Indian Journal of Hematology and Blood Transfusion最新文献_第5页

Red Cell Genotyping Helps in Managing a Multi-Transfused Patient with Serologically Inconclusive Results 红细胞基因分型有助于管理血清学结果不确定的多次输血患者

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-25 DOI: 10.1007/s12288-024-01825-8

Ayesha Sinha, Najla Haneefa Basheela, Durba Biswas, Debapriya Basu, Suvro Sankha Datta

引用次数: 0

Fungal Pneumonia and Pulmonary Embolism in a Child with Refractory Leukemia: Coincidence or Not? 一名难治性白血病患儿的真菌性肺炎和肺栓塞：巧合与否？

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-20 DOI: 10.1007/s12288-024-01823-w

Zühre Kaya, Merve Yazol, Serap Kirkiz, Büşra Topuz Türkcan, Ahmet Bayramlı, Hasan Tezer, Ülker Koçak

引用次数: 0

Unveiling the Unseen: Candida auris Discovered in a Peripheral Smear of Acute Myeloid Leukemia 揭开看不见的面纱急性髓性白血病外周涂片中发现的念珠菌

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-19 DOI: 10.1007/s12288-024-01811-0

Swapnil Tripathi, Himil Parikh, Amiya Ranjan Nayak, Gagandeep Singh, Jasmita Dass, Pradeep Kumar, Mukul Aggarwal

引用次数: 0

Bombay Group Phenotype or Group O Phenotype: A Serological Dilemma 孟买群表型还是 O 群表型？血清学难题

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-19 DOI: 10.1007/s12288-024-01807-w

Brinda Kakkar, Mahesh Kulkarni, Sameer Melinkeri, Sanjiv Ketkar, Amruta Keripale

引用次数: 0

Correlation of Flame Cells and Two Monoclonal Bands in Beta and Gamma Region in IgA Multiple Myeloma IgA 多发性骨髓瘤中火焰细胞与 Beta 和 Gamma 区两条单克隆带的相关性

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-12 DOI: 10.1007/s12288-024-01819-6

Bilal Kazi, Anupam Chakrapani

引用次数: 0

B Lineage Acute Lymphoblastic Leukemia with concurrent IGH and EPOR rearrangements – An Entity with Dismal Outcome 并发 IGH 和 EPOR 重排的 B 系急性淋巴细胞白血病--一种预后不佳的病例

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-10 DOI: 10.1007/s12288-024-01818-7

Nupur Pradhan, Prabhjot Kaur, Venus Thakur, Anshu Anshu, Shailja Rathore, Praveen Sharma, Nabhajit Mallik, Man Updesh Singh Sachdeva, Mirza Saleem Amjad, Reena Das, Arihant Jain, Alka Khadwal, Sreejesh Sreedharanunni

{"title":"B Lineage Acute Lymphoblastic Leukemia with concurrent IGH and EPOR rearrangements – An Entity with Dismal Outcome","authors":"Nupur Pradhan, Prabhjot Kaur, Venus Thakur, Anshu Anshu, Shailja Rathore, Praveen Sharma, Nabhajit Mallik, Man Updesh Singh Sachdeva, Mirza Saleem Amjad, Reena Das, Arihant Jain, Alka Khadwal, Sreejesh Sreedharanunni","doi":"10.1007/s12288-024-01818-7","DOIUrl":"https://doi.org/10.1007/s12288-024-01818-7","url":null,"abstract":"The EPOR rearrangement, an uncommon cytogenetic abnormality linked to BCR::ABL1-like B-ALL, is often underdiagnosed due to the absence of a robust testing strategy, especially in resource-constrained settings. We report six cases of B-ALL with concurrent IGH and EPOR rearrangement from India, representing 1.3% of the tested cases, and reviewed the existing literature. The age ranged from 13 to 37 years (median 17 years), with a 2:1 male dominance. Leukocytosis was observed in 67% of patients (median total leukocyte count-105.9 × 10^9/L), and CD20 expression was seen in 67%. One patient experienced induction failure, while three relapsed within a year of diagnosis and treatment. All six patients died within 6 to 21 months of follow-up. These findings align with previous reports of treatment resistance, frequent relapses, and the need for novel therapeutic agents like JAK inhibitors and CART therapy. In summary, these six B-ALL cases with IGH and EPOR rearrangements highlight the diagnostic challenges and poor outcomes associated with this condition.","PeriodicalId":13314,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141576384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Turnover Markers Levels in a Cohort of Egyptian Children with Sickle Cell Disease 埃及镰状细胞病儿童队列中的骨转换标志物水平

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-10 DOI: 10.1007/s12288-024-01809-8

Mona El-Tagui, Sameh Tawfik, Eman Al-Hussain AbdulGawad, Alaa Gad, Mohamed El Sherbiny, Mariam Saad Nassim

{"title":"Bone Turnover Markers Levels in a Cohort of Egyptian Children with Sickle Cell Disease","authors":"Mona El-Tagui, Sameh Tawfik, Eman Al-Hussain AbdulGawad, Alaa Gad, Mohamed El Sherbiny, Mariam Saad Nassim","doi":"10.1007/s12288-024-01809-8","DOIUrl":"https://doi.org/10.1007/s12288-024-01809-8","url":null,"abstract":"Bony complications are variable and common in sickle cell disease. Bone turnover markers are a reflection of bone new bone formation or degradation. The aim of this study is to assess the level of bone turnover markers in patients with sickle cell disease. This case–control study included 40 patients with sickle cell disease and 40 age and sex matched controls. Detection of serum calcium, phosphorus, alkaline phosphatase, serum creatinine levels were done. Assessment of Urinary deoxypyridinoline, Urinary N-terminal telopeptide of type I collagen, and serum osteocalcin were done. Serum osteocalcin was significantly lower, urinary deoxypyridinoline, Urinary N-terminal telopeptide of type I collagen were significantly higher among cases than the control group. Best cut off point for urinary deoxypyridinoline and urinary N-terminal telopeptide of type I collagen were 85.9ng/mg creatinine and 167.4 ng/mg creatinine respectively. Significant bone disease in patients with sickle cell anemia may be reflected by high levels of urinary Deoxypyridinoline and N-telopeptide of type I collagen at or above the cut off value.","PeriodicalId":13314,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"20 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141576382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematopoietic Stem Cell Transplant of a Congenital Dyserythropoietic Anemia Type II Patient: A Rare Report from the Indian Population 先天性红细胞生成障碍性贫血 II 型患者的造血干细胞移植：印度人群中的罕见报告

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-10 DOI: 10.1007/s12288-024-01796-w

Arati Nandan Saptarshi, Kannan Subramaniam, Sandeep Nemani, Tejashree Anil More, Rashmi Dongerdiye, Prabhakar Kedar

引用次数: 0

Assessment of the Prognostic Importance of The Revised International Staging System Based on Plasmacytoma Presentation in Recently Diagnosed Patients with Multiple Myeloma 根据新近确诊的多发性骨髓瘤患者的浆细胞瘤表现评估修订版国际分期系统的预后重要性

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-10 DOI: 10.1007/s12288-024-01820-z

Rafiye Ciftciler, Ali Erdinc Ciftciler, Mehmet Daglı

{"title":"Assessment of the Prognostic Importance of The Revised International Staging System Based on Plasmacytoma Presentation in Recently Diagnosed Patients with Multiple Myeloma","authors":"Rafiye Ciftciler, Ali Erdinc Ciftciler, Mehmet Daglı","doi":"10.1007/s12288-024-01820-z","DOIUrl":"https://doi.org/10.1007/s12288-024-01820-z","url":null,"abstract":"The rapid development of fluorescence in situ hybridization (FISH) karyotyping led to the discovery of the significant prognostic impact of certain chromosomal abnormalities on the course of Multiple Myeloma (MM). Additionally, high blood lactate dehydrogenase (LDH) levels have been connected to shorter survival periods, more aggressive malignancies, enhanced cell proliferation, and extramedullary illnesses. This study aims to evaluate the prognostic significance of the R-ISS according to plasmacytoma presentation in newly diagnosed MM patients. Retrospective methods were used to conduct this investigation. A total of 166 consecutive patients with newly diagnosed MM and treated in our tertiary care center between the years 2009 and 2023 were evaluated. Of the 166 individuals who were included in this research, 35 (21.1%) had plasmacytomas at diagnosis. Plasmacytoma was not detected in 131 (78.9%) patients at diagnosis. The mean age was 56.8 ± 7.5 for all patients. The age of the patients without plasmacytoma at diagnosis was statistically significantly higher than patients with plasmacytoma at diagnosis (p: 0.04). No statistically significant difference was observed in terms of OS and DFS in the R-ISS 1, 2, and 3 groups in patients with and without plasmacytoma at diagnosis. Due to this study’s results, we think that more needs to be done regarding the R-ISS classification. Perhaps it would be more effective to include other factors in risk classification, such as age, gender, and the presence of plasmacytoma and lytic lesions.","PeriodicalId":13314,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"31 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141576122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imatinib Mesylate Causes Potential Cardiac Dysfunction in Patients With Chronic Myeloid Leukemia: the Results of a Case–control Study 甲磺酸伊马替尼对慢性髓性白血病患者造成潜在心功能障碍：病例对照研究的结果

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-08 DOI: 10.1007/s12288-024-01797-9

Gowri Shankar, Ankur Jain, Ankur Gupta, Aditya Jandial, Neelam Varma, Arihant Jain, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra

{"title":"Imatinib Mesylate Causes Potential Cardiac Dysfunction in Patients With Chronic Myeloid Leukemia: the Results of a Case–control Study","authors":"Gowri Shankar, Ankur Jain, Ankur Gupta, Aditya Jandial, Neelam Varma, Arihant Jain, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra","doi":"10.1007/s12288-024-01797-9","DOIUrl":"https://doi.org/10.1007/s12288-024-01797-9","url":null,"abstract":"Unlike second-generation tyrosine kinase inhibitors, effects of imatinib on the cardiovascular (CV) system are debatable. The current case–control study aimed to evaluate the CV effects of imatinib in patients with chronic myeloid leukemia (CML) using non-invasive 2D-echocardiography testing. Patients with CML ≥ 13 years attending the adult haematology clinic of a tertiary care hospital in north India were prospectively enrolled over 1.5 years. The study population (n = 110) consisted of 35 newly diagnosed patients (treatment-naïve group) and 75 patients under imatinib therapy ≥ 1 year (treated group). All the eligible patients were subjected to 2D-echocardiography to calculate pulmonary artery systolic pressure (PASP), left ventricular ejection fraction (LVEF) and deceleration time (DT). These parameters were compared between the two groups. P-value < 0.05 was considered statistically significant. The median age of study population was 40 years (range, 13–73) and M:F ratio was 1.14:1. Both the groups had similar demographics at the diagnosis including CV risk factors. The median PASP of the treated group was 2 mm Hg higher than the treatment-naïve group (25 vs 23 mm Hg, p-value = 0.919). The median LVEF of the treated group was 3.2% lower than the treatment-naïve group (58.5% vs 61.72%, p-value = 0.577). The median DT of the treated group was 7 ms shorter than treatment-naïve group (211 vs 204 ms, p-value = 0.411). Imatinib causes potential cardiac dysfunction in patients with CML. Large scale prospective follow-up trials in the same cohort of patients are needed to validate the findings of our study.","PeriodicalId":13314,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"31 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141576386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0