Formulation & Development of Self-Micro Emulsifying Drug Delivery System (SMEDDS) for Oral Bioavailability enhancement of a low soluble Anti-Diabetic Drug: Gliclazide

Abstract

The purpose of the present study was to enhance the solubility and to improve bioavailability of low water soluble (lipophilic) drugs by self-micro emulsifying drug delivery systems (SMEDDS) of Gliclazide via oral route resulting in increasing their clinical efficacy. Gliclazide is used for the treatment of Hyperglycaemia. In the present work, SMEDDS were successfully developed using different ratios of surfactant co-surfactant and oil. SMEDDS were prepared using Sunflower oil, Tween 80 (surfactant) and Poly ethylene glycol (PEG-400) (co-surfactant) and water. The range of pH is 7.4. Conventional SMEDDS are mostly prepared in a liquid form. SMEDDS can be orally administered in soft or hard gelatine capsules and form fine relatively stable oilinwater (O/W) emulsions. The results indicated that SMEDDS containing Gliclazide can be a promising vehicle for enhanced oral bioavailability of Gliclazide.