Indian Journal of Pediatrics最新文献

{"title":"Impact of Wasting on the Severity of Rotavirus and Non-rotavirus Diarrhea in Children Aged Under 5 Years Hospitalized with Acute Gastroenteritis in Kerala, India.","authors":"Rose Xavier, Aparna Namboodiripad, Madona Devassikutty Fiji, Vellani Thamunni Ajithkumar, Shermin Nasreen Abdul Jaleel, Priya Sreenivasan, Gibi George, Nithya Thuruthiyath, Varsha Sudhir Chaudhary, Anupama Machathi, Namrata Kharat, Ragavi Lingam, Santhosh Kumar Ganesan, Tintu Varghese, Meera Mary Alappat","doi":"10.1007/s12098-025-05772-8","DOIUrl":"https://doi.org/10.1007/s12098-025-05772-8","url":null,"abstract":"<p><strong>Objectives: </strong>This analysis assessed the relationship between wasting and severity of rotavirus and non-rotavirus diarrhea among children hospitalized with acute gastroenteritis in Kerala.</p><p><strong>Methods: </strong>Children aged under 5 y admitted to sentinel hospitals in North, Central, and South Kerala with acute gastroenteritis between November 2020 and December 2023 were prospectively enrolled. Sociodemographic, anthropometric, and clinical data were collected using a case report form, and stool samples were tested for rotavirus using an enzyme-linked immunosorbent assay. Anthropometry was performed according to World Health Organization guidelines.</p><p><strong>Results: </strong>Of the 1,142 children aged under 5 y admitted to the sentinel hospitals with acute gastroenteritis during the study period, 666 were enrolled in the study. Of the 643 children with stool samples tested for rotavirus, 115 (17.7%) were positive for rotavirus. Compared with children with wasting, children without wasting were (significantly more likely to have received ≥ 1 dose of rotavirus vaccine (69.5% vs. 60.2%; p = 0.022). In a subgroup analysis of children with wasting, compared with rotavirus-negative children, rotavirus-positive children were significantly more likely to develop severe to very severe disease (odds ratio: 5.31, 95% confidence interval: 2.28-12.34; p = 0.001).</p><p><strong>Conclusions: </strong>In children with wasting, rotavirus diarrhea was more severe than non-rotavirus diarrhea. Strategies to prevent and treat diarrhea should target children with wasting, who are at greater risk of severe disease. Maintaining high rotavirus vaccination coverage and measures to reduce the incidence of wasting are necessary to reduce incidence of severe diarrhea.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Levothyroxine Dose and Neurodevelopmental Outcomes in Children with Congenital Hypothyroidism.","authors":"Dan Yu, Bailian Sun, Hui Xu, Mengyuan Shen, Jing Cai, Jun Feng","doi":"10.1007/s12098-025-05748-8","DOIUrl":"https://doi.org/10.1007/s12098-025-05748-8","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Gastroenteritis and Intussusception Surveillance Studies in Seven Indian States Following the Introduction of the Oral, Pentavalent, Rotavirus Vaccine.","authors":"Varsha Sudhir Chaudhary, Namrata Kharat, Venkata Raghava Mohan","doi":"10.1007/s12098-025-05768-4","DOIUrl":"https://doi.org/10.1007/s12098-025-05768-4","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyper IgE Syndrome: Imaging Clues to Diagnosis.","authors":"Supraja Laguduva Mohan, Megha Singh, Ashu Seith Bhalla, Priyanka Naranje, Sushil Kumar Kabra, Kana Ram Jat, Narendra Bagri, Manisha Jana","doi":"10.1007/s12098-025-05758-6","DOIUrl":"https://doi.org/10.1007/s12098-025-05758-6","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Point-of-Care Lung Ultrasound Scoring System with Clinical Score and Chest X-ray Score for Newborns with Respiratory Distress: Correspondence.","authors":"Yunru Lou","doi":"10.1007/s12098-025-05766-6","DOIUrl":"https://doi.org/10.1007/s12098-025-05766-6","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative 3D-Printed Neonatal Chest Simulator for Intercostal Drainage Training: Design and Validation.","authors":"M S Sreedhara, Ashok Chandrasekaran, Thinesh Kumar, Sushma Kalyan Achuta, Prashanth Yn, Binu Ninan, Usha Devi","doi":"10.1007/s12098-025-05782-6","DOIUrl":"https://doi.org/10.1007/s12098-025-05782-6","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Rotavirus Gastroenteritis and Circulating Genotypes Among Hospitalized Children Aged Under 5 Years in Rajkot, Gujarat.","authors":"Rajesh K Chudasama, Pankaj Buch, Varsha Sudhir Chaudhary, Anupama Machathi, Namrata Kharat, Ragavi Lingam, Tintu Varghese","doi":"10.1007/s12098-025-05770-w","DOIUrl":"https://doi.org/10.1007/s12098-025-05770-w","url":null,"abstract":"<p><strong>Objectives: </strong>In Gujarat, indigenous oral pentavalent rotavirus vaccine, ROTASIIL was introduced in July 2019; however, post marketing research on this vaccine is currently lacking. This cross-sectional study was conducted among children aged < 5 y hospitalized with acute gastroenteritis in Rajkot, Gujarat with an aim to investigate the epidemiology of rotavirus gastroenteritis following rotavirus vaccine introduction in the Universal Immunization Program (UIP) of Gujarat.</p><p><strong>Methods: </strong>Children aged < 5 y admitted with acute gastroenteritis between February 2021 and December 2023 were enrolled in the study. Data were collected on sociodemographic and clinical characteristics, and a copy of the child's vaccination card. Stool samples were collected and tested for rotavirus using an enzyme immunoassay. Rotavirus-positive samples were genotyped using reverse-transcription polymerase chain reaction.</p><p><strong>Results: </strong>Of the 288 stool samples tested, 66 (22.9%) were rotavirus positive. The prevalence of rotavirus positivity was higher in children with five or more diarrheal episodes within 24 h than in those with fewer episodes and higher in vaccinated than in unvaccinated children. The prevalence of rotavirus positivity was lower in those with a length of hospital stay ≥ 5 d than in those with shorter stays, and in infants aged 0-5 mo than in older children. G3P[8] (48.5%) was the most prevalent rotavirus genotype, followed by G2P[4] (37.9%).</p><p><strong>Conclusions: </strong>Rotavirus diarrhea remains prevalent among children hospitalized with acute gastroenteritis in Rajkot. G3P[8] and G2P[4] are the predominant circulating rotavirus strains.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Laboratory Findings of Scrub Typhus in Children.","authors":"Lourde Raja L, Pream Kumar Ramasubramani, A Srividya, Senkadhirdasan D, Prahankumar R, Karthikeyan K, Abhijit Vinodrao Boratne, Vanathy K, Agieshkumar Balakrishna Pillai","doi":"10.1007/s12098-025-05763-9","DOIUrl":"https://doi.org/10.1007/s12098-025-05763-9","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotavirus Diarrhea Surveillance and its Molecular Characteristics in Ranchi, Jharkhand, 2019-2023.","authors":"Vidya Sagar, Hirendra Birua, Rajesh Kumar, Dilip Kumar Paswan, Varsha Sudhir Chaudhary, Namrata Kharat, Anupama Machathi, Ragavi Lingam, Tintu Varghese, Dewesh Kumar","doi":"10.1007/s12098-025-05744-y","DOIUrl":"https://doi.org/10.1007/s12098-025-05744-y","url":null,"abstract":"<p><strong>Objectives: </strong>To estimate the burden of rotavirus infection, identify factors associated with acute rotavirus gastroenteritis, and characterize circulating rotavirus genotypes in children hospitalized with acute gastroenteritis.</p><p><strong>Methods: </strong>In this observational study of children aged under 5 y hospitalized with acute gastroenteritis in four tertiary care hospitals in Ranchi, Jharkhand between 2019 and 2023, stool samples were obtained and tested for rotavirus using an enzyme immunoassay. Rotavirus-positive samples were genotyped using reverse-transcription polymerase chain reaction.</p><p><strong>Results: </strong>Of the 470 stool samples tested, 39.4% were positive for rotavirus, with a higher incidence during the winter months (December to March). The likelihood of rotavirus-positivity was significantly lower in the 0-5 mo age group (odds ratio [OR]: 0.28, 95% confidence interval [CI]: 0.14-0.54; p < 0.001) and in children with diarrhea duration ≥ 5 d (OR: 0.40, 95% CI: 0.17-0.96; p = 0.041), and was significantly higher in children with vomiting (OR: 2.48, 95% CI: 1.44-4.26; p < 0.001). The most prevalent genotypes were G2P[4] (35.9%), G1P[8] (30.9%), and G3P[8] (20.4%).</p><p><strong>Conclusions: </strong>The rotavirus positivity rate in Ranchi was higher than that reported in other sites in India, particularly among children in the 12-23-mo age group. The dominant genotypes were G2P[4], G1P[8], and G3P[8]. Changes in the genotypic distribution during the study period indicate that ongoing genotypic surveillance is warranted in children hospitalized with acute gastroenteritis.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Serum Lipid Profile with Severity and Clinical Outcomes in Children with Dengue Fever - A Cross-Sectional Study.","authors":"Sujith Kumar Manickavel, Philo Sandra Tilak Antony, Masanaraj Narayanan, Vinoth Ponnurangam Nagarajan","doi":"10.1007/s12098-025-05764-8","DOIUrl":"https://doi.org/10.1007/s12098-025-05764-8","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}