JURNAL FARMANESIA最新文献_第3页

UJI AKTIVITAS BUAH OKRA(Abelmoschus esculentus L) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS 测试秋葵果实(Abelmoschus esculentus L)的血糖水平下降

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2772

Dicky Yuswardi Wiratma, Kesaktian Manurung, Soraya Syaviera

引用次数: 1

UJI EFEK EKSTRAK ETANOL DAUN SALAM (Syzygiumpolyanthum) SEBAGAI DIURETIKA PADA TIKUS PUTIH JANTAN

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2773

Kesaktian Manurung, N. Marbun, Salomo Joseph Empindonta

{"title":"UJI EFEK EKSTRAK ETANOL DAUN SALAM (Syzygiumpolyanthum) SEBAGAI DIURETIKA PADA TIKUS PUTIH JANTAN","authors":"Kesaktian Manurung, N. Marbun, Salomo Joseph Empindonta","doi":"10.51544/jf.v7i2.2773","DOIUrl":"https://doi.org/10.51544/jf.v7i2.2773","url":null,"abstract":"Bay leaf is a plant that one of its benefits is as a diuretic. Diuretics are drugs that act directly on the kidneys and increase the excretion of urine and sodium salts. The aim of the study was to determine the diuretic effect of ethanol extract of bay leaf (EEDS) on male white rats. The study used 25 male white rats, divided into 5 treatment groups: negative control group (CMC suspension 0.5%), positive control (furosemide suspension at a dose of 3.6 mg/kg BW), and a test group EEDS suspension at a dose of 100 mg/kg. BW, 200 mg/kg BW and 300 mg/kg BW. The test preparation was given orally to rats and then observed in a modified metabolic cage for 6 hours. The results of simplicia phytochemical screening showed positive for flavonoids, saponins and tannins. The results of EEDS characterization included a total ash content of 3.66%, water-soluble extract content of 3.69%, and ethanol-soluble extract content of 3.65%. The results showed that EEDS at a dose of 300 mg/kg BW showed the best diuretic effect compared to 200 mg/kg BW and 100 mg/kg BW, but the effect was lower than S. Furosemide 3.6 mg/kg BW. The results of the ANOVA EEDS test at doses of 100, 200 and 300 mg/kg BW had significant differences.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128488525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENENTUAN KADAR KAFEIN DALAM KOPI INSTAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET 紫外线光谱测定速溶咖啡中的咖啡因含量

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2778

Supartiningsih Supartiningsih, Zuhairiah Zuhairiah, Cut Masyithah Thaib, Naim Bahagia

{"title":"PENENTUAN KADAR KAFEIN DALAM KOPI INSTAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET","authors":"Supartiningsih Supartiningsih, Zuhairiah Zuhairiah, Cut Masyithah Thaib, Naim Bahagia","doi":"10.51544/jf.v7i2.2778","DOIUrl":"https://doi.org/10.51544/jf.v7i2.2778","url":null,"abstract":"Caffeine in coffee has clinically beneficial pharmacological effects, such as stimulating the central nervous system, relieving fatigue, drowsiness and also increasing concentration. However, excessive use of caffeine can cause heart palpitations and stomach upset. According to SNI 01-7152-2006, the maximum limit of caffeine in food and beverages is 150 mg/day and 50 mg/serving. The purpose of this study was to determine the level of caffeine in instant coffee circulating in supermarkets in Medan City by Ultraviolet Spectrophotometry. Determination of caffeine content was carried out by the UV Spectrophotometry method after extraction using chloroform in an alkaline environment. The caffeine concentration can be calculated from the calibration curve regression equation. The results showed that the three instant coffee samples were determined to have different levels of caffeine, namely instant coffee sample code A 5.2585 mg/gram, code sample B 4.2348 mg/gram, and code C 133564. mg/gram. When viewed from the requirements, the caffeine content in the instant coffee samples coded A and B has exceeded the portion limit of 131.4625 mg and 84,768 mg, respectively, but is still within the limits set by SNI 01-7152-2006 if consumed in one pack. per day, henceforth the code C sample does not exceed the caffeine content limit of serving, which is 26.7128 mg of caffeine.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126744308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENGARUH VARIASI WAKTU FERMENTASI TERHADAP KADAR ETANOL HASIL FERMENTASI SINGKONG KUNING (Manihotutillissima Pohl) 发酵时间变化对黄木薯发酵乙醇(Manihotutillissima Pohl)水平的影响

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2775

S. Maimunah, Zuhairiah Zuhairiah, A. Y. Sianipar

引用次数: 0

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN LEGUNDI (Vitextrifolia L.) TERHADAP PERTUMBUHAN Staphylococcus epidermidis 试验利古里亚叶乙醇提取物的抗菌活性。表皮葡萄球菌生长

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2770

Jon Kenedy Marpaung, P. Sitorus, P. Nasution, Roma Devina Yanti

{"title":"UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN LEGUNDI (Vitextrifolia L.) TERHADAP PERTUMBUHAN Staphylococcus epidermidis","authors":"Jon Kenedy Marpaung, P. Sitorus, P. Nasution, Roma Devina Yanti","doi":"10.51544/jf.v7i2.2770","DOIUrl":"https://doi.org/10.51544/jf.v7i2.2770","url":null,"abstract":"Legundi leaves (Vitextrifolia L.) contain flavonoid compounds, alkaloids and saponins, tannins, steroids/triterpenoidsthatact as antiseptic substancesandaid in the wound healing process. Staphylococcusepidermidis (Gram positive) is a mild skin infection-causing bacteria that accompanies the formation of abscesses. As for the purpose of this study To know the absence of antibacterial activity from concentrations of 10%, 15%, 20%, 25% legundileaf extractagainst Staphylococcus epidermid is bacteria and know the effective concentration of legunleaf extract in in hibiting the growth of Staphylococcus epidermidis bacteria. This research methoduses experimental methods and legundileaf extract with concentrations of 10%, 15%, 20%, 25%. The resultsshowedthatconcentrationsof 10%, 15%, 20%, 25% of legundileaf ethanol extract had antibacterial activity against the growth of Staphylococcus epidermidisindicated with a blockable zone diameter of 8 mm, 8.84 mm, 9.84 mm, 10.54 mm, respectively. Base dont here search that has beendone can be concluded that legundileaf extractcan inhibit the growth of bacteria Staphylococcus epidermidis, because around the discpaperthere is a clear zone that indicates the absence of bacterial growth.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122592074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2771

Y. Silalahi, Jon Kennedy Marpaung, Supartiningsih Supartiningsih

引用次数: 0

PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum 利用液态水废物成为Nata de Soya使用二甲酸细菌

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2774

Zuhairiah Zuhairiah, Jon Kennedy Marpaung, Maringan Silitonga

{"title":"PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum","authors":"Zuhairiah Zuhairiah, Jon Kennedy Marpaung, Maringan Silitonga","doi":"10.51544/jf.v7i2.2774","DOIUrl":"https://doi.org/10.51544/jf.v7i2.2774","url":null,"abstract":"Nata de Soya merupakan salah satu jenis pangan yang diperoleh dari pengolahan limbah cair tahu yang berbahan dasar kedelai. Penelitian ini bertujuan untuk memanfaatkan limbah cair tahu yang sering terabaikan dan menjadi penyebab rusaknya lingkungan perairan dekat perindustrian pembuatan tahu. Nata de Soya dibentuk oleh bakteri Acetobacter xylinum yang merupakan bakteria erob. Masing-masing perlakuan difermentasi selama 8-14 hari, parameter yang diamati yaitu berat nata, kadar air, kadar serat dan selulosa Nata de Soya selama 8-14 hari. Pada penelitian ini didapat data ketebalan Nata de Soya dengan perlakuan 1, 2, dan 3 dengan kosentrasi 5, 10, dan 20% starter bakteri yaitu, 2,4503 gr, 2,8922 gr, dan 2,9226. Pada berat nata didapat 0,21 cm, 0,82 cm, dan 1,53 cm. Kandungan kadar air pada Nata de Soya pada perlakuan 1,2 dan 3 dengan kosentrasi masing-masing 5, 10, dan 20% yaitu 82,71, 83,71%, dan 84,17%%. Kandungan kadar serat Nata de Soya pada perlakuan 1, 2, dan 3 dengan kosentrasa bakteri 5, 10 dan 20% didapat 49,90%, 50,74% dan 54,02%. Pada uji kadar selulosa menggunakan FTIR dengan sampel 0,4 g nilai tertinggi didapat sebanyak 3361,12 menunjukan adanya gugus aldehid dari selulosa acetat. Pemanfaatan limbah cair tahu menjadi Nata de Soya menggunakan bakteri acetobacter xylinum dapat menjadi alternative pengolahan limbah cair tahu.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133469491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus 测试抗菌活性肉桂提取物(朱砂)对葡萄球菌aureus的有效性

JURNAL FARMANESIA Pub Date : 2020-12-26 DOI: 10.51544/jf.v7i2.2776

V. Purwandari, Artha Yuliana Sianipar, Yosy Silalahi, D. J. Nasution

{"title":"UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus","authors":"V. Purwandari, Artha Yuliana Sianipar, Yosy Silalahi, D. J. Nasution","doi":"10.51544/jf.v7i2.2776","DOIUrl":"https://doi.org/10.51544/jf.v7i2.2776","url":null,"abstract":"Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsion aims to make nanoparticle-sized nanogel preparations and as an antibacterial active substance in nanogel preparations against Staphylococcus aureus bacteria. Nanogel preparations were made by adding cinnamon extract nanoemulsion with varying concentrations of F1(2%), F2(4%), F3(6%), and blank formula (F0) as the basis for nanogels without cinnamon extract nanoemulsion. The results showed that the cinnamon extract nanoemulsion could be made into nanogels to produce a thick, brown-colored gel with a characteristic cinnamon smell. The result of the pH of the preparation is 6 according to the pH of the skin, has good homogeneity, and is not irritating to the skin. The PSA test produces a nanoparticle size of 24.2 nm, and the antibacterial effectiveness test of the nanogel preparation can inhibit Staphylococcus aureus bacteria. Produced a moderate inhibition zone category (6.7-7.1 mm) and the F3 formulation (6%) was the best formulation.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126340122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULASI SEDIAAN BLUSH ON DARI SARI BUAH STROBERI (Fragaria vesca L) SEBAGAI PERONA PIPI

JURNAL FARMANESIA Pub Date : 2020-06-26 DOI: 10.51544/jf.v7i1.2760

A. Y. Sianipar, Siti Nurbaya, Adiansyah Adiansyah, Eva Priasanti Sitanggang

引用次数: 2

AKTIVITAS PENGHAMBAT ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA DARI SPONGE(Filum Porifera) SECARA IN SILICO 蛋白酶抑制剂的活性为6LU7病毒性cov -2，由SPONGE(Porifera门)中的化合物合成

JURNAL FARMANESIA Pub Date : 2020-06-26 DOI: 10.51544/jf.v7i1.2759

Kesaktian Manurung, Siti Maimunah, Fitri Yulia Sari

{"title":"AKTIVITAS PENGHAMBAT ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA DARI SPONGE(Filum Porifera) SECARA IN SILICO","authors":"Kesaktian Manurung, Siti Maimunah, Fitri Yulia Sari","doi":"10.51544/jf.v7i1.2759","DOIUrl":"https://doi.org/10.51544/jf.v7i1.2759","url":null,"abstract":"The metabolite content in sponge has a unique chemical structure and very interesting pharmacological activity, such as anticancer, antimicrobial, anti-inflammatory, antifouling, antifouling, and inhibiting enzyme activity. The purpose of this study is to find out the value of RMSD in protein validation 6LU7 in silico, to know the ability of Sponge compounds in inhibiting protease enzyme 6LU7 from SARS-CoV-2 Virus in silico, and to know the comparison of the results of docking score of Sponge compounds in the inhibition of protease enzyme 6LU7SARS-CoV-2 virus to visualize docking results to know the amino acids that bond with each other. This research is a descriptive study that is to test the activity of Sponge compounds against inhibition of protease enzyme 6LU7 SARS-CoV-2. The phases in this study include downloading and installation applications needed. And validation of in silico tethering method to protease enzyme 6LU7 SARS-CoV-2 virus, as well as the docking of Sponge compound molecules against protease enzyme 6LU7 SARS-CoV-2 virus in silicon. The results of the study obtained that the process of tethering protease enzyme 6LU7 sars-cov-2 virus is declared valid so that it can be used for molecular tethering of Sponge test compounds in silico. Sponge test compounds can inhibit the protease enzyme 6LU7 Sars-CoV-2 virus. The docking score of Sponge test compounds on protease enzyme 6LU7 SARS-CoV-2 virus is lower than the comparison. As the result of docking visualization, several amino acid residues interact with each other including hydrogen bonds.","PeriodicalId":132191,"journal":{"name":"JURNAL FARMANESIA","volume":"2 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130835107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0