Human Andrology最新文献_第8页

Evaluation of the effect of sildenafil and tadalafil on testosterone blood level 西地那非与他达拉非对血睾酮水平的影响

Human Andrology Pub Date : 2016-09-01 DOI: 10.1097/01.XHA.0000494745.37105.2f

A. Kandel, A. Esawy, Elsaied M. Khater

{"title":"Evaluation of the effect of sildenafil and tadalafil on testosterone blood level","authors":"A. Kandel, A. Esawy, Elsaied M. Khater","doi":"10.1097/01.XHA.0000494745.37105.2f","DOIUrl":"https://doi.org/10.1097/01.XHA.0000494745.37105.2f","url":null,"abstract":"BackgroundErectile dysfunction (ED) is the persistent inability to achieve and/or to maintain an erection for satisfactory sexual relations. In the corpus cavernosum, phosphodiesterase type 5 inhibitor (PDE5I) increase cyclic GMP concentration and cause smooth muscle relaxation of arteries and sinusoids, thus facilitating blood flow. As a consequence, PDE5I, such as sildenafil, tadalafil and vardenafil have proved to be effective, well-tolerated drugs in the treatment of ED. Increasing the frequency of sexual intercourse increases the circulating testosterone levels, and hence PDE5I therapy may affect testicular function of ED patients. ObjectiveThe aim of this study was to evaluate and compare the effect of sildenafil and tadalafil on testosterone blood level. Patients and methodsFifty-six married male patients with ED and age range 40–70 years with low–normal total testosterone level were included. Patients were randomly allocated into two groups: group I included 28 patients with ED who received 25 mg sildenafil once daily oral dose for 2 months, and group II included 28 patients with ED who received 5 mg tadalafil once daily oral dose for 2 months. Serum testosterone and luteinizing hormone (LH) levels were evaluated before starting the treatment and after 2 months of treatment. ResultsThere was increased total testosterone level, a significant decrease in LH and increased post-treatment International Index of Erectile Function values in both groups. There was a significant increase in values of post-treatment total testosterone level and International Index of Erectile Function and a significant decrease in post-treatment LH in group II compared with group I. ConclusionDaily use of sildenafil and tadalafil increased testosterone blood level but the effect was greater with tadalafil than with sildenafil.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"52 1","pages":"92–95"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75365434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Female ejaculation: who is going to sleep on the wet side of the bed? 女性射精:谁会睡在床湿的一边?

Human Andrology Pub Date : 2016-09-01 DOI: 10.1097/01.XHA.0000496448.21165.00

I. Younis, R. Salem

引用次数: 1

Delayed puberty 青春期延迟

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000475202.35073.5f

Alaa M.A. Abdel Aal

引用次数: 0

Management of hypogonadotropic hypogonadism in men with failed puberty 青春期失败男性促性腺功能减退症的治疗

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000479441.49042.58

I. Fahmy, M. Abdel-Salam

{"title":"Management of hypogonadotropic hypogonadism in men with failed puberty","authors":"I. Fahmy, M. Abdel-Salam","doi":"10.1097/01.XHA.0000479441.49042.58","DOIUrl":"https://doi.org/10.1097/01.XHA.0000479441.49042.58","url":null,"abstract":"Delayed, failed, or arrested puberty is the consequence of hypogonadism among adolescent boys. A variety of congenital and acquired conditions that affect the hypothalamus and/or the pituitary gland can lead to hypogonadotropic hypogonadism (HH). Congenital HH is mainly caused by genetic defects and is divided into two main categories based on the integrity of smell sensation: anosmic (Kallmann’s syndrome) and normosmic isolated HH. Hormonal evaluation is the key diagnostic tool for the assessment of hypogonadism and basically includes testosterone, follicle-stimulating hormone, and luteinizing hormone. In borderline cases, several stimulation tests can be used, including luteinizing-hormone-releasing hormone, human chorionic gonadotropin, and clomiphene. Other hormones or imaging tests may be needed according to the cause and clinical presentation. Hormone replacement therapy is the main target in the treatment of HH and it includes either androgen therapy or gonadotropin-releasing hormone (GnRH)/gonadotropin therapy. Androgen replacement therapy is indicated to improve the symptoms and signs of hypogonadism. To achieve conception, GnRH or gonadotropin therapies are used. The proper time to start therapy is not well defined. At least 6–36 months of uninterrupted therapy is needed to achieve conception. Assisted reproductive techniques are indicated in case of failure to achieve conception with GnRH or gonadotropin therapy, depending on the quantity and quality of sperms and the fertility potential of the female. If azoospermia persists, testicular sperm extraction combined with intracytoplasmic sperm injection provides a successful option. Reversal of hypogonadism may occur in some patients receiving gonadotropins; thus short periods of interruption of treatment are advised.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"28 1","pages":"52–59"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82850093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of quality of life and erectile dysfunction in a sample of diabetic Egyptian men 埃及男性糖尿病患者生活质量和勃起功能障碍的评估

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000482696.35333.b1

H. Morsy, Mohammed Essam, Mona Soliman, F. Badry

{"title":"Assessment of quality of life and erectile dysfunction in a sample of diabetic Egyptian men","authors":"H. Morsy, Mohammed Essam, Mona Soliman, F. Badry","doi":"10.1097/01.XHA.0000482696.35333.b1","DOIUrl":"https://doi.org/10.1097/01.XHA.0000482696.35333.b1","url":null,"abstract":"ObjectiveDiabetes mellitus may cause sexual dysfunction among men, medical complications, and psychological disturbances. This study was carried out to assess quality of life and erectile dysfunction among a sample of diabetic men. MaterialsIn the current study, we included 500 diabetic men attending the Andrology outpatient clinic, Diabetes outpatient clinic, diabetic foot outpatient clinic, Assiut University Hospitals, Egypt. The participants were evaluated using the Arabic version of the International Index of Erectile Function questionnaire and the Arabic version of SF-36 questionnaire. ResultsThe mean age was 53.13 ± 11.92 years. Of the 500 participants, erectile dysfunction was severe in 112 patients (22.4%), moderate in 82 patients (16.4%), mild-to-moderate in 116 patients (23.2%), mild in 158 patients (31.6%), and 32 patients (6.4%) had no impairment. Erectile dysfunction increased with age of participants, smoking, and duration of diabetes. ConclusionLifestyle changes and clinical management of accompanying medical complications with better understanding of the psychological problems that face diabetic people with erectile dysfunction can lead to better management and reduction of the incidence of erectile dysfunction.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"26 1","pages":"65–69"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90050893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Precocious puberty: a question to be answered 性早熟:一个有待回答的问题

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000473646.90564.16

T. Mostafa

{"title":"Precocious puberty: a question to be answered","authors":"T. Mostafa","doi":"10.1097/01.XHA.0000473646.90564.16","DOIUrl":"https://doi.org/10.1097/01.XHA.0000473646.90564.16","url":null,"abstract":"Precocious puberty (PP) is allied with accelerated growth, advanced bone age, development of secondary sex characteristics, and early closure of epiphysis. This article aimed to review PP in both sexes. A search for a review of published articles was carried out using PubMed, medical subject heading databases, and Scopus engine. Keywords used to accomplish these concerned associations were puberty, PP, adolescence, adrenarche, menarche, pubarche, and thelarche. Etiologically, PP is divided into gonadotropin-releasing hormone (GnRH)-dependent and GnRH-independent causes. GnRH-dependent PP [central precocious puberty (CPP)] is based on hypothalamic–pituitary–gonadal axis activation associated with progressive pubertal development, accelerated growth rate, and advanced skeletal age. CPP is one of the common forms of PP resembling the normal route of puberty at an age less than 8 and 9 years for girls and boys, respectively. Peripheral precocious puberty is related to sex steroid exposure independent of hypothalamic–pituitary–gonadal axis activation. Therapy is indicated in children with CPP with accelerated bone age, height progress, or psychosocial stress to halt puberty succession to a socially satisfactory age, allowing the child to achieve optimal height potential. GnRH analog is the treatment of preference, with best height result if initiated before 6 years of age.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"30 1","pages":"31–37"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91273207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of chlamydia antibody by using microimmunofluorescence in detection of tubal disease in infertile females 微免疫荧光衣原体抗体在不孕女性输卵管疾病检测中的作用

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000482836.97750.6d

S. A. A. Latif, H. Fekry, A. Altaf, M. Mohammed

引用次数: 0

Management of delayed puberty in boys: tips and tricks 男孩青春期延迟的管理:提示和技巧

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000479440.81161.a2

I. Abdel-Hamid

{"title":"Management of delayed puberty in boys: tips and tricks","authors":"I. Abdel-Hamid","doi":"10.1097/01.XHA.0000479440.81161.a2","DOIUrl":"https://doi.org/10.1097/01.XHA.0000479440.81161.a2","url":null,"abstract":"PurposeDelayed puberty (DP) is a common condition caused by the deficient production or action of gonadotropin-releasing hormone, gonadotropins, or androgens. It is often quite concerning to patients and can affect psychosocial well-being of patients. This review addresses developments in the diagnosis and treatment of male DP, highlighting some clinical tips and tricks in a question (Q) and answer (A) format. MethodsThe author searched electronic databases from 1966 to November 2015, including PubMed, MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using the following keywords: male, boys, adolescent, delayed puberty, diagnosis, and treatment. ResultsClinically, DP can be diagnosed in boys who lack testicular enlargement or secondary sexual development by 14 years or who do not progress to Tanner stage V 4.5 years after the onset of puberty. Constitutional delay of growth and puberty (CDGP) is the most common cause of DP. Initial workup should include a thorough history, physical examination, and targeted investigations. No single test is considered foolproof for differentiation between CDGP and hypogonadotropic hypogonadism (HH). Klinefelter’s syndrome may present with a lack of pubertal progress rather than delayed onset. Spontaneous puberty may start in patients with CDGP; otherwise HH should be reconsidered. Reversal and relapse may occur with HH. Induction of spermatogenesis may be an issue in some cases. ConclusionA range of options now exists for the management of DP. Current therapies have room for innovation in both pharmacological and assisted reproduction. The treating physician should be aware of new advances in the diagnosis and therapy.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"17 1","pages":"38–51"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88216105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual satisfaction among patients with erectile dysfunction on oral phosphodiesterase inhibitors and among patients with penile prosthetic implants 口服磷酸二酯酶抑制剂和阴茎假体植入的勃起功能障碍患者的性满意度

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000482835.83182.13

Rashad M. Mostafa, Yasser S. Nasralla, Atef I. Alakhras, Khalid A. Al-Hitaree

{"title":"Sexual satisfaction among patients with erectile dysfunction on oral phosphodiesterase inhibitors and among patients with penile prosthetic implants","authors":"Rashad M. Mostafa, Yasser S. Nasralla, Atef I. Alakhras, Khalid A. Al-Hitaree","doi":"10.1097/01.XHA.0000482835.83182.13","DOIUrl":"https://doi.org/10.1097/01.XHA.0000482835.83182.13","url":null,"abstract":"IntroductionErectile dysfunction (ED) is a global problem, and although oral phosphodiesterase-5 (PDE-5) inhibitor drugs have revolutionized the treatment of ED, there still are many cases who fail to respond to these drugs or who present with other pathologies that need the penile prosthetic implant (PPI) surgery. PurposeThe aim of the present study was to assess sexual satisfaction in ED patients on penile prosthesis and on oral PDE-5 inhibitors. Materials and methodsThis comparative, cross-sectional study included two groups of ED patients recruited from the Andrology Outpatient Clinic of Suez Canal University Hospital, Ismailia, Egypt: group 1, in which patients were treated with penile prosthesis implantation (29), and group 2, which included patients on PDE-5 inhibitors treatment (35). Patients were asked to answer a validated questionnaire (Erectile Dysfunction Inventory of Treatment Satisfaction). ResultsThe overall score of treatment satisfaction was significantly higher in the group treated with penile prosthesis surgery than that in the group treated with oral drugs: 93.55±7.34 versus 75.06±17.22. Libido and the frequency of intercourse increased with PPI. ConclusionPPI surgery is a valid and successful way of treating ED patients; it provides patients with a higher satisfaction rate than does oral PDE-5 inhibitor.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"61 1","pages":"70–73"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86914264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of soft-core pornography on female sexuality 软性色情对女性性欲的影响

Human Andrology Pub Date : 2016-06-01 DOI: 10.1097/01.XHA.0000481895.52939.a3

Sherine H. Abd El-Rahman, E. Sanad, H. Bayomy

{"title":"Effect of soft-core pornography on female sexuality","authors":"Sherine H. Abd El-Rahman, E. Sanad, H. Bayomy","doi":"10.1097/01.XHA.0000481895.52939.a3","DOIUrl":"https://doi.org/10.1097/01.XHA.0000481895.52939.a3","url":null,"abstract":"BackgroundIn the Arab world, consumption of soft-core pornography has increased in recent years. This type of pornography can motivate sexual behaviors that can affect health either positively or negatively. ObjectiveThe aim of this study was to evaluate the effect of soft-core pornography on female sexuality and to assess its effect on female sexual desire, orgasm, and vaginal lubrication. Participants and methodsThis is a cross-sectional study in which 200 sexually active married women were administered a self-filling questionnaire covering different aspects of female sexuality. All participants were free from any disease known to affect sexual function. ResultsIn total 52% of the participants and 59.5% of their husbands were positive watchers. An overall 51.6% of participants who were aware that their husbands were positive watchers reported experiencing negative emotions (depression, jealous), whereas 77% reported changes in their husbands’ attitude. Negative watchers were more satisfied with their sexual life compared with their counterparts. Although watching soft-core pornography had a statistically significant effect on sexual desire, vaginal lubrication, ability to reach orgasm, and masturbation, it had no statistically significant effect on coital frequency. ConclusionWatching soft-core pornography affects female sexual life by increasing sexual boredom in both men and women, causing relational difficulties.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"61 1","pages":"60–64"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90550801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1