Zagazig Veterinary Journal最新文献

{"title":"Economic Study of Litter Size in New Zealand White Rabbits","authors":"M. Omar, Fardos Mohamed, Nasser Ahmed El-said Amer","doi":"10.21608/zvjz.2022.108387.1167","DOIUrl":"https://doi.org/10.21608/zvjz.2022.108387.1167","url":null,"abstract":"Rabbits are one of best source of meat producing animals because of the short generation interval, high productivity, and rapid growth. The study looked at the effect of litter size on productive traits, carcass characters and economic performance of post weaning rabbits. On the first day after kindling (d 0), the rabbits does were randomly assigned to one of the following three groups according to the litter size (number of kits): G1 (4-5), G2 (6-7), and G3 (8-9) kits in primiparous rabbit does then the growth rate, carcass traits and economic efficiency were determined. The litter size had no significant effect in feed intake (2330.00 ± 68.04, 2401.00 ± 58.42 and 2476.00 ± 66.72), but had significant increase in feed conversion rate (1.68 ± 0.07, 1.88 ± 0.11 and 2.01 ± 0.06), significant decrease in market rabbit weight (2071.50 ± 87.49, 1858.00 ± 58.38 and 1777.50 ± 51.32) for G1, G2 and G3, respectively. Significant increase in hot carcass weight (1468.50 ± 90.36, 1224.00 ± 47.81, 1171.50 ± 50.54) and chilled carcass weight (1468.50 ± 90.36, 1221.50 ± 47.73, 1170.00 ± 50.36) for G1, G2 and G3, respectively was also observed. Litter size had significant decrease in weaning body weight (657.20 ± 79.80, 578.00 ± 61.76, and 541.50 ± 63.01, respectively) among rabbits` groups. Litter size declared significant decrease in market body weight among rabbits groups, also has no significant effect in fixed (5.00 ± 0.00, 5.00 ± 0.00, 5.00 ± 0.00) variable (44.81 ± 0.37, 45.20 ± 0.32, 45.61 ± 0.37) and total costs ( 49.81 ± 0.37 , 50.20 ± 0.32, 50.61 ± 0.37) for G1, G2 and G3, respectively. Litter size showed significance increase in total (84.08 ± 3.35, 75.57 ± 2.27, 72.35 ± 1.99) and net returns ( 34.27 ± 2.98, 25.37 ± 1.95, 21.74 ± 1.63) for G1, G2 and G3, respectively. We can conclude that the does have 4-5 litter size better than those have 6-7 and 8-9 litter size in productive performance, carcass characteristics and economic efficiency of rabbit production with lowering total cost and increase total and net returns in new Zealand white rabbit of current study.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114338842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Role of Zinc Oxide Nanoparticles in the Treatment of Diabetes Mellitus: An Updated Review","authors":"Saydat Abd El-Megeed, W. El-sayed","doi":"10.21608/zvjz.2022.108620.1165","DOIUrl":"https://doi.org/10.21608/zvjz.2022.108620.1165","url":null,"abstract":"Nanotechnology has made serious evolution in several scientific fields. Nanoparticles (NPs) are small-scale compounds having unique characters (at least 100 nm in one dimension). When materials are decreased to the nanoscale, their properties are typically modified, allowing them to act specifically with cell biomolecules. Therapeutic chemicals are loaded into NPs and transported to target cells. Metallic NPs, such as gold, silver, iron, Zn, and metal oxide NPs, have existed serious hurdles in the medical field and their usage in recent years. ZnO nanoparticles (ZnO NPs) have been revealed to show catalytic, electrical, photochemical, anticorrosive, photovoltaic, antifungal, antibacterial, and antiviral characters. ZnO NPs have been utilized in the biomedical field to yield biosensors for many ranges purposes, enhance diagnostics via imaging, regulate medication targeting, and to deliver gene therapy. Multiple studies on the anticancer, antidiabetic, and antibacterial activities of ZnO NPs yield promising scientific data for the treatment of each disease globally. Diabetes mellitus (DM) is a serious health issue that influences people worldwide. The majority of diabetes problems are caused by oxidative stress, which is followed by a decline in cellular zinc levels and zinc-dependent antioxidant enzymes. The pharmacological trials through which ZnO NPs reduce DM and diabetic sequelae are summarized in this review.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125650420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound, Hematological and Biochemical Analysis in Canine with Inflammatory Bowel Disease","authors":"Heba El-Zahar, Z. Abd El-Rahman, Abbas El-Naggar","doi":"10.21608/zvjz.2021.107361.1164","DOIUrl":"https://doi.org/10.21608/zvjz.2021.107361.1164","url":null,"abstract":"Inflammatory bowel disease (IBD) in dogs is a group of disorders characterized by persistent gastrointestinal clinical manifestations. The goal of this study was to investigate the hematobiochemical alterations in association with the clinical outcomes and prognostic markers including cobalamine, folate and vitamin D3 in dogs with IBD. A total of 23 IBD dogs with symptoms of chronic gastrointestinal diseases were chosen for the study, these include vomiting, diarrhea, anorexia, weight loss and abdominal pain. Ultrasonographically, the most common IBD-related abnormalities were dilated intestinal loops with hypermotility, as well as thickening and loss of wall layers in the stomach, duodenum, and jejunum. Hematological findings showed significant increase in the total white blood cell count (14.58 ± 0.49) and neutrophils (69.8 ± 1.6), and significant decrease in hemoglobin (9.83 ± 0.44) and Hematocrit value (30.30 ± 1.24). Biochemical analysis revealed significant increase in serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen and blood creatinine compared to the controls. Whilst significant decrease in serum 25(OH)D, folate and cobalamin levels in IBD dogs was observed which indicate intestinal malabsorption, and these markers are good predictors of IBD.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"799 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116134687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antibiofilm Activity of Nigella sativa and Olive Oils’ Nanoemulsions against Bacillus cereus from Dairy Processing Plants","authors":"Salah Abd-El Aal, A. Mohamed, A. Mohamed","doi":"10.21608/zvjz.2021.106627.1163","DOIUrl":"https://doi.org/10.21608/zvjz.2021.106627.1163","url":null,"abstract":"Kariesh cheese, ice cream, and pasteurized milk are among the popular dairy products with high nutritive values. These products are commonly consumed in Egypt at all ages. However, the surrounding surfaces and equipment might lead to contamination of such dairies with foodborne pathogens such as Bacillus cereus. Microbial biofilm production is a developed mechanism that enhances survival and resistance to harsh environment along with spores. This study aimed to investigate the prevalence of B. cereus in dairy products including kariesh cheese, ice cream as well as pasteurized milk, dairy plant surfaces, and equipment. Besides, the ability of the identified B. cereus isolates to produce biofilm were further examined. In a prevention trial, Nigella sativa and olive oils’ nanoemulsions were used at a concentration of 1%, and 2% to reduce B. cereus biofilm formation. The obtained results revealed isolation of B. cereus from the examined kariesh cheese, ice cream, pasteurized milk, dairy plant surfaces, and equipment at 44%, 16%, 8%, 72%, and 68%, respectively, with average counts of 3.69 ± 0.23, 2.58 ± 0.19, 2.15 ± 0.21, 5.36 ± 0.39, and 4.46 ± 0.59 log 10 cfu/g, respectively. Molecular confirmation of the recovered B. cereus isolates revealed that all isolates harbored B. cereus -specific 16S rRNA, and Cal Y, biofilm-matrix protein. All B. cereus isolates had the ability to produce biofilm. Nigella sativa, and olive oils’ nanoemulsions reduced B. cereus-produced biofilm in a concentration-dependent manner.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123025602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethoxyquin and Butylated Hydroxyl Toluene Induced Hepatotoxic Effect Via Apoptosis, Oxidative Stress in Rats: Tissue Injury-Related CYP1A1 Gene Expression","authors":"D. Hegab, A. Mohammed, M. Metwally, M. Ghoneim, A. Abou-Hadeed","doi":"10.21608/zvjz.2021.104945.1162","DOIUrl":"https://doi.org/10.21608/zvjz.2021.104945.1162","url":null,"abstract":"Animal feed may contain different phenolic antioxidants, such as butylated hydroxyanisole, butylated hydroxy toluene (BHT), and ethoxyquin (EQ). EQ and BHT at high concentrations can have a pro-oxidant effect and can cause adverse health effects in animals. This study was designed to evaluate the hepatotoxic effect of EQ and / or BHT in rats. Fifty male Sprague– Dawley rats were assigned to five groups of 10 rats each as following: the first group served as control and did not receive any treatments; the second group served as vehicle control and was orally given corn oil. The third group was orally administered EQ day after day in a dose of 1/5 of LD50, the fourth group was orally received BHT day after day in a dose of 1/5 LD50. The fifth group was orally administered both EQ and BHT at the same doses and durations described above. The duration of this study was 45 and 90 days. The results revealed that EQ, BHT and their co-exposure caused a significant decrease in levels of antioxidant enzymes (superoxide dismutase (SOD), catalase enzyme (CAT) and reduced glutathione (GSH)) in rats. Also a significant increase in malondialdehyde (MDA) and 8-hydroxyguanosine (8-OH-dG) levels was recorded in serum of rats. Co-exposure group had a significant increase in DNA damage variables (% tail DNA, tail length, and Olive Tail Moment (OTM)), strong immuno positive reactivity of caspase3 and up regulation of CYP1A1 gene expression in the liver cells of exposed rats. In conclusion, we can state that EQ and BHT are potentially hepatotoxic compounds where the oxidative stress could be accepted as a possible mechanism of their toxicity. Therefore, the utilization of such compounds as feed additives should be more controlled and limited.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122912027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycoplasma bovis: Taxonomy, Characteristics, Pathogenesis and Antimicrobial Resistance","authors":"A. Ammar, M. A. Abd El-Hamid, Y. Hashem, R. El-Malt, H. Mohamed","doi":"10.21608/zvjz.2021.103834.1160","DOIUrl":"https://doi.org/10.21608/zvjz.2021.103834.1160","url":null,"abstract":"Mycoplasma bovis (M. bovis) is one of the most significant bacteria, which leads to multiple bovine diseases such as keratoconjunctivitis, otitis media, arthritis, genital disorders, mastitis, and pneumonia in cattle. M. bovis is considered the second most pathogenic mycoplasmas infection after Mycoplasma mycoides sub sp. mycoides (Mmm) that causes contagious bovine pleuropneumonia. M. bovis is a wall-less host-specific bacterium. Currently, it is responsible for important economic problems worldwide such as reducing production, premature culling, and increasing the mortality of the affected animals. The infection caused by M. bovis is hampered due to the lack of effective vaccines and treatment. Besides, antibiotic resistance to macrolides and fluoroquinolones, the drug of choice for M. bovis treatment, has formidable economic losses due to treatment limitations by these antimicrobials. Our review highlights and discusses the taxonomy, general characteristics, economic importance, isolation, identification, and pathogenesis of M. bovis. Finally, it focused on the antimicrobial resistance of this particular bacterium.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130220663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Copper Sulphate Pollution and its Antidote Penicillamine on Liver and Serum Markers of Albino Rats","authors":"M. Fawzy, S. Ahmed, Tarek Khamis, A. Arisha, Doaa M. Abdel-Fattah","doi":"10.21608/zvjz.2021.95736.1155","DOIUrl":"https://doi.org/10.21608/zvjz.2021.95736.1155","url":null,"abstract":"Copper is an essential trace element and is required for many metabolic functions. The present study was designed to study the negative impact of excess copper sulphate (Cuso4) on liver of albino rats and studying how its antidote d-penicillamine play role in the development of its side effects. Seventy albino rats were divided into seven equal groups each containing 10 rats (G1:control group received distilled water) ; (G2: 0.1 LD50 of CuSO4) ; (G3: 0.2 LD50 of CuSO4) ; (G4: 0.4 LD50 of CuSO4) ; (G5: 0.1 LD50 of CuSO4 +100 mg/kg/day of penicillamine) ; (G6: LD50 of CuSO4.+100 mg/kg/day of penicillamine) and (G7: LD50 of CuSO4+ 100 mg/kg/day of penicillamine) for 30 days. At the end of the experiment all rats were sacrificed, and blood samples and liver tissues were collected for biochemical and molecular assaying. The result showed that administration of copper sulphate with different levels induced a significant increase in fasting blood glucose level (FBG), lipid peroxidation marker (MDA), serum copper level, white blood cells (WBCs) and serum tyrosinase activity, but a significant decrease in total antioxidant activity (TAC), Hb and platelet count. Moreover, copper sulphate administration elicited a significant (P ˂ 0.05) downregulation of cytochrome c oxidase (Cyto co) and glucose -6phosphate dehydrogenase (G6PD). It could be approved that dpenicillamine (DPA) can decrease the negative impact of copper sulphate on hepatic tissues and serum enzymes. DPA can reduce hepatotoxicity and oxidative stress caused by copper pollution.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127903739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study on the Effect of A probiotic and Toltrazuril for Controlling Coccidiosis in Japanese Quails (Coturnix Japonica)","authors":"Nasr Nasr ElDeen, S. Ismail, Sahar Abdel hamied, A. Kaser","doi":"10.21608/zvjz.2021.97319.1158","DOIUrl":"https://doi.org/10.21608/zvjz.2021.97319.1158","url":null,"abstract":"This study was carried out to compare between the effect of probiotic (Gro-2-max) and anticoccidial toltrazuril in prevention of coccidiosis in quails and also examine their effects on some blood biochemical, antioxidant and immunological parameters. One hundred and twenty six apparently healthy, one day old quails were divided into 6 equal groups. Group (Gp 1) was kept as control. Gp 2 was treated with a probiotic preparation (1 gm/L drinking water) from a day till 28 days old. Gp 3 was treated with toltrazuril at 16 days old at a dose of 25 ppm (1 ml/L drinking water) for 2 consecutive days. Gp 4 was inoculated with 4.1 x 10 sporulated oocysts of Eimeria spp. intracrop at 14 days old. Gp 5 was treated with a probiotic (1 gm/L drinking water) from a day till 28 days old and experimentally inoculated with 4.1 x 10 sporulated oocysts of Eimeria spp. at 14 days old using intracrop route. Gp 6 was experimentally inoculated with 4.1 x 10 sporulated oocysts of Eimeria spp. at 14 days old and treated with toltrazuril at 16 days old at a dose of 25 ppm (1ml/L drinking water) for 2 consecutive days. Probiotic relatively minimize the infestation and oocysts shedding. Moreover, an improvement in the cecal IFN-γ &IL-2 and antioxidant enzymes with variable effects on the serum cholesterol, triglycerides, HDL, ALT, AST and ALP activities were resulted. It could be concluded that the addition of the used probiotic (1 gm/L drinking water) was found to have a positive effect on coccidiosis and reduce the number of Eimeria oocysts and reduces the damage caused by free radicals and raise immunity.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128740410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue Engineering in Wound Healing Therapy by Using Chitosan and Stem Cells","authors":"Aida El-Shaer, A. Abuel-Atta, Wahid Eid, Dina M. M. AlSadek","doi":"10.21608/zvjz.2021.96509.1156","DOIUrl":"https://doi.org/10.21608/zvjz.2021.96509.1156","url":null,"abstract":"Skin wounds are considered as the most critical, and widespread problems due to the high rate of accidents or burn worldwide. Full-thickness skin loss could be chronic or acute wounds, which found difficulty in medical treatment, because of taking a long time in healing. Therefore, exposure to the infection, which delays the healing process and causing disordered healing, ends with distortion or incomplete closure, which might lead to a fatal complication. Thus, the need for skin grafting is a necessary and critical decision although its side effects and rejection possibilities. This review put a spotlight on one of the latest therapeutic techniques in regenerative medicine “tissue engineering”. It is an up-to-dates field in applications of stem cells and cells culture to replace the traditional tissue or organs transplantation techniques. We discussed the skin organ scaffolding as a simple example of tissue engineering applications in accelerating wound healing using stem cells cultured with chitosan scaffold. The latter is characterized by several medical properties especially in skin regeneration, for fabrication of artificial skin, which mimics the natural skin tissue and applying it in chronic or acute wounds","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128226237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed Tomographic, Echocardiographic, Radiographic, and Morphological Anatomy of the Heart in Goats (Capra Hircus).","authors":"Aly El-Deen Abd-Elbasset, A. El-sayed, Hassan Mohamed, Eman El-Bherey, Doaa S. Nouh","doi":"10.21608/zvjz.2021.98165.1159","DOIUrl":"https://doi.org/10.21608/zvjz.2021.98165.1159","url":null,"abstract":"The heart is the most important organ in the cardiovascular system. It pumps oxygen-rich blood all over the body. The imaging techniques are vital to get details for the best description of the structures of the cardiovascular system. Hence, it is considered an important means for diagnosis and clinical application. The current study was performed on five healthy goats of both sexes from native breeds, weighing about 30–35 kg and aging from one to three years. These goats were used as follows: topographical examination, gum milk injection (Latex 60%), computed tomography followed by frozen cross-section technique, thoracic radiograph, and echocardiography respectively. Ten hearts of apparent healthy goats were dissected for describing the heart morphology. The heart of the goat was situated between the 3rd and the 6th ribs in the thoracic cavity. It was hollow muscular cone-shaped with a slightly pointed apex. It had two surfaces, two borders, a base, and an apex. It was divided into four chambers through coronary and longitudinal grooves. The Computed Tomography sections result was compared with the anatomical images. Radiography and echocardiography were figured, identified, and labeled to create a comprehensive guide for experts in anatomy, surgery, and veterinary education. In conclusion, heart dissection generates anatomical knowledge and description. Besides, the modern imaging modalities such as Computed Tomography, echocardiography, and radiograph, provided non-invasive means for the animal anatomy in living animals.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127675663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}