Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)最新文献

{"title":"Modeling the depressive-like state of learned helplessness in rats of different stocks","authors":"S. Kotelnikova, M. Sadovsky, V. A. Kraineva, E. A. Waldman","doi":"10.29296/2618723x-2022-02-03","DOIUrl":"https://doi.org/10.29296/2618723x-2022-02-03","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130382290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the reproduction of marmosets or common igrunka","authors":"D. Akimov, T. Barmina","doi":"10.57034/2618723x-2023-01-08","DOIUrl":"https://doi.org/10.57034/2618723x-2023-01-08","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121574128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the formation of diets nd feeding regimen of common igrunka in the conditions of a research laboratory","authors":"E.V. Vesnina, M. Akimova, T. Barmina","doi":"10.29296/2618723x-2022-01-06","DOIUrl":"https://doi.org/10.29296/2618723x-2022-01-06","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129510410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of postmortem changes in carcasses of dead laboratory animals","authors":"Y. Gushchin, E. Belyaeva, J.Yu. Ustenko","doi":"10.29296/2618723x-2021-04-08","DOIUrl":"https://doi.org/10.29296/2618723x-2021-04-08","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130548347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nesting behavior as an indicator of the level of distress in laboratory mice","authors":"M. Akimova, M. Makarova, D. Akimov","doi":"10.29296/2618723x-2021-02-05","DOIUrl":"https://doi.org/10.29296/2618723x-2021-02-05","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131374785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the risk of zooanthroponose diseases and diseases characteristic for laboratory dymp pigs in the conditions of the preclinical center","authors":"V. Berezkin, E. Bondareva, N. Semenenko","doi":"10.57034/2618723x-2023-01-02","DOIUrl":"https://doi.org/10.57034/2618723x-2023-01-02","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121964689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective of pharmacokinetic parameters variability in dependence on biological species and number of individuals in the experimental group","authors":"V. Kosman, M. V. Karlina","doi":"10.57034/2618723x-2023-01-06","DOIUrl":"https://doi.org/10.57034/2618723x-2023-01-06","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121195267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative methods for studying toxicity. Bioethical principles","authors":"M. Makarova, V. Makarov","doi":"10.29296/2618723x-2022-01-07","DOIUrl":"https://doi.org/10.29296/2618723x-2022-01-07","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116460783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxorubicin-induced cardiotoxicity model elaboration in rats and rabbits","authors":"E. Mazukina, E. Shekunova, Ya. Guschin, N. Faustova","doi":"10.29296/2618723x-2021-04-05","DOIUrl":"https://doi.org/10.29296/2618723x-2021-04-05","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121458550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability of blood biochemical parameters and establishment of reference intervals in preclinical studies. Part 3: mini pigs","authors":"M. Miroshnikov, M. Makarova","doi":"10.29296/2618723x-2020-03-02","DOIUrl":"https://doi.org/10.29296/2618723x-2020-03-02","url":null,"abstract":"Резюме. На сегодняшний день в распоряжении ученых для проведения токсикологических, фармакокинетических и других исследований, помимо грызунов, находится более десятка других лабораторных животных. Свиней уже давно используют для изучения трансплантации органов и тканей, хирургической подготовки студентов-медиков, однако их применение может быть значительно шире. Анатомическое сходство с человеком и крупные размеры этих животных позволяют успешно проводить исследования сердечно-сосудистой, пищеварительной и мочевыделительной систем, а также использовать в доклинических и токсикологических исследованиях. В связи с этим установление референсных интервалов биохимических показателей крови лабораторных свиней является актуальной задачей. В статье представлены референсные интервалы биохимических показателей крови карликовых свиней, полученные с применением классического подхода. Были использованы результаты биохимического анализа крови 15 самцов и 15 самок клинически здоровых карликовых свиней в возрасте 9–11 мес массой тела 14–26 кг, выращенных в нашем питомнике. Помимо основных биохимических показателей (креатинин, мочевина, аланинаминотрансфераза, аспартатаминотрансфераза, щелочная фосфатаза, холестерин, триглицериды, общий белок, альбумин, глюкоза и общий билирубин), представлены дополнительные параметры – расширенный липидный профиль, концентрация кальция и фосфора, активность ряда ферментов (лактатдегидрогеназа, креатинкиназа, амилаза, гамма-глутамилтрансфераза и холинэстераза), являющихся биохимическими маркерами повреждения различных систем и органов. Наиболее выраженные отличия обнаружены при исследовании липидного профиля самцов и самок карликовых свиней: концентрация общего холестерина и триглицеридов в крови самок была выше в среднем в 1,5 и 2 раза соответственно. Кроме того, в сыворотке крови самок концентрация холестерина липопротеинов низкой плотности была в среднем в 1,8 раз выше, чем в сыворотке крови самцов. Менее выраженные, но статистически значимые различия были обнаружены в отношении концентрации общего белка и глобулинов. Проведенный анализ представленных референсных интервалов с данными литературы показал сопоставимость полученных значений. Несмотря на значительное сходство биохимических профилей человека и лабораторных свиней, необходимо учитывать наличие видовых различий при рассмотрении результатов доклинических исследований.","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"281 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127391450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}