Indo American Journal of Pharmaceutical Research最新文献

STUDIES ON EXTRACTION, ISOLATION AND APPLICATIONS OF LYCOPENE 番茄红素的提取、分离及应用研究

Indo American Journal of Pharmaceutical Research Pub Date : 2017-10-30 DOI: 10.22214/IJRASET.2017.10308

S. Metkar, S. Saptarshi, A. Kadam

引用次数: 4

FORMULATION AND CHARACTERIZATION OF ROSUVASTATIN CALCIUM NANOPARTICLES 瑞舒伐他汀钙纳米粒的制备与表征

Indo American Journal of Pharmaceutical Research Pub Date : 2015-03-04 DOI: 10.6084/M9.FIGSHARE.1322231.V1

R. Ponnuraj, K. Janakiraman, S. Gopalakrishnan, H. Jeyakumar, V. Venkateswarlu, D. Narayanan

{"title":"FORMULATION AND CHARACTERIZATION OF ROSUVASTATIN CALCIUM NANOPARTICLES","authors":"R. Ponnuraj, K. Janakiraman, S. Gopalakrishnan, H. Jeyakumar, V. Venkateswarlu, D. Narayanan","doi":"10.6084/M9.FIGSHARE.1322231.V1","DOIUrl":"https://doi.org/10.6084/M9.FIGSHARE.1322231.V1","url":null,"abstract":"Article history The aim of this study is to formulate and characterize Rosuvastatin loaded Chitosan nanoparticles prepared by ionic-gelation method. Rosuvastatin Calcium has a low bioavailability (20%) due to poor absorption of the drug. Chitosan is a polymer of linear polysaccharide, which enhances transport of drug across epithelial surfaces and is biocompatible and biodegradable. The nanoparticles obtained were evaluated for percentage yield of drug, drug entrapment efficiency, particle size and morphology using Scanning Electron Microscopy (SEM), compatibility studies using Fourier-Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) and in vitro release kinetics. Among the four different drug to polymer ratios, 1:1 ratio showed high encapsulation efficiency and drug loading. The nanoparticles obtained were spherical in shape with a smooth surface with particle size range between 231.52 ± 24.12 nm to 405.25 ± 17.42 nm. The nanoparticles prepared proved to be a promising dosage form of Rosuvastatin, with improved bioavailability.","PeriodicalId":13400,"journal":{"name":"Indo American Journal of Pharmaceutical Research","volume":"55 1","pages":"767-779"},"PeriodicalIF":0.0,"publicationDate":"2015-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73383113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

ANALYSIS OF DISPENSING PRACTICES AT COMMUNITY PHARMACY SETTINGS IN AMBO TOWN, WEST SHEWA, ETHIOPIA 埃塞俄比亚西谢瓦安博镇社区药房配药实践分析

Indo American Journal of Pharmaceutical Research Pub Date : 2015-02-12 DOI: 10.4172/2376-0214.1000329

J. Lenjisa, B. Mosisa, M. Woldu, Dumessa Edessa Negassa, G. T. Tegegne, B. K. Gelaw, Gurmu Tesfaye

引用次数: 12

FORMULATION AND CHARACTERIZATION OF EPIGALLOCATECHIN GALLATE NANOPARTICLES 表没食子儿茶素没食子酸酯纳米颗粒的制备与表征

Indo American Journal of Pharmaceutical Research Pub Date : 2015-01-29 DOI: 10.6084/M9.FIGSHARE.1297305.V1

R. Ponnuraj, K. Janakiraman, S. Gopalakrishnan, K. Senthilnathan, Meganathan, P. Saravanan

引用次数: 22

ASSESSMENT OF COMMUNITY HEALTH AND HEALTH RELATED PROBLEMS IN DEBRE MARKOS TOWN, EAST GOJJAM, ETHIOPIA 评估埃塞俄比亚东戈伊贾姆德布雷马科斯镇社区卫生和与卫生有关的问题

Indo American Journal of Pharmaceutical Research Pub Date : 2014-12-12 DOI: 10.4172/2332-0893.1000125

B. K. Gelaw, G. T. Tegegne, Yeshanew Asinake Bizuye

{"title":"ASSESSMENT OF COMMUNITY HEALTH AND HEALTH RELATED PROBLEMS IN DEBRE MARKOS TOWN, EAST GOJJAM, ETHIOPIA","authors":"B. K. Gelaw, G. T. Tegegne, Yeshanew Asinake Bizuye","doi":"10.4172/2332-0893.1000125","DOIUrl":"https://doi.org/10.4172/2332-0893.1000125","url":null,"abstract":"Community Based Training is an on-site training program tailored to an employer’s specific hiring needs. The training takes place in the actual work area in the workplace, and a professionally trained job coach is located on-site to provide additional support in training. The study was conducted in Keble 05 Debre markos town found in Amhara region, East Gojjam Zone, which is located 299 km for away from Addis Ababa and 265 km away from Bihar Dar town. \u0000The Administration has 8 sefer the keble has 8551 population of these 4447 were female and 4104 male, its climate condition, woynadega and had 45 government and private health institution. The aim of the study was to assess the community health status and health related condition in Keble 05 Debre Markos town, East Gojjam Zone, Ethiopia,2013. \u0000Method: Community based cross sectional survey conducted from 25/08/2013-24/09/2013 by using interviewer administrative questioner and observation. The study conducted in urban population Keble 05 Debire markos town. \u0000Result: The cross sectional descriptive study, 94% of house hold in the keble had latrine facility Among this 50% of house don’t have hand washing facility connected with latrine among women who were pregnant 100% were attained at least 1st ANC and 90 of them deliver in the health facility from breast feeding 18% of children stop breast feeding before the age of 6 month and early and late feeding also present in 9% of children. \u0000Conclusion: Most of the house hold in the kebel had latrine constructed but most of them had no hand washing facility connected with latrine and low coverage of solid and liquid waste disposal system. There were also different \u0000problems like low immunization coverage’s, low family planning, utilization poor wining and exclusive breast feeding","PeriodicalId":13400,"journal":{"name":"Indo American Journal of Pharmaceutical Research","volume":"26 9 1","pages":"1146-1154"},"PeriodicalIF":0.0,"publicationDate":"2014-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79744248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF THIOCOLCHICOSIDE AND DICLOFENAC IN BULK AND ITS PHARMACEUTICAL FORMULATIONS 同时测定硫代秋水仙苷和双氯芬酸原料药及其制剂中含量的反相高效液相色谱法的建立和稳定性验证

Indo American Journal of Pharmaceutical Research Pub Date : 2014-04-04 DOI: 10.21746/IJBIO.2014.04.0013

Satyanarayana Mv, Satyadev Tnvss, G. Ramanaiah, Anuradha

{"title":"METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF THIOCOLCHICOSIDE AND DICLOFENAC IN BULK AND ITS PHARMACEUTICAL FORMULATIONS","authors":"Satyanarayana Mv, Satyadev Tnvss, G. Ramanaiah, Anuradha","doi":"10.21746/IJBIO.2014.04.0013","DOIUrl":"https://doi.org/10.21746/IJBIO.2014.04.0013","url":null,"abstract":"A rapid and sensitive Reverse Phase High Performance Liquid Chromatographic [RP-HPLC] method was developed for the estimation of Thiocolchicoside and Aceclofenac 1,2,3 in pure and its tablet dosage forms. The method was validated as per International Conference on Harmonization [ICH] guidelines 35 . A C18 column (250×4.6mm, 5μm) was used with a mobile phase containing a mixture of potassium phosphate monohydrate buffer (pH-5.0): Acetonitrile: Methanol in the ratio of 40:20:40 % v/v. The analysis was performed with run time of 6 minutes at a flow rate of 1ml/min. The Thiocolchicoside and Aceclofenac was monitored at 263nm with UV detection and Thiocolchicoside and Aceclofenac was eluted at 2.8 min and 4.2 min. The method was linear (r2 =0.999) at concentration ranging from 7.5 to 25μg/ml for Thiocolchicoside and 100-300µg/ml for Aceclofenac, precise (intra-day relative standard deviation [RSD] and inter-day RSD values < 1.0%), accurate (99.3 to 100.9 for Thiocolchicoside and 100.1 to 100.6 for Aceclofenac), specific and robust. Detection limit of 0.82 for Thiocolchicoside and 8.73 μg/ml for Aceclofenac. Similarly quantification limits were 2.49 for Thiocolchicoside and 26.45 for Aceclofenac μg/ml, estimated from linearity by regression respectively. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of Thiocolchicoside and Aceclofeanc in bulk, its combined dosage forms.","PeriodicalId":13400,"journal":{"name":"Indo American Journal of Pharmaceutical Research","volume":"33 1","pages":"1462-1471"},"PeriodicalIF":0.0,"publicationDate":"2014-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91004815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Identification, Isolation and Characterization of Unknown Impurity in Daunorubicin Hydrochloride 盐酸柔红霉素中未知杂质的鉴定、分离与表征

Indo American Journal of Pharmaceutical Research Pub Date : 2013-01-01 DOI: 10.7598/cst2014.685

A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan

引用次数: 4