Indonesian Journal of Obstetrics and Gynecology最新文献

{"title":"Mode of Delivery and Neonatal Outcomes in Preterm Pregnancy","authors":"G. B. Nugraha, N. W. P. Anggraini","doi":"10.32771/inajog.v11i2.1803","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1803","url":null,"abstract":"Objectives: To explain that mode of delivery has a correlation with neonatal outcomes in preterm pregnancies.Methods: This study is a retrospective cohort conducted at Dr. Moewardi Surakarta Hospital, with total sampling of 484 cases divided into early preterm and late preterm from 2019 to 2021. Bivariate analysis was carried out to determine the correlation between Mode of Delivery (MOD) and neonatal outcomes.Results: In the early preterm group, mode of delivery had a significant correlation (p<0.05) with birth weight, APGAR score, and neonatal mortality, however a significant correlation (p<0.05) in the late preterm group was only found in the APGAR score and neonatal mortality outcomes. Cesarean delivery, in both early and late preterm births had a lower rate of asphyxia and neonatal death (p<0.05).Conclusion: There is a significant correlation between mode of delivery and neonatal outcomes in preterm birth. Caesarean delivery by indication can significantly reduce the risk of asphyxia, and neonatal mortality due to premature birth.Keywords: mode of delivery, neonatal outcome, preterm.AbstrakTujuan: Menjelaskan bahwa metode persalinan sangat berkorelasi dengan luaran neonatus pada kehamilan prematur, oleh karena itu penelitian ini dapat menjadi bahan pertimbangan untuk memilih metode persalinan.Metode: Penelitian ini merupakan penelitian kohort retrospektif yang dilakukan di RSUD Dr. Moewardi Surakarta, dengan total sampling sebanyak 484 kasus yang terbagi menjadi early preterm dan late preterm dari tahun 2019 hingga 2021. Analisis bivariat dilakukan dengan menggunakan analisis Chi-square dan Kruskal-Wallis untuk melihat korelasi antara metode persalinan (MOD) dan luaran neonatusHasil: Pada kelompok early preterm, metode persalinan memiliki hubungan yang signifikan (p<0,05) dengan luaran neonatus baik berat lahir, skor APGAR, dan kematian neonatus. Pada kelompok late preterm, hubungan yang signifikan (p<0,05) hanya didapatkan pada luaran skor APGAR dan kematian neonatus. Persalinan Caesar baik early maupun late preterm memiliki angka yang lebih rendah terhadap asfiksia dan kematian neonatus (p<0,05).Kata kunci: metode persalinan, luaran neonatus, preterm.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48533032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Study on Maternal and Perinatal Health Services in Primary Health Care Facility in Banten Province","authors":"O. Madjid, Simon Fongana, D. Ocviyanti, J. Indarti, S. Adjie, I. Kayika, A. Pusponegoro, S. R. F. Harun","doi":"10.32771/inajog.v11i2.1892","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1892","url":null,"abstract":"\u0000 \u0000 \u0000Objective: To determine the effect of clinical governance in PHCs on maternal and perinatal health in Banten Province, Indonesia.Methods: This was an observational analytic study with cross sectional method performed on the PHCs on Banten Province, Indonesia. All PHCs in Banten Province having maternal and perinatal health services were included in the study. Clinical governance and services were measured using a self-made questionnaire filled by the representative of the PHC. Characteristics analyzed in this study were age, education level, completed training, and occupation. Clinical governance aspects analyzed in this study were leadership, culture, competence, governance, and readiness. The services analyzed in this study were antenatal, pathology, and emergency service. Results: There were 117 PHC representatives who were recruited to the study. The PHC which were categorized as “outstanding” for leadership, culture, competence, governance, and readiness were 23.1%, 41%, 98%, 81.2%, and 83.8%, respectively. The PHC which were categorized as having “good” antenatal, pathology, and emergency services were 92.3%, 51.3%, and 90.6%, respectively. The PHCs with better clinical governance aspects delivered better antenatal, pathology, and emergency services for maternal and perinatal care.Conclusions: Primary health cares with better clinical governance aspects delivered better antenatal, pathology, and emergency services for maternal and perinatal care. Therefore, improving clinical governance is essential to improve maternal and perinatal health services quality in Banten Province, IndonesiaKeywords: clinical governance, health service, maternal health, quality assurance.AbstrakTujuan: Untuk mengetahui pengaruh tata kelola klinik di Puskesmas terhadap kesehatan ibu dan perinatal di Provinsi Banten, Indonesia.Metode: Penelitian observasional analitik dengan metode potong lintang yang dilakukan di Puskesmas di Provinsi Banten, Indonesia. Semua Puskesmas di Provinsi Banten yang memiliki layanan kesehatan ibu dan perinatal diikutsertakan dalam penelitian ini. Tata kelola dan layanan klinis diukur menggunakan kuesioner buatan sendiri yang diisi oleh perwakilan Puskesmas. Karakteristik yang dianalisis dalam penelitian ini adalah usia, tingkat pendidikan, pelatihan yang diselesaikan, dan pekerjaan. Aspek tata kelola klinis yang dianalisis dalam penelitian ini adalah kepemimpinan, budaya, kompetensi, tata kelola, dan kesiapan. Pelayanan yang dianalisis dalam penelitian ini adalah pelayanan antenatal, patologi, dan gawat darurat.Hasil: Terdapat 117 perwakilan Puskesmas yang direkrut untuk penelitian. Puskesmas yang dikategorikan “sangat baik” untuk kepemimpinan, budaya, kompetensi, tata kelola, dan kesiapan masing-masing adalah 23,1%, 41%, 98%, 81,2%, dan 83,8%. Puskesmas yang memiliki pelayanan antenatal, patologi, dan gawat darurat yang tergolong “baik” berturut-turut adalah 92,3%, 51,3%, dan 90,6%. Puskesmas dengan aspek tata kelola klinis yang le","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48047613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitude towards COVID-19 Vaccine among Pregnant Women","authors":"Venkatesha K. Vasudevamurthy, Rashmi S Desai, Ashwini H. Rmaswamy, Kasturi V. Donimath, Divyashree Bhat","doi":"10.32771/inajog.v11i2.1873","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1873","url":null,"abstract":"Objective: To assess the perceptions and intentions of pregnant women regarding COVID-19 vaccination and to explore the reasons for vaccine hesitancy as well as acceptance. Methods: This prospective cross-sectional study was conducted in tertiary care hospital in Karnataka. Around 811 pregnant women attending the antenatal clinic were recruited into the study. Data were collected using a face-to-face, anonymous questionnaire written in local language.Results: Eighty six point two percent participants were aged 20 to 30 years and 64.6% had completed their schooling. 94.3% of them were homemakers and 58 % of the participants were in their third trimester. 65.5% of study group members lived in a COVID-supportive environment. Participants with COVID-19 vaccination awareness accounted for 87.4% and 65.4% were willing to receive the same whole heartedly. Our study found that 65.4% of participants were willing to receive covid-19 vaccine. The reasons for refusal were Lack of sufficient information regarding the vaccine, may be harmful to foetus and mother and lack of data proving its quality and efficiency.Conclusion: Pregnant women in the North Karnataka region were highly receptive to COVID-19 immunization. Although a high level of awareness was apparent, the lack of data and fear of side effects were two major concerns for refusal. Confidence in the government and the availability of free vaccines for all have demonstrated a massive impact on vaccination. Keywords: antenatal, covid-19, pregnancy, vaccination.AbstrakTujuan: Menilai persepsi dan keinginan perempuan hamil terkait vaksin COVID-19 dan alasan terkait penerimaan dan juga keraguan terhadap vaksin.Metode: Penelitian ini merupakan penelitian potong lintang dengan pendekatan prospektif yang dilakukan di Rumah Sakit Karnataka. Perempuan hamil sebanyak 811 menjadi subjek penelitian. Data dikumpulkan menggunakan kuesioner yang dituliskan dalam Bahasa lokal dan pengumpulan data dilakukan secara tatap muka. Hasil: Sebanyak 86,2 % sampel penelitian berusia 20 hingga 30 tahun dan 64,6% telah lulus sekolah. Sebanyak 94,3% sampel adalah ibu rumah tangga dan 58% dari sampel dengan usia kehamilan pada trimester ketiga. Sebanyak 65,5% grup tinggal pada kondisi. Sebanyak 87,4% sampel sadar akan keutamaan vaksin dan 65,4% bersedia mendapatkan vaksin. Alasan penolakan terhadap vaksin adalah kurangnya pengetahun mengenai vaksin dan ketakutan akan efek sampingnya.Kesimpulan: Perempuan hamil di Karnatakan Utara terbuka terhadap imunisasi COVID-19. Disamping tingginya angka kesadaran akan imunisasi COVID-19, penolakan umumnya didominasi akibat kurangnya pengetahuan dan ketakutan akan efek samping. Keyakinan pada pemerintah dan ketersediaan vaksin secara gratis sangat berpengaruh pada vaksinasi.Kata kunci: antenatal. covid-19, kehamilan, vaksinasi.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45313826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depo Medroxyprogesterone Acetate (DMPA): Long-Term Effects on Menstrual Cycle Disorders","authors":"N. Nurhayati, Suhermi S, S. H. Hamang","doi":"10.32771/inajog.v11i2.1884","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1884","url":null,"abstract":"bjective: To determine the effect of the duration of using Depo Medroxyprogesterone Acetate (DMPA) on the Menstrual Cycle.Methods: This research is an analytical study of 102 patients who used DMPA for less than 1 year and more than 1 year and then analyzed the types of menstrual disorders experienced while using DMPA contraception at RSIA Masyita Makassar Tahun 2022. Data collection was carried out by direct observation at RSIA. Masyita was then arranged in a checklist that has been prepared.Data is processed using SPSS version 25.0. Results: There is a significant effect between the length of use of Depo Medroxyprogesterone Acetate (DMPA) and the Menstrual Cycle (p=0.000).Conclusion: There are long-term effects of using DMPA on menstrual cycle disorders, the most common one is hypermenorrhea. These results showed that the use of Depo Medroxyprogesterone Acetate (DMPA) for more than 1 year has shown many effects on Menstrual Disorders hence can be used by midwives to provide knowledge to use in the counseling session to patients who wishes to use DMPA regarding the side effects and risks of using longer contraceptives.Keywords: Depo Medroxyprogesterone Acetate (DMPA), duration of use, menstrual cycle.AbstrakObjektif: Untuk mengetahui pengaruh lama penggunaan Depo Medroksiprogesteron Asetat (DMPA) terhadap siklus menstruasi.Metode: Penelitian ini merupakan jenis penelitian analitik terhadap 102 pasien yang menggunakan DMPA kurang dari 1 tahun dan lebih dari 1 tahun kemudian dianalisis jenis gangguan menstruasi yang dialami selama menggunakan kontrasepsi DMPA di RSIA Masyita Makassar. Pengumpulan data dilakukan dengan metode observasi langsung di RSIA Tahun 2022. Masyita kemudian disusun dalam checklist yang telah disiapkan.Data diolah menggunakan SPSS versi 25.0.Hasil: Ada pengaruh yang signifikan antara lama penggunaan Depo Medroksiprogesteron Asetat (DMPA) dengan siklus menstruasi (p=0,000).Kesimpulan: Adanya Efek dari Jangka Panjang Penggunaan DMPA terhadap gangguan siklus Mentsruasi yang terbanyak yaitu Hipermenore. Hasil ini menunjukkan bahwaPenggunaan Depo Medroksiprogesteron Asetat (DMPA) selama lebih dari 1 tahun telah menunjukkan banyak efek pada gangguan menstruasi dan selanjutnya dapat digunakan oleh bidan dalam memberikan pengetahuan dan konseling kepada pasien yang akan menggunakan DMPA mengenai efek samping dan resiko penggunaan kontrasepsi yang lebih lama.Kata kunci: Depo Medroksiprogesteron Asetat (DMPA), lama pemakaian, siklus menstruasi.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46458426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Utero Ultrasonography Parameters as a Children Growth Prediction at Age 2 – 3","authors":"Radiva H. Mazaya, J. Dewantiningrum, F. A. Rahmadi, D. T. Anantyo","doi":"10.32771/inajog.v11i2.1791","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1791","url":null,"abstract":"ltrasound parameters during pregnancy and the growth of children aged 2 – 3 years.Methods: This was an analytic observational study with a longitudinal approach using data from the first 1,000 days of life. Study conducted at the Faculty of Medicine, Diponegoro University. The research subjects were children aged 2 – 3 years old with good nutritional status and democratic parenting from 14 City Health Centers in Semarang. The ultrasound parameters obtained were Biparietal Diameter (BPD), Abdomen Circumference (AC), Head Circumference (HC), Femur Length (FL) at 20 – 24 weeks of gestation. Data were obtained during the second trimester. Data on the growth of children at the age of 2 years obtained are height, weight, and HC. Statistical test using Pearson correlation test, with p<0.1 is considered significant.Results: The level of confidence used in this study was 90% and obtained 45 research subjects with a female gender of 26 children (57.8%) and 19 male children (42.2%). The Pearson test showed that there was no significant relationship between BPD and height (p=0.18; r=-0.20), AC and height (p=0.12; r=-0.23), and FL and height (p=0.17; r=-0.20). There was a significant relationship between HC and height (p=0.04; r=-0.29), BPD and weight (p=0.06; r=-0.28), HC and weight (p=0.01; r=-0,.5), AC and weight (p=0.08; r=-0.26), FL and weight (p=0.05; r=-0.29) and prenatal HC and postnatal HC (p=0.03; r=-0.32).Conclusion: There is a significant relationship between ultrasound parameters during pregnancy and the growth of children aged 2 – 3 years.Keywords: abdominal circumference, biparietal diameter, child growth, femur length, head circumference, pregnancy.AbstrakTujuan: Untuk mengetahui hubungan antara parameter ultrasonografi saat kehamilan dengan pertumbuhan anak usia 2-3 tahun.Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan longitudinal menggunakan data penelitian 1.000 hari pertama kehidupan yang dilakukan di Fakultas Kedokteran Universitas Diponegoro. Subjek penelitian adalah anak usia 2 – 3 tahun dengan gizi baik dan pola asuh demokratis dari 14 Puskesmas Kota Semarang. Parameter USG yang diperoleh adalah diameter biparietal (BPD), lingkar abdomen (AC), lingkar kepala (HC), dan panjang femur (FL) pada usia kehamilan 20 – 24 minggu. Data diperoleh selama trimester kedua. Data tumbuh kembang anak usia 2 tahun yang diperoleh adalah tinggi badan, berat badan, dan lingkar kepala. Uji statistik menggunakan uji korelasi Pearson, dengan p<0,1 dianggap signifikan.Hasil: Tingkat kepercayaan yang digunakan dalam penelitian ini adalah 90% dan diperoleh 45 subjek penelitian dengan jenis kelamin perempuan 26 anak (57,8%) dan 19 anak laki-laki (42,2%). Uji Pearson menunjukkan bahwa tidak ada hubungan yang signifikan antara BPD dengan tinggi badan (p=0,18; r=-0,20), AC dan tinggi badan (p=0,12; r=-0,23), dan FL dan tinggi (p=0,17; r=-0,20). Terdapat hubungan yang signifikan antara HC dengan tinggi badan (p=0,04; r=-0,29), B","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46845978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Nanocurcumin in Combination with Methotrexate on Telomerase Activity, NF-kb Expression, and Proliferation Index of Bewo Choriocarcinoma Cells","authors":"S. Subandi, S. Purbadi","doi":"10.32771/inajog.v11i2.1733","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1733","url":null,"abstract":"Objectives: To determine the anti-cancer effect of nanocurcumin on choriocarcinoma. Methods: This study observes the telomerase activity, NF-κ B expression, and BrdU proliferation index in cultures of BeWo choriocarcinoma cell line (ATCC CCL-98) exposed to MTX and nanocurcumin in various doses. The sample used in this study consisted of 4 groups of BeWo cells that received a combination of MTX and nanocurcumin, and 2 other groups for positive and negative control. Results: There was a decrease in telomerase activity, NF-κ B expression, and BrdU proliferation index in the 4 treatment groups compared to the negative and positive control group (p ≤ 0.05). Conclusion: Nanocurcumin and MTX decrease telomerase expression, NF-κ B expression, and the BrdU proliferation index in choriocarcinoma BeWo cell line culture faster than MTX alone.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46381587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Platelet-Rich Plasma Application on Mesh-Tissue Integration","authors":"Alfa P. Meutia, B. Santoso, Suskhan Djusad","doi":"10.32771/inajog.v11i2.1721","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1721","url":null,"abstract":"AbstractObjective: To review the advantage of PRP use on mesh-augmented surgery.Methods: Literature review of PRP application of mesh.Results: The application of PRP on mesh shows potential promising outcome.Conclusion: PRP may improve the mesh-tissue integration.Keywords: mesh-augmented surgery, pelvic organ prolapse, platelet-rich plasma, wound healing.AbstrakTujuan: Untuk menganalisa keuntungan penggunaan PRP pada pembedahan rekonstruktif dengan mesh.Metode: Kajian pustaka dari penggunaan PRP pada pembedahan rekonstruktif dengan mesh.Hasil: Aplikasi PRP pada mesh menunjukkan hasil yang positif.Kesimpulan: Aplikasi PRP dapat meningkatkan integrasi mesh dengan jaringanKata kunci: pembedahan rekonstruksi dengan mesh, penyembuhan luka, platelet-rich plasma, prolaps organ panggul.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41401011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Use in Caesarean Section among Obstetricians and Gynaecologists in the Second Largest City in Indonesia","authors":"Penggunaan Antibiotik, Operasi Sesar, Dokter Obstetri, dan Ginekologi, M. Akbar, R. Ulhaq, Indra Yuliati, M. Yusuf, B. Prasetyo, B. A. Tjokroprawiro","doi":"10.32771/inajog.v11i2.1888","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1888","url":null,"abstract":"Objective: To evaluate the pattern of antibiotic use incesarean section `by obstetricians in Surabaya, Indonesia.Methods: This was a descriptive observational study witha cross-sectional method. Study data were obtained fromonline interviews using electronic forms. This study useda total sampling method taken from obstetricians andgynecologists in Surabaya, Indonesia. The primary outcomeof this study was a pattern of antibiotic use, includingprophylactic use, selection of antibiotics, the timing ofadministration, additional antibiotics during and aftersurgery, and consideration of choice.Results: The majority of antibiotics used in CS are in linewith the guidelines. The types of prophylactic antibiotics(iv) used are varied; the majority were cefazoline (74.5%),ceftriaxone (14.5%), and cefotaxime (11.6%). Most antibioticswere administered <30 minutes before surgery. 2.5% ofobstetricians routinely added antibiotics during a cesarean,while 33% were based on a particular condition such asprolonged surgery, massive bleeding, or risk of infections.The selection of antibiotics by obstetricians was based onprotocols followed in the hospital (44.5%).Conclusion: This study demonstrates that most obstetriciansutilized antibiotic prophylaxis appropriately and followedguidelines for Cesarean Section.Keywords: antibiotic, cesarean section, maternal health,obstetricians.AbstrakTujuan: Untuk mengevaluasi pola penggunaan antibiotikpada seksio sesarea oleh dokter kandungan di Surabaya,Indonesia.Metode: Ini merupakan studi deskriptif observasionaldengan metode pengambilan data potong lintang. Datastudi diperoleh dari wawancara online dengan menggunakanformulir elektronik. Studi ini menggunakan total samplingdari dokter obstetri dan ginekologi di Surabaya, Indonesia.Hasil utama dari penelitian ini adalah pola penggunaanantibiotik, termasuk penggunaan profi laksis, pemilihanantibiotik, waktu pemberian, antibiotik tambahan selamadan setelah operasi, dan pertimbangan pilihan antibiotiktersebut.Hasil: Mayoritas antibiotik yang digunakan pada seksiosesarea sesuai dengan pedoman. Jenis antibiotik profi laksis(iv) yang digunakan bervariasi, mayoritas adalah cefazoline(74,5%), ceftriaxone (14,5%), dan cefotaxime (11,6%).Sebagian besar antibiotik diberikan <30 menit sebelumoperasi. 2,5% dokter kandungan rutin menambahkanantibiotik saat operasi sesar, sedangkan 33% didasarkanpada kondisi tertentu seperti operasi yang berkepanjangan,perdarahan masif, atau risiko infeksi. Pemilihan antibiotikoleh dokter kandungan berdasarkan protokol yang diikutidi rumah sakit (44,5%).Kesimpulan: Studi ini menunjukkan bahwa sebagian besardokter kandungan menggunakan profi laksis antibiotikdengan tepat dan mengikuti pedoman untuk operasi seksiosesaria.Kata kunci: antibiotik, dokter kandungan, kesehatan ibu,operasi sesar.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43071802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELA mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs11820062 Gene Variant","authors":"Benedikta D. Saraswati, D. Suryandari, R. Kodariah, D. Sukmawati, L. Yunaini, P. Rustamadji, P. Sari, Sakit Dr. Cipto, Indonesia Mangunkusumo","doi":"10.32771/inajog.v11i2.1872","DOIUrl":"https://doi.org/10.32771/inajog.v11i2.1872","url":null,"abstract":"and its correlation to i mRNA expression in low-grade and high-grade EOC’s patients from Dr. Cipto Mangunkusumo General hospital, Indonesia. Methods: This study is cross-sectional with a total of 65 healthy subjects and 80 ovarian biopsies (15 ovarian cysts as expression calibrators, 36 low-grade EOC, and 29 high-grade EOC) were used in this study. The distribution of genotypes and alleles was analyzed using ARMS PCR. The mRNA expressions of RELA were determined by real-time polymerase chain reaction (qPCR) analysis.Results: There was no significant difference between genotype and allele distributions for RELA rs11820062 in normal and case group. RELA relative mRNA expression was significantly higher in low-grade and high-grade EOC compared to in ovarian cysts (p<0.01). RELA rs11820062 CC genotype correlated to higher RELA mRNA relative expression and the TT genotype of RELA rs11820062 correlated with lower RELA mRNA relative expression in low-grade and high-grade EOC.Conclusion: C allele in rs11820062 caused an increased expression of RELA mRNA, which individuals with CC genotype correlated with higher RELA expression in low-grade and high-grade EOC. In contrast, individuals with the T allele of RELA rs11820062 had a protective effect against EOC risk because the RELA TT genotype tended to have a lower RELA mRNA expression in EOC.Keywords: epithelial ovarian cancer, NF-kB, RELA, rs11820062.AbstrakTujuan: Mengetahui distribusi RELA rs11820062 dan korelasinya dengan ekspresi mRNA RELA pada pasien EOC low-grade dan high-grade di Rumah Sakit Dr. Cipto Mangunkusumo, Indonesia.Metode: Penelitian ini merupakan peneliatan potong lintang terhadap 65 sampel darah perempuan normal dan total 80 biopsi kanker ovarium dengan rincian: 15 kista ovarium sebagai kalibrator ekspresi, 36 EOC low-grade, dan 29 EOC high-grade. Distribusi genotipe dan alel dianalisis menggunakan ARMS PCR dan ekspresi mRNA RELA dikuantifikasi menggunakan teknik qPCR. Hasil: Tidak terdapat perbedaan distribusi genotipe dan alel antara kelompok normal dengan kasus EOC. Ekspresi relatif mRNA RELA meningkat secara signifikan pada kelompok EOC low-grade dan high-grade. Individu dengan genotipe RELA rs11820062 homozigot CC memiliki ekspresi mRNA yang lebih tinggi dibandingkan genotipe lain. Sebaliknya individu dengan genotipe TT memiliki korelasi dengan ekspresi mRNA RELA yang lebih rendah pada tipe low-grade dan high-grade EOC. Kesimpulan: Alel C pada RELA rs11820062 menyebabkan peningkatan ekspresi mRNA RELA pada pasien EO yang dilihat dari individu dengan genotipe CC cenderung memiliki ekspresi mRNA RELA yang lebih tinggi pada tipe EOC low-grade dan high-grade. Sebaliknya, individu dengan alel T RELA rs11820062 diduga memiliki efek protektif terhadap risiko EOC karena adanya korelasi antara genotipe TT dengan ekspresi mRNA RELA yang lebih rendah pada EOC.Kata kunci: kanker ovarium epitelial, NF-kB, RELA, rs11820062.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45544926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentzer and RDW Index in the Establishment of Iron Deficiency Anemia Diagnosis in the First Trimester of Pregnant Woman","authors":"Jane Belinda, Edihan Mardjuki, S. R. Bororing","doi":"10.32771/inajog.v11i1.1676","DOIUrl":"https://doi.org/10.32771/inajog.v11i1.1676","url":null,"abstract":"Objective: To determine the sensitivity and specificity of the Mentzer and RDW index to assist in the diagnosis of iron deficiency anemia in first trimester pregnant women at RSIA Asih. Methods: This research was conducted by a cross-sectional method using the medical records of 100 samples of first trimester pregnant women with iron deficiency anemia by consecutive sampling and 100 samples of controls, which is also first trimester pregnant women with anemia. The data is then analyzed using Kolmogorov-Smirnov test and the independent-T test. Result: This study showed a significant relationship between the Mentzer index and the RDW index in iron deficiency anemia patients and control with p value = 0.000. Calculated by the ROC curve, the cut-off of Mentzer and RDW indices were 18.33 (sensitivity 37%, specificity 36%) and 249.2 (sensitivity 36%, spesificity 36%). Calculated by chi-square, the sensitivity and specificity values of the Mentzer index were 69% and 22% (literacy cut-off = 13), while the sensitivity and specificity values of the RDW index were 63% and 34% (literacy cut-off = 220). Conclusion: Mentzer index and RDW index cannot be proposed as the main parameter to help the establisment of iron deficiency anemia diagnosis in first trimester pregnant women.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41893905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}