Helicobacter最新文献

{"title":"Roles of Gastric Non-Helicobacter pylori Helicobacter Species in Gastric Disease Development: A Review","authors":"Mitsushige Sugimoto,&nbsp;Emiko Rimbara,&nbsp;Masaki Murata,&nbsp;Yoshio Yamaoka","doi":"10.1111/hel.70051","DOIUrl":"https://doi.org/10.1111/hel.70051","url":null,"abstract":"<div>\u0000 \u0000 <p>Gastric <i>Helicobacter</i> species, including <i>Helicobacter pylori</i> and non-<i>Helicobacter pylori Helicobacter</i> (NHPH) species, are gram-negative fastidious bacteria that colonize the stomachs of both humans and animals such as pigs, dogs, cats, and monkeys. The <i>H. pylori</i> infection rate is decreasing due to improved living conditions and increased opportunities for <i>H. pylori</i> eradication therapy in developed countries. However, concerns about NHPH infection-induced gastric diseases are growing, especially low-grade gastric mucosa-associated lymphoid tissue lymphoma. Although NHPH infections have been reported for 30 years, especially <i>H. suis</i> infections, evidence of the correct infection rate, route of infection to humans, and direct and indirect associations with gastric diseases are insufficient. Presently, NHPH infection can be diagnosed using histopathological and immunohistochemical findings, polymerase chain reaction, culture tests, or enzyme-linked immunosorbent assays. Several basic and clinical studies have begun to report the bacteriologic characteristics and routes of NHPH infection. In addition, the high effectiveness of eradication therapy using a combination of an acid inhibitor and two types of antibiotics, which is the same eradication regimen for <i>H. pylori</i> infection, has been reported. However, evidence on antibiotic resistance, appropriate dosing dosage, or drug type provided by randomized control trials is lacking. Several issues regarding the etiology, virulence, diagnosis, and treatment of NHPH infections should be addressed in the future.</p>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: “Parietal Cell Antibody Levels Among Chronic Gastritis Patients in a Country With Low Helicobacter pylori Infection: Epidemiology, Histopathological Features, and H. pylori Infection”","authors":"Xiaopei Guo,&nbsp;Manon C W Spaander,&nbsp;Gwenny M Fuhler","doi":"10.1111/hel.70053","DOIUrl":"https://doi.org/10.1111/hel.70053","url":null,"abstract":"&lt;p&gt;We read with great interest the article titled “Parietal Cell Antibody Levels Among Chronic Gastritis Patients in a Country with Low &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection: Epidemiology, Histopathological Features, and &lt;i&gt;H. pylori&lt;/i&gt; infection” by Amalia et al. [&lt;span&gt;1&lt;/span&gt;]. In this study, the authors investigated the prevalence of autoimmune gastritis (AIG), and its association with &lt;i&gt;Helicobacter pylori&lt;/i&gt; (&lt;i&gt;H. pylori&lt;/i&gt;) infection status and gastric histopathological features in the Indonesian population. Given the previously reported high incidence of gastritis and relatively low &lt;i&gt;H. pylori&lt;/i&gt; infection rates in this region, exploring other causes of gastritis, such as AIG, is essential for improving diagnostic accuracy and guiding clinical risk management [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;While the authors conducted a comprehensive analysis of parietal cell antibody (PCA) levels and its association with clinicopathological features, several aspects of the study's methodology and interpretation raise concerns and warrant further clarification. A key observation of this study is the reported 78.99% prevalence of PCA positivity among 113 Indonesian patients with chronic gastritis and 25 healthy controls, while only one patient was diagnosed with AIG. The authors suggest that this discrepancy might be due to &lt;i&gt;H. pylori&lt;/i&gt;-associated immune activation. However, we think it may also reflect the combined impact of overly strict diagnostic criteria for AIG and the inappropriate interpretation of PCA results.&lt;/p&gt;&lt;p&gt;In the diagnostic methods, AIG was defined based on the PCA positivity, absence of &lt;i&gt;H. pylori&lt;/i&gt; infection, histopathological features associated with AIG, and sparing of the antrum. We understand the concern that coexisting &lt;i&gt;H. pylori&lt;/i&gt; infection may complicate the diagnosis of AIG, as it can cause histopathological changes that resemble AIG. But we note that neither antrum sparing nor negative &lt;i&gt;H. pylori&lt;/i&gt;-negative status should be a required criterion for AIG diagnosis. Our previous findings have shown that AIG can coexist with &lt;i&gt;H. pylori&lt;/i&gt; infection, and hence patients may present with antral inflammation or atrophy. Such patients still show characteristic serological features similar to AIG patients without &lt;i&gt;H. pylori&lt;/i&gt; infection, including decreased pepsinogen (PG) I levels and elevated gastrin 17 [&lt;span&gt;3&lt;/span&gt;]. Additionally, they may exhibit pathological findings such as enterochromaffin-like (ECL) cell hyperplasia [&lt;span&gt;4&lt;/span&gt;], which was not investigated in the study by Amalia et al. Therefore, we think the criteria used may have led to underdiagnosis of AIG in the Indonesia cohort. Rather than excluding patients with &lt;i&gt;H. pylori&lt;/i&gt; infection or antrum inflammation/atrophy, more specific diagnostic tests should be considered to improve the diagnosis of AIG, especially given this is the first study reporting AIG prevalence in this region.&lt;/p&gt;&lt;p&gt;Adding to these diagnostic challenges Beyond these di","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Systemic Impact of Helicobacter pylori Infection on the Microbiome of Whole Digestive Tract Based on Mucosal, Gastric Juice, and Fecal Specimens","authors":"Yuxin Wang,&nbsp;Kai Zhou,&nbsp;Yuexi Zhang,&nbsp;Cailing Li,&nbsp;Yuxin Zhang,&nbsp;Xinlu Ren,&nbsp;Changmin Mi,&nbsp;Lingling Ma,&nbsp;Yuqi Duan,&nbsp;Mengqi Liu,&nbsp;Guangjie Ping,&nbsp;Xueli Tian,&nbsp;Zhiqiang Song","doi":"10.1111/hel.70047","DOIUrl":"https://doi.org/10.1111/hel.70047","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Recent studies have found that in addition to directly impacting the gastric microbiome, &lt;i&gt;Helicobacter pylori&lt;/i&gt; (&lt;i&gt;H. pylori&lt;/i&gt;) infection may cause intestinal microbial dysbiosis. However, most existing studies on the influence of &lt;i&gt;H. pylori&lt;/i&gt; infection on the intestinal microbiome used fecal specimens with inconsistent conclusions. Only one limited study on 8 &lt;i&gt;H. pylori&lt;/i&gt;-infected patients has previously assessed the impact of &lt;i&gt;H. pylori&lt;/i&gt; infection on the microbiome of the entire gastrointestinal tract, finding no significant effect on the bacterial composition of the lower gastrointestinal tract.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This single-center cross-sectional study collected mucosa of the esophagus, stomach, small intestine, and colon, as well as gastric juice and feces from 120 participants of the &lt;i&gt;H. pylori-&lt;/i&gt;infected group (HIG) and 30 of the healthy control group (HCG). 16S rRNA sequencing was applied to analyze the bacterial composition and functional pathways, and metagenomics was adopted to assess the composition of viruses, eukaryotes, and archaea in the feces, as well as the antibiotic resistance gene (ARG) and virulence factors of bacteria (VF).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Compared with the HCG, the alpha and beta diversity of bacteria in the mucosa of the whole digestive tract and the gastric juice of the HIG showed significant changes, with increased microbial dysbiosis index and significantly different compositions at the phylum and genus levels. Functional pathway analysis revealed that the metabolic characteristics of the flora changed in the HIG, with site-specific differences. Fecal specimens demonstrated no significant differences in the above indicators between the two groups. In addition, feces-based metagenomic analysis revealed that only eukaryotes had higher diversity in the HIG, whereas viruses and archaea showed no significant changes; the Shannon index of ARG increased; and VF showed no significant change.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study revealed that &lt;i&gt;H. pylori&lt;/i&gt; infection significantly influenced the diversity, composition, and metabolic functional pathway of bacteria in different parts of the digestive tract and the gastric juice. Moreover, fecal microbial composition may not fully represent the mucosal microbial composition of the gastrointestinal tract.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Registration&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Chinese Clinical Trial Registry: ChiCTR2300073419&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr Martin Bingham Skirrow—A Passionate Microbiologist and Early Advocate for Helicobacter pylori","authors":"Cliodna McNulty","doi":"10.1111/hel.70048","DOIUrl":"https://doi.org/10.1111/hel.70048","url":null,"abstract":"","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gankyrin Inhibition Can Control Helicobacter pylori Generated Gastric Cancer Using In Vivo Xenograft Models","authors":"Dharmendra Kashyap,&nbsp;Pranit Hemant Bagde,&nbsp;Siddharth Singh,&nbsp;Nidhi Varshney,&nbsp;Tarun Prakash Verma,&nbsp;Anamika Singh,&nbsp;Hamendra Singh Parmar,&nbsp;Hem Chandra Jha","doi":"10.1111/hel.70046","DOIUrl":"https://doi.org/10.1111/hel.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection recognized as a significant risk factor. <i>H. pylori</i> infects approximately 50% of the global population, contributing to chronic gastritis, peptic ulcers, and the development of GC. The oncoprotein Gankyrin (PSMD10) has been implicated in various human cancers, including hepatocellular carcinoma, gastric cancer, and lung cancer, by modulating autophagy and inflammatory pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we explored the role of Gankyrin in <i>H. pylori</i>-induced gastric tumorigenesis via a Swiss albino mouse xenograft model. Mice were subcutaneously injected with <i>H. pylori</i>-infected AGS cells with or without Gankyrin knockdown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We assessed tumor growth and inflammatory markers (TNF-α and IL-6) levels and Gankyrin's downstream signaling molecules (p53, pRb, and NF-κB). Our results demonstrated that Gankyrin knockdown significantly decreased tumor formation in Swiss albino mice engrafted with <i>H. Pylori</i>-infected AGS cells. Notably, treatment with cyclosporine A significantly decreased the expression of TNF-α in all the AGS-engrafted mice except the PBS group. Moreover, our results show that the downregulation of Gankyrin significantly elevated the expression of NF-κB, pRb, and p53.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that Gankyrin plays a crucial role in <i>H. pylori</i>-mediated GC progression by modulating inflammatory and tumor suppressor pathways. Targeting Gankyrin could provide a therapeutic strategy to mitigate the development of GC associated with <i>H. pylori</i> infection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Capabilities of Novel Open-Source Artificial Intelligence—DeepSeek in Helicobacter pylori-Related Queries","authors":"Ren-Chun Du,&nbsp;Yu-Chen Zhu,&nbsp;Yu-Tian Xiao,&nbsp;Bei-Ning Yang,&nbsp;Yong-Kang Lai,&nbsp;Zhi-Xiang Zhou,&nbsp;Hao Deng,&nbsp;Xu Shu,&nbsp;Nong-Hua Lu,&nbsp;Yin Zhu,&nbsp;Yi Hu","doi":"10.1111/hel.70045","DOIUrl":"https://doi.org/10.1111/hel.70045","url":null,"abstract":"","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study","authors":"Young Sin Cho,&nbsp;Sun Moon Kim,&nbsp;Sun Hyung Kang,&nbsp;Hee Seok Moon,&nbsp;Jae Kyu Sung,&nbsp;Ki Bae Bang,&nbsp;Sung Hyeok Ryou,&nbsp;Ki Bae Kim,&nbsp;Hae Joung Sul,&nbsp;Seung-Woo Lee","doi":"10.1111/hel.70040","DOIUrl":"https://doi.org/10.1111/hel.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The increasing trend of clarithromycin resistance in <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the primary cause of failure of standard triple therapy. Concomitant therapy is recommended as an alternative in regions with high rates of clarithromycin resistance. Recently, tailored therapies based on resistance testing have emerged as viable treatment approaches. We aimed to compare the eradication rates and adverse effects of concomitant and tailored therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We enrolled 319 patients diagnosed with <i>H. pylori</i> infection using dual-priming oligonucleotide (DPO) polymerase chain reaction (PCR) tests conducted in six hospitals across the Daejeon and Chungcheong regions of Korea. Based on DPO-PCR results, patients were randomly assigned to either the concomitant therapy group (non-bismuth quadruple therapy) or the tailored therapy group (standard triple therapy for clarithromycin-sensitive cases and bismuth quadruple therapy for clarithromycin-resistant cases). Demographics, eradication success rates, adverse effects, and patient compliance were assessed. Data were analyzed using modified intention-to-treat (mITT) and per-protocol (PP) analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The eradication rate was significantly higher in the tailored therapy group than in the concomitant therapy group in PP analysis (92.62% vs. 85.21%, <i>p</i> = 0.026). The severity of adverse effects was significantly greater in the concomitant therapy group than in the tailored therapy group (<i>p</i> = 0.025).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Considering the high eradication success rate and low severity of adverse effects, tailored therapy based on DPO-PCR is preferable to concomitant therapy without resistance testing for the treatment of <i>H. pylori</i> infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Clinical Research Information Service (CRIS): KCT0004162</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis”","authors":"","doi":"10.1111/hel.70044","DOIUrl":"https://doi.org/10.1111/hel.70044","url":null,"abstract":"<p>V. Mishra, D. Dash, A. K. Panda, et al., “Efficacy of <i>Lactobacillus</i> spp. Supplementation in <i>Helicobacter pylori</i> Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis,” Helicobacter 29, no. 6 (2024): e70006, doi: https://doi.org/10.1111/hel.70006.</p><p>In the Abstract, Results (Sections 3.3–3.4), and GRADE evidence profile (Table 1), the risk ratio (RR) 95% CI values were mistakenly reported from Egger's regression 95% CI values (Table S3). Below, we provide a table of actual 95% CI values for RR as reported in the Forest plots (Figures 1–4).</p><p>We apologize for this error.</p>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Is Tailored Bismuth Quadruple Therapy (With Clarithromycin or Furazolidone) Based on Fecal Molecular Susceptibility Testing in First-Line Helicobacter pylori Eradication Treatment More Effective? A Three-Arm, Multicenter Randomized Clinical Trial","authors":"Xinlu Ren,&nbsp;Zhiqiang Song","doi":"10.1111/hel.70043","DOIUrl":"https://doi.org/10.1111/hel.70043","url":null,"abstract":"","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Fecal Microbial Communities in Patients With Type 2 Diabetes Mellitus Combined With Helicobacter pylori Infection","authors":"Xiaoyan He,&nbsp;Han Chen,&nbsp;Fengdan Chen,&nbsp;Wei Su,&nbsp;Yan Wang,&nbsp;Die Hu,&nbsp;Jianwen Hu,&nbsp;Xiaoying Zhou","doi":"10.1111/hel.70041","DOIUrl":"https://doi.org/10.1111/hel.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection has the capacity to alter the gut microbiota composition. There is a significant correlation between <i>H. pylori</i> infection and type 2 diabetes mellitus (T2DM). Further research is necessary to explore whether gut microbiota plays a role in the relationship between <i>H. pylori</i> and T2DM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Fecal samples were obtained from 44 patients with T2DM, including 20 who tested positive for <i>H. pylori</i> and 24 who tested negative. Intestinal microbiota composition was analyzed via 16S rRNA V3-V4 amplicon sequencing. Differences in microbial distribution and significant microbial biomarkers were identified between <i>H. pylori</i> positive and negative groups. A Spearman correlation analysis assessed the relationship between intestinal microbiota and glycemic parameters. Additionally, PICRUSt2 was used to predict intestinal bacterial functions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results indicate that in <i>H. pylori</i> (+) T2DM patients, HbA1c levels were significantly higher (8.9% vs. 8.1%, <i>p</i> = 0.021), while both the C-peptide peak (3.70 vs. 5.98 ng/mL, <i>p</i> = 0.040) and fasting C-peptide levels (1.42 vs. 2.31 ng/mL, <i>p</i> = 0.008) were significantly lower compared to <i>H. pylori</i> (−) T2DM groups. A total of 11 colonic phyla and 100 genera were identified in all fecal samples. In groups positive for <i>H. pylori</i>, there was a significant enrichment of the phylum <i>Proteobacteria</i>, while the genera <i>Lactobacillus</i>, <i>Butyricimonas</i>, and <i>Akkermansia</i> were significantly reduced (all <i>p</i> &lt; 0.05). Correlation analysis showed that the abundance of the genera <i>Butyricimonas</i> (<i>p</i> = 0.01) and <i>Akkermansia</i> (<i>p</i> = 0.048) were negatively correlated with fasting plasma glucose. KEGG pathway analysis indicated a significant enrichment of methylmalonyl-CoA mutase and succinyl-CoA in <i>H. pylori</i>-infected T2DM patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests that T2DM patients with <i>H. pylori</i> infection exhibit more impaired pancreatic islet function potentially due to <i>H. pylori</i>-induced alterations in the gut microbiota.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"30 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}