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Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry最新文献

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An efficient synthesis of Vildagliptin intermediates 维格列汀中间体的高效合成
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30478
Yufei Li, Lan Jiang, Li Zhang, Jingyu Wang, Peng Xiang, J. Pan, Xiangnan Hu
{"title":"An efficient synthesis of Vildagliptin intermediates","authors":"Yufei Li, Lan Jiang, Li Zhang, Jingyu Wang, Peng Xiang, J. Pan, Xiangnan Hu","doi":"10.56042/ijcb.v60i8.30478","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30478","url":null,"abstract":"Efficient and high yielding methods for the preparation of vildagliptin 1 intermediate of (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile 2 and 3-amino-1-adamantane alcohol 3 respectively have been described. (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 2 has been synthesized from L-proline 2a via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot reactions. 3-Amino-1-adamantane alcohol 3 has been prepared from amantadine hydrochloride via oxidation by sulfuric acid/nitric acid and boric acid as catalyst, and has been subjected to ethanol extraction. The overall yield is about 95%.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77649431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and antimicrobial evaluation of some novel (3-methyl-5-((3-phenylisoxazol-5-yl)methoxy)benzofuran-2-yl)(phenyl)methanones 新型(3-甲基-5-((3-苯基异恶唑-5-基)甲氧基)苯并呋喃-2-基)(苯基)甲烷的合成、表征及抗菌评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30912
A. Kumar, V. Sunithab, P. Shankaraiaha, P. Jalapathic
{"title":"Synthesis, characterization and antimicrobial evaluation of some novel (3-methyl-5-((3-phenylisoxazol-5-yl)methoxy)benzofuran-2-yl)(phenyl)methanones","authors":"A. Kumar, V. Sunithab, P. Shankaraiaha, P. Jalapathic","doi":"10.56042/ijcb.v60i8.30912","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30912","url":null,"abstract":"A Kishore Kumar*, V Sunitha, P Shankaraiah & P Jalapathi a Department of Humanities and Sciences, Vardhaman College of Engineering, Shamshabad, Hyderabad 501 218, India b Department of Chemistry, University College of Science, Osmania University, Saifabad, Hyderabad 500 004, India c Department of Chemistry, University College of Engineering, Osmania University, Hyderabad 500 007, India E-mail: kishoreangajala@gmail.com","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74131750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Computational design, synthesis, structural analysis and biological evaluation some novel N-methylated indole incorporating pyrazole moieties 新型含吡唑基团n -甲基化吲哚的计算设计、合成、结构分析及生物学评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30351
{"title":"Computational design, synthesis, structural analysis and biological evaluation some novel N-methylated indole incorporating pyrazole moieties","authors":"","doi":"10.56042/ijcb.v60i8.30351","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30351","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75614682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing a new vanillin Schiff base (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one: Synthesis, characterization, crystal structure and biological studies 新型香兰素希夫碱(Z)-4-((2-羟基-3-甲氧基苄基)氨基)-1,5-二甲基-2-苯基-1,2-二氢- 3h -吡唑-3-酮的合成、表征、晶体结构及生物学研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.27844
{"title":"Designing a new vanillin Schiff base (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one: Synthesis, characterization, crystal structure and biological studies","authors":"","doi":"10.56042/ijcb.v60i8.27844","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.27844","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76140874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological activity of 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one 7-(2-(1h -1,2,4-三唑-1-基)乙氧基)-4-(苯乙烯基/4-取代苯乙烯基)- 2h - chromen2 -one的合成及生物活性
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30157
{"title":"Synthesis and biological activity of 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one","authors":"","doi":"10.56042/ijcb.v60i8.30157","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30157","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83158312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from Acacia nilotica var. ad stringens 金合欢7,3′，4′-三羟基黄酮醇的抑菌活性研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.29194
A. M. Alraih, M. A. Mohamed, M. Alansari, A. Osman, K. Ahmed, Ayda Y. Abdelrahman, M. Hamid
{"title":"Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from Acacia nilotica var. ad stringens","authors":"A. M. Alraih, M. A. Mohamed, M. Alansari, A. Osman, K. Ahmed, Ayda Y. Abdelrahman, M. Hamid","doi":"10.56042/ijcb.v60i8.29194","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.29194","url":null,"abstract":"Acacia species (Mimosaceae) is widely distributed in tropical and subtropical countries and has a variety of ethnomedicinal uses. There is inadequate laboratory investigation to identify bioactive compounds and therapeutic effect of Acacia nilotica var. adstringens. This research was conducted to extract, isolate and identify major compounds from heartwood of Acacia nilotica var. adstringens and to test them against representative bacteria. Powdered air-dried heartwood of A. nilotica var. adstringens was extracted with methanol/water, 4:1 and the extracted was then purified using chromatographic techniques (column and paper chromatography). A pure flavonoid compound was isolated and the structure was elucidated based on extensive spectroscopic analysis procedures (IR, UV, 1H-NMR, and MS spectrometery). The isolated compound was then evaluated for antimicrobial potential against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus) using cub-plate agar diffusion method. The spectroscopic analysis of the isolated compound led to its identification as 7, 3`, 4`-trihydroxyflavonol. The compound showed varying antimicrobial responses with high potency against Gram-negative human pathogens. The Gram-positive bacteria which were inhibited were Bacillus cereus, Corynebacterium sp., Enterococcus faecalis, Staphylococcus aureus, and Streptococcus agalactiae. The Gram-negative bacteria were Acinetobacter baumannii, Acinetobacter sp., Escherichia coli, Pseudomonas aeruginosa and yeasts were Candida albicans and Cryptococcus neoformans. The present study demonstrated that 7, 3`, 4`-trihydroxyflavonol is an effective antimicrobial compound. If applied in suitable pharmaceutical formulations it could be valuable for treating various bacterial infections or introduced as adjunct treatment along with standard agents.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90877372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave assisted synthesis of hybrid heterocyclics 杂化杂环的微波辅助合成
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30135
{"title":"Microwave assisted synthesis of hybrid heterocyclics","authors":"","doi":"10.56042/ijcb.v60i8.30135","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30135","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73999549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological evaluation of some novel chalcones and their derivatives 一些新型查尔酮及其衍生物的生物学评价
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-07 DOI: 10.56042/ijcb.v60i8.30567
{"title":"Biological evaluation of some novel chalcones and their derivatives","authors":"","doi":"10.56042/ijcb.v60i8.30567","DOIUrl":"https://doi.org/10.56042/ijcb.v60i8.30567","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74084579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of N-aminoimidazol-2-thione derivatives using tandem approach 串联法合成n -氨基咪唑-2-硫酮衍生物
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-05 DOI: 10.56042/ijcb.v60i7.44455
{"title":"Synthesis of N-aminoimidazol-2-thione derivatives using tandem approach","authors":"","doi":"10.56042/ijcb.v60i7.44455","DOIUrl":"https://doi.org/10.56042/ijcb.v60i7.44455","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79179803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and antimicrobial activity of some novel 1-amino dibenzofuran derivatives 新型1-氨基二苯并呋喃衍生物的合成、表征及抗菌活性研究
IF 0.5 4区 化学
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-10-05 DOI: 10.56042/ijcb.v60i7.29363
{"title":"Synthesis, characterization and antimicrobial activity of some novel 1-amino dibenzofuran derivatives","authors":"","doi":"10.56042/ijcb.v60i7.29363","DOIUrl":"https://doi.org/10.56042/ijcb.v60i7.29363","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76016281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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