The effect of Transferosomes on skin permeation of Ketorolac tromethamine

To overcome lipophilicity problem, associated side effects and frequent dosing of Tromethamine, it is needed to develop some newer and safer. Ketorolac Tromethamine Transferosomes may help to increase the depth of skin permeation and the amount of drug delivered to systemic circulation (help in overcoming lipophilicity problem). At the same time if may provide the alternative of oral route (to minimize the side effects), or parenteral route (prevent the pain at injection site) and also can provide the long duration of action, to overcome the problem of frequent dosing. The transfersomal vesicles were prepared by conventional rotary evaporation sonication method using Soya phosphatidylcholine and edge activator (Span 80 and Sodium cholate). Optimizations of the transfersomal formulation were done by selecting various process variables such as effect of Soya phosphatidylcholine-edge activator ratio, effect of various edge activator and solvents. The skin permeation was tested using Franz diffusion cell and rat skin. Vesicles composition had a major effect on the morphological characterization, size and size distribution, percent entrapment efficiency, degree of deformability and in vitro release pattern of the vesicular system. Herein, it is observed that complex lipid molecules transfersomes can increase the transdermal flux and prolong the release of Ketorolac Tromethamine. Present investigation showed that Ketorolac tromethamine could be a potential drug carrier in the form of new ultra-flexible transferosomes.