International Journal of Clinical Rheumatology最新文献_第7页

Domino effect in a patient with Epstein-Barr Virus infection and autoimmunity: A case report eb病毒感染和自身免疫患者的多米诺骨牌效应:1例报告

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(6).193-197

M. Matossian, Carrie E Crook, Alec Goldberg, A. Stathopoulos, J. Tien, S. Sheth, Osaid Saqqa Christopher Dale Shamburger

{"title":"Domino effect in a patient with Epstein-Barr Virus infection and autoimmunity: A case report","authors":"M. Matossian, Carrie E Crook, Alec Goldberg, A. Stathopoulos, J. Tien, S. Sheth, Osaid Saqqa Christopher Dale Shamburger","doi":"10.37532/1758-4272.2020.15(6).193-197","DOIUrl":"https://doi.org/10.37532/1758-4272.2020.15(6).193-197","url":null,"abstract":"The link between autoimmune diseases and viral infections has been characterized, but specific mechanisms behind this association remain a current area of investigation. Whether viral infections trigger or unmask autoimmunity, or if the pathologies occur concurrently, is not yet completely understood. Specifically, Epstein - Barr virus (EBV) is implicated in several autoimmune disorders, including Systemic Lupus Erythematosus (SLE). It is hypothesized that common immunologic pathways are activated in the two pathologic states. This case report is an example of this confusing presentation, and the importance of recognizing the association between autoimmunity and viral infections. This patient presented with symptoms concerning for SLE and hepatic autoimmunity with serology suggesting a recent infection with EBV. Given this complicated presentation, it is difficult to determine which disease state presented first in patients with evidence of both SLE and EBV infection and whether this information is clinically relevant for ongoing treatment and monitoring. Here, we provide an in-depth discussion of current genomic and immunological research that supports the associations amongst these disease pathologies.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"64 1","pages":"193"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84959354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient Osteoporosis of hip during pregnancy 妊娠期髋关节短暂性骨质疏松症

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(6).175-177

K. Nassar, Omar Amriss Saadia Janani

引用次数: 0

Occurrence of cervical spine arthritis with prominent bone edema highly responsive to adalimumab in a patient with psoriatic peripheral arthritis and long-standing remission 银屑病周围性关节炎患者对阿达木单抗高度敏感的颈椎关节炎伴显著骨水肿的发生并长期缓解

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(3).60-63

M. C. Miceli, L. Bruno, C. Provenzano

{"title":"Occurrence of cervical spine arthritis with prominent bone edema highly responsive to adalimumab in a patient with psoriatic peripheral arthritis and long-standing remission","authors":"M. C. Miceli, L. Bruno, C. Provenzano","doi":"10.37532/1758-4272.2020.15(3).60-63","DOIUrl":"https://doi.org/10.37532/1758-4272.2020.15(3).60-63","url":null,"abstract":"Cervical spine involvement frequently occurs in patients with psoriatic arthritis (PsA) even in absence of sacroiliitis. Long disease duration, high disease activity in the first five years and presence of peripheral involvement are all predictors of this peculiar articular involvement. We describe the case of a PsA patient, with an initial oligoarthritis pattern of disease highly responsive to etanercept monotherapy and long-standing clinical remission, who developed cervical spine involvement with bone marrow edema of odontoid process and early atlo-axial instability. Notably, he did not exhibit any other clinical symptom or sign of disease activity and was highly responsive to switching to a second anti-TNF drug (adalimumab). The case stresses the importance of strict monitoring PsA patients and considering the possible changing pattern of disease. Early identification of cervical spine involvement requires proper use and interpretation of imaging techniques. Interestingly different articular manifestations of PsA may show different response to therapy even in the same patient.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"6 1","pages":"60"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78526730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid arthritis and gouty arthritis in an adult patient with Down's syndrome 唐氏综合症成人患者的类风湿性关节炎和痛风性关节炎

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2019.15(2).18-20

Shaima N. Elgenaid, Z. I. Mahmoud, M. Essa, Shahd H. A. Elwidaa, Latifa M. Elsheikh, A. Abdelhalim, M. Hussein, Mutwaly Defealla Yousif Haron, Ayman Ahmed

{"title":"Rheumatoid arthritis and gouty arthritis in an adult patient with Down's syndrome","authors":"Shaima N. Elgenaid, Z. I. Mahmoud, M. Essa, Shahd H. A. Elwidaa, Latifa M. Elsheikh, A. Abdelhalim, M. Hussein, Mutwaly Defealla Yousif Haron, Ayman Ahmed","doi":"10.37532/1758-4272.2019.15(2).18-20","DOIUrl":"https://doi.org/10.37532/1758-4272.2019.15(2).18-20","url":null,"abstract":"Down’s syndrome is a chromosomal disorder caused by trisomy of chromosome 21. It presents with different phenotypes including autoimmune diseases and arthritis. The aim of this case report is to describe and document rheumatoid arthritis and gouty arthritis in patient with Down's syndrome. Here we are reporting a case of 44 year-old female with Down's syndrome who was diagnosed with epilepsy 10 months ago. She presented with a one-year history of swelling of knees, bilateral big toes and the metacrpopharyngal joints. In addition, on examination she had ulnar deviation of her hands, limited range of motion and severe tenderness of the noted joints, hair loss and scoliosis. Her serum uric acid, ESR and CRP levels were elevated and rheumatoid factor was strongly positive; however, ANA profile and anti CCP antibodies were negative. Therefore, she was diagnosed with rheumatoid arthritis and gouty arthritis. Currently she is on hydroxychoroquine, allopurinl, baclofen, methotrexate, folic acid and sodium valproate.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"23 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76734564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregabalin-induced focal myositis: A report of two cases and review of literature 普瑞巴林致局灶性肌炎2例报告并文献复习

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(4).114-118

S. Manohar

引用次数: 1

Relapsing polychondritis presenting in a patient with cryptogenic organizing pneumonia 隐匿性组织性肺炎患者复发性多软骨炎

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(5).140-142

Kathlyn Camargo, A. Chawla, Ashwini Komarla Sujatha Vuyyuru

{"title":"Relapsing polychondritis presenting in a patient with cryptogenic organizing pneumonia","authors":"Kathlyn Camargo, A. Chawla, Ashwini Komarla Sujatha Vuyyuru","doi":"10.37532/1758-4272.2020.15(5).140-142","DOIUrl":"https://doi.org/10.37532/1758-4272.2020.15(5).140-142","url":null,"abstract":"Relapsing Polychondritis (RP) is an autoimmune disease that affects cartilaginous tissues in the body, including lower respiratory tract. Involvement of the pulmonary interstitium is very rare. We present a 67-year-old Caucasian man presented to the clinic with one-year of recurrent dyspnea and dry cough along with worsening anemia and thrombocytopenia. CT of the chest demonstrated diffuse, bilateral (left > right) multifocal peribronchovascular ground glass opacities with mediastinal lymphadenopathy. All rheumatologic serology workup was negative as well as infectious workup. Lung biopsy of the left lower lobe consolidation showed plugs of fibroblastic tissue incorporated into alveolar walls and airspaces consistent with COP. No features of malignancy or granulomatous process were seen. Oral prednisone was started and tapered over the next 3 months with improvement of his respiratory symptoms. Two weeks later, he developed bilateral ear pain/redness and conjunctivitis. CT of the sinuses revealed mild prominence in the left nasopharyngeal soft tissue. Biopsy of this lesion showed inflammatory infiltrative changes and RP was diagnosed. Adalimumab was started. However, the patient developed worsening dyspnea that required supplemental oxygen and hospitalization. High dose steroids were again added, along with oral cyclophosphamide. The patient had significant clinical and radiological improvement over the next 6 months. Interstitial lung disease has been rarely associated with RP. Most of the lower respiratory track involvement is in the trachea. We present a case of cryptogenic organizing pneumonia in association with relapsing polychondritis.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"10 1","pages":"140"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74283833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Rheumatoid Arthritis and disease activity on work productivity and quality of life 类风湿关节炎和疾病活动对工作效率和生活质量的影响

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(5).123-127

S. Boussaid, N. B. Ayed, M. Bani, Takoua Issaoui, S. Jammali, E. Hannech, H. Sahli, E. Cheour, S. Elleuch

{"title":"Impact of Rheumatoid Arthritis and disease activity on work productivity and quality of life","authors":"S. Boussaid, N. B. Ayed, M. Bani, Takoua Issaoui, S. Jammali, E. Hannech, H. Sahli, E. Cheour, S. Elleuch","doi":"10.37532/1758-4272.2020.15(5).123-127","DOIUrl":"https://doi.org/10.37532/1758-4272.2020.15(5).123-127","url":null,"abstract":"Introduction: Rheumatoid Arthritis (RA) physical disability can impair the Quality of Life (QoL) and professional activity. Aim of the work: to assess the impact of RA on work productivity and functional impairment in Tunisian patients. Relation to the disease activity was also considered. Patients and mehods: The study included 25 RA patients having a professional occupation at the time of disease onset. The Disease Activity Score (DAS28), Health Assessment Questionnaire (HAQ) and 'Work Productivity and Activity Impairment' (WPAI) questionnaire were assessed. Results: The mean age of the patients was 50.4 ± 8.3 years with a female: male ratio of 1.08. The mean age at onset was 40.6 ± 9.8 years and the mean disease duration was 9.8 ± 9.68 years. The patients' occupation involved a manual job in 84% of cases. The mean of DAS28 was 4.3 ± 1.6; 72% had moderate to severe disease activity. The mean HAQ was 1.4 ± 0.7 and 76% had moderate to severe disability. The evaluation of the work productivity and activity impairment objectified an absenteeism of 30.7 ± 39.4%, presenteeism of 46.7 ± 26.4%, work productivity loss of 60.4 ± 33.8% and an activity impairment of 57.2 ± 25.4%. A significant correlation was noted between WPAI parameters and HAQ (p<0.0001) and of the decline in productivity and daily activity with DAS28 (p=0.01). Conclusion: Functional impairment and disease activity affected productivity and work ability in Tunisian RA patients. Absenteeism, increase of presenteeism, decline of productivity and daily activity were associated with the HAQ and the latter 2 with the disease activity but not with the age of patients or disease duration.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"60 1","pages":"123"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88016379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Sonographic detection of sacroiliitis - An appraisal 骶髂炎的超声检测-评价

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(3).43-47

Plamen Todorov Anastas Batalov

引用次数: 0

Chronic dry cough: Could it be your polymyalgia rheumatica? 慢性干咳:是风湿病多肌痛吗?

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2021.16(1).015

引用次数: 0

B-mode ultrasound in the uveitis in the psoriatic arthritis without skin lesion b超显示银屑病关节炎中葡萄膜炎无皮肤病变

International Journal of Clinical Rheumatology Pub Date : 2020-01-01 DOI: 10.37532/1758-4272.2020.15(3).64-66

J. Alex, R. Mendonça, V. Le, Rosaria Aquino

{"title":"B-mode ultrasound in the uveitis in the psoriatic arthritis without skin lesion","authors":"J. Alex, R. Mendonça, V. Le, Rosaria Aquino","doi":"10.37532/1758-4272.2020.15(3).64-66","DOIUrl":"https://doi.org/10.37532/1758-4272.2020.15(3).64-66","url":null,"abstract":"Introduction: The involvement of inflammatory ocular and joint manifestations can be better evaluated by ultrasound, but the application of this image method in the eyes is a universe that is still very little explored in inflammatory joint diseases. Objective: The aim of this case report was to detect inflammatory ocular and joint changes by ultrasound with a high frequency linear probe in patients without prior established diagnosis. Case report: This case describes a caucasoid patient of the female sex, 32 years of age, without diagnosis. The patient referred red eyes when using a computer, with weak nails and left ankle arthritis, for 6 months. An ultrasound with 12 MHz high frequency linear probe was used to evaluate the eyes and a frequency of 15 to 18 MHZ for joint investigates. Discussion: The ultrasound showed in eyes the following findings: floating hypoecogenic images in vitreous humor more intensely to the left, characterizing vitritis, in all of the distal interphalangicas evaluated, with loss of the plate nail pattern trilaminar, effusion tibio - talar, tenosynovitis peroneus longus tendon and entesopathy Achilles tendon, without the presence of power Doppler. Conclusion: B-mode ultrasound can an important adjunct to the clinical evaluation in patients with arthritis e uveitis. Future studies will better signal the intensity of these findings of vitreous humor alterations, and also define this relationship with the subclinical and inflammatory, ocular and joint activity condition.","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":"77 1","pages":"64"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79288363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5