Bone Turnover Markers Levels in a Cohort of Egyptian Children with Sickle Cell Disease

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-10 DOI:10.1007/s12288-024-01809-8

Mona El-Tagui, Sameh Tawfik, Eman Al-Hussain AbdulGawad, Alaa Gad, Mohamed El Sherbiny, Mariam Saad Nassim

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Abstract

Bony complications are variable and common in sickle cell disease. Bone turnover markers are a reflection of bone new bone formation or degradation. The aim of this study is to assess the level of bone turnover markers in patients with sickle cell disease. This case–control study included 40 patients with sickle cell disease and 40 age and sex matched controls. Detection of serum calcium, phosphorus, alkaline phosphatase, serum creatinine levels were done. Assessment of Urinary deoxypyridinoline, Urinary N-terminal telopeptide of type I collagen, and serum osteocalcin were done. Serum osteocalcin was significantly lower, urinary deoxypyridinoline, Urinary N-terminal telopeptide of type I collagen were significantly higher among cases than the control group. Best cut off point for urinary deoxypyridinoline and urinary N-terminal telopeptide of type I collagen were 85.9ng/mg creatinine and 167.4 ng/mg creatinine respectively. Significant bone disease in patients with sickle cell anemia may be reflected by high levels of urinary Deoxypyridinoline and N-telopeptide of type I collagen at or above the cut off value.

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埃及镰状细胞病儿童队列中的骨转换标志物水平

骨骼并发症是镰状细胞病的常见并发症。骨转换标志物是骨骼新骨形成或退化的反映。本研究旨在评估镰状细胞病患者的骨转换标志物水平。这项病例对照研究包括 40 名镰状细胞病患者和 40 名年龄和性别匹配的对照者。研究人员检测了血清钙、磷、碱性磷酸酶和血清肌酐水平。还对尿脱氧吡啶啉、尿 I 型胶原 N 端端肽和血清骨钙素进行了评估。与对照组相比，病例的血清骨钙素明显降低，而尿脱氧吡啶啉和尿 I 型胶原 N 端端肽则明显升高。尿脱氧吡啶啉和尿 I 型胶原 N 端端肽的最佳切点分别为 85.9ng/mg 肌酐和 167.4 ng/mg 肌酐。镰状细胞性贫血患者尿中脱氧吡啶啉和 I 型胶原蛋白 N 端端肽的含量达到或超过临界值，可能反映出患者存在严重的骨病。

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Indian Journal of Hematology and Blood Transfusion Medicine-Hematology

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期刊介绍： Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. It publishes peer-reviewed articles on a variety of aspects of clinical hematology, laboratory hematology and hemato-oncology. The journal exists to encourage scientific investigation in the study of blood in health and in disease; to promote and foster the exchange and diffusion of knowledge relating to blood and blood-forming tissues; and to provide a forum for discussion of hematological subjects on a national scale. The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion.