A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan
{"title":"Identification, Isolation and Characterization of Unknown Impurity in Daunorubicin Hydrochloride","authors":"A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan","doi":"10.7598/cst2014.685","DOIUrl":null,"url":null,"abstract":"An unknown impurity in the bulk drug daunorubicin hydrochloride observed at 1.79 RRT was detected by the means of reverse phase isocratic High performance liquid chromatography (HPLC). This impurity was isolated, enriched and was subjected to mass and NMR spectral studies. Based on the spectral data the impurity was identified as (8S,10S)-8-ethyl-10-((2S,4S,5S,6S)-4-amino- 5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12- dione also known as 13-deoxy-daunorubicin.","PeriodicalId":13400,"journal":{"name":"Indo American Journal of Pharmaceutical Research","volume":"61 1","pages":"3099-3113"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indo American Journal of Pharmaceutical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2014.685","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
An unknown impurity in the bulk drug daunorubicin hydrochloride observed at 1.79 RRT was detected by the means of reverse phase isocratic High performance liquid chromatography (HPLC). This impurity was isolated, enriched and was subjected to mass and NMR spectral studies. Based on the spectral data the impurity was identified as (8S,10S)-8-ethyl-10-((2S,4S,5S,6S)-4-amino- 5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12- dione also known as 13-deoxy-daunorubicin.
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