British Journal of Surgery最新文献

{"title":"Pathological response guides adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy in surgically resected gastro-oesophageal cancer (SPACE-FLOT): international cohort study.","authors":"","doi":"10.1093/bjs/znaf056","DOIUrl":"10.1093/bjs/znaf056","url":null,"abstract":"<p><strong>Background: </strong>Many patients with locally advanced gastro-oesophageal cancers are unable to complete adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy, raising questions about its therapeutic utility. The aim of this study was to examine whether pathological response to neoadjuvant FLOT can guide its adjuvant use.</p><p><strong>Methods: </strong>Patients with non-metastatic gastro-oesophageal adenocarcinoma who received neoadjuvant FLOT and underwent surgery from 1 January 2017 to 1 January 2022 from 43 hospitals across 12 countries were analysed. Pathological response was assessed using tumour regression grading systems, trichotomized into minimal responders (MR; worst category), complete responders (CR; pCR), and partial responders (PR; between MR and CR). Survival outcomes of patients who did and did not receive adjuvant FLOT were compared using Kaplan-Meier, Cox regression, propensity score matched, and sensitivity analysis.</p><p><strong>Results: </strong>A total of 1887 patients (459 MR, 221 CR, and 1207 PR) were evaluated. The median follow-up was 25.5 (interquartile range 15.0-39.1) months. In the MR group, there was no difference in disease-free survival (DFS; HR 1.03 (95% c.i. 0.78 to 1.36), P = 0.836) between those who did and did not receive adjuvant FLOT. Whilst there was a difference in non-adjusted OS, this became statistically non-significant after adjusting for baseline characteristics (HR 0.96 (95% c.i. 0.70 to 1.30), P = 0.801). In the CR group, there was no difference in DFS (HR 0.88 (95% c.i. 0.41 to 1.85), P = 0.724) or OS (HR 0.69 (95% c.i. 0.31 to 1.54), P = 0.343) between those who did and did not receive adjuvant FLOT. In the PR group, adjuvant FLOT conferred a significant DFS (HR 0.68 (95% c.i. 0.55 to 0.86), P < 0.001) and OS (HR 0.55 (95% c.i. 0.44 to 0.69), P < 0.001) benefit.</p><p><strong>Conclusion: </strong>Pathological response to neoadjuvant FLOT may guide the use of adjuvant FLOT, enabling personalized approaches to treatment.</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database.","authors":"","doi":"10.1093/bjs/znaf061","DOIUrl":"https://doi.org/10.1093/bjs/znaf061","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and treatment of ruptured abdominal aortic aneurysm.","authors":"Maria Elisabeth Leinweber, Fajar S Rahmaditya, Robert J Hinchliffe","doi":"10.1093/bjs/znaf051","DOIUrl":"https://doi.org/10.1093/bjs/znaf051","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small bowel obstruction outcomes according to compliance with the World Society of Emergency Surgery Bologna guidelines.","authors":"Lewis J Kaplan, Isidro Martinez-Casas, Shahin Mohseni, Matteo Cimino, Hayato Kurihara, Matthew J Lee, Gary A Bass","doi":"10.1093/bjs/znaf080","DOIUrl":"https://doi.org/10.1093/bjs/znaf080","url":null,"abstract":"<p><strong>Background: </strong>Small bowel obstruction (SBO) is a common surgical emergency associated with substantial morbidity, hospital length of stay (LOS), and healthcare cost. The World Society of Emergency Surgery (WSES) Bologna guidelines provide evidence-informed recommendations for managing adhesive SBO, promoting timely surgical intervention (or non-operative management (NOM) when ischaemia, strangulation, or peritonitis are absent). However, guideline adoption and its impact on outcomes remain under studied. Compliance with the Bologna guidelines was evaluated to determine the impact of compliance on outcomes.</p><p><strong>Methods: </strong>SnapSBO, a prospective, multicentre, time-bound, observational cohort study, captured data on patients with adhesive SBO across diverse healthcare settings and patient populations. Patient care was categorized into: successful NOM, surgery after an unsuccessful appropriate trial of NOM (NOM-T), and direct to surgery (DTS). Compliance with diagnostic, therapeutic, and postoperative Bologna guideline recommendations was assessed as either complete or partial. Primary outcomes included adherence to the Bologna guidelines, LOS, complications, and the incidence of the composite metric 'optimal outcomes' (LOS ≤5 days, discharge without complications, and no readmission within 30 days).</p><p><strong>Results: </strong>Among 982 patients with adhesive SBO, successful NOM occurred in 561 (57.1%), 224 (22.8%) underwent NOM-T, and 197 (20.1%) proceeded DTS. The mean(s.d.) LOS was 5.3(9.0), 12.9(11.4), and 7.7(8.0) days respectively (P < 0.001). Optimal outcomes were achieved in 61.0%, 16.1%, and 37.6% respectively (P < 0.001) and full guideline compliance was observed in 17.2%, 10.1%, and 0.4% respectively.</p><p><strong>Conclusion: </strong>Patients with adhesive SBO whose care was aligned with the Bologna guidelines had a shorter LOS and a greater incidence of optimal outcomes. Addressing evidence-to-practice gaps through implementation strategies that consider contextual factors will enhance guideline adoption and patient outcomes.</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of gross extrathyroidal extension to the recurrent laryngeal nerve alone on survival in papillary thyroid carcinoma.","authors":"Victoria Harries,Daniel W Scholfield,Alana Eagan,R Michael Tuttle,Ashok R Shaha,Jatin P Shah,Richard J Wong,Snehal G Patel,Ian Ganly","doi":"10.1093/bjs/znaf030","DOIUrl":"https://doi.org/10.1093/bjs/znaf030","url":null,"abstract":"BACKGROUNDGross extrathyroidal extension (ETE) is one of the most important predictors of survival in papillary thyroid carcinoma (PTC). The aim of this study is to determine the impact of gross ETE to the recurrent laryngeal nerve alone (RLNT4aETE) on survival.METHODSAfter institutional review board approval, adult PTC patients were identified from an institutional database undergoing initial surgery for well-differentiated thyroid carcinoma from 1986 to 2020. Patients were classified as having no gross ETE, gross ETE to strap muscles only (T3bETE), RLNT4aETE, or gross ETE involving other adjacent structures (otherT4aETE). Disease-specific survival (DSS) was calculated using the Kaplan-Meier method and groups were compared using the log-rank test.RESULTSThere were 8030 patients included in the analysis; 7578 patients (94.2%) with no gross ETE, 197 (2.4%) with T3bETE, 40 (0.5%) with RLNT4aETE, and 215 (2.7%) with otherT4aETE. The estimated 10-year DSS for patients with no gross ETE, T3bETE, RLNT4aETE, and otherT4aETE in the whole cohort were 99.2%, 95.7%, 96.9%, and 82.5% respectively (P < 0.0001). After controlling for age, nodal and distant disease stage, RLNT4aETE patients had a similar DSS to T3bETE patients, when compared to no gross ETE patients (HRs 2.91 versus 2.28 respectively). In the ≥55-year-old cohort, the 10-year DSS for patients with no gross ETE, T3bETE, RLNT4aETE, and otherT4aETE were 97.7%, 89.4%, 90.9% and 67.6% respectively.CONCLUSIONRLNT4aETE patients appear to have a similar DSS to T3bETE patients. This highlights the heterogeneity within the current T4a cohort and supports the downstaging of RLNT4aETE patients to the T3b classification.","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"1 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of aqueous olanexidine compared with alcohol-based chlorhexidine for surgical skin antisepsis regarding the incidence of surgical-site infections in clean-contaminated surgery: a randomized superiority trial.","authors":"Masashi Takeuchi, Hideaki Obara, Tasuku Furube, Hirofumi Kawakubo, Minoru Kitago, Koji Okabayashi, Hiroto Fujisaki, Junya Aoyama, Yosuke Morimoto, Ryusuke Amemiya, Junichi Sano, Jumpei Nakadai, Rei Goto, Yasunori Sato, Yuko Kitagawa","doi":"10.1093/bjs/znaf065","DOIUrl":"10.1093/bjs/znaf065","url":null,"abstract":"<p><strong>Background: </strong>Surgical-site antisepsis is used to prevent surgical-site infections (SSIs). Although several guidelines have indicated the efficacy of antiseptics, such as chlorhexidine, povidone-iodine, and olanexidine, in reducing the SSI rate, an optimal recommendation is still not established. The aim of this study was to evaluate the efficacy of aqueous olanexidine compared with chlorhexidine-alcohol as the optimal antiseptic for preventing SSI in clean-contaminated surgery.</p><p><strong>Methods: </strong>This multicentre randomized trial for surgical skin antisepsis in clean-contaminated gastrointestinal and hepatobiliary-pancreatic surgeries in five hospitals evaluated the efficacy of olanexidine and chlorhexidine-alcohol. The primary endpoint was 30-day SSI. Secondary outcomes included the occurrence of SSI types, intervention-related toxicity, and reoperation caused by SSI.</p><p><strong>Results: </strong>Overall, 700 patients from five institutions underwent randomization; 347 received olanexidine and 345 received chlorhexidine-alcohol in the full analysis set. The 30-day SSI rate was 12.4% (43 of 347) in the olanexidine group and 13.6% (47 of 345) in the chlorhexidine-alcohol group (adjusted risk ratio (aRR) 0.911 (95% c.i. 0.625 to 1.327); P = 0.626). No significant differences were observed between the groups regarding the secondary outcomes, including the occurrence of superficial incisional SSI, deep incisional SSI, organ/space SSI, and reoperation caused by SSI. Overall adverse effects were seen in two patients (0.58%) in the olanexidine group and in three patients (0.87%) in the chlorhexidine-alcohol group (aRR 0.663 (95% c.i. 0.111 to 3.951)).</p><p><strong>Conclusion: </strong>Olanexidine did not significantly reduce the occurrence of overall SSI compared with chlorhexidine-alcohol. Nevertheless, these findings provide valuable insights for developing novel surgical SSI management protocols.</p><p><strong>Registration number: </strong>UMIN 000049712 (University Hospital Medical Information Network Clinical Trials Registry).</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Words that hurt: addressing the gender gap in surgery.","authors":"Elena Giacomelli, Walter Dorigo, Flavia Ciavarelli, Raffaele Pulli","doi":"10.1093/bjs/znaf059","DOIUrl":"https://doi.org/10.1093/bjs/znaf059","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation and short-term outcomes of minimally invasive liver surgery in France.","authors":"Stylianos Tzedakis, Diana Berzan, Ugo Marchese, Alexandre Challine, Vincent Mallet, Anthony Dohan, Heithem Jeddou, Alexandra Nassar, Sandrine Katsahian, David Fuks","doi":"10.1093/bjs/znaf017","DOIUrl":"https://doi.org/10.1093/bjs/znaf017","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital triage of trauma patients: predicting major surgery using artificial intelligence as decision support.","authors":"Andreas S Millarch, Fredrik Folke, Søren S Rudolph, Haytham M Kaafarani, Martin Sillesen","doi":"10.1093/bjs/znaf058","DOIUrl":"https://doi.org/10.1093/bjs/znaf058","url":null,"abstract":"<p><strong>Background: </strong>Matching the necessary resources and facilities to attend to the needs of trauma patients is traditionally performed by clinicians using criteria-directed triage protocols. In the present study, it was hypothesized that an artificial intelligence (AI) model should be able to predict the need for major surgery based on data available at the scene.</p><p><strong>Methods: </strong>Prehospital and in-hospital electronic health record data were available for 4578 patients in the Danish Prehospital Trauma Data set. Data included demographics (age and sex), clinical scores (airway, breathing, circulation, disability (ABCD) and Glasgow Coma Scale scores), and sequential vital signs (heart rate, blood pressure, and oxygen saturation). The data from the first 5, 10, and 20 min of prehospital contact were used for predicting the need for surgery up to 12 h after hospital arrival. Surgeries were stratified into all major surgical procedures and specialty-specific procedures (neurosurgery, abdominal surgery, and vascular surgery). The data set was split into training (70%), validation (20%) and holdout test (10%) data sets. Three hybrid neural networks were trained and performance was evaluated on the holdout test data set using the area under the receiver operating characteristic curve (ROC-AUC).</p><p><strong>Results: </strong>Overall, the model achieved an ROC-AUC of 0.80-0.86 for predicting the need for major surgery. For predicting the need for major neurosurgery the ROC-AUC was 0.90-0.95, for predicting the need for major vascular surgery the ROC-AUC was 0.69-0.88, and for predicting the need for major abdominal surgery the ROC-AUC was 0.77-0.84.</p><p><strong>Conclusion: </strong>Utilizing AI early in the prehospital phase of a trauma patient's trajectory can predict specialized surgical needs. This approach has the potential to aid the early triage of trauma patients.</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-technical error leading to patient fatalities in the Australian surgical population.","authors":"Jesse D Ey, Victoria Kollias, Octavia Lee, Kelly Hou, Matheesha B Herath, John B North, Ellie C Treloar, Martin H Bruening, Adam J Wells, Guy J Maddern","doi":"10.1093/bjs/znaf083","DOIUrl":"https://doi.org/10.1093/bjs/znaf083","url":null,"abstract":"<p><strong>Introduction: </strong>Many surgical adverse events are due to errors in non-technical skills (NTS); consequently, improving NTS is a priority. However, evidence to guide NTS improvement activities is lacking. This study aimed to investigate the incidence and characteristics of non-technical errors linked to fatalities in a large, representative surgical-patient population to guide future NTS improvement.</p><p><strong>Methods: </strong>All fatality cases with known or suspected adverse events reported to the Australian and New Zealand Audit of Surgical Mortality (ANZASM) between 2012 and 2019 were retrospectively assessed using a validated tool developed by the study authors. Outcomes included the incidence of non-technical errors linked to death (overall and by NTS domain), the identification of non-technical error predictors through multivariate analysis, and change in non-technical error incidence over time using statistical process control charts.</p><p><strong>Results: </strong>Some 30 971 cases of surgical fatality were reported between 2012 and 2019, of which 3829 met the inclusion criteria. Due to insufficient information, 134 were excluded, leaving 3695 for analysis. Non-technical errors associated with patient death were identified in 63.7%. Of these, 58.4% had Decision-Making errors, 56.4% had Situational Awareness errors, 15.2% had Communication/Teamwork errors, and 5.44% had Leadership errors. Statistically significant predictors of Communication/Teamwork, Decision-Making, and Situational Awareness errors were identified. The incidence of overall non-technical errors decreased significantly between 2012 and 2019 and periods of significant decrease in Communication/Teamwork and Leadership errors were demonstrated. No significant decrease in Decision-Making or Situational Awareness errors were demonstrated.</p><p><strong>Conclusion: </strong>The incidence of non-technical errors associated with surgical mortality rate is high. Future NTS improvement efforts should be targeted towards Decision-Making and Situational Awareness errors.</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":"112 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}