively. Mean± SD age for GD, SAT and TNG were 36.88±10.55, 37.44±5.96 and 61±11.36 years, respectively. Most of patients were female (77.63%). Goiter was present in 81.25%, 55.56% and 100% of GD, SAT and TNG patients respectively. Mean TT3/TT4 ratio was higher (20.15±5.45 verses 12.72±0.77) in GD as compared to SAT patients. The area under ROC curve of the TT3/TT4 for diagnosis of GD was 0.964. Cut off level of TT3/TT4 ratio >14.1 offered best sensitivity, specificity, PPV (positive predictive value) and accuracy. Conclusions: This first report from India on sub-classification of thyrotoxicosis shows that GD is the commonest cause of thyrotoxicosis. TT3/TT4 ratio of >14.1 may help in differentiating the cause of thyrotoxicosis.","PeriodicalId":13827,"journal":{"name":"International Journal of Advances in Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0