Integrative medicine最新文献

{"title":"CPAP Therapy Linked False Reassurance to Obstructive Sleep Apnea Patients: A Retrospective Observational Study.","authors":"Sahil Chopra, Savit Raj Malhotra, Quynh Theresa Do, Stacey Gunn, Keilah Oberstein-Wright, Cali Bahrenfuss, Robert Joseph Thomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Exocrine Insufficiency Is Surprisingly Common.","authors":"Lara Pizzorno, Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Once again, an old-time concept once dismissed has now been shown as valid with modern research. Natural health clinicians have long recognized that digestive disturbances greatly contribute to chronic disease. To the roles in maldigestion of hypochlorhydria and dysbiosis we can now add pancreatic exocrine insufficiency (EPI). At least 20% of the population aged >50 to 75 years with no diagnosed disease has EPI, with higher percentages found in those with disease, especially diabetes. This editorial explores the prevalence of EPI and its diagnosis, causes, and interventions.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Diagnosis: A Clinical Framework for Assessing Micronutrient Deficiency in High-Risk Care.","authors":"Layth Tumah, James Carter, Ramona Wallace, Ashley Siuda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"77-79"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture and Low-Level Laser Therapy for the Management of Ménière's Disease-Case Report.","authors":"Kelly Hsu, Alan Chung, Nikki Capetz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Ménière's Disease (MD) typically presents with the classic triad of symptoms of vertigo, tinnitus, and hearing loss. MD significantly impacts a patient's quality of life and their ability to carry out basic daily functions. This case report describes how electroacupuncture and Low-Level Laser Therapy (LLLT) were used concurrently to assist a patient suffering from MD to achieve substantial recovery and improve her subjective quality of life.</p><p><strong>Case presentation: </strong>A 62-year-old female patient was diagnosed with MD by her otolaryngologist in July 2020. She received pharmaceutical therapies, including oral prednisone and round window membrane dexamethasone infusion. Her vertigo symptoms initially improved but deteriorated gradually since the initial treatment. She came to the Meridian Integrative Medicine (MIM) acupuncture clinic in October 2021, with chief complaints of vertigo, tinnitus, and hearing loss. At that time, the patient had been suffering from severe vertigo attacks averaging two to three attacks per week with progressively worsening hearing disorders. The patient had a total of 28 vertigo attacks during the two months before coming to MIM for treatment. After 9 sessions of electroacupuncture and LLLT treatments in 2 months, the patient's episodic vertigo attacks were eliminated.</p><p><strong>Discussion: </strong>Treating MD with acupuncture and LLLT can help reduce or eliminate the severity and frequency of episodic vertigo attacks, relieve the severity of tinnitus symptoms, and improve the patient's quality of life.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.","authors":"Angela D Mazza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyroid disorders, particularly autoimmune conditions such as Hashimoto's thyroiditis, are frequently associated with persistent systemic symptoms despite biochemical normalization with standard hormone replacement, prompting investigation into adjunctive strategies that target immune, metabolic, and neuroendocrine contributors to thyroid dysfunction. Peptide-based therapeutics are an emerging area of research in regenerative and endocrine medicine, with experimental studies demonstrating effects on immune signaling, inflammatory regulation, tissue repair, and cellular stress responses. This review examines the mechanistic rationale for peptide interventions relevant to thyroid biology and summarizes the current state of evidence for selected peptides, including thymosin alpha-1, thymosin beta-4, BPC-157, and growth hormone secretagogues. Available data consist primarily of preclinical investigations, mechanistic studies, and early exploratory clinical reports rather than large, randomized trials focused on thyroid-specific outcomes. Safety profiles vary across peptide classes, and clinical use remains largely investigational in the context of thyroid disease. This review presents potential biologic pathways linking peptide activity to immune and metabolic aspects of thyroid disorders, as well as regulatory and ethical considerations surrounding emerging peptide applications. Substantial evidence gaps persist, and well-designed thyroid-focused clinical trials are needed to clarify safety, efficacy, and appropriate clinical roles. Peptide therapeutics, therefore, represent a developing research domain whose relevance to thyroid care remains to be established through rigorous investigation.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Resistance Screening in Perimenopausal Musculoskeletal Care: A Functional Medicine-Informed Framework.","authors":"Tara Moore","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial.","authors":"Michael Jurgelewicz, Christopher R D'Adamo, Christopher A Malaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production. Although preclinical research and a recent human study have indicated a potential role for GG in modulating testosterone levels, its effects in middle-aged adults remain unclear.</p><p><strong>Aim: </strong>This study aimed to assess the effects of GG supplementation on testosterone status, coenzyme Q10 concentrations, and validated questionnaires of overall and sexual health in middle-aged healthy adults.</p><p><strong>Method: </strong>This 18-week, single-group, crossover, placebo-controlled trial involved participants aged 40 to 65 years. The intervention consisted of 8 weeks of placebo followed by a 2-week washout and 8 weeks of GG supplementation (300 mg/day). Outcomes were assessed at baseline, Week 8 (after blinded placebo), Week 10 (post-washout), and Week 18 (after blinded intervention).</p><p><strong>Results: </strong>Thirty-four participants completed the study. No significant changes were observed in total testosterone, free testosterone, or sex hormone binding globulin (all <i>P</i> > .05) in the full study sample or within the female subgroup. In the subgroup of men with lower baseline testosterone (<600 ng/dL, <i>n</i> = 8), total testosterone increased significantly following GG supplementation (mean difference = 28.44 ng/dL, 95% CI: 7.45-49.43, <i>P</i> = .015), with a large effect size (Cohen's <i>d</i> = 1.13), indicating a meaningful physiological response. Serum CoQ10 declined significantly during placebo (mean difference = -0.10 μg/mL, <i>P</i> = .03) but remained stable during GG supplementation (<i>P</i> = .9), suggesting a potential maintenance effect.</p><p><strong>Conclusion: </strong>These results highlight GG as a promising natural strategy to support endogenous testosterone production and CoQ10 homeostasis in age-related declines. Further investigation in larger, targeted populations such as men with late-onset hypogonadism or individuals on statin therapy is warranted.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Periodontal Outcomes with Genomics and Functional Medicine: A Case Report.","authors":"Mary Ellen S Chalmers, Clare Cattarin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"71-73"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Medicine Approach to Autoimmune Hypothyroidism: A Case Report.","authors":"Jamie Marie Punzi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"74-76"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting Autonomic Physiology with Diet and Minerals to Improve Health.","authors":"Linda L Isaacs","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of diet and mineral supplementation in modulating autonomic balance was commonly studied in the early 20^th century, but is rarely discussed today. This paper reviews historical findings by academic researchers, such as Hans Eppinger, Leo Hess, André-Charles Guillaume, S.G. Zondek, and Francis Pottenger, connecting their discoveries to the dentist William Donald Kelley's dietary model and treatment methods, with further refinements by Nicholas Gonzalez and the author. The central hypothesis is that dietary composition and mineral supplementation-particularly of calcium, magnesium, and potassium-affect sympathetic and parasympathetic tone, thereby influencing disease susceptibility. Calcium and acid-forming diets stimulate sympathetic activity, whereas magnesium, potassium, and alkalinizing diets support parasympathetic function. Early physiologic research and modern studies on heart rate variability, electrolyte balance, and immune activation suggest that an imbalance in autonomic tone may underlie various forms of ill health. Research in this area declined following World War II, but renewed investigation into autonomic individuality may explain conflicting outcomes of dietary intake and mineral supplementation. This integrative model proposes that tailoring diet and mineral supplementation to restore autonomic balance can optimize physiological function, offering a biologically grounded approach to personalized health.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 2","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}