Henry Ford Hospital medical journal最新文献_第5页

Evaluation of children with medullary thyroid carcinoma. 儿童甲状腺髓样癌的评价。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

A Libroia, F Muratori, U Verga, G Di Sacco, A Grattieri, D Gelli

引用次数: 0

The epidemiology of prostate cancer in black men. 黑人男性前列腺癌的流行病学。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

D A Burks, R H Littleton

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Training the urban health care provider: one department's first steps. 培训城市卫生保健提供者:一个部门的第一步。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

J Schindler

引用次数: 0

The structure and function of urban pharmacies: visits to community pharmacies in inner-city Chicago. 城市药房的结构与功能:对芝加哥内城社区药房的考察。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

T J Reutzel, L A Wilson

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The emerging role of HTLV-I/II and HIV-1 among intravenous drug users in Detroit. HTLV-I/II和HIV-1在底特律静脉注射吸毒者中的新作用。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

A F Ognjan, C A Lewandowski, B T Belian, J Burczak, N Markowitz, H Lee, L D Saravolatz

{"title":"The emerging role of HTLV-I/II and HIV-1 among intravenous drug users in Detroit.","authors":"A F Ognjan, C A Lewandowski, B T Belian, J Burczak, N Markowitz, H Lee, L D Saravolatz","doi":"","DOIUrl":"","url":null,"abstract":"During 1987-1988, a seroprevalence study of the human immunodeficiency virus (HIV-1) and the human T-cell lymphoma/leukemia virus (HTLV-I/II) was performed among Detroit intravenous drug users unaffiliated with substance abuse programs. Seroprevalence data along with patient demographic information were compared to a similar study performed in 1985-1986. In the earlier study, 12 (12.5%) of 96 individuals tested positive for HIV-1. Of the 74 available negative samples retested in 1987-1988 for retroviruses, 7 (9.5%) tested positive for HTLV-I/II. Thus, the overall retroviral (HIV-1, HTLV-I/II) seropositive rate for 1985-1986 was 22%. In 1987-1988, 11 (15.7%) of 70 individuals tested positive for HIV-1 and 7 (10%) tested positive for HTLV-I/II. Concomitant infection with both viruses was found in 2 (2.9%) of the 70 individuals. Thus, retrovirus seroprevalence in 1987-1988 was 22.9%. In 1987-1988, significant differences between the retroviral-positive group and the retroviral-negative group consisted of intravenous drug use greater than 16 years (P = 0.059) for an odds ratio of 3.80 (CI 1.12-12.89) and sex with female prostitutes (P = 0.029) for an odds ratio of 5.38 (CI 1.38-20.95).","PeriodicalId":12988,"journal":{"name":"Henry Ford Hospital medical journal","volume":"40 1-2","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12599796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Ca2+ sensing in C-cells and parathyroid cells. 细胞外Ca2+感应在c细胞和甲状旁腺细胞。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

H Scherubl, M L Brandi, J Hescheler

{"title":"Extracellular Ca2+ sensing in C-cells and parathyroid cells.","authors":"H Scherubl, M L Brandi, J Hescheler","doi":"","DOIUrl":"","url":null,"abstract":"An essential function of C-cells and parathyroid cells is to monitor the extracellular Ca2+ concentration. The Ca(2+)-dependent secretion of calcitonin (CT) and parathyroid hormone is known to be mediated by corresponding changes in the intracellular Ca2+ concentration. To address the question of whether Ca2+ influx through voltage-dependent Ca2+ channels couples the extracellular to the intracellular Ca2+, we applied the patch clamp technique to C-cells of the rMTC 44-2 cell line and to parathyroid cells of the PT-r cell line. The rMTC cells displayed dihydropyridine-sensitive, voltage-dependent, high-threshold Ca2+ channels which allowed ion influx even at the resting potential of about -40 mV. Increases of the concentration of the extracellular divalent cation or adding the Ca2+ channel agonist Bay K 8644 stimulated the steady state ion influx. In contrast, PT-r cells exhibited only fast inactivating, low-threshold Ca2+ channel currents with no steady state conductivity for Ca2+ at the resting potential of around -40 mV. We conclude that dihydropyridine-sensitive Ca2+ channels allow steady state transmembranous Ca2+ influx in C-cells, thereby increasing the cytosolic Ca2+ and CT secretion. Parathyroid cells, however, lack long-lasting Ca2+ channel currents and obviously sense the extracellular Ca2+ concentration by other mechanisms.","PeriodicalId":12988,"journal":{"name":"Henry Ford Hospital medical journal","volume":"40 3-4","pages":"303-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12457618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urban health and the social contract: poverty, race, and death. 城市健康和社会契约:贫穷、种族和死亡。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

H J Geiger

引用次数: 0

Role of insulin-like growth factor-I in the autocrine regulation of cell growth in TT human medullary thyroid carcinoma cells. 胰岛素样生长因子- 1在TT人甲状腺髓样癌细胞生长的自分泌调节中的作用。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

K P Yang, N A Samaan, Y F Liang, S G Castillo

引用次数: 0

Microsurgical lymph node dissection for metastatic asymptomatic C-cell carcinoma. 转移性无症状c细胞癌的显微手术淋巴结清扫。

Henry Ford Hospital medical journal Pub Date : 1992-01-01

H J Buhr, F Kallinowski, F Raue, C Herfarth

引用次数: 0

High-sensitivity serum calcitonin assays applied to screening for thyroid C-cell disease in multiple endocrine neoplasia type 2A. 高灵敏度血清降钙素测定在多发性内分泌肿瘤2A型甲状腺c细胞病筛查中的应用

Henry Ford Hospital medical journal Pub Date : 1992-01-01

M M Kaplan, G M Stall, T Cummings, A MacAulay, P Motté, H J Wolfe, S Reichlin, A H Tashjian

{"title":"High-sensitivity serum calcitonin assays applied to screening for thyroid C-cell disease in multiple endocrine neoplasia type 2A.","authors":"M M Kaplan, G M Stall, T Cummings, A MacAulay, P Motté, H J Wolfe, S Reichlin, A H Tashjian","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: Two serum calcitonin assays with sensitivities < or = 10 pg/mL were compared to our standard radioimmunoassay (sensitivity 100 pg/mL) in multiple endocrine neoplasia type 2A (MEN 2A) screening. Values from the Nichols displacement radioimmunoassay averaged 38% higher than values from the CIS immunoradiometric assay; values from both were highly correlated, r = 0.845. In three individuals, both of the newer assays revealed abnormalities in pentagastrin tests three to four years before abnormalities were detected by the standard assay. Pentagastrin tests after total thyroidectomy were assayed by the newer methods in patients with medullary thyroid carcinoma (MTC) diagnosed at initial testing (group I); in patients with early MTC diagnosed by prospective screening (group II); and in patients with pure C-cell hyperplasia detected by prospective screening (group III). At least 64% of group I, at least 25% of group II, but none of group III had detectable postoperative C-cell function.Conclusions: 1) The previous estimate of 12 years as median age of onset of C-cell disease in MEN 2A is probably three to four years too old. 2) Patients diagnosed with early MTC by screening had not necessarily skipped a preneoplastic phase of C-cell hyperplasias. At least some early disease was not detected by the standard assay. Higher sensitivity assay should improve screening for C-cell disease by earlier disease detection. 3) Biochemical cure by thyroidectomy after the development of MTC is not as frequent as previously thought, but the apparent cure rate of pure C-cell hyperplasia remains 100%.","PeriodicalId":12988,"journal":{"name":"Henry Ford Hospital medical journal","volume":"40 3-4","pages":"227-31"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12535691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0