Infectious Diseases of Poverty最新文献

{"title":"Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020.","authors":"Zhe Dong,&nbsp;Qi-Qi Wang,&nbsp;Shi-Cheng Yu,&nbsp;Fei Huang,&nbsp;Jian-Jun Liu,&nbsp;Hong-Yan Yao,&nbsp;Yan-Lin Zhao","doi":"10.1186/s40249-022-01009-4","DOIUrl":"https://doi.org/10.1186/s40249-022-01009-4","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) poses a severe public health challenge in China and worldwide. This study evaluated the effects of age, period, and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk groups.</p><p><strong>Methods: </strong>Aggregate data that reported pulmonary tuberculosis (PTB) cases from China Tuberculosis Management Information System (TBIMS) from 2006 to 2020 were used to analyze effect coefficients through the age-period-cohort (APC) model based on intrinsic estimator (IE) method, and converted them into relative risk (RR) to estimate trends.</p><p><strong>Results: </strong>A total of 14.82 million cases of PTB were reported in China from 2006 to 2020, showing a continuous downward trend. The reporting rate increased with age by age group, with 70-74 years old being 2-3 times higher than that in 20-24 years old. APC analysis model showed that age effects were bimodal in 20-24 years old [RR = 2.29, 95% confidence interval (CI): 1.73-3.03] and 70-74 years old (RR = 1.95, 95% CI: 1.67-2.27), and lower than the overall average in the groups under 15 years old. Stratified results showed that the risk was higher for women under age 40 than men and higher for men over 40. The risk was higher in urban than in rural areas under 30 years old and slightly higher in rural than in urban between 30 and 64 years old. The risk for 15-34 years old was significantly higher in the east than in other regions. The period effects showed a decreasing trend, and the risk was higher in rural in recent years. Except for cohorts born in 1961-1965 and 2001-2005, where the RR increased, the later the cohort was born, the lower the risk. The cohort 1926-1930 in eastern had the highest risk (RR = 3.49, 95% CI: 2.44-4.98).</p><p><strong>Conclusions: </strong>The reported incidence of PTB continued to decline in China from 2006 to 2020. The young (20-24 years old) and the elderly (70-74 years old) were equally at high risk. There were differences in the age, period and cohort effects on PTB incidence among gender, urban-rural and regions. Our findings better reflected the characteristics of high-risk populations, thus contributing to the development of timely and effective intervention strategies, and providing clues for etiological research.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":" ","pages":"85"},"PeriodicalIF":8.1,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40654126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis.","authors":"Yiguo Zhou, Wan-Xue Zhang, Elijah Tembo, Ming-Zhu Xie, Shan-Shan Zhang, Xin-Rui Wang, Ting-Ting Wei, Xin Feng, Yi-Lin Zhang, Juan Du, Ya-Qiong Liu, Xuan Zhang, Fuqiang Cui, Qing-Bin Lu","doi":"10.1186/s40249-022-01005-8","DOIUrl":"10.1186/s40249-022-01005-8","url":null,"abstract":"<p><strong>Background: </strong>Indoor residual spraying (IRS) is one of the key interventions recommended by World Health Organization in preventing malaria infection. We aimed to conduct a systematic review and meta-analysis of global studies about the impact of IRS on malaria control.</p><p><strong>Method: </strong>We searched PubMed, Web of Science, Embase, and Scopus for relevant studies published from database establishment to 31 December 2021. Random-effects models were used to perform meta-analysis and subgroup analysis to pool the odds ratio (OR) and 95% confidence interval (CI). Meta-regression was used to investigate potential factors of heterogeneity across studies.</p><p><strong>Results: </strong>Thirty-eight articles including 81 reports and 1,174,970 individuals were included in the meta-analysis. IRS was associated with lower rates of malaria infection (OR = 0.35, 95% CI: 0.27-0.44). The significantly higher effectiveness was observed in IRS coverage ≥ 80% than in IRS coverage < 80%. Pyrethroids was identified to show the greatest performance in malaria control. In addition, higher effectiveness was associated with a lower gross domestic product as well as a higher coverage of IRS and bed net utilization.</p><p><strong>Conclusions: </strong>IRS could induce a positive effect on malaria infection globally. The high IRS coverage and the use of pyrethroids are key measures to reduce malaria infection. More efforts should focus on increasing IRS coverage, developing more effective new insecticides against malaria, and using multiple interventions comprehensively to achieve malaria control goals.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":" ","pages":"83"},"PeriodicalIF":4.8,"publicationDate":"2022-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40617459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks.","authors":"Robert J Rolfe,&nbsp;Hassaan Shaikh,&nbsp;L Gayani Tillekeratne","doi":"10.1186/s40249-022-00998-6","DOIUrl":"https://doi.org/10.1186/s40249-022-00998-6","url":null,"abstract":"<p><strong>Background: </strong>Mass drug administration (MDA) is a strategy to improve health at the population level through widespread delivery of medicine in a community. We surveyed the literature to summarize the benefits and potential risks associated with MDA of antibacterials, focusing predominantly on azithromycin as it has the greatest evidence base.</p><p><strong>Main body: </strong>High-quality evidence from randomized controlled trials (RCTs) indicate that MDA-azithromycin is effective in reducing the prevalence of infection due to yaws and trachoma. In addition, RCTs suggest that MDA-azithromycin reduces under-five mortality in certain low-resource settings that have high childhood mortality rates at baseline. This reduction in mortality appears to be sustained over time with twice-yearly MDA-azithromycin, with the greatest effect observed in children < 1 year of age. In addition, observational data suggest that infections such as skin and soft tissue infections, rheumatic heart disease, acute respiratory illness, diarrheal illness, and malaria may all be treated by azithromycin and thus incidentally impacted by MDA-azithromycin. However, the mechanism by which MDA-azithromycin reduces childhood mortality remains unclear. Verbal autopsies performed in MDA-azithromycin childhood mortality studies have produced conflicting data and are underpowered to answer this question. In addition to benefits, there are several important risks associated with MDA-azithromycin. Direct adverse effects potentially resulting from MDA-azithromycin include gastrointestinal side effects, idiopathic hypertrophic pyloric stenosis, cardiovascular side effects, and increase in chronic diseases such as asthma and obesity. Antibacterial resistance is also a risk associated with MDA-azithromycin and has been reported for both gram-positive and enteric organisms. Further, there is the risk for cross-resistance with other antibacterial agents, especially clindamycin.</p><p><strong>Conclusions: </strong>Evidence shows that MDA-azithromycin programs may be beneficial for reducing trachoma, yaws, and mortality in children < 5 years of age in certain under-resourced settings. However, there are significant potential risks that need to be considered when deciding how, when, and where to implement these programs. Robust systems to monitor benefits as well as adverse effects and antibacterial resistance are warranted in communities where MDA-azithromycin programs are implemented.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":" ","pages":"77"},"PeriodicalIF":8.1,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40467220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-temporal analysis of leprosy risks in a municipality in the state of Mato Grosso-Brazilian Amazon: results from the leprosy post-exposure prophylaxis program in Brazil.","authors":"Lúbia Maieles Gomes Machado, Emerson Soares Dos Santos, Arielle Cavaliero, Peter Steinmann, Eliane Ignotti","doi":"10.1186/s40249-022-00943-7","DOIUrl":"10.1186/s40249-022-00943-7","url":null,"abstract":"<p><strong>Background: </strong>Leprosy post-exposure prophylaxis (LPEP) with single dose rifampicin (SDR) can be integrated into different leprosy control program set-ups once contact tracing has been established. We analyzed the spatio-temporal changes in the distribution of index cases (IC) and co-prevalent cases among contacts of leprosy patients (CP) over the course of the LPEP program in one of the four study areas in Brazil, namely the municipality of Alta Floresta, state of Mato Grosso, in the Brazilian Amazon basin.</p><p><strong>Methods: </strong>Leprosy cases were mapped, and socioeconomic indicators were evaluated to explain the leprosy distribution of all leprosy cases diagnosed in the period 2016-2018. Data were obtained on new leprosy cases [Notifiable diseases information system (Sinan)], contacts traced by the LPEP program, and socioeconomic variables [Brazilian Institute of Geography and Statistics (IBGE)]. Kernel, SCAN, factor analysis and spatial regression were applied to analyze changes.</p><p><strong>Results: </strong>Overall, the new case detection rate (NCDR) was 20/10 000 inhabitants or 304 new cases, of which 55 were CP cases among the 2076 examined contacts. Changes over time were observed in the geographic distribution of cases. The highest concentration of cases was observed in the northeast of the study area, including one significant cluster (Relative risk = 2.24; population 27 427, P-value < 0.001) in an area characterized by different indicators associated with poverty as identified through spatial regression (Coefficient 3.34, P-value = 0.01).</p><p><strong>Conclusions: </strong>The disease distribution was partly explained by poverty indicators. LPEP influences the spatial dynamic of the disease and results highlighted the relevance of systematic contact surveillance for leprosy elimination.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"21"},"PeriodicalIF":4.8,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39944160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the surveillance and response system to achieve and maintain malaria elimination: a retrospective analysis in Jiangsu Province, China.","authors":"Yuanyuan Cao,&nbsp;Guangyu Lu,&nbsp;Chris Cotter,&nbsp;Weiming Wang,&nbsp;Mengmeng Yang,&nbsp;Yaobao Liu,&nbsp;Cheng Liang,&nbsp;Huayun Zhou,&nbsp;Yan Lu,&nbsp;Jun Yan,&nbsp;Guoding Zhu,&nbsp;Jun Cao","doi":"10.1186/s40249-022-00939-3","DOIUrl":"https://doi.org/10.1186/s40249-022-00939-3","url":null,"abstract":"<p><strong>Background: </strong>Following initiation of China's National Malaria Elimination Action Plan (NMEAP) in 2010, the '1-3-7' approach was developed and rolled out in China to facilitate the malaria elimination programme and accelerate malaria elimination. This study aims to summarize and condense these experiences through a retrospective analysis in Jiangsu Province, which could be adapted and applied in other malaria elimination settings worldwide.</p><p><strong>Methods: </strong>A retrospective analysis of imported malaria cases into China identified through an improved surveillance and response system in Jiangsu Province was carried out for the period of 2001-2020. To improve the malaria surveillance and response system, Centers for Diseases Control and Prevention from the prefectures and counties in Jiangsu province conducted population-level health education to improve healthcare seeking behavior, strengthened capacity of health facilities to improve performance of malaria diagnosis and treatment, and raised the capacity of public health providers to improve implementation of the '1-3-7' approach. Categorical variables were carried out by Chi square tests with Fisher's exact correction.</p><p><strong>Results: </strong>From 2001 to 2020, a total of 9,879 malaria cases were reported in Jiangsu Province. Since 2012, no indigenous malaria cases have been reported in Jiangsu Province. However, in recent years, there has been a substantial increase of imported falciparum malaria cases. Between 2012 and 2020, an estimated 61.57 million individuals have benefited from population-level health education in Jiangsu Province. For healthcare-seeking services among the 2,423 imported malaria cases, 687 (28.4%) and 1,104 (45.6%) cases visited hospitals on the first day and the second day from symptom onset, respectively. A total of 1,502 (61.9%) cases were diagnosed on the first day at medical facilities. Jiangsu Province achieved 100%, 99.4% and 98.3% completion rate in terms of case detection and notification (within one day), case investigation (within three days) and foci response and disposition (within seven days), respectively. The improved surveillance and response system in Jiangsu Province plays an important role in preventing the re-introduction of malaria and maintaining the malaria-free status.</p><p><strong>Conclusions: </strong>Jiangsu Province has maintained its malaria-free status since 2012. The continuous improvement of a surveillance and response system plays an important role in the early detection and rapid response of potential malaria-related outbreaks in Jiangsu, China, and has important lessons for other malaria eliminating settings. Remaining vigilant in the detection of imported malaria cases and maintaining an active surveillance and response system is critical to sustain the success of malaria elimination.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"20"},"PeriodicalIF":8.1,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39647488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing different machine learning techniques for predicting COVID-19 severity.","authors":"Yibai Xiong,&nbsp;Yan Ma,&nbsp;Lianguo Ruan,&nbsp;Dan Li,&nbsp;Cheng Lu,&nbsp;Luqi Huang","doi":"10.1186/s40249-022-00946-4","DOIUrl":"https://doi.org/10.1186/s40249-022-00946-4","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) is still ongoing spreading globally, machine learning techniques were used in disease diagnosis and to predict treatment outcomes, which showed favorable performance. The present study aims to predict COVID-19 severity at admission by different machine learning techniques including random forest (RF), support vector machine (SVM), and logistic regression (LR). Feature importance to COVID-19 severity were further identified.</p><p><strong>Methods: </strong>A retrospective design was adopted in the JinYinTan Hospital from January 26 to March 28, 2020, eighty-six demographic, clinical, and laboratory features were selected with LassoCV method, Spearman's rank correlation, experts' opinions, and literature evaluation. RF, SVM, and LR were performed to predict severe COVID-19, the performance of the models was compared by the area under curve (AUC). Additionally, feature importance to COVID-19 severity were analyzed by the best performance model.</p><p><strong>Results: </strong>A total of 287 patients were enrolled with 36.6% severe cases and 63.4% non-severe cases. The median age was 60.0 years (interquartile range: 49.0-68.0 years). Three models were established using 23 features including 1 clinical, 1 chest computed tomography (CT) and 21 laboratory features. Among three models, RF yielded better overall performance with the highest AUC of 0.970 than SVM of 0.948 and LR of 0.928, RF also achieved a favorable sensitivity of 96.7%, specificity of 69.5%, and accuracy of 84.5%. SVM had sensitivity of 93.9%, specificity of 79.0%, and accuracy of 88.5%. LR also achieved a favorable sensitivity of 92.3%, specificity of 72.3%, and accuracy of 85.2%. Additionally, chest-CT had highest importance to illness severity, and the following features were neutrophil to lymphocyte ratio, lactate dehydrogenase, and D-dimer, respectively.</p><p><strong>Conclusions: </strong>Our results indicated that RF could be a useful predictive tool to identify patients with severe COVID-19, which may facilitate effective care and further optimize resources.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"19"},"PeriodicalIF":8.1,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39630003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triatoma williami in intradomiciliary environments of urban areas in Mato Grosso State, Brazil: domiciliation process of a wild species?","authors":"Mirian Francisca Martins,&nbsp;Sinara Cristina de Moraes,&nbsp;Jader Oliveira,&nbsp;Janaina Cipriana Dos Santos,&nbsp;Ludier Kesser Santos-Silva,&nbsp;Cleber Galvão","doi":"10.1186/s40249-022-00938-4","DOIUrl":"https://doi.org/10.1186/s40249-022-00938-4","url":null,"abstract":"<p><strong>Background: </strong>Triatomines in Latin America are natural Chagas disease (ChD) vectors. Triatomine domiciliation is one of the main factors increasing the occurrence risk of this disease in humans. There are 66 triatomine species in Brazil, with three genera of significant epidemiological importance-Panstrongylus, Rhodnius, and Triatoma. Among the Triatoma species, Triatoma williami, a wild species, has been reported in Goiás, Mato Grosso, and Mato Grosso do Sul. In the Barra do Garças, Mato Grosso, the invasion by triatomines has been reported, with T. williami being the most common species. This study aimed to survey triatomine fauna and determine the Trypanosoma cruzi natural infection rates in triatomines in the urban area of Barra do Garças, Mato Grosso, Brazil.</p><p><strong>Methods: </strong>Triatomine specimens were sampled by passive surveillance or active search by agents combating endemic diseases from 2019 to 2020. A parasitological feces diagnosis was performed to detect the presence of T. cruzi after the specimens were identified. Concerning T. cruzi identification, molecular diagnosis and genetic sequencing were performed to determine the strain, also called discrete typing units (DTUs).</p><p><strong>Results: </strong>The 211 triatomines were collected, distributed in specimens of T. williami (84.4%), P. geniculatus (3.3%), P. diasi (1.4%), and R. neglectus (10.9%). Two colonies of T. williami were found through morphological analyses. These insects were sampled inside domiciles in an urban area neighboring Jardim Pitaluga (15° 51'57.7″ N, 052° 16' 04.5 E). The records were sampled in September 2019 and January 2021. The rate of natural infection by T. cruzi was 39.4%. Two T. williami specimens from the sampled colonies were positive for the T. cruzi strain DTU IV.</p><p><strong>Conclusions: </strong>This is the first time that T. williami has been confirmed in an urban area of Barra do Garças, Mato Grosso, Brazil. Further studies are needed for a clearer understanding of the ecology of this species for prevention and control mechanisms since its sampled specimens had a high rate of natural infection by T. cruzi.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"18"},"PeriodicalIF":8.1,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39924082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From concept to action: a united, holistic and One Health approach to respond to the climate change crisis.","authors":"Renhe Zhang,&nbsp;Xu Tang,&nbsp;Jian Liu,&nbsp;Martin Visbeck,&nbsp;Huadong Guo,&nbsp;Virginia Murray,&nbsp;Catherine Mcgillycuddy,&nbsp;Bing Ke,&nbsp;Gretchen Kalonji,&nbsp;Panmao Zhai,&nbsp;Xiaoming Shi,&nbsp;Jiahai Lu,&nbsp;Xiaonong Zhou,&nbsp;Haidong Kan,&nbsp;Qunli Han,&nbsp;Qian Ye,&nbsp;Yong Luo,&nbsp;Jianmin Chen,&nbsp;Wenjia Cai,&nbsp;Huiling Ouyang,&nbsp;Riyanti Djalante,&nbsp;Alexander Baklanov,&nbsp;Lu Ren,&nbsp;Guy Brasseur,&nbsp;George Fu Gao,&nbsp;Lei Zhou","doi":"10.1186/s40249-022-00941-9","DOIUrl":"https://doi.org/10.1186/s40249-022-00941-9","url":null,"abstract":"<p><p>It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"17"},"PeriodicalIF":8.1,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39907239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV.","authors":"Jingjing Hu,&nbsp;Ling Gu,&nbsp;Yueming Shao,&nbsp;Renfang Zhang,&nbsp;Tangkai Qi,&nbsp;Jianjun Sun,&nbsp;Zhenyan Wang,&nbsp;Wei Song,&nbsp;Yang Tang,&nbsp;Jiangrong Wang,&nbsp;Shuibao Xu,&nbsp;Junyang Yang,&nbsp;Yinzhong Shen,&nbsp;Li Liu,&nbsp;Jun Chen,&nbsp;Hongzhou Lu","doi":"10.1186/s40249-022-00942-8","DOIUrl":"https://doi.org/10.1186/s40249-022-00942-8","url":null,"abstract":"<p><strong>Background: </strong>Few data are available regarding the long-term case-fatality rate (CFR) among people living with HIV (PLWH) with nontuberculous mycobacteria (NTM) disease. The aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their death.</p><p><strong>Methods: </strong>A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1, 2012, to December 31, 2020, in Shanghai, China. We used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM (DNTM) and localized NTM disease. Univariate Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term CFR.</p><p><strong>Results: </strong>The cohort was followed up for a median of 26 months. The total CFR was 15.7% by one year and increased to 22.6% at 5 years after the diagnosis of NTM disease. The 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM (26.7% vs 19.6% for DNTM and localized NTM disease, respectively). Older age [hazard ratio (HR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P < 0.001], comorbidity (HR = 2.05, 95% CI: 1.21-3.49, P < 0.01), DNTM (HR = 2.08, 95% CI: 1.17-3.68, P < 0.05), and HIV viral load (HR = 1.32, 95% CI: 1.12-1.55, P < 0.001) were all independent risk factors for long-term CFR. In the subgroup analysis, time to culture positivity was negatively correlated with CFR in patients with DNTM (HR = 0.90, 95% CI: 0.82-0.98, P < 0.05).</p><p><strong>Conclusions: </strong>NTM was associated with a high long-term CFR in PLWH. Further approaches to prevent NTM disease in PLWH are urgently needed.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"16"},"PeriodicalIF":8.1,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients.","authors":"Hongye Wang,&nbsp;Dongshan Yan,&nbsp;Ya Li,&nbsp;Yanfei Gong,&nbsp;Yulin Mai,&nbsp;Bingxiang Li,&nbsp;Xiaoyong Zhu,&nbsp;Xinrui Wan,&nbsp;Liyun Xie,&nbsp;HuaKe Jiang,&nbsp;Min Zhang,&nbsp;Ming Sun,&nbsp;Yufeng Yao,&nbsp;Yongzhang Zhu","doi":"10.1186/s40249-022-00940-w","DOIUrl":"https://doi.org/10.1186/s40249-022-00940-w","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 pandemic continues, clarifying signatures in clinical characters and antibody responses between severe and non-severe COVID-19 cases would benefit the prognosis and treatment.</p><p><strong>Methods: </strong>In this study, 119 serum samples from 37 severe or non-severe COVID-19 patients from the First People's Hospital of Yueyang were collected between January 25 and February 18 2020. The clinical features, antibody responses targeting SARS-CoV-2 spike protein (S) and its different domains, SARS-CoV-2-specific Ig isotypes, IgG subclasses, ACE2 competitive antibodies, binding titers with FcγIIa and FcγIIb receptors, and 14 cytokines were comprehensively investigated. The differences between severe and non-severe groups were analyzed using Mann-Whitney U test or Fisher's exact test.</p><p><strong>Results: </strong>Severe group including 9 patients represented lower lymphocyte count, higher neutrophil count, higher level of LDH, total bile acid (TBA) (P < 1 × 10^-4), r-glutaminase (P = 0.011), adenosine deaminase (P < 1 × 10^-4), procalcitonin (P = 0.004), C-reactive protein (P < 1 × 10^-4) and D-dimer (P = 0.049) compared to non-severe group (28 patients). Significantly, higher-level Igs targeting S, different S domains (RBD, RBM, NTD, and CTD), FcγRIIa and FcγRIIb binding capability were observed in a severe group than that of a non-severe group, of which IgG1 and IgG3 were the main IgG subclasses. RBD-IgG were strongly correlated with S-IgG both in severe and non-severe group. Additionally, CTD-IgG was strongly correlated with S-IgG in a non-severe group. Positive RBD-ACE2 binding inhibition was strongly associated with high titers of antibody (S-IgG1, S-IgG3, NTD-IgG, RBD-IgA, NTD-IgA, and CTD-IgA) especially RBD-IgG and CTD-IgG in the severe group, while in the non-severe group, S-IgG3, RBD-IgG, NTD-IgG, and NTD-IgM were correlated with ACE2 blocking rate. S-IgG1, NTD-IgM and S-IgM were negatively associated with illness day in a severe group, while S-IgG3, RBD-IgA, CTD-IgA in the severe group (r = 0.363, P = 0.011) and S-IgG1, NTD-IgA, CTD-IgA in the non-severe group were positively associated with illness day. Moreover, GRO-α, IL-6, IL-8, IP-10, MCP-1, MCP-3, MIG, and BAFF were also significantly elevated in the severe group.</p><p><strong>Conclusion: </strong>Antibody detection provides important clinical information in the COVID-19 process. The different signatures in Ig isotypes, IgG subclasses, antibody specificity between the COVID-19 severe and non-severe group will contribute to future therapeutic and preventive measures development.</p>","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":"15"},"PeriodicalIF":8.1,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39881828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}