British Journal of Haematology最新文献

{"title":"Methodological considerations in 'Risk factors for silent cerebral infarction in immune-mediated thrombotic thrombocytopenic survivors'.","authors":"Jinlin Liu","doi":"10.1111/bjh.70528","DOIUrl":"https://doi.org/10.1111/bjh.70528","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blastic plasmacytoid dendritic cell neoplasm (BPDCN): Morphological mimicry of lymphoid neoplasms.","authors":"Hong Guo, Yan Wei, Chenglei Wang, Xinying Guo, Guanghui Zhao","doi":"10.1111/bjh.70496","DOIUrl":"https://doi.org/10.1111/bjh.70496","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deacetylase inhibitors CM-444 and CM-1758 enhance chemotherapy response in AML via ALOX5.","authors":"Naroa Gimenez-Camino, Edurne San José-Enériz, Leire Garate, Estibaliz Miranda, Elena Sáez, Antonio Pineda-Lucena, Felipe Prósper, Xabier Agirre","doi":"10.1111/bjh.70520","DOIUrl":"https://doi.org/10.1111/bjh.70520","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA profile in paediatric ITP: Comparison with healthy controls and prognostic implications.","authors":"Jesús González de Pablo, Yessenia L Molina, José Luis Vicario, Miguel Ángel Moreno Hidalgo, Ana de la Cruz, Almudena Galán, Josune Zubicaray, Guzmán López de Hontanar, Alejandro Sanz, Luis Marín, Jorge Verdejo de Antonio, Julián Sevilla, Elena Sebastián","doi":"10.1111/bjh.70483","DOIUrl":"https://doi.org/10.1111/bjh.70483","url":null,"abstract":"<p><p>Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated low platelet counts. Although several studies have explored the relationship between the human leucocyte antigen (HLA) system and ITP, findings have been inconsistent. We compared HLA typing between paediatric ITP patients and healthy controls to assess its role in ITP susceptibility. We also evaluated the association between HLA alleles and clinical outcomes in our paediatric ITP cohort. This retrospective observational study included 135 patients with primary ITP and a control group of 929 healthy individuals. The median age of ITP patients was 5.71 years (Interquartile range 2.71-10.21). The HLA-DRB1*07 and HLA-DRB1*13 alleles were more prevalent in healthy controls than in ITP patients, suggesting a potential protective role (p < 0.05). In contrast, HLA-A*68, HLA-B*40 and HLA-DRB1*14 alleles were associated with an increased risk of ITP (p < 0.05). Regarding prognosis, HLA-A*26 allele correlated with lower recovery rates, while HLA-C*03 allele was associated with a higher recovery likelihood (p < 0.05). In addition, HLA-A*02 and HLA-C*04 alleles and the HLA-A02 supertype showed a significant association with a higher probability of chronicity (p < 0.05). Our results highlight the potential role of HLA typing as a diagnostic and prognostic tool for ITP. However, larger studies are required to validate these associations.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating erythropoietin concentration associates with thromboembolism in sickle cell disease.","authors":"Xu Zhang, Binal N Shah, Jin Han, Mehdi Nouraie, Yingze Zhang, Roberto F Machado, Mark T Gladwin, Santosh L Saraf, Victor R Gordeuk","doi":"10.1111/bjh.70517","DOIUrl":"https://doi.org/10.1111/bjh.70517","url":null,"abstract":"<p><p>Elevated erythropoietin (EPO) concentration associates with thrombotic risk in hypoxic conditions, hereditary erythrocytosis and treatment of anaemia with recombinant EPO. We evaluated sickle cell disease (SCD) patients from the University of Illinois at Chicago (UIC) and the Treatment of Pulmonary Hypertension and SCD with Sildenafil Therapy (Walk-PHaSST) study and found that higher serum EPO concentration associated with increased thromboembolic risk (combined odds ratio [OR] = 1.9, p = 0.0029, N = 557). Percent haemoglobin F and haemoglobin concentration strongly correlated with EPO concentration in SCD, and the haemoglobin F locus BCL11A affected EPO concentration through percent haemoglobin F. In peripheral blood mononuclear cells from 159 UIC patients, we identified an expression quantitative trait locus for EPOR encoding EPO receptor, in which the G allele of rs322139 associated with higher EPOR expression (β = 0.055, p = 2.0 × 10^-5). This G allele associated with lower EPO concentration in Walk-PHaSST (β = -0.23, p = 6.4 × 10^-5, N = 327) and UIC (β = -0.18, p = 0.017, N = 179), but not in normal populations. The G allele of rs322139 also associated with a trend to decreased thromboembolism (combined OR = 0.64, p = 0.054, N = 665). In summary, our study indicates that higher serum EPO concentration associates with thromboembolic risk in SCD and reveals a novel role of EPOR expression variation in modulating EPO concentration and, possibly, thromboembolic risk in this condition.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elranatamab therapy in relapsed refractory multiple myeloma patients with chronic kidney disease: A case series.","authors":"Gráinne Marron, Niklesh Warrier, Kelvin Chan, Bradley Augustson","doi":"10.1111/bjh.70510","DOIUrl":"https://doi.org/10.1111/bjh.70510","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world comparison of peripheral neuropathy and treatment delivery between Pola-R-CHP and R-CHOP in DLBCL.","authors":"Nobuhiko Nakamura, Koichi Ohata, Tomohiro Aizaki, Yuto Kaneda, Yoshikazu Ikoma, Takuro Matsumoto, Hiroshi Nakamura, Serika Banno Matsuoka, Shiori Hishida Sadaka, Akio Suzuki, Nobuhiro Kanemura, Masahito Shimizu","doi":"10.1111/bjh.70524","DOIUrl":"https://doi.org/10.1111/bjh.70524","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective implementation of the HCT frailty scale in adults with lymphoproliferative syndromes candidates for autologous haematopoietic stem cell transplantation: Results from a multicentre GETH-TC study.","authors":"Javier Cornago, Mónica Baile, Marina Acera, Laura Fox, María Del Mar Pérez-Artigas, Ana Santamaría, María Del Carmen Quintela, Andrés Sánchez-Salinas, Joaquina M Salmerón, Verónica Illana, Zahra Abdallahi-Lefdil, Laura Pardo, Laura Solán, José Luis López-Lorenzo, Sara Fernández-Luis, Leddy Patricia Vega, Sara Villar, Patricia Beorlegui-Murillo, Mónica Molina, Albert Esquirol, Isabel Izquierdo, Julia Ribes, Alberto Mussetti, Esperanza Lavilla, Olga Alda, Javier López-Marín, Leyre Bento, Silvia Filaferro, Pascual Balsalobre, Anna Sureda, María Queralt Salas","doi":"10.1111/bjh.70505","DOIUrl":"https://doi.org/10.1111/bjh.70505","url":null,"abstract":"<p><p>This prospective study evaluated the incidence and dynamics of frailty in 156 adults with lymphoproliferative syndromes undergoing autologous haematopoietic stem cell transplantation (HSCT). Frailty was assessed using the haematopoietic cell transplantation (HCT) frailty scale in patients from 15 Spanish institutions at initial consultation, transplant admission and day +100. Quality of life (QoL) was measured using the EuroQoL. At first consultation, 45 patients (28.8%) were classified as fit, 93 (59.6%) as pre-frail and 18 (11.6%) as frail. Frailty was more frequent among older patients, those with Karnofsky performance status (KPS) below 90%, and abnormal Mini-Cog scores (<3). Rates of relapse, death, readmission and median hospital stay were similar across frailty groups. However, frail patients reported significantly worse QoL. One-year non-relapse mortality was higher in frail patients than in pre-frail and fit patients, although differences were not statistically significant (p = 0.19). At day +100, 33.6% of patients were fit, 57.9% pre-frail and 8.5% frail, demonstrating significant transitions in frailty over time (p = 0.001). Moreover, frail patients showed lower relapse-free [53.3% (17.7-79.6) vs. 85.3% (68.3-93.6), p = 0.05] and overall survival [77.8% (36.5-93.9) vs. 100%, p = 0.16], and worse perceived QoL than fit ones. Overall, frailty was dynamic and clinically relevant, supporting routine assessment and targeted interventions to mitigate adverse outcomes.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of CD34⁺ cell dose on outcomes of related allogeneic PBSCT in adult AML patients.","authors":"Yusuke Toda, Tomoyasu Jo, Yasuyuki Arai, Kaito Harada, Masamitsu Yanada, Takahiro Fukuda, Satoshi Yoshihara, Noriko Doki, Naoyuki Uchida, Yasuo Mori, Yuta Hasegawa, Yukio Kondo, Toshiro Kawakita, Tetsuya Eto, Tetsuya Nishida, Masatsugu Tanaka, Makoto Onizuka, Katsuhiro Shono, Masayuki Hino, Tatsuo Ichinohe, Yoshiko Atsuta, Takaaki Konuma","doi":"10.1111/bjh.70506","DOIUrl":"https://doi.org/10.1111/bjh.70506","url":null,"abstract":"<p><p>CD34⁺ cell dose is believed to impact the outcomes of allogeneic peripheral blood stem cell transplantation (PBSCT), yet the optimal dose remains unclear. We retrospectively reviewed 2407 adult patients with acute myeloid leukaemia who underwent their first related PBSCT between 2000 and 2019. The median infused CD34⁺ cell dose was 3.67 × 10⁶/kg. Patients were divided into three groups based on infused CD34⁺ cell dose: low (1.0-2.0 × 10⁶/kg), intermediate (2.0-4.0 × 10⁶/kg) and high (4.0-10.0 × 10⁶/kg) groups. The 5-year overall survival rates were 37.2%, 40.2% and 37.4% in the low, intermediate and high groups respectively (p = 0.176). Although the high-group patients experienced faster neutrophil engraftment, cumulative incidences of infection and primary engraftment failure were comparable across groups. Platelet engraftment was significantly delayed in the low group, with 21.7% failing to engraft at day 100, compared to 14.6% and 13.4% in the intermediate and high groups (p < 0.001). Furthermore, the incidence of secondary graft failure was significantly higher in the low group. In conclusion, a CD34⁺ cell dose >2.0 × 10⁶/kg improves platelet engraftment and reduces the risk of secondary graft failure but does not confer additional long-term benefits.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD8⁺ T cells surpass NK cells in granule release assay: Implications for diagnosing primary HLH.","authors":"Maya Gupta, Shweta Shinde, Aparna Dalvi, Reetika Malik Yadav, Umair Ahmed Bargir, Lavina Temkar, Manisha Madkaikar","doi":"10.1111/bjh.70508","DOIUrl":"https://doi.org/10.1111/bjh.70508","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}