Immunopharmacology最新文献_第10页

Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics. 补体抑制剂:在抗炎治疗中一个复兴的概念。

Immunopharmacology Pub Date : 2000-08-01 DOI: 10.1016/s0162-3109(00)80299-4

A Sahu, J D Lambris

引用次数: 156

Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement. 宿主识别和靶标分化因子H，补体替代途径的调节因子。

Immunopharmacology Pub Date : 2000-08-01 DOI: 10.1016/s0162-3109(00)80300-8

M K Pangburn

{"title":"Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement.","authors":"M K Pangburn","doi":"10.1016/s0162-3109(00)80300-8","DOIUrl":"https://doi.org/10.1016/s0162-3109(00)80300-8","url":null,"abstract":"Factor H is responsible for recognition of host cells and tissues and mediates discrimination among microbial pathogens during activation of the alternative pathway of complement (AP). Its unique structure of 20 SCR domains arranged in a flexible chain permits a variety of functional sites to interact with complement proteins and surface markers in a biological example of single-molecule combinatorial chemistry. In addition to the complement regulatory site located in the N-terminal four SCR domains, two other sites bind complement protein C3b and three sites appear to recognize a variety of polyanions that serve as host markers. Recent studies indicate that cooperativity among several C3b- and polyanion-binding sites influences the biological functions of factor H and that the degree of influence of each site varies on different cells. The engagement of one or more of the host marker recognition sites enables factor H to control activation of the AP. The absence of host-like markers allows AP activation, but many common pathogens have developed receptors for factor H or mimics of host markers of varying degrees of authenticity allowing them to escape detection by this innate defense system. Organisms using one or more of these evasive techniques include Neisseria gonorrhoeae, Streptococcus pyogenes, Yersinia enterocolitica, Trypanosoma cruzi, and the HIV virus.","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"49 1-2","pages":"149-57"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0162-3109(00)80300-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 187

Complement components of the innate immune system in health and disease in the CNS. 先天免疫系统的补体成分在健康和疾病的中枢神经系统。

Immunopharmacology Pub Date : 2000-08-01 DOI: 10.1016/s0162-3109(00)80302-1

P Gasque, Y D Dean, E P McGreal, J VanBeek, B P Morgan

{"title":"Complement components of the innate immune system in health and disease in the CNS.","authors":"P Gasque, Y D Dean, E P McGreal, J VanBeek, B P Morgan","doi":"10.1016/s0162-3109(00)80302-1","DOIUrl":"https://doi.org/10.1016/s0162-3109(00)80302-1","url":null,"abstract":"The innate immune system and notably the complement (C) system play important roles in host defense to recognise and kill deleterious invaders or toxic entities, but activation at inappropriate sites or to an excessive degree can cause severe tissue damage. C has been implicated as a factor in the exacerbation and propagation of tissue injury in numerous diseases including neurodegenerative disorders. In this article, we review the evidence indicating that brain cells can synthesise a full lytic C system and also express specific C inhibitors (to protect from C activation and C lysis) and C receptors (involved in cell activation, chemotaxis and phagocytosis). We also summarise the mechanisms involved in the antibody-independent activation of the classical pathway of C in Alzheimer's disease, Huntington's disease and Pick's disease. Although the primary role of C activation on a target cell is to induce cell lysis (particularly of neurons), we present evidence indicating that C (C3a, C5a, sublytic level of C5b-9) may also be involved in pro- as well as anti-inflammatory activities. Moreover, we discuss evidence suggesting that local C activation may contribute to tissue remodelling activities during repair in the CNS.","PeriodicalId":13327,"journal":{"name":"Immunopharmacology","volume":"49 1-2","pages":"171-86"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0162-3109(00)80302-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 348

Delayed resolution of inflammation in heterologous nephrotoxic nephritis in C1q deficient mice C1q缺陷小鼠异源肾毒性肾炎炎症的延迟消退

Immunopharmacology Pub Date : 2000-08-01 Epub Date: 2002-07-10 DOI: 10.1016/S0162-3109(00)80086-7

M.G. Robson, H.T. Cook, M. Botto, M.J. Walport, K.A. Davies

引用次数: 0

Engineering donor organs by perfusion with membrane-targeted biopharmaceuticals: In situ blockade of reperfusion-associated complement activation in experimental renal transplantation 膜靶向生物药物灌注工程供体器官:实验性肾移植中再灌注相关补体激活的原位阻断

Immunopharmacology Pub Date : 2000-08-01 Epub Date: 2002-07-10 DOI: 10.1016/S0162-3109(00)80016-8

J.R. Pratt , J. Dong , S.H. Sacks , R.A.G. Smith

引用次数: 0

Pig-P, the fourth protein associated with Pig-A that is responsible for paroxysmal nocturnal hemoglobinuria 猪- p，与猪- a相关的第四种蛋白质，负责阵发性夜间血红蛋白尿

Immunopharmacology Pub Date : 2000-08-01 DOI: 10.1016/S0162-3109(00)80272-6

T. Kinoshita, R. Watanabe, Y. Murakami, N. Inoue, Y. Maeda, J. Hino, K. Kangawa