{"title":"Guidebook to the extracellular matrix and adhesion proteins","authors":"","doi":"10.1016/0020-711X(94)90116-3","DOIUrl":"https://doi.org/10.1016/0020-711X(94)90116-3","url":null,"abstract":"","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 6","pages":"Page 855"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90116-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90021358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ján Chandoga , Ladislav Hampl , Ladislav Turecký , Iveta Rojeková, Eva Uhliková, Gabriel Hocman
{"title":"Cetaben is an exceptional type of peroxisome proliferator","authors":"Ján Chandoga , Ladislav Hampl , Ladislav Turecký , Iveta Rojeková, Eva Uhliková, Gabriel Hocman","doi":"10.1016/0020-711X(94)90168-6","DOIUrl":"10.1016/0020-711X(94)90168-6","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Cetaben in contrast to fibrates affect differently peroxisomal constituents.</p></span></li><li><span>2.</span><span><p>2. Changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of equal doses (200 mg/kg/day) of cetaben and clofibric acid to male Wistar rats.</p></span></li><li><span>3.</span><span><p>3. Clofibric acid treatment increased markedly the activities of FAD-glycerol-3-P dehydrogenase, β-hydroxyacyl-CoA dehydrogenase, cytochrome-<em>c</em> oxidase, malic enzyme, NAD-glycerol-3-P dehydrogenase, ethoxycoumarine deethylase, <em>p</em>-nitroanisol demethylase and amounts of cytochrome <em>P</em> -450 and <em>b</em><sub>5</sub>.</p></span></li><li><span>4.</span><span><p>4. However no analogical changes were observed after cetaben treatment in the livers of experimental animals.</p></span></li><li><span>5.</span><span><p>5. Both drugs increased the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase—enzymes with proven mitochondrial and peroxisomal location.</p></span></li><li><span>6.</span><span><p>6. Cetaben contrary to clofibric acid does not increase solubilization of peroxisomal enzymes.</p></span></li><li><span>7.</span><span><p>7. Enhanced acetylcarnitine transferase and alanine-glyoxylate aminotransferase-1 activities were distributed in mitochondria as well as in peroxisomes after clofibric acid treatment, however only peroxisomes were enriched after cetaben administration.</p></span></li><li><span>8.</span><span><p>8. The results obtained suggest that cetaben represents an exceptional type of peroxisome proliferator, specifically affecting peroxisomes, without having a negative influence on the processes of peroxisome biogenesis.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 5","pages":"Pages 679-696"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90168-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antiviral drugs: Present status and future prospects","authors":"I.Heleen van der Sus , Ed.H. wiltink","doi":"10.1016/0020-711X(94)90161-9","DOIUrl":"10.1016/0020-711X(94)90161-9","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. There is a limited number of antiviral drugs available for therapy. Many investigations and new analytical techniques have unraveled the development and progression of a viral infection. Nowadays there is a good understanding of the multiplication cycle of viruses, including the human immunodeficiency virus.</p></span></li><li><span>2.</span><span><p>2. In this article the currently available antiviral drugs are presented arranged by their mode of action that can be understood by the multiplication cycle of the virus.</p></span></li><li><span>3.</span><span><p>3. Clinical use and side-effects are discussed as well as place in current therapy. Some attention is paid on promising investigational antivirals.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 5","pages":"Pages 621-630"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90161-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18998522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C.Garrido-del Solo , R. Varón , F. GarcíA-Cánovas , B.H. Havsteen
{"title":"Kinetic analysis of the michaelis-menten mechanism in which the substrate and the product are unstable","authors":"C.Garrido-del Solo , R. Varón , F. GarcíA-Cánovas , B.H. Havsteen","doi":"10.1016/0020-711X(94)90164-3","DOIUrl":"10.1016/0020-711X(94)90164-3","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. A kinetic analysis of the Michaelis-Menten mechanism for the case in which both the substrate and the product are unstable, either spontaneously or as the result of the addition of a reagent, has been made.</p></span></li><li><span>2.</span><span><p>2. The explicit time course equations of the immediate product and the species into which it subsequently is transformed have been derived under the conditions of rapid equilibrium and limiting substrate concentration.</p></span></li><li><span>3.</span><span><p>3. The validity of these equations has been checked using numerical simulations.</p></span></li><li><span>4.</span><span><p>4. The kinetic data analysis which we suggest is based on the time progress curves of the product or, in the case in which the product accumulation cannot be monitored experimentally, on the time progress curve of the species into which the immediate product is transformed.</p></span></li><li><span>5.</span><span><p>5. This analysis allows the determination of the rate and the equilibrium constants if adequate experimental results are available.</p></span></li><li><span>6.</span><span><p>6. We have chosen a numerical example, with which we illustrate the procedure of the kinetic data analysis by simulating some curves with assumed experimental errors.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 5","pages":"Pages 645-651"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90164-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88896941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Purification and characterization of casein kinase II from lactating rabbit mammary gland","authors":"Vanio Mitev, Alain Pauloin, Louis-Marie Houdebine","doi":"10.1016/0020-711X(94)90167-8","DOIUrl":"10.1016/0020-711X(94)90167-8","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Highly purified 200 kDa casein kinase II from rabbit lactating mammary gland (MG-CK II) was obtained by means of a new purification procedure consisting of one phosphocellulose and three Mono Q steps.</p></span></li><li><span>2.</span><span><p>2. Its <em>K</em><sub><em>m</em></sub> for ATP was 2.22 μM and 0.57 mg/ml and 0.13 mg/ml for partially dephosphorylated casein and phosvitin respectively. Stathmine was also suitable as substrate. 2-aminopurine and 6-dimethylaminopurine inhibited efficiently MG-CK II <em>K</em><sub><em>i</em></sub> = 5 and 1 mM respectively).</p></span></li><li><span>3.</span><span><p>3. MG-CK II autophosphorylated on its α-, α '- and β-subunits. The β-subunit auto-phosporylation was enhanced in presence of exogenous substrate. Its modulation was highly dependent on ATP concentration.</p></span></li><li><span>4.</span><span><p>4. The effects of basic compounds which affected dramatically the phosphorylation of dephosphorylated casein in presence of various ATP concentrations were reported.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 5","pages":"Pages 667-677"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90167-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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