Indian Journal of Pediatrics最新文献_第5页

Genetic Modulation of One-Carbon Metabolism in Autism Spectrum Disorder: An MTHFR-Based Cross-Sectional Study with Neurotypical Controls. 自闭症谱系障碍中一碳代谢的遗传调节：一项基于mthfr的神经典型对照横断面研究。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-09-21 DOI: 10.1007/s12098-026-06424-1

Priyanshu Mathur, Sakshi Mathur, Ashmeet Kaur, Urvashi Vijay, Aruna Vyas, Gayatri Danger

{"title":"Genetic Modulation of One-Carbon Metabolism in Autism Spectrum Disorder: An MTHFR-Based Cross-Sectional Study with Neurotypical Controls.","authors":"Priyanshu Mathur, Sakshi Mathur, Ashmeet Kaur, Urvashi Vijay, Aruna Vyas, Gayatri Danger","doi":"10.1007/s12098-026-06424-1","DOIUrl":"10.1007/s12098-026-06424-1","url":null,"abstract":"Objectives: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition in which disruptions in one-carbon metabolism, regulated by methylenetetrahydrofolate reductase (MTHFR), may contribute to phenotypic variability. This study investigated MTHFR C677T and A1298C polymorphisms and their association with serum vitamin B12, folate, and ASD risk in children.Methods: One hundred children with ASD and 100 age-matched neurotypical controls were enrolled. MTHFR genotyping was performed by allele-specific real-time PCR. Serum vitamin B12 and folate by enzyme-linked immunosorbent assay. Associations were assessed using logistic regression under dominant, additive, and recessive genetic models. Discrimination was evaluated by receiver operating characteristic analysis.Results: The C677T TT genotype was overrepresented in ASD cases (57% vs. 43% controls), with significant Hardy-Weinberg deviation (χ² = 21.812, p <0.0001). Mutant A1298C genotypes were observed in 79% of cases. Vitamin B12 declined with increasing C677T T-allele dosage (p <0.001) and folate with A1298C C-allele burden (p = 0.003). Higher vitamin B12 independently associated with reduced ASD odds (OR 0.36, 95% CI 0.17-0.76, p = 0.008). C677T TT homozygosity was significantly associated with increased ASD odds under the recessive model (OR 1.76, 95% CI 1.00-3.08, p = 0.049). A1298C was non-significant across all models, indicating modest discrimination suitable for exploratory purposes only.Conclusions: Children with ASD showed a high burden of functional MTHFR variants with genotype-linked metabolic variation. TT homozygosity was associated with ASD risk under recessive model, supporting a threshold-dependent genetic effect on one-carbon metabolism. These findings warrant prospective validation in larger independent cohorts.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"1190-1195"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing Hypothermia Among Intramural Vaginally Born Preterm Neonates Admitted in Neonatal Intensive Care Unit at a Tertiary Care Centre Using Quality Improvement Approach. 利用质量改进方法降低三级护理中心新生儿重症监护室内阴道分娩早产儿的体温过低。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-07-30 DOI: 10.1007/s12098-026-06361-z

Sahiba Madaan, Saikat Patra, Chinmay Chetan, Ashok Kumar Deorari, Ruchira Nautiyal, Rashmi Rajput, Enas Mushtaq

{"title":"Reducing Hypothermia Among Intramural Vaginally Born Preterm Neonates Admitted in Neonatal Intensive Care Unit at a Tertiary Care Centre Using Quality Improvement Approach.","authors":"Sahiba Madaan, Saikat Patra, Chinmay Chetan, Ashok Kumar Deorari, Ruchira Nautiyal, Rashmi Rajput, Enas Mushtaq","doi":"10.1007/s12098-026-06361-z","DOIUrl":"10.1007/s12098-026-06361-z","url":null,"abstract":"Objectives: To reduce admission hypothermia (<36.5°C) in intramural preterm neonates delivered vaginally and admitted to the neonatal intensive care unit (NICU) at a tertiary care hospital in India. The study aimed to decrease the incidence of neonatal admission hypothermia from 80% by 50% using quality improvement (QI) approach.Methods: This QI study was conducted at a tertiary care centre in North India. The study included 138 preterm neonates (gestation <37 wk) born vaginally and admitted to the NICU. The Point of Care Quality Improvement tool (POCQI) was used with multiple Plan-Do-Study-Act (PDSA) cycles. Following baseline admission temperature data collection, the root cause analysis was conducted using fishbone analysis. Change ideas tested included maintaining labor room (LR) temperature, deferring weighing and vitamin K administration from LR to NICU, stabilizing temperature in LR before shifting to NICU, using pre-warming linens, additional layers of cloth and blankets along with plastic wraps during transport and staff education on standard operating procedures (SOP) to reduce admission hypothermia. Data were analyzed using RUN charts for effectiveness.Results: Baseline hypothermia incidence was 80%, with a median admission temperature of 35.3°C. Following implementation of QI interventions, hypothermia rates reduced significantly to near nil over the study period. Seasonal variations led to temporary fluctuations, but sustained improvements were achieved with continuous staff training and adherence to new SOPs.Conclusions: The structured QI approach effectively reduced admission hypothermia among preterm neonates by implementing evidence-based thermoregulatory interventions.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"1169-1174"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared Decision Making in the Neonatal Intensive Care Unit in Low Middle Income Countries - A Myth or A Path to Reality: Correspondence. 中低收入国家新生儿重症监护病房的共同决策——一个神话还是一条通往现实的道路：对应。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-08-29 DOI: 10.1007/s12098-026-06446-9

Nalakath A Uvais

引用次数: 0

Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India: Authors' Reply. 北印度1型糖尿病患者胰岛自身抗体的模式和持久性及其免疫遗传学相关性：作者的答复。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-09-17 DOI: 10.1007/s12098-026-06399-z

Shreya Sharma, Alpesh Goyal, Dona Maria Philip, Nikhil Tandon

引用次数: 0

Pre-discharge Outcomes of Very Preterm and Very Low Birth Weight Infants from a Tertiary Care Neonatal Center in India. 印度三级新生儿护理中心的极早产和极低出生体重儿的出院前结局。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-08-08 DOI: 10.1007/s12098-026-06391-7

Rachana R D, Venkateshwarlu Vardhelli, Pallavi Chandra Ravula, Ridhima Gadepalli, Sireesha Tirumalaraju, Sruthi Nair, Sumayya Hafeez, Sruthi Thiruveedi, Sajal Das, Saikiran Deshabhotla, Tejo Pratap Oleti

{"title":"Pre-discharge Outcomes of Very Preterm and Very Low Birth Weight Infants from a Tertiary Care Neonatal Center in India.","authors":"Rachana R D, Venkateshwarlu Vardhelli, Pallavi Chandra Ravula, Ridhima Gadepalli, Sireesha Tirumalaraju, Sruthi Nair, Sumayya Hafeez, Sruthi Thiruveedi, Sajal Das, Saikiran Deshabhotla, Tejo Pratap Oleti","doi":"10.1007/s12098-026-06391-7","DOIUrl":"10.1007/s12098-026-06391-7","url":null,"abstract":"Objectives: This study reports pre-discharge survival and clinical outcomes of very preterm infants (VPI) and very low birth weight (VLBW) infants from a tertiary-care, inborn neonatal unit in India.Methods: In this retrospective study, inborn neonates admitted between 2013 and 2022 over a 10-y period were included. VLBW group included infants with birth weight (BW) of 500-1499 g with GA ≥26 wk and VPI group included infants with 26⁰/₇-31⁶/₇ wk gestational age (GA). Infants with major congenital anomalies, inborn errors of metabolism, or those transferred to another hospital before completion of treatment were excluded.Results: A total of 2063 VLBW infants and 1663 VPI were analyzed. In the VLBW group, the mean GA and birth weight were 30.4 wk and 1173 g, respectively. Survival was 90.6% among VLBW infants and 76.9% among extremely low birth weight infants. Major morbidities included late-onset culture-positive sepsis (LOS: 18.1%), intraventricular hemorrhage (IVH) ≥ Grade II (7.1%), and retinopathy of prematurity (ROP) requiring treatment (2.2%). In the VPI group, mean GA and birth weight were 30.0 wk and 1180 g. Survival rates were 89.1% for VPI and 66.8% for the extremely preterm subgroup. Rates of LOS, IVH ≥ Grade II, ROP requiring treatment, and bronchopulmonary dysplasia in VPI were 20.9%, 8.8%, 2.5%, and 2.9%, respectively.Conclusions: Very preterm and VLBW infants demonstrated high survival with low rates of major morbidities. However, improvement in survival at lower gestational ages remains a key area for improvement.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"1196-1202"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Kawasaki Disease with Delayed-Onset Coronary Artery Dilatation and Late Normalization. 复发性川崎病伴迟发性冠状动脉扩张和晚期正常化。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-09-09 DOI: 10.1007/s12098-026-06425-0

Manel Weli, Imene Moalla, Rihab Daoud, Mariem Ammar, Bayene Maalej, Lamia Gargouri

引用次数: 0

Pain Response and Cerebral Oxygenation Changes During Retinopathy of Prematurity Screening. 早产儿视网膜病变筛查过程中的疼痛反应和脑氧合变化。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-08-29 DOI: 10.1007/s12098-026-06418-z

Shikhar Garg, Pavanakumar Karigoudar, Mayank Priyadarshi, Suman Chaurasia, Poonam Singh, Sriparna Basu

引用次数: 0

Coexisting Neurocysticercosis and CNS Tuberculosis in a Child. 小儿脑囊虫病合并中枢神经系统结核1例。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-09-26 DOI: 10.1007/s12098-026-06459-4

Ruhani Pathania, Shivani Randev, Viresh Vohra, Narinder Kaur, Subina Narang

引用次数: 0

Household Agarbatti (Incense Stick) and Combustion-Based Ritual Item Use as Indoor Air Pollutant Exposure in Pediatric Allergy Patients: A Cross-Sectional Analytical Study. 儿童过敏患者室内空气污染物暴露的家庭香烛和以燃烧为基础的仪式物品：一项横断面分析研究

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-10-05 DOI: 10.1007/s12098-026-06481-6

Chandan Narwani, Priti Narwani

引用次数: 0

Chlorocresol-Induced Acquired Methemoglobinemia Following Peri-Stomal Application of Topical Corticosteroid Cream. 局部皮质类固醇乳膏口周应用后氯甲酚诱导获得性高铁血红蛋白血症。

IF 2.4 4区医学

Indian Journal of Pediatrics Pub Date : 2026-11-01 Epub Date: 2026-08-29 DOI: 10.1007/s12098-026-06426-z

Pradeep Babu Uppaluri, Mrinali Deerpaul, Sai Charan Madugula, Arun Bansal, Suresh Kumar Angurana

引用次数: 0