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Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry最新文献

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Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides 新型3-芳基-4-甲氧基n -烷基马来酰亚胺的合成及生物学评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-03-16 DOI: 10.56042/ijcb.v60i3.41338
{"title":"Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides","authors":"","doi":"10.56042/ijcb.v60i3.41338","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.41338","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"36 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74807996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New macromolecular structures based on benzene core, synthesis and characterization 基于苯核的新型大分子结构、合成及表征
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-03-16 DOI: 10.56042/ijcb.v60i3.28816
{"title":"New macromolecular structures based on benzene core, synthesis and characterization","authors":"","doi":"10.56042/ijcb.v60i3.28816","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.28816","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"12 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79059434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents 香豆素-1,4-二氢吡啶衍生物的合成、体外生物学评价及分子对接研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-03-16 DOI: 10.56042/ijcb.v60i3.31796
{"title":"Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents","authors":"","doi":"10.56042/ijcb.v60i3.31796","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.31796","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"27 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83208670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives 一些1,4-二氢吡啶衍生物的合成及其抗惊厥活性
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-03-16 DOI: 10.56042/ijcb.v60i3.32259
{"title":"Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives","authors":"","doi":"10.56042/ijcb.v60i3.32259","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.32259","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"43 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86633856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, in silico pharmacokinetic analysis and anticancer activity evaluation of benzothiazole-triazole hybrids 苯并噻唑-三唑复合物的合成、药代动力学分析及抗癌活性评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-03-16 DOI: 10.56042/ijcb.v60i3.38659
{"title":"Synthesis, in silico pharmacokinetic analysis and anticancer activity evaluation of benzothiazole-triazole hybrids","authors":"","doi":"10.56042/ijcb.v60i3.38659","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.38659","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85675676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological activity of novel pentasubstituted cyclohexanol against some microorganisms 新型五取代环己醇对微生物的生物活性研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI: 10.56042/ijcb.v60i2.29657
I. Mamedov, Y. Mamedova
{"title":"Biological activity of novel pentasubstituted cyclohexanol against some microorganisms","authors":"I. Mamedov, Y. Mamedova","doi":"10.56042/ijcb.v60i2.29657","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.29657","url":null,"abstract":"The aromatic ketones are effective compounds in organic synthesis and have important significance for synthesis of different practical compounds, which have physiological activity. Due to the their different functionality these compounds confer biological activities, such as antimicrobial, antibacterial, antifungal, anticancer, antiviral, anti-inflammatory, antihyperglycemic. Taking into account of their pharmaceutical actuality the 1,2,3,4,5-pentasubstituted cyclohexanol and its forming chalcone against S. aureus, E. coli, KES (Klebsiella, Enterobacter, Serratia) and A. niger were investigated.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77550494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro anticancer activity of thiazole based β-amino carbonyl derivatives against HCT116 and H1299 colon cancer cell lines; study of pharmacokinetics, physicochemical, medicinal properties and molecular docking analysis 噻唑基β-氨基羰基衍生物对HCT116和H1299结肠癌细胞的体外抗癌活性研究药物动力学、理化、药性及分子对接分析研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI: 10.56042/ijcb.v60i2.30155
{"title":"In vitro anticancer activity of thiazole based β-amino carbonyl derivatives against HCT116 and H1299 colon cancer cell lines; study of pharmacokinetics, physicochemical, medicinal properties and molecular docking analysis","authors":"","doi":"10.56042/ijcb.v60i2.30155","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.30155","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82935982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis of 4-[2-(substituted phenyl) hydrazono]-3-(1-hydroxyethyl)-1-phenyl/methyl-3,4-dihydroquinolin-2(1H)-one derivatives and evaluation of their in vitro tyrosine kinase inhibitor activity 4-[2-(取代苯基)肼]-3-(1-羟乙基)-1-苯基/甲基-3,4-二氢喹啉-2(1H)- 1衍生物的设计、合成及其体外酪氨酸激酶抑制剂活性评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI: 10.56042/ijcb.v60i2.32682
Viveka Fonsecaa, S. Chandavarkar, Renuka Dabholkara, Prachita Gauns Dessaia, Mangirish Deshpandec, Shivalingrao N Mamle Desaia
{"title":"Design, synthesis of 4-[2-(substituted phenyl) hydrazono]-3-(1-hydroxyethyl)-1-phenyl/methyl-3,4-dihydroquinolin-2(1H)-one derivatives and evaluation of their in vitro tyrosine kinase inhibitor activity","authors":"Viveka Fonsecaa, S. Chandavarkar, Renuka Dabholkara, Prachita Gauns Dessaia, Mangirish Deshpandec, Shivalingrao N Mamle Desaia","doi":"10.56042/ijcb.v60i2.32682","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.32682","url":null,"abstract":"The present investigation deals with molecular docking, synthesis, characterization, and evaluation of in vitro tyrosine kinase inhibitor activity of a series of 4-[2-(substituted phenyl) hydrazono]-3-(1-hydroxyethyl)-1-phenyl/methyl-3,4-dihydroquinolin-2(1 H )-one derivatives {III-a(1-12)/III-b(1-12)}. Molecular docking studies of the title compounds were carried out using Molegro Virtual Docker (MVD-2013, 6.0) software. The MolDock scores of the derivatives ranged from ( − 66.508) to ( − 101.274); whereas the MolDock score of standard 4-anilinoquinazoline ligand was found to be ( − 105.219). Most of the synthesized qunolin-2-one derivatives showed better affinity towards EGFRK protein as compared to standard drug imatinib ( − 104.253). All the synthesized compounds were satisfactorily characterized by physical and spectral analysis (UV, IR, 1 H NMR and 13 C NMR and mass spectral data). Twelve derivatives were tested for their in vitro tyrosine kinase inhibitor activity using MDA-MB cell line. Compound 4-[2-(4-bromophenyl)hydrazono]-3-(1-hydroxyethyl)-1-methyl- 3,4-dihydroquinolin-2(1 H )-one (III-b4) was found to be the most cytotoxic compound as compared to other synthesized derivatives, with IC 50 value of 0.0515 μ M against MDA- MB cell line.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"47 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89941995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of a new heterocyclic dye compound as an indicator in acid and base reactions 一种新型杂环染料化合物的合成及其在酸碱反应中的指示作用
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI: 10.56042/ijcb.v60i2.30182
{"title":"Synthesis of a new heterocyclic dye compound as an indicator in acid and base reactions","authors":"","doi":"10.56042/ijcb.v60i2.30182","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.30182","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"23 5 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80921432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic study on acylation of methyl 3-aminocrotonate with acid chlorides of aliphatic, aromatic and α, β-unsaturated acids: A comparative evaluation of the preference for regio- and stereoselectivity vis-à-vis 3-aminocrotononitrile 3-氨基丙酮酸甲酯与脂肪族、芳香族和α、β-不饱和酸的酰化反应的系统研究:对-à-vis 3-氨基丙酮腈的区域选择性和立体选择性的比较评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI: 10.56042/ijcb.v60i2.30279
Attreyee Mukherjeea, K. K. Mahalanabis
{"title":"Systematic study on acylation of methyl 3-aminocrotonate with acid chlorides of aliphatic, aromatic and α, β-unsaturated acids: A comparative evaluation of the preference for regio- and stereoselectivity vis-à-vis 3-aminocrotononitrile","authors":"Attreyee Mukherjeea, K. K. Mahalanabis","doi":"10.56042/ijcb.v60i2.30279","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.30279","url":null,"abstract":"Acylation of methyl 3-aminocrotonate 1a in benzene with a variety of aliphatic and aromatic acid chlorides including α , β -unsaturated acid chloride in the presence of an added organic base, (either pyridine or triethylamine) is reported. The preferred N, C-site selectivity in these reactions has been compared with the terminal selectivity of the products obtained previously on acylation of methyl 3-aminocrotononitrile 1b . A strong preference either for N- or C- selectivity in N, C-acylation has been observed for both 1a and 1b based on the choice of acid chlorides and added organic base. Interestingly, irrespective of the enamine 1a or 1b , acylation with α , β -unsaturated acid chlorides in the presence of triethylamine afforded 3,4-dihydropyridin-(2 H )-one via [3.3] sigmatropic rearrangement of the corresponding intermediary N(E)-enamide. Accrued results show methyl 3-aminocrotonate to be a better precursor for preparation of enamides (N-acylated products) whereas 3-aminocrotononitrile is found to be a preferred choice for preparation of enaminones (C-acylated products). An attempt is made to offer a preliminary theoretical interpretation for observed site selectivity.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"20 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84986864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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