Hepato-gastroenterology最新文献_第8页

Clinical implication of peritoneal cytology in the pancreatic cancer patients who underwent curative resection followed by adjuvant gemcitabine or S-1 chemotherapy. 胰腺癌患者行根治性切除后辅助吉西他滨或S-1化疗腹膜细胞学的临床意义。

Hepato-gastroenterology Pub Date : 2015-01-20 DOI: 10.1200/JCO.2015.33.3_SUPPL.252

T. Aoyama, Yusuke Katayama, M. Murakawa, M. Shiozawa, M. Morimoto, N. Yamamoto, T. Yoshikawa, Y. Rino, M. Masuda, S. Morinaga

{"title":"Clinical implication of peritoneal cytology in the pancreatic cancer patients who underwent curative resection followed by adjuvant gemcitabine or S-1 chemotherapy.","authors":"T. Aoyama, Yusuke Katayama, M. Murakawa, M. Shiozawa, M. Morimoto, N. Yamamoto, T. Yoshikawa, Y. Rino, M. Masuda, S. Morinaga","doi":"10.1200/JCO.2015.33.3_SUPPL.252","DOIUrl":"https://doi.org/10.1200/JCO.2015.33.3_SUPPL.252","url":null,"abstract":"BACKGROUND/AIMS\u0000The clinical implications of peritoneal lavage cytology (CY) status in the patients who received curative resection and adjuvant chemotherapy have not been established.\u0000\u0000\u0000METHODOLOGY\u0000We retrospectively analyzed clinical data from 143 consecutive patients who underwent macroscopically curative resection and received adjuvant gemcitabine or S-1 chemotherapy for pancreatic cancer from 2005 to 2014 in our institution. Correlations between CY status and survival and clinicopathological features were investigated.\u0000\u0000\u0000RESULTS\u0000Of the 143 patients, 21 patients were peritoneal washing cytology positive (CY+) (14.7%). Although significant difference was observed in the tumor size, no other correlation between cytology status and clinicopathological parameter existed. The recurrence free survival (RFS) rates at 3 and 5 years after surgery were 5.1% and 0% in CY+ patients, respectively, and were 21.5% and 16.1% in peritoneal washing cytology negative (CY-) patients, respectively, which were significantly different (p=0.001). The OS rates at 3 and 5 years after surgery were 17.1% and 8.6% in CY+ patients, respectively, and were 26.1% and 16.1% in CY- patients, respectively, which were trend to worse in the CY+ patients (p=0.254).\u0000\u0000\u0000CONCLUSION\u0000The patients with CY+ are likely to experience recurrence, even after they received curative resection and adjuvant Gemcitabine or S-1 adjuvant chemotherapy.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"157 1","pages":"200-6"},"PeriodicalIF":0.0,"publicationDate":"2015-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65879553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Living donor right lobe liver transplantation as a treatment for hepatic alveolar echinococcosis: report of three cases. 活体右叶肝移植治疗肝肺泡包虫病3例报告。

Hepato-gastroenterology Pub Date : 2015-01-01

Tolga Demirbas, Murat Akyildiz, Murat Dayangac, Onur Yaprak, Gulen Dogusoy, Nuray Bassullu, Yildiray Yuzer, Yaman Tokat

引用次数: 0

A new strategy with a grading system for liver metastases from colorectal cancer. 结直肠癌肝转移分级的新策略

Hepato-gastroenterology Pub Date : 2015-01-01

Koji Komeda, Michihiro Hayashi, Yoshihiro Inoue, Tetsunosuke Shimizu, Mitsuhiro Asakuma, Fumitoshi Hirokawa, Yoshiharu Miyamoto, Kazuhisa Uchiyama

{"title":"A new strategy with a grading system for liver metastases from colorectal cancer.","authors":"Koji Komeda, Michihiro Hayashi, Yoshihiro Inoue, Tetsunosuke Shimizu, Mitsuhiro Asakuma, Fumitoshi Hirokawa, Yoshiharu Miyamoto, Kazuhisa Uchiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: The optimal indications, including timing, for resection of liver metastases from colorectal cancer (CRCLM) remain controversial. The Japanese Society of Cancer of the Colon and Rectum has proposed \"H-classification\" based on the maximum size and number of CRCLM, and has advocated the \"CRCLM-grade system\", which involves adding the presence of primary lymph node metastasis status to H-classification. We evaluated clinicopathological factors in order to elucidate the optimal indications for and timing of hepatectomy.Methodology: Ninety-six patients who underwent initial hepatectomy for CRCLM between August 1995 and May 2009 were retrospectively analyzed with respect to characteristics of primary colorectal metastatic hepatic tumors, operation details and prognosis.Results: Multivariate analysis identified depth of invasion in primary colorectal cancer (within sub-serosal (non-se) vs. beyond serosal (se)) and CRCLM-grade as independent risk factors. We then performed analyses using the combination of non-se/se and CRCLM-grade. Kaplan-Meier analysis identified significant differences between non-se+gradeA and se+gradeA, between non-se+gradeB and se+gradeB, and between non-se+gradeC and se+gradeC groups.Conclusions: We could retrospectively predict survival in CRCLM patients by adopting this new simple classification. This method may allow more precise assessment of operative indications and timing for both operations and perioperative adjuvant treatment.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"111-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33125419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and mortality of liver cancer in mainland China: changes in first decade of 21st century. 中国大陆肝癌发病率和死亡率:21世纪第一个十年的变化。

Hepato-gastroenterology Pub Date : 2015-01-01

Rui Wang, Xin-Zu Chen, Ming-Guang Zhang, Li Tang, Hao Wu

{"title":"Incidence and mortality of liver cancer in mainland China: changes in first decade of 21st century.","authors":"Rui Wang, Xin-Zu Chen, Ming-Guang Zhang, Li Tang, Hao Wu","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: To longitudinally analyze changes of primary liver cancer incidence and mortality in mainland China during the first decade of 21st century.Methodology: Available data of crude incidence and mortality of primary liver cancer from annual reports of the National Central Cancer Registry in mainland China were retrieved and analyzed.Results: Either the incidence or mortality of primary liver cancer in mainland China kept increasing and didn't reach peaks during the first decade of the 21st century, particularly among the female population with great incremental rates of incidence (8.76%) and mortality (11.99%) at 2007-2008 and 2009-2010, respectively. The crude incidence increased from 26.18/100,000 persons at 2004 to 29.00/100,000 persons at 2010, while the crude mortality from 25.08/100,000 persons to 28.10/100,000 persons (r=0.857, p=0.014). The incidence and mortality in males kept 2.5-2.9 folds to those in females. The incidence and mortality in rural region were always higher than those in urban regions, but among males both tended to decline in rural region, while in contrast increased in urban region.Conclusions: Liver cancer still has high incidence and mortality in mainland China, and further effort is required to prevent and control liver cancer, particularly for male and rural population.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"118-21"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33125420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative treatment and percutaneous catheter drainage improve outcome of necrotizing pancreatitis. 保守治疗和经皮导管引流可改善坏死性胰腺炎的预后。

Hepato-gastroenterology Pub Date : 2015-01-01

Junjun Sun, Cheng Yang, Weifeng Liu, Yanhui Yang, Shifang Qi, Zhijie Chu, Shiyong Xin, Xiaohui Zhang

{"title":"Conservative treatment and percutaneous catheter drainage improve outcome of necrotizing pancreatitis.","authors":"Junjun Sun, Cheng Yang, Weifeng Liu, Yanhui Yang, Shifang Qi, Zhijie Chu, Shiyong Xin, Xiaohui Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: To investigate the clinical effects of the maximum conservative treatment algorithm with percutaneous catheter drainage (PCD) as the first choice for necrotizing pancreatitis (NP).Methodology: Retrospectively analyzed NP patients who had fine needle aspiration (FNA) for proven infection of necrosis which was considered an indication for surgery (n=22, group 1) compared to patients subjected to maximum conservative treatment with PCD in NP patients (n=30, group 2).Results: On admission, most baseline data did not show any statistical difference between the two groups, In group 2, all patients were implemented maximum conservative treatment, 25 of 30 patients were cured by PCD (83.3%), open necrosectomy were needed for 3 patients (10.0%) and 2 dead during hospitalization (6.7%). Whereas, in group 1, surgical operation rate was 45.6% and hospital mortality 31.8%, both of the ratios differed significantly compared with group 2 (45.6% vs. 10%, P=0.004; 31.8% vs. 6.7%, P=0.046 respectively). Furthemore, Hospital stay were significantly higher in group 1 compared with group 2 (90±18.5 vs. 39±13.4; P=0.033).Conclusions: A conservative approach with PCD as the first choice to treatment NP might decrease the rate of surgical operation and mortality, and improve the outcome of NP.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33249363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

K-Ras mutation and prognosis of colorectal cancer: a meta-analysis. K-Ras突变与结直肠癌预后的meta分析

Hepato-gastroenterology Pub Date : 2015-01-01

Yuanyi Rui, Cun Wang, Zongguang Zhou, Xi Zhong, Yongyang Yu

{"title":"K-Ras mutation and prognosis of colorectal cancer: a meta-analysis.","authors":"Yuanyi Rui, Cun Wang, Zongguang Zhou, Xi Zhong, Yongyang Yu","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Kirsten ras (K-ras) gene is considered to participate in the progression from adenoma to carcinoma of colorectal neoplasms. The correlation between K-ras mutation and the prognosis of CRC is sill controversial. This study aimed at quantitatively summarizing the evidence for such a relationship.Methodology: The literature search was based on Pub Med. Population-based and hospital-based case-control studies concerning K-ras mutation and prognosis were eligible for analysis.Results: 13 literatures were included in the meta-analysis, with 1 multicenter study and 12 case control studies. Totally, 3771 patients were enrolled in the analysis, 1202 of which had K-ras mutation. There were significant difference between the survival of patients with normal and mutated K-ras gene, but no statistic differences were found between either Condon 12 or Condon 13 mutations and prognosis.Conclusion: Current available evidences demonstrated the K-ras mutation is a predictive molecular mark of colorectal cancer patients' survivals, further studies are needed to investigate the race difference and the relationship between certain K-ras mutation and prognosis.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33249641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional management of anastomotic leakage after colorectal cancer surgery using elemental diet jelly. 元素饮食胶对结直肠癌术后吻合口瘘的营养管理。

Hepato-gastroenterology Pub Date : 2015-01-01

A Ishibe, M Ota, A Kanazawa, J Watanabe, K Tatsumi, K Watanabe, T Godai, S Yamagishi, S Fujii, Y Ichikawa, C Kunisaki, I Endo

{"title":"Nutritional management of anastomotic leakage after colorectal cancer surgery using elemental diet jelly.","authors":"A Ishibe, M Ota, A Kanazawa, J Watanabe, K Tatsumi, K Watanabe, T Godai, S Yamagishi, S Fujii, Y Ichikawa, C Kunisaki, I Endo","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Anastomotic leakage is major complication of colorectal surgery. Total parenteral nutrition (TPN) and fasting are conservative treatments for leakage in the absence of peritonitis in Japan. Elemental diet (ED) jelly is a completely digested formula and is easily absorbed without secretion of digestive juices. The purpose of this study was to assess the safety of ED jelly in management of anastomotic leakage.Methodology: Six hundred and two patients who underwent elective surgery for left side colorectal cancer from January 2008 to December 2011 were included in the study. Pelvic drainage was performed for all patients. Sixty-three (10.5%) patients were diagnosed with an anastomotic leakage, and of these, 31 (5.2%) without diverting stoma were enrolled in this study.Results: Sixteen patients received TPN (TPN group) and 15 patients received ED jelly (ED group). The duration of intravenous infusion was significantly shorter in the ED group than in the TPN group (15 days versus 25 days, P= 0.008). In the TPN group, catheter infection was occurred in 2 patients who required re-insertion of the catheter.Conclusion: Conservative management of anastomotic leakage after colorectal surgery with ED jelly appears to be a safe and useful approach.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"30-3"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33249642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of single-incision laparoscopic surgery for colorectal cancer: a systematic literature review. 单切口腹腔镜手术治疗结直肠癌的价值:系统文献综述。

Hepato-gastroenterology Pub Date : 2015-01-01

Cong-Chao Ma, Ping Li, Liu-Hua Wang, Zhao-Yun Xia, Sheng-Wen Wu, Shao-Jun Wang, Chun-Ming Lu

{"title":"The value of single-incision laparoscopic surgery for colorectal cancer: a systematic literature review.","authors":"Cong-Chao Ma, Ping Li, Liu-Hua Wang, Zhao-Yun Xia, Sheng-Wen Wu, Shao-Jun Wang, Chun-Ming Lu","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Recently, single-incision laparoscopic colectomy (SILC) for colorectal malignancy is rapidly becoming the central issue for explorers of minimally invasive surgery worldwide. The aim of this systematic review was to establish the safety and efficacy of SILC for colorectal malignancy when implemented by experienced surgeons.Methodology: PubMed, WHO international trial register and Embase were searched for publications concerning SILC and MLC from 2000 to 2013, with the last search on September 10, 2013. Only pure single-incision laparoscopic colonic surgery for malignant disease was included. Primary outcomes were the early postoperative complication profiles of SILC. Secondary outcomes were duration of operation time, blood loss, lymph node yields, conversion rate, distal margin of the resected tumor, and duration of hospital stay.Results: Eight studies involving 547 patients met the inclusion criteria. Compared with multiport laparoscopic colectomy (MLC), SILC has less postoperative complication and bleeding. The conversion, the median lymph node retrieval, proximal margin of the resected tumor and distal margin of the resected tumor for malignant disease achieved with SILC was acceptable. There was no significant reduction in length of hospital stay with SILC.Conclusion: SILC is a technically reliable and realistic approach with short-term results similar to those obtained with the MLC procedure.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33249645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal growth factor receptor in CRC patients in the era of the RAS. RAS时代结直肠癌患者表皮生长因子受体的研究。

Hepato-gastroenterology Pub Date : 2015-01-01

Mustafa Teoman Yanmaz, Gokhan Demir, Sibel Erdamar, Serkan Keskin, Muhammet Fatih Aydin, Sebnem Izmir Guner

{"title":"Epidermal growth factor receptor in CRC patients in the era of the RAS.","authors":"Mustafa Teoman Yanmaz, Gokhan Demir, Sibel Erdamar, Serkan Keskin, Muhammet Fatih Aydin, Sebnem Izmir Guner","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to investigate EGFR expression patterns and the effect of EGFR expression on stage, prognosis and response to conventional chemotherapy agents other than monoclonal antibodies in CRC patients. This study included 59 metastatic CRC patients. The expression of EGFR was quantified by immunochemistry in biopsy specimens that were obtained before treatment was initiated. The cases were considered to be positive for EGFR if >1% of the tumor cells had complete circumferential membranous staining. The median age of the patients was 54.6 years, and 59% of the patients were male. Twenty-six patients presented with stage IV disease, and the remaining patients developed distant metastasis during follow-up. Fifty-one patients were treated with regimens containing irinotecan. The numbers of patients with EGFR expression in the primary tumors, the metastatic lymph nodes and the normal colonic tissue were 34 (65.4%), 10 (76.9%) and 34 (65.4%) respectively. The initial disease stage and lymph node stage were correlated with EGFR expression (p<0.05). Additionally, EGFR positivity was correlated with a statistically significant reduction in the response rate to chemotherapy, the overall survival (21 vs. 28 months) and the progression-free survival (15 vs. 22 months) in metastatic patiens treated with chemotherapy other than targeted therapies. In conclusion, EGFR expression in correlated with stage in all CRC patients and response to chemotherapy and survival in metastatic CRC patients.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 137","pages":"40-4"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33249647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic gastrectomy for gastric cancer in China: an overview. 中国腹腔镜胃癌切除术:综述。

Hepato-gastroenterology Pub Date : 2015-01-01

Huanrong Lan, Naibiao Zhu, Yuefu Lan, Ketao Jin, Lisong Teng

引用次数: 0