A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan
{"title":"盐酸柔红霉素中未知杂质的鉴定、分离与表征","authors":"A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan","doi":"10.7598/cst2014.685","DOIUrl":null,"url":null,"abstract":"An unknown impurity in the bulk drug daunorubicin hydrochloride observed at 1.79 RRT was detected by the means of reverse phase isocratic High performance liquid chromatography (HPLC). This impurity was isolated, enriched and was subjected to mass and NMR spectral studies. Based on the spectral data the impurity was identified as (8S,10S)-8-ethyl-10-((2S,4S,5S,6S)-4-amino- 5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12- dione also known as 13-deoxy-daunorubicin.","PeriodicalId":13400,"journal":{"name":"Indo American Journal of Pharmaceutical Research","volume":"61 1","pages":"3099-3113"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Identification, Isolation and Characterization of Unknown Impurity in Daunorubicin Hydrochloride\",\"authors\":\"A. Rawat, V. Buchude, K. Chauhan, Divyesh Patel, Ritesh G. Patel, Chandrakant Belwal, A. Vardhan\",\"doi\":\"10.7598/cst2014.685\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An unknown impurity in the bulk drug daunorubicin hydrochloride observed at 1.79 RRT was detected by the means of reverse phase isocratic High performance liquid chromatography (HPLC). This impurity was isolated, enriched and was subjected to mass and NMR spectral studies. Based on the spectral data the impurity was identified as (8S,10S)-8-ethyl-10-((2S,4S,5S,6S)-4-amino- 5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12- dione also known as 13-deoxy-daunorubicin.\",\"PeriodicalId\":13400,\"journal\":{\"name\":\"Indo American Journal of Pharmaceutical Research\",\"volume\":\"61 1\",\"pages\":\"3099-3113\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indo American Journal of Pharmaceutical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7598/cst2014.685\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indo American Journal of Pharmaceutical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2014.685","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Identification, Isolation and Characterization of Unknown Impurity in Daunorubicin Hydrochloride
An unknown impurity in the bulk drug daunorubicin hydrochloride observed at 1.79 RRT was detected by the means of reverse phase isocratic High performance liquid chromatography (HPLC). This impurity was isolated, enriched and was subjected to mass and NMR spectral studies. Based on the spectral data the impurity was identified as (8S,10S)-8-ethyl-10-((2S,4S,5S,6S)-4-amino- 5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12- dione also known as 13-deoxy-daunorubicin.