Advances In Pharmaceutical Research最新文献

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The effect of Transferosomes on skin permeation of Ketorolac tromethamine 转移体对酮咯酸三聚氰胺皮肤渗透的影响

Advances In Pharmaceutical Research Pub Date : 1900-01-01 DOI: 10.36218/APR/1949694

Anand Krishnan Prakash, K. Pramod

{"title":"The effect of Transferosomes on skin permeation of Ketorolac tromethamine","authors":"Anand Krishnan Prakash, K. Pramod","doi":"10.36218/APR/1949694","DOIUrl":"https://doi.org/10.36218/APR/1949694","url":null,"abstract":"To overcome lipophilicity problem, associated side effects and frequent dosing of Tromethamine, it is needed to develop some newer and safer. Ketorolac Tromethamine Transferosomes may help to increase the depth of skin permeation and the amount of drug delivered to systemic circulation (help in overcoming lipophilicity problem). At the same time if may provide the alternative of oral route (to minimize the side effects), or parenteral route (prevent the pain at injection site) and also can provide the long duration of action, to overcome the problem of frequent dosing. The transfersomal vesicles were prepared by conventional rotary evaporation sonication method using Soya phosphatidylcholine and edge activator (Span 80 and Sodium cholate). Optimizations of the transfersomal formulation were done by selecting various process variables such as effect of Soya phosphatidylcholine-edge activator ratio, effect of various edge activator and solvents. The skin permeation was tested using Franz diffusion cell and rat skin. Vesicles composition had a major effect on the morphological characterization, size and size distribution, percent entrapment efficiency, degree of deformability and in vitro release pattern of the vesicular system. Herein, it is observed that complex lipid molecules transfersomes can increase the transdermal flux and prolong the release of Ketorolac Tromethamine. Present investigation showed that Ketorolac tromethamine could be a potential drug carrier in the form of new ultra-flexible transferosomes.","PeriodicalId":130777,"journal":{"name":"Advances In Pharmaceutical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127519137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation & Development of Self-Micro Emulsifying Drug Delivery System (SMEDDS) for Oral Bioavailability enhancement of a low soluble Anti-Diabetic Drug: Gliclazide 用于提高低溶性抗糖尿病药物格列齐特口服生物利用度的自微乳化给药系统的研制

Advances In Pharmaceutical Research Pub Date : 1900-01-01 DOI: 10.36218/APR/6657176

S. Anand, R. Gupta, S. Prajapati

引用次数: 1

Neuroprotective activity of Santalum album seeds in Sepsis encephalopathy 泻泻子对败血症脑病的神经保护作用

Advances In Pharmaceutical Research Pub Date : 1900-01-01 DOI: 10.36218/apr/9636944

Asmita Ojha, Jangra Meenu, Saraf Shailendra Kumar

{"title":"Neuroprotective activity of Santalum album seeds in Sepsis encephalopathy","authors":"Asmita Ojha, Jangra Meenu, Saraf Shailendra Kumar","doi":"10.36218/apr/9636944","DOIUrl":"https://doi.org/10.36218/apr/9636944","url":null,"abstract":"Septic encephalopathy is a systemic inflammatory disease and is characterized by change in neurotransmitter release, dysregulated production of cytokines, organ dysfunction and long-term cognitive and emotional impairments. In the present study, it was investigated whether administration of ethanolic extract and chloroform fraction of Santalum album can affect the behavioural, oxidative stress parameters and brain oedema in sepsis-surviving mice. Septic encephalopathy was induced in albino mice of either sex (20-30 gm body weight) by cecal ligation and puncture technique. Ethanolic extract of Santalum album was prepared by microwave assisted extraction and various fractions were prepared. Behavioural parameters like neurological examination and exploratory behaviour were studied after 3 hours and 24 hours of sepsis induction. Santalum album extract showed significant (p<0.001) improvement in depression, memory, neurological severity score and exploratory behaviour in surviving animals. Further glutathione level and catalase level was found to be elevated with ethanolic extract and chloroform fraction at 200mg/kg body weight whereas level of malondialdehyde (MDA) was found to decrease in chloroform fraction, at a dose of 200 mg/kg body weight. Brain oedema was found to be increased approximately 20% in diseased group, which was reduced after treatment. Thus, based on the results, it may be concluded that Santalum album shows neuroprotective effect against septic encephalopathy via reduction of oxidative stress and improvement in learning and memory, neurological severity score and exploratory behaviour.","PeriodicalId":130777,"journal":{"name":"Advances In Pharmaceutical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116594176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3