Cendekia Journal of Pharmacy最新文献

{"title":"UJI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK TEMU MANGGA ( CURCUMA MANGGA VALETON & ZIJP ) DENGAN VARIASI KONSENTRASI PELARUT","authors":"Dwi Susiloningrum, Dessy Erliani Mugita Sari","doi":"10.31596/cjp.v5i2.148","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.148","url":null,"abstract":"Rimpang temu mangga (Curcuma mangga Valeton Zijp) merupakan tanaman dari keluarga Zingiberaceae. Tanaman ini memiliki kandungan metabolit sekunder antara lain flavonoid, kurkumin, saponin, minyak atsiri, terpenoid dan polifenol. Flavonoid merupakan salah satu metabolit sekunder yang berperan dalam aktivitas antioksidan. Berdasarkan hal tersebut maka penelitian ini dilakukan untuk mengetahui aktivitas antioksidan dan kadar flavonoid dari rimpang temu mangga dengan variasi konsentrasi pelarut. Proses ekstraksi dilakukan dengan menggunakan metode UAE (Ultrasound Assisted Extraction) menggunakan variasi pelarut konsentrasi 50%, 70%, 96%. Penentuan kadar flavonoid dan pengujian aktivitas antioksidan dilakukan dengan menggunakan spektrofotometri Uv-vis. Hasil penentuan kadar flavonoid ekstrak rimpang temu manggadilakukan menggunakan larutan baku kuersetin dengan  seri konsentrasi 40 ppm, 60 ppm, 80 ppm, 100 ppm, 120 ppm  pada panjang gelombang 400 – 500 nm. Kadar flavonoid tertinggi terdapat pada ekstrak etanol 70%, 50%, 96%. Kadar flavonoid ekstrak rimpang temu mangga yang dihasilkan berturut turut 9,99%, 10,19%, 10,22%. Aktivitas antioksidan ditunjukan dengan IC50 ekstrak etanol 50%, 70%, 96% dengan total IC50 berturut turut 95,05 ppm; 88,51 ppm; dan 75,06 ppm. ","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133498345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAN AIR RANTING BUAH PARIJOTO (Medinilla speciosa Blume) DENGAN PEREDAMAN RADIKAL BEBAS DPPH","authors":"Endra Pujiastuti, Ricka Islamiyati","doi":"10.31596/cjp.v5i2.143","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.143","url":null,"abstract":"Radikal bebas adalah molekul yang tidak mempunyai pasangan elektron di kulit bagian luar menyebabkan bersifat sangat reaktif. Oksidasi akibat radikal bebas dapat dicegah dan dihambat oleh substansi yaitu antioksidan. Antioksidan dapat menghambat kerusakan sel akibat radikal bebas. Antioksidan alami didapatkan dari tanaman atau buah-buahan. Indonesia memiliki daerah hutan tropis yang sangat besar, tetapi sebagian besar dari spesies hayati hutan tropis belum dimanfaatkan sepenuhnya. Salah satu kearifan lokal yang digunakan masyarakat Desa Colo kecamatan Dawe Kabupaten Kudus yaitu menggunakan tanaman parijoto (Medinilla speciosa Blume). Tanaman parijoto mengandung saponin, flavonoid dan tanin pada ranting buahnya. Senyawa flavonoid memiliki kemampuan mencegah kerusakan pada sel ? pancreas, sehingga merupakan salah satu fungsi dari antioksida. Tujuan dilakukan penelitian ini adalah untuk mengetahui aktivitas antioksidan fraksi etil asetat dan air ranting buah parijoto (Medinilla speciosa Blume) dengan peredaman radikal bebas DPPH. Hasil dari penelitian didapatkan nilai IC50 pada fraksi etil asetat sebesar 257,25 ppm sedangkan fraksi air ranting parijoto sebesar 338,17 ppm yang termasuk golongan antioksidan yang lemah. Sedangkan IC50 pembanding kuersetin sebesar 6,09 ppm yang mempunyai aktivitas antioksidan sangat kuat.","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114832231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALISIS EFEKTIFITAS BIAYA KOMBINASI ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2","authors":"Aji Tetuko, Diesty Anita Nugraheni","doi":"10.31596/cjp.v5i2.156","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.156","url":null,"abstract":"Pembuatan keputusan dalam kebijakan farmasi di rumah sakit didukung oleh ilmu farmakoekonomi, antara lain keputusan terapi pasien yang cost effective, kebijakan formularium, kebijakan obat, dan alokasi sumber daya farmasi. American Diabetes Association (ADA) menyebutkan jumlah pasien DM yang tidak mencapai target terapi dengan monoterapi antidiabetika oral jumlahnya cukup banyak. Penggunaan akarbose atau metformin pada pasien NIDDM {Non Insulin Dependent Diabetes Mellitus) efektif digunakan sebagai kombinasi dengan sulfonilurea yang tidak terkendali dengan monoterapi sulfonilurea. Penelitian bertujuan untuk menganalisis efektivitas-biaya penggunaan kombinasi metformin-gliklazid dibandingkan akarbose-gliklazid pada pasien diabetes melitus tipe 2 rawat jalan di rumah sakit. Penelitian menggunakan rancangan cross sectional dengan metode deskriptif non-eksperimental. Kriteria inklusi subyek penelitian adalah pasien DM tipe 2 rawat jalan di RS, yang telah menggunakan minimal tiga bulan terapi kombinasi metformin-gliklazid atau akarbose-gliklazid. Pengambilan sampel dilakukan dengan teknik accidental sampling selama 1 bulan. Subyek penelitian yang menggunakan kombinasi metformin-gliklazid dan akarbose-gliklazid masing-masing berjumlah 50 dan 27 pasien. Evaluasi ekonomi dilakukan dengan metode cost effectiveness analysis (CEA) dengan menggunakan Average Cost Effectiveness Ratio (ACER) dan analisis sensitivitas. Efektivitas diukur menggunakan persentase kadar glukosa darah puasa (GDP) dan glukosa darah post prandial (GDPP) yang mencapai target terapi. Hasil penelitian menunjukkan bahwa kelompok metformin-gliklazid dapat mencapai target terapi lebih besar dibandingkan akarbose-gliklazid. Menggunakan perspektif rumah sakit, jumlah biaya medik langsung pasien DM tipe 2 rawat jalan untuk kelompok metformin-gliklazid dan akarbose-gliklazid masing-masing sebesar  Rp90.878,84 ± 65.246,5 dan Rp217.309,73 ± 87.198,66. Simpulan penelitian adalah pasien rawat jalan rumah sakit dengan diabetes melitus type 2 menunjukkan penggunaan kombinasi metformin-gliklazid lebih cost-effective dibandingkan akarbose-gliklazid.","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129098678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Penggunaan Antibiotik pada Pasien Bedah di RSUD dr Slamet Martodirjo Pamekasan dengan Metode ATC/DDD","authors":"Ratri Rokhani, Mariah Ulfa, Lisa Narulita, Muhammad Akram, Sumarno Sumarno","doi":"10.31596/cjp.v5i2.162","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.162","url":null,"abstract":"Meluasnya penggunaan antibiotik yang tidak tepat merupakan isu besar dalam kesehatan masyarakat dan keamanan pasien. Penelitian Antimicrobial Resistance in Indonesia (AMRIN) menunjukkan sebanyak 42% penggunaan antibiotik terindikasi tidak tepat pada pasien bedah. Penggunaan antibiotik secara bijak merupakan solusi atas masalah resistensi antibiotik. World Health Organization (WHO) dan Kementerian Kesehatan Republik Indonesia merekomendasikan penggunaan metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) untuk menilai kuantitas penggunaan antibiotik.. Penelitian ini merupakan penelitian deskriptif-analitik (crosssectional) dengan pengambilan data secara retrospektif pada pasien bedah RSUD Dr. H. Slamet Martodirdjo Pamekasan selama periode Januari-Maret 2020. Kriteria inklusi yaitu pasien rawat inap bedah yang menggunakan antibiotik. Kriteria eksklusi yaitu pasien yang menggunakan antibiotik sediaan topikal, pasien yang meninggal selama penelitian, dan pasien anak-anak (","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129941011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus epidermidis DAN Propionibacterium acnes","authors":"Lili Sugiarti, Jihaan Maila Shofa","doi":"10.31596/cjp.v5i2.159","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.159","url":null,"abstract":"Jerawat atau acne vulgaris merupakan penyakit kulit yang sering timbul serta dapat mengganggu para remaja. Pengobatan jerawat yang umumnya digunakan yaitu antibiotik seperti ampicillin, klindamisin dan lain-lain. Oleh karena itu, diperlukan alternatif lain sebagai pengobatan jerawat dengan memanfaatkan bahan alam yaitu tanaman mengkudu (Morinda citrifolia L.). Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dan Konsentrasi Hambat Minimal (KHM) ekstrak etanol daun parijoto terhadap bakteri Staphylococcus epidermidis dan Propionobacterium acnes serta untuk mengetahui adanya korelasi antara aktivitas antibakteri dan konsentrasi ekstrak etanol. Metode yang dilakukan yaitu pengolahan sampel sampai diperoleh serbuk dan diekstraksi menggunakan metode maserasi serta diujikan pada bakteri dengan metode difusi cakram. Hasil yang didapatkan di analisis dengan menggunakan uji One Way Anova, korelasi dan regresi linear, sedangkan perbedaan daya hambat antara dua bakteri menggunakan uji Independent Samples T- Test. Hasil uji One Way Anova menunjukkan perbedaan yang bermakna dengan nilai signifikasi 0,05. Uji korelasi menunjukkan hubungan yang sangat kuat dengan nilai Asymp Sig (2-tailed) 0,05 dengan pengaruh konsentrasi ekstrak terhadap diameter zona hambat Staphylococcus epidermidis sebesar 93,33% dan sebesar 98,19% pada Propionibacterium acnes. Konsentrasi ekstrak etanol daun mengkudu lebih efektif dalam menghambat pertumbuhan bakteri Staphylococcus epidermidis daripada Propionibacterium acnes. Ekstrak Etanol Daun Mengkudu memiliki potensi sebagai antibakteri terhadap bakteri Staphylococcus epidermidis dan Propionibacterium acnes. Ekstrak etanol lebih efektif dalam menghambat pertumbuhan bakteri Staphylococcus epidermidis daripada Propionibacterium acnes.","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129952403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECTIVENESS TEST OF CIPLUKAN (Physalis angulate L.) LEAF EXTRACT ON WOUND HEALING IN MALE RABBIT (Oryctolagus cuniculus) WISTAR STRAIN","authors":"Baiq Mahmudah, Recta Olivia Umboro, Fitri Apriliany","doi":"10.31596/cjp.v5i2.122","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.122","url":null,"abstract":"  An incision wound is a wound that occurs because of a sharp incision on the skin. This wound can occur in the dermis and epidermis of the skin with a depth 0,3cm, and length of 1,5cm. If not handle properly, the cut can develop into an infected wound. Ciplukan leaves (Physialis angulata L.) contain tannins compounds. Tanin compound can accelerate wound healing with cellular mechanism. The purpose of this study is to determine the ability of ciplukan leaves extract as an alternative medicine in healing the incisions.This study is an experimental study using a completely randomized design wich using 3 treatment groups of male rabbit (Oryctolagus cuniculus) consisted of: 1st group  negative control (vaselin flava), 2nd group positive control (povidone iodine), 3rd group ciplukan leaves extract test with 3 different concentrations (15%, 30%, 45%). Wound healing was observed for 20 days.The results of the analysis using One-way ANOVA, Kruskal Wallis obtained a value of p?0.05, showed the extract of ciplukan leaves is effective in healing incisions . The healing ability equivalent to positive control with a healing time of 13 days was shown at a concentration of 45%. ","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124830340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEVEL OF KNOWLEDGE ABOUT STORAGE AND DISPOSAL OF MEDICINE AT HOME IN THE COMMUNITY OF BANJARBARU CITY, SOUTH KALIMANTAN","authors":"Okta Muthia Sari, Khoerul Anwar, Indah Pebriani Putri","doi":"10.31596/cjp.v5i2.141","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.141","url":null,"abstract":"In Indonesia, the percentage of household-scale drug storage is quite large. People keep drugs for self-medication. Drugs should not be stored carelessly because it will affect the stability of the drug. In addition, the improper disposal of drugs still occurs in the community. Improper disposal of drugs can harm the environment. It is important for the public to have the correct knowledge regarding drugs in order to avoid the adverse health effects of themselves and the environment. The purpose of this study was to describe the level of knowledge of the people of Banjarbaru City about the storage and disposal of drugs at home. This research is descriptive analytic cross sectional approach with sampling technique using quota sampling. The population of this research is the entire community of Banjarbaru City, South Kalimantan. The sample size used in this study based on the Lemeshow sample calculation formula was 247 respondents. The data was taken with a validated questionnaire. The data obtained were analyzed using percentages. A total of 247 respondents met the inclusion criteria. The results showed that the majority of them were 38-47 years old, had high school and college education and worked as housewives. The level of knowledge of the people of Banjarbaru City about storing medicines at home is 39.2% less knowledge, 44.5% sufficient knowledge and 16.1% good knowledge. The level of knowledge of the people of Banjarbaru City about disposing of drugs at home is 52.6% with poor knowledge, 40.5% sufficient knowledge and 6.8% good knowledge. The knowledge of the people of Banjarbaru City about storing drugs at home is included in the sufficient level (44.5%). While the knowledge of the people of Banjarbaru City about the disposal of drugs at home is included in the level of less (52.6%).","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116944225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SINTETIS HAND WASH ECO GREEN SEBAGAI ANTISEPTIK DARI EKSTRAK ETANOL DAUN PARIJOTO (MEDINILLA SPECIOSA, BLUME)","authors":"Fian Nada Muluuchah, Aditiya Putri Suryani, M. Zaenuri, Triyas Septiana Fatmawati","doi":"10.31596/cjp.v5i2.146","DOIUrl":"https://doi.org/10.31596/cjp.v5i2.146","url":null,"abstract":"Parijoto (Medinilla speciosa, Blume) merupakan tanaman yang tumbuh subur di lereng, bukit dan di dalam hutan Gunung Muria Kudus, Jawa tengah. Selain buah tanaman parijoto juga mempunyai daun yang banyak manfaat salah satunya sebagai antibakteri. Kandungan bahan aktif dari parijoto yaitu flavonoid, saponin dan tanin. Produk sabun cuci tangan antiseptik banyak beredar di Indonesia. Banyak produk sabun antiseptik yang menggunakan bahan aktif kimia sintesis tetapi memiliki beberapa efek samping. Untuk itu senyawa antibakteri yang terdapat dalam daun parijoto dapat dimanfaatkan sebagai alternatif senyawa antibakteri sabun cuci tangan antiseptik yang ramah lingkungan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun parijoto pada sintesis Hand Wash Eco Green sebagai antiseptik sekaligus mengetahui konsentrasi optimal ekstrak etanol daun parijoto untuk menghambat pertumbuhan bakteri. Ekstrak etanol daun parijoto diperoleh dengan metode maserasi. Uji aktivitas antibakteri ekstrak dilakukan dengan metode difusi cakram. Uji stabilitas fisika kimia dilakukan dengan metode cycling test. Zona hambat ektrak etanol daun parijoto terhadap bakteri S. aureus yang optimal adalah 8,45 mm dan terhadap E. Coli adalah 6,98 mm. Ekstrak etanol daun parijoto dapat diformulasikan menjadi hand wash pada konsentrasi 3%. Uji Stabilitas menunjukkan bahwa perubahan organoletis, uji pH, uji daya busa dan Uji bobot jenis masih dalam nilai yang dipersyaratkan. Formulasi hand wash ekstrak etanol daun parijoto mempunyai aktivitas antibakteri terhadap S. aureus dan E. Coli.","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130574482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULASI BLUSH ON STICK DENGAN ZAT PEWARNA ALAMI EKSTRAK KERING BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS L.)","authors":"Benni Iskandar, Meri Ernilawati, Ferdy Firmansyah, Neni Frimayanti","doi":"10.31596/CJP.V5I1.117","DOIUrl":"https://doi.org/10.31596/CJP.V5I1.117","url":null,"abstract":"Blush On is a cosmetic preparation that applies color to the cheek with an artistic touch so that it it can enhance the aesthetics of Make up. One of the natural ingridients that can used as a dye is Red Dragon fruit (Hylocereus polyrhizus L.) because they contain the pigments betasianin that function as a color pigment. The Purpose of this study was to determine wheter the dry extract of red dragon fruit can be use as dye in blush on stick form and to evaluate the blush on form.The Blush on formula made using dyes from the dry extract of red dragon fruit with different concentration of 0%, 10%, 15% and 20% with additional ingridients of glycerin, zinc oxide, lanolin, isopropyl myristate, sodium metabisulfite, carnauba wax, talc and oleum rosae. The evaluation of product included organoleptic test, homogeneity test, pigment stability test, sotarge stability test, pH test, polish test, crack test, hedonic test and irritation test. All formulas have met the requirements of the homogeneity test, pH test, polish test and crack test. Organoleptic test showed the blush preparation has the specific odor of oleum rosae and the the blush has a solid stick. The blush with a concentration of 0% is white, the blush with a concentration of 10% is pink, the blush with a concentration of 15% is light purplish red, the blush with a concentration of 20% is dark purplish red. For F1 (10%), F2 (15%) and F3 (20%) preparations were only stable until week 5 and were unstable to light. The result of the irritation test showed that the blush preparation did not show any irritation reactions. The result of the hedonic test showed that F3 (20%) was the most preferred by the panelists","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114202682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GAMBARAN KADAR DAN KEAMANAN ASAM BENZOAT DALAM MINUMAN RINGAN YANG BEREDAR DI PASAR BULU SECARA SPEKTROFOTOMETRI","authors":"Jumiyati Jumiyati, Komala Larasati","doi":"10.31596/CJP.V5I1.94","DOIUrl":"https://doi.org/10.31596/CJP.V5I1.94","url":null,"abstract":"Penggunaan minuman ringan dalam jangka waktu tertentu perlu ditambahkan pengawet. Salah satu pengawet sintetik yang sering digunakan dalam minuman yaitu asam benzoat. Asam benzoat dapat bekerja efektif dalam pH 2-4. Asam benzoat penggunaan dalam jangka waktu lama dapat membahayakan bagi kesehatan tubuh, menyebabkan karsinogenik. Penelitian ini bertujuan untuk mengetahui kadar asam benzoat, keamanan penggunaan  dalam minuman ringan dan kesesuaian dengan peraturan BPOM RI No 36 tahun 2013 tentang batas penggunaan bahan tambahan pangan. Metode dalam penelitian ini adalah kualitatif dan kuantitatif. Penetapan kadar asam benzoat menggunakan spektrofotometri ultraviolet. Sampel minuman ringan sebelumnya dilakukan ekstraksi dulu dengan eter, ekstrak eter dianalisis secara kualitatif dan dilanjutkan secara kuantitatif. Hasil penelitian analisis secara kualitatif semua sampel mengandung asam benzoat dan analisis secara kuantitatif kadar asam benzoat sempel merk A : 378,53 mg/kg, merk B : 477,84 mg/kg dan merk C : 589,85  mg/kg. Dari hasil analisis tersebut semua sampel sesuai dengan Peraturan BPOM RI No 36 tahun 2013 yaitu batas maksimum penggunaan pengawet tidak lebih dari 600 mg/kg dihitung sebagai asam benzoat. Adapun keamanan penggunaan minuman ringan merk A : maksimal 5 kemasan/hari, merk B : maksimal 4 kemasan/hari dan merk C :maksimal 4 kemasan/hari. ","PeriodicalId":135893,"journal":{"name":"Cendekia Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124224714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}