Trends in Pharmaceuticals and Nanotechnology最新文献

Formulation and Evaluation of Colon Targeted Ciprofloxacin Microspheres 结肠靶向环丙沙星微球的研制与评价

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2023-09-30 DOI: 10.46610/tpnt.2023.v05i02.004

Ch. Srilatha, T Giriraj kulkarni

{"title":"Formulation and Evaluation of Colon Targeted Ciprofloxacin Microspheres","authors":"Ch. Srilatha, T Giriraj kulkarni","doi":"10.46610/tpnt.2023.v05i02.004","DOIUrl":"https://doi.org/10.46610/tpnt.2023.v05i02.004","url":null,"abstract":"In the present study, Colon-targeted Ciprofloxacin hydrochloride microspheres were formulated and their in vitro properties were assessed to determine whether or not the antibiotic could be delivered to the colon. By utilizing span-80 as an emulsifying agent, ciprofloxacin hydrochloride microspheres for colon targeting were prepared using the emulsion-solvent evaporation method. According to the preliminary trial findings, the ratio of drug to polymer had an impact on the microspheres' properties. The Ciprofloxacin: Eudragit S-100+HPMC 6cps ratio of 1:1, 1:2, 1:3, 1:4, 1:5, and 1:6 were used to make the colon targeting microspheres, in which the ratio of Eudragit S-100 to HPMC was always 1:1. The combination of Eudragit S-100 and HPMC demonstrated increased release lag time and regulated release rate, which improved protection of the drug-containing core. For the majority of the formulations examined, zero-order release followed a time delay caused by the hydrogel's swelling/retarding behaviour before the medication started to come out of the microspheres. The colon-targeting microspheres were also tested for micrometrics, particle size and surface properties, percentage drug content, encapsulation effectiveness, and in vitro drug release study in the three different pH environments (0.1 N HCL, Phosphate buffer pH 6.8 and Phosphate buffer pH 7.4) for 12 hours. The kinetics of drug release in vitro and the drug release mechanism of the microspheres were further investigated. With a particle size of 58.9 m, an almost spherical shape, and free-flowing characteristics, the best formulation batch had the highest drug entrapment efficiency of 86.81%. It was followed by a zero-order rate release with a non-fiction-diffusion mechanism, which had an 82.77% drug release rate.","PeriodicalId":134570,"journal":{"name":"Trends in Pharmaceuticals and Nanotechnology","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136336634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-Printed Composites: Multiple Applications, Recent Advances, and Emerging Prospects 3d打印复合材料:多种应用，最新进展和新兴前景

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2023-09-30 DOI: 10.46610/tpnt.2023.v05i02.003

Vivek Kahale, Madhukar Shende

引用次数: 0

Global Contributions on Nanotechnology of Regulatory Aspects of Drugs 纳米技术在药物监管方面的全球贡献

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2023-08-24 DOI: 10.46610/tpnt.2023.v05i02.002

Sai Grandhi Meena, Koushik Yetukuri

{"title":"Global Contributions on Nanotechnology of Regulatory Aspects of Drugs","authors":"Sai Grandhi Meena, Koushik Yetukuri","doi":"10.46610/tpnt.2023.v05i02.002","DOIUrl":"https://doi.org/10.46610/tpnt.2023.v05i02.002","url":null,"abstract":"Background and Objective: The food, pharmaceutical, and agricultural industries can contribute to, develop, and benefit from the use of nanotechnology, which is a major advanced technology. The manufacture of healthier, safer, and high-quality functional foods that are perishable or semi-perishable could be led qualitatively and quantitatively by nonmaterial. Nanotechnology has become one of the most significant frontline areas in many traditional study areas of science and technology. Methods: It contains several international regulations that have helped spread awareness of the value of nanotechnology in pharmaceuticals. The article on pharmaceuticals and food was framed following the regulatory authorities of each country's criteria. Results: Nanotechnology's uses in emerging nations' products, including medicine, and other goods. Conclusion: The potential for nanotechnology to advance food research across a wide range of disciplines is considerable. These nanomaterial devices have numerous uses in the food industry, including food processing, preservation, and packaging. Different nanomaterials have been used for a variety of biomedical applications, including drug delivery systems, optical imaging, and bioimaging, depending on the physical and chemical properties of their surfaces. For the benefit of all people, it justifies paying attention to the incredibly promising topic of nanotechnology.","PeriodicalId":134570,"journal":{"name":"Trends in Pharmaceuticals and Nanotechnology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121563601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Sensitive and Selective Cu-doped ZnO Thin film for No2 Sensing with Chemical Root Method 化学根法高敏选择性cu掺杂ZnO薄膜No2传感

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2023-02-21 DOI: 10.46610/tpnt.2023.v05i01.003

S. J.

{"title":"High Sensitive and Selective Cu-doped ZnO Thin film for No2 Sensing with Chemical Root Method","authors":"S. J.","doi":"10.46610/tpnt.2023.v05i01.003","DOIUrl":"https://doi.org/10.46610/tpnt.2023.v05i01.003","url":null,"abstract":"Copper Doped Zinc Oxide-Thin films are prepared by the Sol-Gel method and annealing at 400°C, For sol preparation, we prepare 2- different types of solution, one is zinc nitrate hexahydrate and the second is copper nitrate, that are deeply discussed in this paper. The thin size was varied by XRD, the detected (h k l) peaks are confirmed with 2θ values and the morphology was also studied by field emission scanning electron microscopy (FESEM), the Nano-bubbles and nano-balls was observed. Electrical properties and VI- Characteristics were also done, and getting highly sensitive Performing results, finally, the gas sensing characteristic was taken by chemiresistive process. And the Gas Sensing performance was done with closed chamber methods and the High sensitive and selective performance result have been shown. The sensing parameters such as electrical properties, and VI- characteristics, for gases, are also observed we shown the response time and recovery time, The S=Rg/Ra formula is used for calculate the response of the films. The best of lower gas detection limits, towards NO2 gas, and also finalize the selectivity and sensitivity performance of the thin film. The final result shown that ZnO thinfilm can act as NO2 sensor and breath analyzer, for diabetes.","PeriodicalId":134570,"journal":{"name":"Trends in Pharmaceuticals and Nanotechnology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114210993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on Synthesis and Application of Zinc Oxide Nanoparticles 氧化锌纳米颗粒的合成及应用综述

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2023-01-31 DOI: 10.46610/tpnt.2023.v05i01.002

A. Jamal, Kashina Aslam, Amara Anwar, S. Rafiq, H. Shaheen

{"title":"A Comprehensive Review on Synthesis and Application of Zinc Oxide Nanoparticles","authors":"A. Jamal, Kashina Aslam, Amara Anwar, S. Rafiq, H. Shaheen","doi":"10.46610/tpnt.2023.v05i01.002","DOIUrl":"https://doi.org/10.46610/tpnt.2023.v05i01.002","url":null,"abstract":"ZnO which are used as nanoparticles have been used in many varieties of paint, beautifiers, elastics, and covering. Just because of its biocompatibility, low toxicity as well as economic viability which are known as its exceptional cases, it has been the most used nanoparticle of metal oxides in many applications for the last twenty years. It can release particles of zinc, ability to induce cell death as well as the ability for producing oxygen species in excessive amounts. Due to its vast application in technology, it is also used in applications of biomedicines such as anticancer as well as antibacterial. Zinc also play important role in maintaining insulin credibility. Nanoparticles of zinc have been widely used for diabetes treatment. Additionally, it has been exceptionally dazzling applications that have leading them to be a candidate for use in bio imaging. Here, we are going to summarize the synthesis as well as continuing developments of nanoparticles of ZnO in the sector of biomedical, which may useful for fostering more advancement in the field of medicine and focusing on the areas of biomedical.","PeriodicalId":134570,"journal":{"name":"Trends in Pharmaceuticals and Nanotechnology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127739625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Inspired Synthesis of Zinc and Zinc Oxide Nanoparticles and Their Administration in Biomedical Sphere: An Overview 锌和氧化锌纳米颗粒的仿生合成及其在生物医学领域的应用综述

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2022-11-14 DOI: 10.46610/tpnt.2022.v04i02.005

Apoorva Bangroo, Akshay Malhotra, A. Kaur

{"title":"Bio-Inspired Synthesis of Zinc and Zinc Oxide Nanoparticles and Their Administration in Biomedical Sphere: An Overview","authors":"Apoorva Bangroo, Akshay Malhotra, A. Kaur","doi":"10.46610/tpnt.2022.v04i02.005","DOIUrl":"https://doi.org/10.46610/tpnt.2022.v04i02.005","url":null,"abstract":"As of late, an organic methodology of combining nanomaterials through ecological green-based procedures including regular materials, for example, plants, microscopic organisms, parasites, ocean growth, polysaccharides, biodegradable polymers, e-waste, plant-mediated things, and green methodology has persisted to be utilized as an elective technique for the combination of zinc and zinc oxide nanoparticles. Besides expanding energy for proficient green science, biosynthetic procedures intended for creating nanoparticles have stimulated many intrigues since they are ecologically amicable, no intermediate addition of stabilizing agent, less costly, and clean innovation. They neither include perilous synthetic concoctions nor have impurities and consequences. Of these bio-elements, plant concentrates have extraordinary consideration because of their capacity to decrease and balance out metal nanoparticles in a solitary advanced combination utilizing their regular qualities. This owes to their multitudinous and convoluted compositions, natural organic Phyto- ingredients biomolecules being in- factory separates (alkaloids, flavonoids, polyphenols, terpenoids, and tannins) as reducing as well as stabilizing instrumentalities. Primarily, this paper gives revived check of zinc oxide nanoparticles and the changes, headlines, and current employments of verdant ways exercising natural coffers. Farther, this review aims to analogize colourful hiatuses and terminations of conflation and characterization styles. Also, this review has covered biomedical operations with emphasis on cancer treatment, anti-microbial exertion, and medicine quittance fields.","PeriodicalId":134570,"journal":{"name":"Trends in Pharmaceuticals and Nanotechnology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132977983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on Synthesis of Electro Chemical Cell by Nano Materials and its uses for Drug Delivery Systems 纳米材料合成电化学电池及其在药物传递系统中的应用研究进展

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2022-08-30 DOI: 10.46610/tpnt.2022.v04i02.002

A. Jamal, Afia Abdul Wahid, Naffisa Naveed, Hafiz Qamar ul Ghofoor, Tanveer Ahmad

引用次数: 0

A Comprehensive review on Photocatalytic activity of CdO Nanoparticles 纳米CdO光催化活性研究综述

Trends in Pharmaceuticals and Nanotechnology Pub Date : 2022-07-15 DOI: 10.46610/tpnt.2022.v04i02.001

A. Jamal, H. Shaheen, S. Rafiq, J. Saif, Kashina Aslam

引用次数: 0