Infection Control & Hospital Epidemiology最新文献

{"title":"Spatiotemporal distribution of community-acquired phenotypic extended-spectrum beta-lactamase Escherichia coli in United States counties, 2010–2019","authors":"Matthew W. Smith, Margaret Carrel, Qianyi Shi, Shinya Hasegawa, Gosia Clore, Zhuo Tang, Eli Perencevich, Michihiko Goto","doi":"10.1017/ice.2023.266","DOIUrl":"https://doi.org/10.1017/ice.2023.266","url":null,"abstract":"<p>Using data from the Veterans’ Health Administration from 2010 to 2019, we examined the distribution and prevalence of community-acquired phenotypic extended-spectrum β-lactamase (ESBL) <span>E. coli</span> in the United States. ESBL prevalence slowly increased during the study period, and cluster analysis showed clustering in both urban and rural locations.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcomes of hospital-associated respiratory virus infections by viral species","authors":"Joshua G. Petrie, Riley Moore, Adam S. Lauring, Keith S. Kaye","doi":"10.1017/ice.2023.263","DOIUrl":"https://doi.org/10.1017/ice.2023.263","url":null,"abstract":"<span>Background:</span><p>Although the incidence of hospital-associated respiratory virus infection (HARVI) is well recognized, the risk factors for infection and impact on patient outcomes are not well characterized.</p><span>Methods:</span><p>We identified a cohort of all inpatient admissions ≥24 hours duration at a single academic medical center from 2017 to 2020. HARVI were defined as respiratory virus detected in a test ordered after the 95th percentile of the virus-specific incubation period. Risk factors for HARVI were assessed using Cox proportional hazards models of the competing outcomes of HARVI and discharge. The associations between time-varying HARVI status and the rates of ICU admission, discharge, and in-hospital death were estimated using Cox-proportional hazards models in a competing risk framework.</p><span>Results:</span><p>HARVI incidences were 8.8 and 3.0 per 10,000 admission days for pediatric and adult patients, respectively. For adults, congestive heart failure, renal disease, and cancer increased HARVI risk independent of their associations with length of stay. HARVI risk was also elevated for patients admitted in September–June relative to July admissions. For pediatric patients, cardiovascular and respiratory conditions, cancer, medical device dependence, and admission in December increased HARVI risk. Lengths of stay were longer for adults with HARVI compared to those without, and hospital-associated influenza A was associated with increased risk of death. Rates of ICU admission were increased in the 5 days after HARVI identification for adult and pediatric patients. HARVI was not associated with length of stay or death among pediatric patients.</p><span>Conclusions:</span><p>HARVI is associated chronic health conditions and increases morbidity and mortality.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an antibiotic stewardship initiative on urgent-care respiratory prescribing across patient race, ethnicity, and language","authors":"Allan M. Seibert, Adam L. Hersh, Payal K. Patel, Lauri A. Hicks, Nora Fino, Valoree Stanfield, Edward A. Stenehjem","doi":"10.1017/ice.2023.258","DOIUrl":"https://doi.org/10.1017/ice.2023.258","url":null,"abstract":"<p>We conducted a post hoc analysis of an antibiotic stewardship intervention implemented across our health system’s urgent-care network to determine whether there was a differential impact among patient groups. Respiratory urgent-care antibiotic prescribing decreased for all racial, ethnic, and preferred language groups, but disparities in antibiotic prescribing persisted.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacille Calmette-Guérin preparation and intravesical administration to patients with bladder cancer: Risks to healthcare personnel and patients, and mitigation strategies","authors":"Ashley H. Marx, Diana N. Nowicki, Rebecca B. Carlson, Katherine M. Schultz, Emily Sickbert-Bennett, David J. Weber","doi":"10.1017/ice.2023.259","DOIUrl":"https://doi.org/10.1017/ice.2023.259","url":null,"abstract":"<p>Intravesical Bacillus Calmette-Guérin (BCG) is a standard therapy for non–muscle-invasive bladder cancer used in urology clinics and inpatient settings. We present a review of infection risks to patients receiving intravesical BCG, healthcare personnel who prepare and administer BCG, and other patients treated in facilities where BCG is prepared and administered. Knowledge of these risks and relevant regulations informs appropriate infection prevention measures.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a diagnostic stewardship intervention to improve blood-culture utilization in 2 surgical ICUs: Time for a blood-culture change","authors":"Jessica L. Seidelman, Rebekah Moehring, Erin Gettler, Jay Krishnan, Lynn McGugan, Rachel Jordan, Margaret Murphy, Heather Pena, Christopher R. Polage, Diana Alame, Sarah Lewis, Becky Smith, Deverick Anderson, Nitin Mehdiratta","doi":"10.1017/ice.2023.249","DOIUrl":"https://doi.org/10.1017/ice.2023.249","url":null,"abstract":"<span>Objective:</span><p>We compared the number of blood-culture events before and after the introduction of a blood-culture algorithm and provider feedback. Secondary objectives were the comparison of blood-culture positivity and negative safety signals before and after the intervention.</p><span>Design:</span><p>Prospective cohort design.</p><span>Setting:</span><p>Two surgical intensive care units (ICUs): general and trauma surgery and cardiothoracic surgery</p><span>Patients:</span><p>Patients aged ≥18 years and admitted to the ICU at the time of the blood-culture event.</p><span>Methods:</span><p>We used an interrupted time series to compare rates of blood-culture events (ie, blood-culture events per 1,000 patient days) before and after the algorithm implementation with weekly provider feedback.</p><span>Results:</span><p>The blood-culture event rate decreased from 100 to 55 blood-culture events per 1,000 patient days in the general surgery and trauma ICU (72% reduction; incidence rate ratio [IRR], 0.38; 95% confidence interval [CI], 0.32–0.46; <span>P</span> &lt; .01) and from 102 to 77 blood-culture events per 1,000 patient days in the cardiothoracic surgery ICU (55% reduction; IRR, 0.45; 95% CI, 0.39–0.52; <span>P</span> &lt; .01). We did not observe any differences in average monthly antibiotic days of therapy, mortality, or readmissions between the pre- and postintervention periods.</p><span>Conclusions:</span><p>We implemented a blood-culture algorithm with data feedback in 2 surgical ICUs, and we observed significant decreases in the rates of blood-culture events without an increase in negative safety signals, including ICU length of stay, mortality, antibiotic use, or readmissions.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Bio-K+ for the prevention of Clostridioides difficile infection: Stepped-wedge cluster-randomized controlled trial","authors":"Jenine Leal, Ye Shen, Peter Faris, Bruce Dalton, Deana Sabuda, Wrechelle Ocampo, Lauren Bresee, Blanda Chow, Jared R. Fletcher, Elizabeth Henderson, Jaime Kaufman, Joseph Kim, Maitreyi Raman, Scott Kraft, Nicole C. Lamont, Oscar Larios, Bayan Missaghi, Jayna Holroyd-Leduc, Thomas Louie, John Conly","doi":"10.1017/ice.2023.169","DOIUrl":"https://doi.org/10.1017/ice.2023.169","url":null,"abstract":"<span>Objective:</span><p>To evaluate the impact of administering probiotics to prevent <span>Clostridioides difficile</span> infection (CDI) among patients receiving therapeutic antibiotics.</p><span>Design:</span><p>Stepped-wedge cluster-randomized trial between September 1, 2016, and August 31, 2019.</p><span>Setting:</span><p>This study was conducted in 4 acute-care hospitals across an integrated health region.</p><span>Patients:</span><p>Hospitalized patients, aged ≥55 years.</p><span>Methods:</span><p>Patients were given 2 probiotic capsules daily (Bio-K+, Laval, Quebec, Canada), containing 50 billion colony-forming units of <span>Lactobacillus acidophilus</span> CL1285, <span>L. casei</span> LBC80R, and <span>L. rhamnosus</span> CLR2. We measured hospital-acquired CDI (HA-CDI) and the number of positive <span>C. difficile</span> tests per 10,000 patient days as well as adherence to administration of Bio-K+ within 48 and 72 hours of antibiotic administration. Mixed-effects generalized linear models, adjusted for influenza admissions and facility characteristics, were used to evaluate the impact of the intervention on outcomes.</p><span>Results:</span><p>Overall adherence of Bio-K+ administration ranged from 76.9% to 84.6% when stratified by facility and periods. Rates of adherence to administration within 48 and 72 hours of antibiotic treatment were 60.2% –71.4% and 66.7%–75.8%, respectively. In the adjusted analysis, there was no change in HA-CDI (incidence rate ratio [IRR], 0.92; 95% confidence interval [CI], 0.68–1.23) or <span>C. difficile</span> positivity rate (IRR, 1.05; 95% CI, 0.89–1.24). Discharged patients may not have received a complete course of Bio-K+. Our hospitals had a low baseline incidence of HA-CDI. Patients who did not receive Bio-K+ may have differential risks of acquiring CDI, introducing selection bias.</p><span>Conclusions:</span><p>Hospitals considering probiotics as a primary prevention strategy should consider the baseline incidence of HA-CDI in their population and timing of probiotics relative to the start of antimicrobial administration.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICE volume 44 issue 12 Cover and Front matter","authors":"Nile Moss, Tsun Sheng, Mayar N. Ku, Al Mohajer, James A. Newton, Marie H. Wilson, Elizabeth A. Monsees, Mary K. Hayden, Kevin Messacar, Jamie J. Kisgen, Daniel J. Diekema, Daniel J. Morgan, C. Sifri, Valerie M. Vaughn, Alexandre R. Marra, Priya Nori, Bradley J. Langford, Takaaki Kobayashi, Gonzalo Bearman, Sanjay Saint, M. Greene, Sarah L. Krein, K. Fowler, Kathleen A Linder, D. Ratz, J. Meddings, Kalvin C. Yu, Molly Jung, Nathaniel S. Soper, Owen R. Albin, K. Claeys, Lauren E. Weston, Lisa Pineles, Madeline L. Berg, Carla Baxter, Ashley M. Ayres, Ashley Chung, Julie Slaughter, Andrew Bilderback, Kristian Feterik, R. Ambrosino, Suzanne Wagester, Graham M. Snyder, J. Edman-Wallér, Michael Toepfer, Johan Karp, K. Rizzardi, Gunnar Jacobsson, Maria Werner, S. S. Partha, Sara M. Malone, Melissa Bizzle, Geoffrey Ikpeama, Patrick J. Reich, C. Schuetz, Stephanie A. Fritz, Isabelle Vock, L. Aguilar-Bultet, D. Goldenberger, Silvio Ragozzino, Sabine Kuster, S. Tschudin-Sutter, Souza Sampaio, M. Ozahata, Rafael Lopes","doi":"10.1017/ice.2023.275","DOIUrl":"https://doi.org/10.1017/ice.2023.275","url":null,"abstract":"","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICE volume 44 issue 12 Cover and Back matter","authors":"","doi":"10.1017/ice.2023.276","DOIUrl":"https://doi.org/10.1017/ice.2023.276","url":null,"abstract":"","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139188658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICE volume 44 issue 11 Cover and Front matter","authors":"Clostridioides difficile, colonization and the, frequency of, treatment for, G. Sanchez-García, María B Cortés-Lara, Pilar, Berdonces-Gonzalez, J. María, de Goikoetxea, Antonio Oliver, Satoshi Atsushi Saito, Takahashi, H． Chiba，, Traditional, definition of healthcare-associated, healthcare-associated, influenza underestimates, cases, with other, Healthcare, exposures in a population-based, population-based surveillance, system, Erin B. Gettler, H. K. Talbot, Yuwei Zhu Danielle, Edward Mitchel Ndi, Tiffanie M. Markus, William, Bryan Schaffner, Harris and Thomas, R. Talbot, Diagnostic Stewardship, to support, optimal use of multiplex, molecular respiratory panels, A. S. F. S. for, Healthcare, Epidemiology, of America Research, Network, Jonathan, D. Baghdadi, M. O'Hara, J. K. Johnson, Sarah L. Krein, D. Anthony, .. Harris, J. andDaniel, Morgan, exposures in, common, areas—Epidemiological and, whole-genome sequencing, investigation, Dylan C. Kain, Sandra Isabel, Mariana, Karel, Richard De Boissinot, Borja, N.","doi":"10.1017/ice.2023.268","DOIUrl":"https://doi.org/10.1017/ice.2023.268","url":null,"abstract":"","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICE volume 44 issue 11 Cover and Back matter","authors":"","doi":"10.1017/ice.2023.267","DOIUrl":"https://doi.org/10.1017/ice.2023.267","url":null,"abstract":"","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139294462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}