Interface Focus最新文献_第10页

In vitro and in silico approaches to engineering three-dimensional biological tissues and organoids 三维生物组织和类器官工程的体外和计算机方法

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-08-12 DOI: 10.1098/rsfs.2022.0046

H. Byrne

引用次数: 1

Quantitative models for building and growing fated small cell networks. 建立和发展小型蜂窝网络的定量模型。

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-08-06 DOI: 10.1098/rsfs.2021.0082

Rocky Diegmiller, Hayden Nunley, Stanislav Y Shvartsman, Jasmin Imran Alsous

{"title":"Quantitative models for building and growing fated small cell networks.","authors":"Rocky Diegmiller, Hayden Nunley, Stanislav Y Shvartsman, Jasmin Imran Alsous","doi":"10.1098/rsfs.2021.0082","DOIUrl":"https://doi.org/10.1098/rsfs.2021.0082","url":null,"abstract":"Small cell clusters exhibit numerous phenomena typically associated with complex systems, such as division of labour and programmed cell death. A conserved class of such clusters occurs during oogenesis in the form of germline cysts that give rise to oocytes. Germline cysts form through cell divisions with incomplete cytokinesis, leaving cells intimately connected through intercellular bridges that facilitate cyst generation, cell fate determination and collective growth dynamics. Using the well-characterized Drosophila melanogaster female germline cyst as a foundation, we present mathematical models rooted in the dynamics of cell cycle proteins and their interactions to explain the generation of germline cell lineage trees (CLTs) and highlight the diversity of observed CLT sizes and topologies across species. We analyse competing models of symmetry breaking in CLTs to rationalize the observed dynamics and robustness of oocyte fate specification, and highlight remaining gaps in knowledge. We also explore how CLT topology affects cell cycle dynamics and synchronization and highlight mechanisms of intercellular coupling that underlie the observed collective growth patterns during oogenesis. Throughout, we point to similarities across organisms that warrant further investigation and comment on the extent to which experimental and theoretical findings made in model systems extend to other species.","PeriodicalId":13795,"journal":{"name":"Interface Focus","volume":"12 4","pages":"20210082"},"PeriodicalIF":4.4,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184967/pdf/rsfs.2021.0082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media 以典型无序多孔介质为模型的血管外生物组织中的红细胞动力学

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-06-19 DOI: 10.1101/2022.06.18.496666

Qi Zhou, Kerstin Schirrmann, Eleanor Doman, Qi Chen, Naval Singh, P. Selvaganapathy, M. Bernabeu, O. Jensen, A. Juel, I. Chernyavsky, T. Krüger

{"title":"Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media","authors":"Qi Zhou, Kerstin Schirrmann, Eleanor Doman, Qi Chen, Naval Singh, P. Selvaganapathy, M. Bernabeu, O. Jensen, A. Juel, I. Chernyavsky, T. Krüger","doi":"10.1101/2022.06.18.496666","DOIUrl":"https://doi.org/10.1101/2022.06.18.496666","url":null,"abstract":"The dynamics of blood flow in the smallest vessels and passages of the human body, where the cellular character of blood becomes prominent, plays a dominant role in the transport and exchange of solutes. Recent studies have revealed that the micro-haemodynamics of a vascular network is underpinned by its interconnected structure, and certain structural alterations such as capillary dilation and blockage can substantially change blood flow patterns. However, for extravascular media with disordered microstructure (e.g., the porous intervillous space in the placenta), it remains unclear how the medium’s structure affects the haemodynamics. Here, we simulate cellular blood flow in simple models of canonical porous media representative of extravascular biological tissue, with corroborative microfluidic experiments performed for validation purposes. For the media considered here, we observe three main effects: first, the relative apparent viscosity of blood increases with the structural disorder of the medium; second, the presence of red blood cells (RBCs) dynamically alters the flow distribution in the medium; third, increased structural disorder of the medium can promote a more homogeneous distribution of RBCs. Our findings contribute to a better understanding of the cellscale haemodynamics that mediates the relationship linking the function of certain biological tissues to their microstructure.","PeriodicalId":13795,"journal":{"name":"Interface Focus","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47564753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Time-keeping and decision-making in living cells: Part II 活细胞的计时和决策:第二部分

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-06-10 DOI: 10.1098/rsfs.2022.0024

J. Tyson, A. Csikász-Nagy, D. Gonze, Jae Kyoung Kim, Silvia Santos, J. Wolf

引用次数: 3

Initial source of heterogeneity in a model for cell fate decision in the early mammalian embryo. 哺乳动物早期胚胎细胞命运决定模型中异质性的初始来源。

IF 3.6 3区生物学

Interface Focus Pub Date : 2022-06-10 eCollection Date: 2022-08-06 DOI: 10.1098/rsfs.2022.0010

Corentin Robert, Francisco Prista von Bonhorst, Yannick De Decker, Geneviève Dupont, Didier Gonze

{"title":"Initial source of heterogeneity in a model for cell fate decision in the early mammalian embryo.","authors":"Corentin Robert, Francisco Prista von Bonhorst, Yannick De Decker, Geneviève Dupont, Didier Gonze","doi":"10.1098/rsfs.2022.0010","DOIUrl":"10.1098/rsfs.2022.0010","url":null,"abstract":"During development, cells from a population of common progenitors evolve towards different fates characterized by distinct levels of specific transcription factors, a process known as cell differentiation. This evolution is governed by gene regulatory networks modulated by intercellular signalling. In order to evolve towards distinct fates, cells forming the population of common progenitors must display some heterogeneity. We applied a modelling approach to obtain insights into the possible sources of cell-to-cell variability initiating the specification of cells of the inner cell mass into epiblast or primitive endoderm cells in early mammalian embryo. At the single-cell level, these cell fates correspond to three possible steady states of the model. A combination of numerical simulations and bifurcation analyses predicts that the behaviour of the model is preserved with respect to the source of variability and that cell-cell coupling induces the emergence of multiple steady states associated with various cell fate configurations, and to a distribution of the levels of expression of key transcription factors. Statistical analysis of these time-dependent distributions reveals differences in the evolutions of the variance-to-mean ratios of key variables of the system, depending on the simulated source of variability, and, by comparison with experimental data, points to the rate of synthesis of the key transcription factor NANOG as a likely initial source of heterogeneity.","PeriodicalId":13795,"journal":{"name":"Interface Focus","volume":"12 4","pages":"20220010"},"PeriodicalIF":3.6,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184963/pdf/rsfs.2022.0010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9955561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cycle dynamics and synchronization in a coupled network of peripheral circadian clocks. 外围生物钟耦合网络中的周期动力学和同步。

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-06-06 DOI: 10.1098/rsfs.2021.0087

Odile Burckard, Michèle Teboul, Franck Delaunay, Madalena Chaves

引用次数: 6

Time-keeping and decision-making in living cells: Part I 活细胞中的计时和决策:第1部分

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-04-15 DOI: 10.1098/rsfs.2022.0011

J. Tyson, A. Csikász-Nagy, D. Gonze, Jae Kyoung Kim, Silvia Santos, J. Wolf

引用次数: 2

Principles, mechanisms and functions of entrainment in biological oscillators 生物振荡器中夹带的原理、机制和功能

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-04-15 DOI: 10.1098/rsfs.2021.0088

Alba Jiménez, Ying Lu, A. Jambhekar, G. Lahav

引用次数: 6

Multi-synchronization and other patterns of multi-rhythmicity in oscillatory biological systems 振荡生物系统中多重同步和多重节律性的其他模式

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-04-15 DOI: 10.1098/rsfs.2021.0089

A. Goldbeter, Jie Yan

{"title":"Multi-synchronization and other patterns of multi-rhythmicity in oscillatory biological systems","authors":"A. Goldbeter, Jie Yan","doi":"10.1098/rsfs.2021.0089","DOIUrl":"https://doi.org/10.1098/rsfs.2021.0089","url":null,"abstract":"While experimental and theoretical studies have established the prevalence of rhythmic behaviour at all levels of biological organization, less common is the coexistence between multiple oscillatory regimes (multi-rhythmicity), which has been predicted by a variety of models for biological oscillators. The phenomenon of multi-rhythmicity involves, most commonly, the coexistence between two (birhythmicity) or three (trirhythmicity) distinct regimes of self-sustained oscillations. Birhythmicity has been observed experimentally in a few chemical reactions and in biological examples pertaining to cardiac cell physiology, neurobiology, human voice patterns and ecology. The present study consists of two parts. We first review the mechanisms underlying multi-rhythmicity in models for biochemical and cellular oscillations in which the phenomenon was investigated over the years. In the second part, we focus on the coupling of the cell cycle and the circadian clock and show how an additional source of multi-rhythmicity arises from the bidirectional coupling of these two cellular oscillators. Upon bidirectional coupling, the two oscillatory networks generally synchronize in a unique manner characterized by a single, common period. In some conditions, however, the two oscillators may synchronize in two or three different ways characterized by distinct waveforms and periods. We refer to this type of multi-rhythmicity as ‘multi-synchronization’.","PeriodicalId":13795,"journal":{"name":"Interface Focus","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48651962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The role of SARS-CoV-2 aerosol transmission during the COVID-19 pandemic 新冠肺炎大流行期间SARS-CoV-2气溶胶传播的作用

IF 4.4 3区生物学

Interface Focus Pub Date : 2022-02-11 DOI: 10.1098/rsfs.2022.0003

Julian W. Tang, L. Marr, Yuguo Li, Ian Eames

引用次数: 2