Hormones最新文献

{"title":"Incidental thyroid nodules on COVID-19-related thoracic tomography scans: a giant cohort","authors":"Burcak Cavnar Helvacı, Didem Ozdemir, Kubra Turan, Caglar Keskin, Narin Nasiroglu İmga, Ahmet Dirikoc, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir","doi":"10.1007/s42000-023-00516-9","DOIUrl":"https://doi.org/10.1007/s42000-023-00516-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Computerized thoracic tomography (CT) imaging was extensively employed, especially in the early months of the COVID-19 pandemic. An incidental thyroid nodule (ITN) is defined as a nodule not previously detected or suspected clinically but identified via an imaging study. The present study aimed to determine the incidence of thyroid nodules incidentally detected in thoracic CTs for the suspicion of COVID-19 pneumonia.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>Adult patients who underwent thoracic CT in our hospital for COVID-19 management were retrospectively identified between March 2020 and September 2020. Medical information registered in the hospital and national health system was reviewed. The prevalence of incidental thyroid nodules at CT, thyroid function test results of patients with incidental lesions, correlation of CT findings with ultrasonography (US) findings, and fine-needle aspiration biopsy (FNAB) results were evaluated.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We analyzed 35,113 patients who had COVID-19-indicated CT scans. There was information about the thyroid gland in CT reports of 3049 patients. The prevalence of ITN was 3.82% (1343/35,113 patients) and thyroid heterogeneity was 1.11% (388/35,113 patients). While it was explicitly stated that no pathology was found in the patient’s thyroid gland in 3.75% of patients (1318/35,113), no information was given about the thyroid gland in 91.32% of the patients (32064/35,113). Thus, the number of patients informed about their thyroid was 3049 (8.68%) and the number of patients with thyroid pathology was 1731 (4.93%). It was observed that 308 of 1731 patients (17.80%) had follow-up thyroid US. An FNAB was indicated in 238 patients (87.50%). Of the 238 patients with indication for biopsy, only 115 (48.31%) underwent a thyroid FNAB. The cytological diagnosis was benign in 59 (51.30%), non-diagnostic in 30 (26.08%), atypia of uncertain significance in 22 (19.13%), and suspected follicular neoplasia/follicular neoplasia in four patients (3.46%). Thyroidectomy was performed in six more patients due to large nodules and the final diagnosis was benign in two and papillary thyroid cancer in three patients.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Increased use of thoracic CT during the COVID-19 pandemic probably enabled improved detection of ITNs. In this large-scale study, the prevalence of thyroid nodules reported with thoracic CT was 3.82%, while thyroid cancer was detected in 1.30% of patients evaluated with US. We recommend against using thoracic CT scans as a direct means of assessing thyroid disease owing to the low number of detected cancer cases in our cohort of 35,113 patients. However, thoracic CT scans obtained for various reasons might provide the opportunity for early diagnosis and treatment of thyroid disease, including cancers.</p>","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138692190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrinopathies in beta thalassemia: a narrative review","authors":"Theodora-Maria Venou, Fani Barmpageorgopoulou, Melpomeni Peppa, Efthimia Vlachaki","doi":"10.1007/s42000-023-00515-w","DOIUrl":"https://doi.org/10.1007/s42000-023-00515-w","url":null,"abstract":"<p>Beta thalassemia is the most common genetic blood disorder, characterized by reduced production or complete absence of beta-globin chains. The combination of systematic red blood cell transfusion and iron chelation therapy is the most readily available supportive treatment and one that has considerably prolonged the survival of thalassemia patients. Despite this, the development of endocrine abnormalities correlated with beta thalassemia still exists and is mostly associated with iron overload, chronic anemia, and hypoxia. A multifactorial approach has been employed to investigate other factors involved in the pathogenesis of endocrinopathies, including genotype, liver disease, HCV, splenectomy, socioeconomic factors, chelation therapy, and deficiency of elements. The development of specific biomarkers for predicting endocrinopathy risk has been the subject of extensive discussion. The objective of the present narrative review is to present recent data on endocrinopathies in beta thalassemia patients, including the prevalence, the proposed pathogenetic mechanisms, the risk factors, the diagnostic methods applied, and finally the recommended treatment options.</p>","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138692272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum testosterone with chronic obstructive pulmonary disease (COPD) in a nationally representative sample of White, Black, and Hispanic men","authors":"Samuel V. David, Derrick Gibson, Alejandro Villasante-Tezanos, Laith Alzweri, Jesus Gibran Hernández-Pérez, Luisa Elvira Torres-Sánchez, Jacques Baillargeon, David S. Lopez","doi":"10.1007/s42000-023-00506-x","DOIUrl":"https://doi.org/10.1007/s42000-023-00506-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The association between total testosterone (T) and chronic obstructive pulmonary disease (COPD), remains poorly understood. We aim to investigate this association and how it varies by smoking status, body fatness, and race/ethnicity in a nationally representative sample of American men.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Data included a full sample (NHANES 1988–1991, 1999–2004, 2011–2012) and subset sample (excluding 2011–2012, no estradiol and SHBG levels available) of 2748 and 906 men (≥20 years), respectively. COPD was measured by self-report or spirometry test. Total T (ng/mL) was measured among men who participated in a morning examination session. Weighted multivariable-adjusted logistic regression models were conducted.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Low T was positively associated with self-reported COPD in the full sample (OR = 2.10, 95% CI = 1.18–3.74, <i>P</i>_trend = 0.010), and when stratified by current smokers and body fatness. When examined across race and ethnicity strata, this association persisted among White men (OR = 2.50, 95% CI = 1.30–4.79, <i>P</i>_trend = 0.002) but not among Hispanic or Black men. In the subset sample, low T was positively associated with self-reported COPD (OR = 1.42, 95% CI, 0.57,3.55, <i>P</i>_trend = 0.04), including among smokers and White men, but not body fatness. No significant associations were observed with COPD defined with spirometry plus self-report.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Low levels of T were associated with an increased prevalence of self-reported COPD in the full and subset samples. Similar associations were observed after stratifying by smoking status, body fatness, and race/ethnicity in the full sample and subset sample. Prospective studies are warranted to confirm these significant associations among understudied and underserved populations.</p>","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138555498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of action of the epidermal growth factor. 3. Stimulation of the uptake of labeled precursors into RNA, DNA and proteins induced by EGF in isolated tumor cells.","authors":"I Covelli,&nbsp;R Mozzi,&nbsp;R Rossi,&nbsp;L Frati","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 3","pages":"183-91"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15775700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity of leucine stimulation of insulin release.","authors":"A Lernmark","doi":"10.1159/000178253","DOIUrl":"https://doi.org/10.1159/000178253","url":null,"abstract":"The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β -cells","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15453494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormones and water movement through the vertebrate intestine.","authors":"A J Matty,&nbsp;H M Noble","doi":"10.1159/000178257","DOIUrl":"https://doi.org/10.1159/000178257","url":null,"abstract":"A review of the current state of knowledge and speculation on fluid absorption by the gastro-intestinal tract of vertebrates and more specifically the role of hormones in fluid movement has been made.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 1","pages":"42-64"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15753878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioimmunoassay for human antithyroglobulin antibodies. I. The relationship between tanned cell haemagglutination and a double antibody technique.","authors":"G B Salabé,&nbsp;S Fontana,&nbsp;M Andreoli","doi":"10.1159/000178252","DOIUrl":"https://doi.org/10.1159/000178252","url":null,"abstract":"The present study describes a double antibody technique to evaluate antithyroglobulin autoantibodies in human serum. Rabbit anti-human γG is used to precipitate the immunocomplexes between labelled thyroglobulin and autoantibodies. Thyroglobulin has been labelled either in vivo, or chemically by electrolysis of iodide, a procedure which also produced substantial dissociation of the protein. The double antibody technique was compared with haemagglutination of sheep red blood cells coated with human thyroglobulin. A good correlation was established between the tanned red cell haemagglutination titre and the double antibody technique when ‘ in vivo’ labelled thyroglobulin was employed. The use of chemically iodinated thyroglobulin, purified after labelling, increased the sensitivity of the test 100 fold so that 38% of sera from patients with thyroid diseases having negative haemagglutination titres precipitate between 15% and 65% of the labelled antigen. The sensitivity and simplicity of this method provide a useful tool in clinical as well as in experimental work.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15230762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticoadrenal and adrenergic overactivity and hyperlipidemia in prolonged emotional stress.","authors":"A E Argüelles,&nbsp;M A Martínez,&nbsp;C Hoffman,&nbsp;G A Ortiz,&nbsp;M Chekherdemian","doi":"10.1159/000178266","DOIUrl":"https://doi.org/10.1159/000178266","url":null,"abstract":"A group of 23 Air Force Lieutenant Colonels who attended a long General Staff Course were studied with assays of blood lipid fractions, 11-hydroxycorticoids and excretion of epinephrine, norepinephrin","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 3","pages":"167-74"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15373495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake and oxidation of glutamic acid in mammalian pancreatic islets.","authors":"J Sehlin","doi":"10.1159/000178265","DOIUrl":"https://doi.org/10.1159/000178265","url":null,"abstract":"Microdissected islets from obese-hyperglycemic mice were used to study the uptake, oxidation and insulin-releasing capacity of glutamic acid. Glutamic acid was taken up slowly by the islets, yielding distribution ratios around unity. The uptake of glutamic acid was depressed by alanine, whereas glucose had a minor stimulatory effect Glibenclamide, leucine, arginine or galactose had no effect on the uptake of glutamic acid. The low rate of oxidationof glutamic acid was substantially increased when glucose was added to the incubation medium. Glutamic acid did not stimulate insulin release regardless of whether glucose was present in the incubation medium. The data suggest that the pancreatic β-cells are equipped with membrane transport systems for glutamic acid which do not serve as trigger sites for insulin release.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 3","pages":"156-66"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15733161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thyroidectomy and of several goitrogens on -glucuronidase activity and insulin levels of rats.","authors":"T Jolin,&nbsp;J Nuñez,&nbsp;R J Mora","doi":"10.1159/000178273","DOIUrl":"https://doi.org/10.1159/000178273","url":null,"abstract":"Thyroidectomized rats present lower plasma β -glucuronidase activity than age-paired controls. A very small daily dose of L-thyroxine (0.2 µg/100 g body wt.) which reinitiated growth","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 4","pages":"228-34"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15753477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}