{"title":"Neurocognitive Disorders","authors":"T. Gossard, E. S. Louis","doi":"10.1093/med/9780190929671.003.0025","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0025","url":null,"abstract":"Recent evidence for a strong bidirectional relationship between sleep and neurocognitive disorders has emerged. A key function of sleep in brain health is drainage of metabolites and toxins such as beta-amyloid that accumulate with continued wakefulness, making insufficient sleep, and sleep disorders possible contributors toward development of neurodegeneration. Sleep disturbances are frequent in patients with dementia and neurocognitive disorders, including poor sleep efficiency and architecture, sleep disordered breathing, sleep-related limb movements, and parasomnias. This chapter highlights current DSM-5 classifications for the major and mild neurocognitive disorders, including Alzheimer’s and Lewy body diseases and the related prodromal states of amnestic and nonamnestic mild cognitive impairment; less common neurodegenerative dementias are also reviewed. Diagnostic and therapeutic approaches to key sleep comorbidities in patients with neurocognitive disorders including insomnia, hypersomnia, sleep-disordered breathing, nocturnal movements, and parasomnias are also discussed.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129949083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain Disorders","authors":"T. Roehrs, T. Roth","doi":"10.1093/med/9780190929671.003.0027","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0027","url":null,"abstract":"Information and appreciation regarding the role of insufficient sleep in chronic pain is now emerging. This chapter reviews the sleep, daytime sleepiness, and fatigue of people with various chronic pain disorders. The bidirectional relation of sleep and pain is described in this chapter, and the modulating effects of mood and cognitive factors on the sleep-pain nexus are discussed. Central and peripheral mechanisms underlying the sleep–pain nexus are explored. Finally, pharmacological and behavioral treatments for sleep and pain are reviewed with a focus on the association of improved sleep leading to improved pain. It is concluded that further research is necessary to better understand the interrelation of sleep and pain, which may lead to better therapies for sleep and pain.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123170730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep-Related Movement Disorders","authors":"Ravi Gupta","doi":"10.1093/MED/9780190929671.003.0014","DOIUrl":"https://doi.org/10.1093/MED/9780190929671.003.0014","url":null,"abstract":"Sleep-related movement disorders include disorders that manifest as simple and mostly stereotyped movements occurring at sleep–wake interface or during sleep. Restless legs syndrome (RLS), the most common sleep-related movement disorder. RLS is a treatable condition that psychiatrists must be familiar with due to its common comorbidity with a broad range of psychiatric disorders. In addition, commonly used psychotropic medications are known to induce or worsen RLS symptoms in predisposed individuals, and these symptoms may be mistaken for akathisia or sleep-initiation insomnia and lead to mismanagement. This chapter discusses, among other RLS-related topics, the diagnosis, epidemiology, predisposing factors, genetic factors, and the role of iron metabolism.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123760021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep and Cognition","authors":"Lilia Roshchupkina, Philippe Peigneux","doi":"10.1093/MED/9780190929671.003.0005","DOIUrl":"https://doi.org/10.1093/MED/9780190929671.003.0005","url":null,"abstract":"How does sleep affect our brain functioning, and what happens when we do not receive our necessary “portion” of sleep? It is a well-known fact that sleep is essential for restoration of body and mind efficiency, while a lack of appropriate sleep adversely impacts mood, motor functions, and cognition, eventually affecting the quality of everyday life. Recent studies highlighted links between the amount of sleep disturbance and the severity of deterioration in some cognitive functions. Moreover, clinical observations indicate that sleep disturbances might be one of the earliest signs of neurodegenerative disorders, including early Alzheimer’s disease and dementia. This chapter briefly reviews the relationships between sleep and cognition, and consider the evidence suggesting that sleep deprivation and sleep disorders are associated with poor cognitive functioning and, in clinical population, with cognitive decline.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131156303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breathing-Related Sleep Disorders","authors":"Ahmed S. Bahammam, Sulaiman Alhifzi, S. Aleissi","doi":"10.1093/MED/9780190929671.003.0015","DOIUrl":"https://doi.org/10.1093/MED/9780190929671.003.0015","url":null,"abstract":"Breathing-related sleep disorders (BRSD) encompass obstructive sleep apnea (OSA), central sleep apnea, and hypoventilation disorders. Risk factors for BRSD include obesity, metabolic dysfunction, smoking, use of respiratory depressant medications (like opiates and benzodiazepines), and alcohol consumption, all of which are highly prevalent among patients with psychiatric disorders. BRSDs are associated with substantial morbidity, disturbed quality of life, and worse prognosis of comorbid psychiatric disorders. Therefore, it is essential for psychiatric care providers to have the clinical skills to recognize BRSDs. Recent studies suggest that the prevalence rates of OSA in psychiatric patients are higher than the general population. Moreover, BRSD’s share common symptoms and risk-factors with psychiatric disorders. A comprehensive clinical approach including a thorough sleep history and examination along with the use of validated screening questionnaires like the STOP-BANG questionnaire, particularly for at-risk patients, is effective in identifying BRSD.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127154977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delirium","authors":"K. Hatta","doi":"10.1093/med/9780190929671.003.0024","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0024","url":null,"abstract":"The fundamental concept of delirium is altered consciousness and its fluctuation. Sleep–wake cycle disturbance is one of the common clinical features of delirium. Evidence suggests that disturbed sleep plays a key role in pathogenesis of delirium and restoration of sleep–wake cycle provides a clinical opportunity for prevention of delirium. It is essential to evaluate clinical factors such as medical illnesses, psychiatric disorders, substance use disorders, medication side effects, and environmental factors leading to sleep disturbance in delirium. In addition, multicomponent nonpharmacologic delirium prevention interventions are effective in reducing delirium incidence and preventing falls, with trend toward decreasing length of stay, but nonsignificant reductions in mortality. Approaches to regulating functions of melatonin or orexin on sleep–wake cycle lead to pharmacological interventions, and preventive effects of melatonin receptor agonists and an orexin receptor antagonist on delirium have been shown. This evidence suggests importance of treating sleep–wake cycle disturbance to prevent delirium. More research is warranted to develop comprehensive clinical strategies, targeting sleep disturbance to predict, prevent and treat delirium.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122999713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Dinerman, Brett J Davis, Jessica A. Janos, Samantha Walsh, L. Sylvia
{"title":"Bipolar and Related Disorders","authors":"J. Dinerman, Brett J Davis, Jessica A. Janos, Samantha Walsh, L. Sylvia","doi":"10.1093/med/9780190929671.003.0018","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0018","url":null,"abstract":"Bipolar disorder is a debilitating mental health condition marked by episodes of mania or hypomania and depression. A person with bipolar disorder cycles between these mood episodes throughout his or her lifetime, leading to significant impairment in functioning and overall quality of life. Sleep disturbances pervade the course of bipolar disorder, occurring before, during, and after mood episodes. Sleep disturbances also negatively impact the treatment outcome for individuals with bipolar disorder. Thus, interventions aimed at improving sleep in this clinical population are needed. This chapter discusses sleep disturbances in the context of bipolar disorder as well as empirically validated strategies to improve sleep specifically for bipolar disorder.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127353050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurobiology of Sleep and Wakefulness","authors":"A. Chopra, R. Patel, P. Das","doi":"10.1093/MED/9780190929671.003.0003","DOIUrl":"https://doi.org/10.1093/MED/9780190929671.003.0003","url":null,"abstract":"Over the last century, multiple advancements in the field of neuroscience have furthered our understanding of the complex phenomenon of sleep and wakefulness in humans. As outlined in this chapter, electrophysiological markers broadly differentiate between the sleep and wakefulness states, which are essentially regulated by intricate neural networks and neurotransmitter systems in conjunction with circadian, homeostatic, allostatic, and other factors. Alterations of normal mechanisms regulating sleep and wakefulness not only have clinical implications in terms of understanding the genesis of sleep–wake disturbances in primary sleep-wake and psychiatric disorders but also offer the opportunity for development of effective therapeutic interventions.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130699481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurodevelopmental Disorders","authors":"A. R. Shelton, Jessica Duis, B. Malow","doi":"10.1093/med/9780190929671.003.0023","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0023","url":null,"abstract":"Compared to typically developing children, sleep disturbances are exceedingly prevalent in children with neurodevelopmental disorders. The diagnostic criteria for many neurodevelopmental disorders includes sleep problems. Sleep disturbance in this population is often multifactorial and caused by the interplay of genetic, neurobiological and environmental overlap. These disturbances often present either as insomnia or hypersomnia. Different sleep disorders present with these complaints and based on the clinical history and findings from diagnostic tests, an appropriate diagnosis can be made. The chapter covers autism spectrum disorder, Down syndrome, Prader–Willi syndrome, Angelman syndrome, Rett syndrome, Fragile X syndrome, Williams syndrome, and Smith–Magenis syndrome.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126008523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eating Disorders","authors":"Anoop Narahari, R. Baweja, P. Das, A. Chopra","doi":"10.1093/med/9780190929671.003.0030","DOIUrl":"https://doi.org/10.1093/med/9780190929671.003.0030","url":null,"abstract":"Sleep and eating behavior are complimentary homeostatic functions and adequate sleep is fundamental for the nutritional balance of the body. Short sleep duration has been linked to development of obesity and abnormal eating patterns in children and adults. Individuals with eating disorders report significantly higher sleep disturbances of sleep apnea, insomnia, circadian rhythm disorders, and impairment of daytime functioning, as compared to controls. Sleep disturbances have been implicated in suicidal behaviors in patients with eating disorders. This chapters outline the current evidence examining the pathophysiology and comorbidity of sleep disturbance in daytime eating disorders and focus on clinical assessment and management of nocturnal eating disorders including night eating syndrome and particularly sleep-related eating disorder, which is a combination of parasomnia and eating disorder. There is an imminent need to develop evidence-based pharmacological and psychological treatments for management of nocturnal eating disorders and the sleep disturbances associated with daytime eating disorders.","PeriodicalId":130366,"journal":{"name":"Management of Sleep Disorders in Psychiatry","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124093587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}