Journal of Pathology Research Reviews and Reports最新文献

{"title":"Complementry Role of Bone Marrow Aspiration and Biopsy","authors":"Nirali V Shah, Vidhi J. Shah, F. Goswami, R. Gidwani","doi":"10.47363/jpr/2021(3)130","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)130","url":null,"abstract":"Introduction: Bone marrow examination is an important diagnostic tool to evaluate various hematological and non-hematological disorders. The two most important techniques used for the diagnosis are bone marrow aspiration and bone marrow biopsy which play complementary role with each other when performed simultaneously. Aims and Objectives: Study was done to compare the results of BMA and BMB and by that to prove the complementary role of both techniques to each other. Material and Methods: We evaluated total 74 cases in central laboratory, department of pathology, at tertiary care centre. All aspirations were stained by giemsa and iron stain while all biopsy were stained by routine H&E stain. Reticulin stain and IHC markers were used as and when required. Result: Out of total 74 cases, 40 cases showed positive corelation between these two techniques (54%). In two cases aspiration was not possible. In 8 cases biopsy was not done. 4 cases showed crushing artefact in BMB while 3 cases of aspiration were either diluted or dry tap. In all these cases diagnosis became possible by the alternate technique. BMB replaced BMA and vice versa as and when required. Conclusion: BMA and BMB are complementary procedure which yields extra support in diagnosing various hematological and non hematological disorders when one or other technique fails due to some reason","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117131436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunostimulatory CpG Oligonucleotides as an Adjuvant with Recombinant DNA Vaccine Encoding Hepatitis C Virus Core Protein","authors":"A. Karami","doi":"10.47363/jpr/2021(3)127","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)127","url":null,"abstract":"The immunogenicity and protective efficacy of DNA vaccines have been amply demonstrated in numerous animal models against infectious diseases. In order to increase the potency of DNA vaccines, we have compared the immune response of conventional adjuvants such as aluminum phosphates, Dendrosome, CpG motif and mixture of aluminum phosphate and CpG motif. Female BALB/c mice were immunized with 10, 25 and 50 microgram of HCV core pcDNA3 plasmid mixed with the adjuvants. Each dose of recombinant pcDNA3 and different adjuvant were used as an immunogen in three IM injection periods. Blood samples were collected at four different times. The data indicate that the antibody response achieved following DNA immunization can be enhanced by CpG motif as molecular adjuvant","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120993802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Educational Status on Underweight among Lactating Women in Ethiopia A Systemic Review and Meta-Analysis","authors":"Wosenyeleh Semeon Bagajjo, Kaleab Tesfaye Tegegne, Berhanu Bifato, Abiyu Ayalew Assefa","doi":"10.47363/jpr/2021(3)126","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)126","url":null,"abstract":"Objective: The objective of this systemic review and meta-analysis was to examine the relationship between educational status and underweight among lactating women in Ethiopia The studies conducted before indicate in consistence association between educational status and underweight among lactating women in Ethiopia. We include 7 studies in different regions of Ethiopia. Materials and Methods: The databases, including PubMed, Google scholar were systematically searched from 2015 to 2020. Data were extracted and tabulated by two reviewers using a table containing the following variables: author, title, date of publication, city(s)/ Region / study design, sample size, percentage women with informal education and percentage women with formal education and underweight. The Newcastle-Ottawa Scale for cross-sectional studies quality assessment tool was adapted and used to assess the quality of each study. The combined adjusted Odds ratios (OR)) and 95% confidence intervals were calculated using random effect model. Results: In the current meta-analysis seven observational studies involving 3113 lactating women’s were used to estimate the pooled effect size of underweight. The result of 7 included studies indicated that the pooled odd ratio of underweight among women with informal education compared with women with formal education in Ethiopia was 2.47 (95% CI: 1.69, 3.83). Publication bias for estimating the odd ratio of underweight for women with informal education compared to women with formal education (p = 0.881) and (p = 0.649 ) respectively Heterogeneity was statistically significant (I2=76% Q=25.06; P<0•001). From 54.35% (1692) women who have informal education 16.35% (509) women have underweight. The overall proportion of underweight was 16.35% and 6.58% for those having informal education and formal education respectively. Conclusions: There was evidence that lactating mothers with informal education are more likely to experience underweight. Based on our findings, we strongly recommended that the health education activities about nutrition should be targeted among lactating women with informal education through health extension workers","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126082661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 11 Week’s Gestation Ruptured Tubal Ectopic Pregnancy : A Case Report","authors":"Derqaoui Sabrine, EL Majoudi Salma, R. Lamia, Lamalmi Najat","doi":"10.47363/jpr/2021(3)124","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)124","url":null,"abstract":"Background and Objectives: (Eleusine coracana) is a rich source of proteins, phytochemicals, and fibers with several health benefits. Cancer accounts for 12c/o of death worldwide, which requires superior therapeutic strategies. Polyphenols are a class of phytochemicals in plant derived compounds, that has been reported to exhibit anticancer, antioxidant, anti-inflammatory and antimicrobial properties. The objective was to investigate the binding potential of selected polyphenols against probable drug targets of various types of cancer and provide an insight on the anti-inflammatory, antioxidant, and antimicrobial properties by using molecular docking method. Materials and Methods: Ten receptors were analyzed for anticancer, two receptors for anti- inflammatory, three receptors for antioxidant, and five receptors for antimicrobial studies. The binding competences of polyphenol towards selected targets were studied by molecular docking. Results: Affinity of polyphenols as an anticancer agent with respect specific targets viz CDKN1A, FOXO1, FGFR2, CTNNB1, and GST-PI was evident. The binding energies of docked complexes were found to be -116.56, -114.5, -110.38, -106.9, and -105.07 kcal/mol, respectively. In case of anti-inflammatory the best binding was seen in between COX-2 receptor with and COX-1 receptors. Antioxidant studies it was observed that SOD2 showed the best binding energy followed by SOD3. Followed by antimicrobial studies the best binding interaction some how were shown by IARS and PBP1a receptors. Conclusion: Present studies revealed that polyphenols has superior interacting properties towards these cancer targets than their normal ligands and shows a strong approach to anti-inflammatory, antioxidant, and antimicrobial activity","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132759250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Mathematical Modelling Techniques in Breast Cancer Dynamics","authors":"Mashasha Maxwell, Chigidi Esther","doi":"10.47363/jpr/2021(3)125","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)125","url":null,"abstract":"Cancer is an age related autoimmune disease initiated by genetic mutations leading to increased proliferation rate and tumor formation. Accumulation of various genetic and epigenetic changes, in normal cells gives cancer cells a selective advantage over healthy cells, and lead to cancer initiation and progression. Interactions of tumor cells with other cells within their reach, the microenvironment, is an important component in carcinogenesis. Its treatment is based on our level of understanding of its biology. Breast cancer is a collection of complex and heterogeneous diseases with distinct histopathological features. It arises due to abnormal growths of the cells lining the breast lobules hence men and women can develop it, although very rare in men (less than ). There are different types of breast cancer, and the most common are the invasive and non-invasive cancers. Usually, it is common to study breast cancer tumors as isolated entities, but its biological and molecular structure are indicative of an unstable heterogeneous disease with multiple subtypes coexisting within a tumor. Many studies with different methodologies have been carried out to understand cancer development and progression, however, another approach of mathematical oncology has emerged. This approach uses mathematical and computational techniques to unpack generation, growth and evolution of cancer cells. With this work we would like to review what has been done by others so as to improve our understanding of cancer dynamics","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"263 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122469420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Antimicrobial, Antioxidant, Anti-inflammatory, and Anticancer Properties of Polyphenols in Ragi Plant","authors":"V. Ramesh, Megha Mathur, S. Kiran, N. Rajeswari, Shashank A. Tidke","doi":"10.47363/jpr/2021(3)123","DOIUrl":"https://doi.org/10.47363/jpr/2021(3)123","url":null,"abstract":"Background and Objectives: (Eleusine coracana) is a rich source of proteins, phytochemicals, and fibers with several health benefits. Cancer accounts for 12c/o of death worldwide, which requires superior therapeutic strategies. Polyphenols are a class of phytochemicals in plant derived compounds, that has been reported to exhibit anticancer, antioxidant, anti-inflammatory and antimicrobial properties. The objective was to investigate the binding potential of selected polyphenols against probable drug targets of various types of cancer and provide an insight on the anti-inflammatory, antioxidant, and antimicrobial properties by using molecular docking method. Materials and Methods: Ten receptors were analyzed for anticancer, two receptors for anti- inflammatory, three receptors for antioxidant, and five receptors for antimicrobial studies. The binding competences of polyphenol towards selected targets were studied by molecular docking. Results: Affinity of polyphenols as an anticancer agent with respect specific targets viz CDKN1A, FOXO1, FGFR2, CTNNB1, and GST-PI was evident. The binding energies of docked complexes were found to be -116.56, -114.5, -110.38, -106.9, and -105.07 kcal/mol, respectively. In case of anti-inflammatory the best binding was seen in between COX-2 receptor with and COX-1 receptors. Antioxidant studies it was observed that SOD2 showed the best binding energy followed by SOD3. Followed by antimicrobial studies the best binding interaction some how were shown by IARS and PBP1a receptors. Conclusion: Present studies revealed that polyphenols has superior interacting properties towards these cancer targets than their normal ligands and shows a strong approach to anti-inflammatory, antioxidant, and antimicrobial activity","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117299213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Challenge: Présence of ICAM1 Gene in Echinodermata (Invertebrates)","authors":"M. Leclerc","doi":"10.47363/JPR/2020(1)109","DOIUrl":"https://doi.org/10.47363/JPR/2020(1)109","url":null,"abstract":"ICAM1 Gene we met usually in human, was discovered, for the first time, in invertebrates, in echinodermata. Its parameters, its sequence in 5’-3’ was clearly demonstrated in ophiocomina nigra (ophuirids).it is in correlation to nuclear factor b we discovered also in echinodermata. The interaction nfkappab -icam1 gene in human is well-known","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127584085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Gene-Xpert in the Diagnosis of Negative Microscopy Pulmonary Tuberculosis in Brazzaville, Republic Of Congo","authors":"L. S. G. Linguissi, C.A.G. Nyanga‐Koumou, Christ Eya","doi":"10.47363/jpr/2020(2)110","DOIUrl":"https://doi.org/10.47363/jpr/2020(2)110","url":null,"abstract":"Setting: Xpert MTB/Rif has become an integral part of tuberculosis diagnostic algorithms in many low- and middle-income countries and no published data was retrieved regarding the diagnostic accuracy of Xpert MTB/RIF in sputum smear-negative pulmonary TB in RoC. Objectives: This study aimed at determining the diagnostic accuracy of Xpert MTB/RIF in diagnosing sputum smear-negative pulmonary tuberculosis keeping AFB microscopy as the gold standard. Design: For 4 months, one morning sputum smear was performed for every TB suspect (cough lasting >3 weeks, as defined in Congolese’s national guidelines) with AFB microscopy and GeneXpert. Results: Of 90 TB suspects for whom AFB microscopy and GeneXpert were performed, 79 (87.78%) sputum smear-negative 17 (21.52%) GeneXpert positive cases were identified. During the study, 11 (12.22%) sputum smear-positive cases were diagnosed. GeneXpert has greatly contributed to increasing the total number of bacteriologically proven cases. Conclusion: These results confirms the utility of GeneXpert in the diagnosis of tuberculosis especially smear negative pulmonary tuberculosis, and demonstrates that the expected number of smear-negative TB cases in Republic of Congo is probably much higher than the World Health Organization’s current annual estimates","PeriodicalId":137237,"journal":{"name":"Journal of Pathology Research Reviews and Reports","volume":"93 Pt A 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115786622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}