{"title":"Precision immune-guided management of cytomegalovirus (CMV) after allogeneic haematopoietic stem cell transplantation in the letermovir era: A pragmatic framework.","authors":"Xinyi Jiang, Ziwei Xu, Huafang Wang","doi":"10.1111/bjh.70327","DOIUrl":"10.1111/bjh.70327","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1482-1485"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manar Aleid, Riad El Fakih, Amr Hanbali, Feras Alfraih, Haya Alothaimeen, Tusneem Elhassan, Ali Alahmari, Walid Rasheed, Fahad Almohareb, Naeem Chaudhri, Shaykhah Alotaibi, Fahad Alsharif, Marwan Shaheen, Saud Alhayli, Hanan Alkhaldi, Ruah Alyamany, Alfadel Alshaibani, Ahmad S Alotaibi, Abdullah Alamer, Abdulwahab A Albabtain, Syed Osman Ahmed, Hazzaa Alzahrani, Mahmoud Aljurf, Ayman Saad, Mansour Alfayez
{"title":"Transplant outcomes in adolescents and young adults with Philadelphia-positive B-cell acute lymphoblastic leukaemia.","authors":"Manar Aleid, Riad El Fakih, Amr Hanbali, Feras Alfraih, Haya Alothaimeen, Tusneem Elhassan, Ali Alahmari, Walid Rasheed, Fahad Almohareb, Naeem Chaudhri, Shaykhah Alotaibi, Fahad Alsharif, Marwan Shaheen, Saud Alhayli, Hanan Alkhaldi, Ruah Alyamany, Alfadel Alshaibani, Ahmad S Alotaibi, Abdullah Alamer, Abdulwahab A Albabtain, Syed Osman Ahmed, Hazzaa Alzahrani, Mahmoud Aljurf, Ayman Saad, Mansour Alfayez","doi":"10.1111/bjh.70347","DOIUrl":"10.1111/bjh.70347","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1467-1471"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia Song, Huijuan Jiang, Kai Ding, Hui Liu, Yihao Wang, Shan Gao, Yue Ren, Zhaoyun Liu, Jie Zhuo, Bing Li, Guokai Wang, Zongjiu Jiao, Da Gao, Rong Fu
{"title":"Zanubrutinib, lenalidomide, rituximab, temozolomide ± methotrexate as first-line treatment for primary central nervous system lymphoma: A prospective, open-label, multicentre clinical trial.","authors":"Jia Song, Huijuan Jiang, Kai Ding, Hui Liu, Yihao Wang, Shan Gao, Yue Ren, Zhaoyun Liu, Jie Zhuo, Bing Li, Guokai Wang, Zongjiu Jiao, Da Gao, Rong Fu","doi":"10.1111/bjh.70335","DOIUrl":"10.1111/bjh.70335","url":null,"abstract":"<p><p>In this prospective, multicentre clinical trial, we evaluated zanubrutinib combined with lenalidomide, temozolomide and rituximab monoclonal antibody ± methotrexate (RLZT ± MTX) as first-line treatment for primary central nervous system lymphoma. RLZT ± MTX demonstrated good efficacy and safety, especially for elderly patients who cannot undergo intensive chemotherapy.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1424-1428"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel P Schrum, Erin Eberwein, Sikai Cheng, Amber Feng, Erin Kennedy, Taewoong Choi, Jonathan Huggins, Yubin Kang, Suzanne Kirby, Matthew McKinney, Sendhilnathan Ramalingam, Alexandra Stefanovic, Jie Wang, Mitchell E Horwitz, Chenyu Lin
{"title":"Single-centre analysis of prophylactic dexamethasone on the incidence and severity of cytokine release syndrome and immune effector cell-associated neurotoxicity in patients receiving axicabtagene ciloleucel.","authors":"Daniel P Schrum, Erin Eberwein, Sikai Cheng, Amber Feng, Erin Kennedy, Taewoong Choi, Jonathan Huggins, Yubin Kang, Suzanne Kirby, Matthew McKinney, Sendhilnathan Ramalingam, Alexandra Stefanovic, Jie Wang, Mitchell E Horwitz, Chenyu Lin","doi":"10.1111/bjh.70343","DOIUrl":"10.1111/bjh.70343","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1458-1461"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maymoon M Madkhali, Alex Mitchell, Callum Wright, Kim Pearce, Srishty Aku, Sarah Pagan, Louise Duncan, Jason Lam, Jamie Macdonald, Paul Milne, Amy Publicover, Erin Hurst, Venetia Bigley, Geoffrey Hale, Matthew Collin
{"title":"Dose de-escalation of alemtuzumab in matched unrelated donor haematopoietic stem cell transplantation.","authors":"Maymoon M Madkhali, Alex Mitchell, Callum Wright, Kim Pearce, Srishty Aku, Sarah Pagan, Louise Duncan, Jason Lam, Jamie Macdonald, Paul Milne, Amy Publicover, Erin Hurst, Venetia Bigley, Geoffrey Hale, Matthew Collin","doi":"10.1111/bjh.70318","DOIUrl":"10.1111/bjh.70318","url":null,"abstract":"<p><p>Alemtuzumab in vivo T-cell depletion is safe and effective at a single dose of 30 mg in reduced-intensity matched unrelated donor transplants.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1477-1481"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nihar Desai, Mohammed Althobaiti, Carol Chen, Eshrak Al-Shaibani, Tommy Alfaro Moya, Igor Novitzky-Basso, Ivan Pasic, Fotios V Michelis, Dennis D Kim, Rajat Kumar, Jonas Mattsson, Arjun D Law, Auro Viswabandya
{"title":"Improved early transplant outcomes with reduced-dose PTCy and low-dose ATG in matched unrelated donor allogeneic transplantation for acute myeloid leukaemia.","authors":"Nihar Desai, Mohammed Althobaiti, Carol Chen, Eshrak Al-Shaibani, Tommy Alfaro Moya, Igor Novitzky-Basso, Ivan Pasic, Fotios V Michelis, Dennis D Kim, Rajat Kumar, Jonas Mattsson, Arjun D Law, Auro Viswabandya","doi":"10.1111/bjh.70380","DOIUrl":"10.1111/bjh.70380","url":null,"abstract":"<p><p>Post-transplant cyclophosphamide (PTCy) is associated with infectious and organ toxicities. Dose optimization may reduce these risks while maintaining efficacy. We initiated a prospective pilot study in July 2024 evaluating reduced-dose PTCy (35 mg/kg on days +3 and +4; PTCy70) with low-dose anti-thymocyte globulin (ATG) (2 mg/kg) in adults with acute myeloid leukaemia (AML) undergoing matched unrelated donor (MUD) transplantation. Outcomes were compared with a contemporary cohort receiving PTCy100 with ATG 2 mg/kg. Of 173 patients, 41 received PTCy70. Platelet engraftment was faster with PTCy70, 13 vs. 16 days (p < 0.001). In multivariable analysis, PTCy70 was associated with lower risk of bloodstream infections (hazard ratio [HR] 0.39, 95% confidence interval [CI], 0.19-0.78, p = 0.007). At day+100, the incidence of grade II-IV (30.4% vs. 20.3%, p = 0.17), grade III-IV acute graft-versus-host disease (GVHD) (3% vs. 3%, p = 0.08) and non-relapse mortality (3.8% vs. 2.8%, p = 0.67) were similar between groups. Cardiac events were less frequent with PTCy70 (5% vs. 17%; p = 0.06). No cases of sinusoidal obstruction syndrome were observed in the PTCy70 group. At 12 months, relapse (11.1% vs. 15.3%, p = 0.88) and overall survival (79.6% vs. 83.2%, p = 0.87) did not differ between groups. PTCy70 was associated with faster platelet engraftment, fewer bloodstream infections and cardiac events without compromising GVHD, relapse or survival, supporting evaluation in randomized trials.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1359-1368"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye Jee Shim, Jae Hee Lee, Talya Wittmann Dayagi, Robert J Klaassen, Yves D Pastore, Sharon Abish, MacGregor Steele, Catherine Corriveau-Bourque, Vicky R Breakey, Roona Sinha, Soumitra Tole, Lisa Goodyear, Josee Brossard, Stephanie Villeneuve, Bruce Crooks, Meera Rayar, Laura Wheaton, Sara Ogle, Michaela Cada, Hongbing Li, Rinu Mathew, Yigal Dror
{"title":"Expanding genetic landscape of inherited bone marrow failure syndromes: Insights from the Canadian Inherited Marrow Failure Registry (CIMFR) (2001-2023).","authors":"Ye Jee Shim, Jae Hee Lee, Talya Wittmann Dayagi, Robert J Klaassen, Yves D Pastore, Sharon Abish, MacGregor Steele, Catherine Corriveau-Bourque, Vicky R Breakey, Roona Sinha, Soumitra Tole, Lisa Goodyear, Josee Brossard, Stephanie Villeneuve, Bruce Crooks, Meera Rayar, Laura Wheaton, Sara Ogle, Michaela Cada, Hongbing Li, Rinu Mathew, Yigal Dror","doi":"10.1111/bjh.70387","DOIUrl":"10.1111/bjh.70387","url":null,"abstract":"<p><p>Inherited bone marrow failure syndromes (IBMFSs) are genetically heterogeneous with an expanding spectrum of causative genes. Recent molecular advances are thought to have contributed to genetic identification, yet the true gain in diagnostic yield remains unclear. Accordingly, this study aims to investigate the evolving genetic landscape of IBMFSs using data from the Canadian Inherited Marrow Failure Registry by analysing patients enrolled from the 2001-2010 cohort to the 2011-2023 cohort. Among 407 genetically tested patients, 308 (75.7%) underwent molecular diagnosis, with variants identified in 62 distinct genes. These genes encompass diverse cellular pathways, including DNA repair, telomere maintenance, transcription, RNA splicing, ribosome biogenesis, nuclear envelope, Golgi, endoplasmic reticulum and mitochondrial integrity, cell signalling, cytokine receptor activity and cytoskeletal regulation. A total of 453 variants were identified, including pathogenic copy number variants in 12.7% (39/308) of cases, representing 10.4% (47/453) of all variants. Diagnostic yield increased from 51.6% in 2001-2010 to 75.7% in 2001-2023, and genetic testing enabled classification of 17.5% (54/308) of previously unclassified cases. These findings underscore the rapid growth of IBMFS genetic knowledge and the crucial value of comprehensive testing, although 24.3% of cases remain unresolved, likely due to novel syndromes and unrecognised IBMFS-related genes.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1407-1418"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Li, Youming Wang, Yingxiang Wang, Li Ding, Sujun Li, Miaomiao Wu, Qianwen Xu, Yuanli Chen, Xingbing Wang
{"title":"MEK inhibition alleviates macrophage overactivation without compromising the efficacy of CAR-T-cell therapy.","authors":"Hui Li, Youming Wang, Yingxiang Wang, Li Ding, Sujun Li, Miaomiao Wu, Qianwen Xu, Yuanli Chen, Xingbing Wang","doi":"10.1111/bjh.70364","DOIUrl":"10.1111/bjh.70364","url":null,"abstract":"<p><p>This study presents mitogen-activated protein kinase kinase (MEK) inhibition as a strategy for cytokine release syndrome (CRS) and secondary haemophagocytic lymphohistiocytosis (sHLH) in chimeric antigen receptor (CAR)-T therapy, utilizing MEK's regulatory actions that target macrophage activation, cytokine secretion from both macrophages and CAR-T cells, supported by evidence of unimpaired CAR-T-cell therapeutic efficacy of alleviated CAR-T-related inflammation.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1448-1453"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takafumi Furumoto, Koji Ando, Eo Toriyama, Tomoko Hata, Hikaru Sakamoto, Masahiko Chiwata, Hideaki Kitanosono, Jun Nakashima, Takeharu Kato, Masataka Taguchi, Makiko Horai, Hidehiro Itonaga, Shinya Sato, Yasushi Sawayama, Daisuke Imanishi, Yoshitaka Imaizumi, Tatsuro Jo, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi Miyazaki
{"title":"Improvement in survival of patients with higher risk but not lower risk myelodysplastic syndromes over 20 years: A retrospective study from Nagasaki, Japan.","authors":"Takafumi Furumoto, Koji Ando, Eo Toriyama, Tomoko Hata, Hikaru Sakamoto, Masahiko Chiwata, Hideaki Kitanosono, Jun Nakashima, Takeharu Kato, Masataka Taguchi, Makiko Horai, Hidehiro Itonaga, Shinya Sato, Yasushi Sawayama, Daisuke Imanishi, Yoshitaka Imaizumi, Tatsuro Jo, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi Miyazaki","doi":"10.1111/bjh.70345","DOIUrl":"10.1111/bjh.70345","url":null,"abstract":"","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":" ","pages":"1443-1447"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}