Gut and Liver最新文献

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Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations. 优化英夫利昔单抗在真实世界炎症性肠病中的使用:从整合静脉注射和皮下制剂的人群药代动力学模型的见解。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-05-15 DOI: 10.5009/gnl250154
Sung Hoon Jung, Sang-Bum Kang
{"title":"Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations.","authors":"Sung Hoon Jung, Sang-Bum Kang","doi":"10.5009/gnl250154","DOIUrl":"10.5009/gnl250154","url":null,"abstract":"","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":"19 3","pages":"299-300"},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Differences in the Effect of Changes in Body Mass Index on the Risk of Developing Gastric Cancer: Findings from a Nationwide Retrospective Cohort Study. 体重指数变化对胃癌发生风险影响的性别差异:一项全国性回顾性队列研究的结果
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-04-25 DOI: 10.5009/gnl240555
Jieun Jang, Yonghoon Choi, Nayoung Kim
{"title":"Sex Differences in the Effect of Changes in Body Mass Index on the Risk of Developing Gastric Cancer: Findings from a Nationwide Retrospective Cohort Study.","authors":"Jieun Jang, Yonghoon Choi, Nayoung Kim","doi":"10.5009/gnl240555","DOIUrl":"https://doi.org/10.5009/gnl240555","url":null,"abstract":"<p><strong>Background/aims: </strong>This study examined sex differences in the effect of changes in body mass index (BMI) on the development of gastric cancer (GC) in South Korea.</p><p><strong>Methods: </strong>Using data from the National Health Insurance Service-Health Screening Cohort, a retrospective cohort study involving 333,169 Koreans with a median follow-up of 12 years was conducted. BMI was categorized into five groups (<18.5, 18.5-22.9, 23.0-24.9 [reference], 25.0-29.9, and ≥30.0 kg/m<sup>2</sup>) and the risk of developing GC was evaluated according to changes in BMI by calculating the hazard ratio (HR) using Cox proportional hazard regression.</p><p><strong>Results: </strong>Among males, BMI ≥30.0 kg/m<sup>2</sup> was associated with a 1.27-fold higher overall risk of developing GC (95% confidence interval [CI], 1.02 to 1.57), but not in females. For non-cardia GC, a U-shaped association between BMI and risk of developing GC was observed in males, although statistical significance was observed only for BMI 18.5-22.9 kg/m<sup>2</sup>. Additionally, an increase in BMI to 23.0-24.9 kg/m<sup>2</sup> was associated with a decreased non-cardia GC risk among males. In females, the largest waist circumference category was significantly associated with an increased risk of developing overall GC (HR, 1.37; 95% CI, 1.07 to 1.74).</p><p><strong>Conclusions: </strong>This study demonstrated that maintaining a BMI in the range of 23.0-24.9 kg/m<sup>2</sup> is optimal for minimizing the risk of non-cardia GC, particularly in males. In females, visceral obesity, represented by a large waist circumference as a proxy, was associated with an increased risk of developing GC.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models. 改进肝细胞癌的免疫治疗:从患者和临床前模型中学习。
IF 3.2 3区 医学
Gut and Liver Pub Date : 2025-04-03 DOI: 10.1038/s44355-025-00018-y
Romain Desert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder, Pierre Nahon, Thomas F Baumert
{"title":"Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models.","authors":"Romain Desert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder, Pierre Nahon, Thomas F Baumert","doi":"10.1038/s44355-025-00018-y","DOIUrl":"10.1038/s44355-025-00018-y","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC), the third cause of cancer-related deaths worldwide, continues to present significant therapeutic challenges. Despite significant therapeutic advancement in the last decade, the efficacy of systemic treatments for patients with advanced HCC remains unsatisfactory. While the clinical introduction of immune checkpoint inhibitors has improved response rates and overall survival, their clinical success remains still limited. Here we provide a comprehensive review of current and emerging strategies aimed at enhancing the efficacy of immunotherapy for the treatment of HCC. Both clinical studies conducted in patients as well as studies in preclinical models have markedly advanced our understanding of resistance as well as uncovered novel approaches to overcome resistance. Recent progress is paving the way for improved efficacy and safety of novel approaches that will improve the dismal prognosis of patients with advanced HCC.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":"2 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics and Outcomes of Acute Mesenteric Ischemia in Young Adults: A KASID Multicenter Study. 青壮年急性肠系膜缺血的临床特征和结局:一项KASID多中心研究。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl250003
Sunghyeok Ryou, Kwangwoo Nam, Seong Ran Jeon, Joo Hye Song, Seong-Eun Kim
{"title":"Clinical Characteristics and Outcomes of Acute Mesenteric Ischemia in Young Adults: A KASID Multicenter Study.","authors":"Sunghyeok Ryou, Kwangwoo Nam, Seong Ran Jeon, Joo Hye Song, Seong-Eun Kim","doi":"10.5009/gnl250003","DOIUrl":"https://doi.org/10.5009/gnl250003","url":null,"abstract":"<p><strong>Background/aims: </strong>Acute mesenteric ischemia occurs mainly in elderly individuals; however, it can also affect young adults, and some of these patients experience a poor disease course because of delayed diagnosis and treatment. This study aimed to assess the clinical characteristics and outcomes of young adults with acute mesenteric ischemia.</p><p><strong>Methods: </strong>We retrospectively reviewed young adult patients aged 20 to 39 years diagnosed with acute mesenteric ischemia between 2002 and 2022 at four tertiary medical centers in Korea. Their clinical characteristics were compared with those of young middle-aged adults aged 40 to 49 years.</p><p><strong>Results: </strong>A total of 86 patients were included. The median age of the patients was 42 years, and 71% of the patients were male. Twenty-three percent of the patients had a history of abdominal procedures or surgery. The most common cause of acute mesenteric ischemia was mesenteric venous thromboembolism (33.7%), followed by mesenteric artery thromboembolism (30.2%), nonocclusive mesenteric ischemia (18.6%), and mesenteric artery dissection (17.4%). Patients aged 20 to 39 years were more frequently affected by mesenteric venous thromboembolism (44.0% vs 26.0%) and less frequently affected by mesenteric arterial thromboembolism (13.9% vs 42.0%) than patients aged 40 to 49 years (p=0.013). However, no significant differences were observed in terms of disease involvement, treatment method, or treatment outcome during follow-up (median, 769 days).</p><p><strong>Conclusions: </strong>Young adults with acute mesenteric ischemia may exhibit clinical characteristics distinct from those of young middle-aged adults. Venous thromboembolism is prominent etiology of acute mesenteric ischemia in young adults.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Validity of the AASLD Surgical Treatment Algorithm in Patients with Early-Stage Hepatocellular Carcinoma. 评估早期肝癌患者AASLD手术治疗算法的有效性。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2025-02-11 DOI: 10.5009/gnl240214
Aryoung Kim, Byeong Geun Song, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh, Dong Hyun Sinn
{"title":"Assessing the Validity of the AASLD Surgical Treatment Algorithm in Patients with Early-Stage Hepatocellular Carcinoma.","authors":"Aryoung Kim, Byeong Geun Song, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh, Dong Hyun Sinn","doi":"10.5009/gnl240214","DOIUrl":"10.5009/gnl240214","url":null,"abstract":"<p><strong>Background/aims: </strong>The aim of this study was to investigate the effect of a surgical treatment algorithm recently proposed by the American Association for the Study of Liver Diseases (AASLD) on survival outcomes in patients with early-stage hepatocellular carcinoma (HCC) and identify effective alternative treatment modalities when liver transplantation (LT) is not available.</p><p><strong>Methods: </strong>We studied the clinical data of 1,442 patients who were diagnosed with early-stage HCC (a single lesion measuring 2-5 cm in size or 2 to 3 lesions measuring ≤3 cm in size) between 2013 and 2018 and classified as Child-Turcotte-Pugh (CTP) A or B. Analyses were separately performed for individuals recommended for resection (single lesion, CTP A and no clinically significant portal hypertension) and those recommended for LT (single lesion with impaired liver function such as CTP B or clinically significant portal hypertension or multiple lesions).</p><p><strong>Results: </strong>Of 791 patients recommended for surgical resection, 85.8% underwent resection. The 5-year survival rate was higher for patients who underwent surgical resection than for those who received other treatments (89.4% vs 72.3%). Among 651 patients recommended for LT, only 3.4% underwent the procedure. The most common alternative treatment modalities were transarterial therapy (39.3%) followed by resection (28.9%) and ablation (27.8%). The overall survival rate associated with transarterial therapy was lower than that for resection and ablation, whereas that of the latter two treatments were comparable.</p><p><strong>Conclusions: </strong>The survival outcomes of treatment strategies that most closely aligned with the algorithm proposed by the AASLD were superior to those of alternative treatment approaches. However, LT in patients with early-stage HCC can be challenging. When LT is not feasible, resection and ablation can be considered first-line alternative options.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":"265-274"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Long Noncoding RNA DUXAP8 Facilitates the Malignant Progression of Colon Cancer via the microRNA-378a-3p/FOXQ1 Axis. 长非编码 RNA DUXAP8 通过 microRNA-378a-3p/FOXQ1 轴促进结肠癌的恶性进展
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2024-11-20 DOI: 10.5009/gnl240178
Rui Shang, Jianqin Jin, Yuecheng Wang
{"title":"The Long Noncoding RNA DUXAP8 Facilitates the Malignant Progression of Colon Cancer via the microRNA-378a-3p/FOXQ1 Axis.","authors":"Rui Shang, Jianqin Jin, Yuecheng Wang","doi":"10.5009/gnl240178","DOIUrl":"10.5009/gnl240178","url":null,"abstract":"<p><strong>Background/aims: </strong>The long noncoding RNA DUXAP8 is a pivotal regulator in cancer pathogenesis, but the molecular mechanism underlying the role of DUXAP8 in colon cancer progression is underexplored.</p><p><strong>Methods: </strong>In addition to bioinformatic analyses, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to assess DUXAP8, microRNA-378a-3p, FOXQ1 expression in colon cancer tissues, and clinical data were analyzed to determine the correlation between DUXAP8 expression and colon cancer patient outcomes. Nuclear/cytoplasmic RNA fractionation was utilized to analyze the subcellular distribution of DUXAP8. Dual-luciferase and RNA immunoprecipitation assays were performed to confirm the binding of DUXAP8/FOXQ1 and microRNA-378a-3p. After cell transfection, qRT-PCR was performed to evaluate the modulatory relationship of DUXAP8/microRNA-378a-3p/FOXQ1. Cell Counting Kit-8, MTT, scratch healing, and Transwell assays were performed to evaluate the impact of DUXAP8/microRNA-378a-3p/FOXQ1 expression on colon cancer cell functions.</p><p><strong>Results: </strong>The results revealed that the expression of DUXAP8 and FOXQ1 was upregulated in colon cancer tissues, while the expression of microRNA-378a-3p was down-regulated. The increased DUXAP8 expression was positively correlated with lymph node metastasis and TNM stage. Dual-luciferase and RNA immunoprecipitation assays demonstrated that DUXAP8 was a sponge for microRNA-378a-3p and targeted the ability of microRNA-378a-3p to regulate FOXQ1. In addition, functional experiment results revealed that overexpressed DUXAP8 facilitated the growth and migratory ability of colon cancer cells. DUXAP8 also reversed the tumor-suppressive effect of microRNA-378a-3p. However, silencing FOXQ1 could reverse the cancer-promoting effects of high DUXAP8 expression.</p><p><strong>Conclusions: </strong>DUXAP8 expression was significantly increased in colon cancer, which was associated with lymph node metastasis and unfavorable outcomes in colon cancer patients. DUXAP8 may hasten malignant progression of colon cancer cells through its effects on microRNA-378a-3p/FOXQ1.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":"219-235"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features. 韩国胃肿瘤患者的自身免疫性胃炎:临床病理相关性和诊断性组织学特征
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2024-11-07 DOI: 10.5009/gnl240223
Soomin Ahn, Tae-Se Kim, Ryoji Kushima, Jun Haeng Lee, Kyoung-Mee Kim
{"title":"Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features.","authors":"Soomin Ahn, Tae-Se Kim, Ryoji Kushima, Jun Haeng Lee, Kyoung-Mee Kim","doi":"10.5009/gnl240223","DOIUrl":"10.5009/gnl240223","url":null,"abstract":"<p><strong>Background/aims: </strong>Autoimmune gastritis (AIG) is a corpus-dominant atrophic gastritis in which patients are positive for antiparietal cell antibody (APCA) and/or anti-intrinsic factor antibody. The risk of developing gastric cancer in patients with AIG remains unclear, and reliable frequency data of AIG in patients with gastric cancer are lacking.</p><p><strong>Methods: </strong>We included 624 Korean patients with gastric tumors (612 gastric cancers and 12 neuroendocrine tumors) who had APCA results and were available for AIG evaluation. In patients with positive APCA results, endoscopy and histology findings were reviewed to diagnose AIG.</p><p><strong>Results: </strong>Of the 624 patients, 37 (5.9%) tested positive for APCA, and ultimately, 11 (1.8%) met the diagnostic criteria for AIG (5 both endoscopy and histology findings, 4 endoscopy-only findings, 2 histology-only findings). The frequency of AIG in patients with gastric cancer was 1.3% (8/612), and that in patients with neuroendocrine tumors was 25.0% (3/12). Of the 11 patients with AIG, serum <i>Helicobacter pylori</i> antibody was positive in six patients (54.5%), all of whom had gastric cancer. Histologically, three patients showed pure AIG, four patients exhibited concurrent AIG and <i>H. pylori</i> gastritis, and the findings for four were indefinite for AIG. The pepsinogen (PG) I levels and PG I/II ratio were significantly lower in patients with gastric cancer with AIG than in patients with gastric cancer without AIG (p=0.042 and p=0.016, respectively).</p><p><strong>Conclusions: </strong>The frequency of AIG in gastric cancer patients was very low compared to that in patients with neuroendocrine tumors. Rather, concurrent AIG and <i>H. pylori</i> gastritis was common in patients with AIG with gastric cancer.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":"177-188"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiety and Depression Are Associated with Poor Long-term Quality of Life in Moderate-to-Severe Ulcerative Colitis: Results of a 3-Year Longitudinal Study of the MOSAIK Cohort. 焦虑和抑郁与中重度溃疡性结肠炎患者长期生活质量低下有关:MOSAIK队列3年纵向研究结果。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2024-11-07 DOI: 10.5009/gnl240146
Shin Ju Oh, Chang Hwan Choi, Sung-Ae Jung, Geun Am Song, Yoon Jae Kim, Ja Seol Koo, Sung Jae Shin, Geom Seog Seo, Kang-Moon Lee, Byung Ik Jang, Eun Suk Jung, Youngdoe Kim, Chang Kyun Lee
{"title":"Anxiety and Depression Are Associated with Poor Long-term Quality of Life in Moderate-to-Severe Ulcerative Colitis: Results of a 3-Year Longitudinal Study of the MOSAIK Cohort.","authors":"Shin Ju Oh, Chang Hwan Choi, Sung-Ae Jung, Geun Am Song, Yoon Jae Kim, Ja Seol Koo, Sung Jae Shin, Geom Seog Seo, Kang-Moon Lee, Byung Ik Jang, Eun Suk Jung, Youngdoe Kim, Chang Kyun Lee","doi":"10.5009/gnl240146","DOIUrl":"10.5009/gnl240146","url":null,"abstract":"<p><strong>Background/aims: </strong>We previously reported that patients with moderate-to-severe ulcerative colitis (UC) often experience common mental disorders (CMDs) such as anxiety and depression, necessitating immediate psychological interventions within the first 4 weeks of diagnosis. In this 3-year follow-up study of the MOSAIK cohort in Korea, we examined the effects of CMDs at initial diagnosis on clinical outcomes and health-related quality of life (HRQoL).</p><p><strong>Methods: </strong>We examined differences in clinical outcomes (evaluated based on clinical response, relapse, hospitalization, and medication use) and HRQoL (assessed using the Inflammatory Bowel Disease Questionnaire [IBDQ] and Short Form 12 [SF-12]) according to Hospital Anxiety and Depression Scale (HADS) scores at diagnosis.</p><p><strong>Results: </strong>In a study involving 199 UC patients, 47.7% exhibited significant psychological distress (anxiety and/or depression) at diagnosis. Clinical follow-up showed no major differences in outcomes, including remission rates, response rates, or hospitalization rates, between patients with anxiety or depression at diagnosis and patients without anxiety or depression at diagnosis. The HRQoL at the end of follow-up was notably lower in those with baseline CMDs, particularly anxiety, across all domains of the IBDQ and SF-12. Linear mixed-effect models revealed that higher HADS scores, as well as higher Mayo scores, were independently associated with lower IBDQ scores and both summary domains of the SF-12. Additionally, regular attendance at follow-up visits during the study period was also related to improvements in HRQoL (all p<0.05).</p><p><strong>Conclusions: </strong>While CMDs present at the time of UC diagnosis did not influence long-term clinical outcomes, they persistently impaired HRQoL. Our findings support the routine incorporation of psychological interventions into the long-term management of moderate-to-severe UC.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":"253-264"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in Endoscopic Treatment for Gastric Subepithelial Tumors. 胃上皮下肿瘤的内镜治疗进展。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2025-01-08 DOI: 10.5009/gnl240358
Osamu Goto, Kazutoshi Higuchi, Eriko Koizumi, Katsuhiko Iwakiri
{"title":"Advancements in Endoscopic Treatment for Gastric Subepithelial Tumors.","authors":"Osamu Goto, Kazutoshi Higuchi, Eriko Koizumi, Katsuhiko Iwakiri","doi":"10.5009/gnl240358","DOIUrl":"10.5009/gnl240358","url":null,"abstract":"<p><p>Peroral flexible endoscopy is a minimally invasive technique that enables the local resection of gastric subepithelial tumors (SETs) with malignant potential. Resection techniques are mainly chosen on the basis of the lesion size. Minute SETs less than 1 cm should be managed through a watch and wait strategy, with the exception of histologically diagnosed superficial lesions, which require endoscopic mucosal resection or endoscopic submucosal dissection. For 1- to 3-cm small SETs, endoscopic enucleation techniques, such as endoscopic submucosal excavation, submucosal tunneling endoscopic resection, and peroral endoscopic tumor resection, can be used. However, endoscopic full-thickness resection is preferred for histologically complete removal with negative surgical margins. When endoscopic full-thickness resection is considered technically difficult, laparoscopic and endoscopic cooperative surgery (LECS) is a safe and dependable alternative. Moderate-sized SETs (3 to 5 cm) require surgical intervention because the lesions must be removed transabdominally. LECS is a less invasive surgical procedure as it reduces the resection area; however, some LECS techniques that require transoral tumor retrieval are not available. Endoscopic intervention for lesions larger than 5 cm should be used with caution for research purposes. With advancements in endoscopic diagnosis, the indications for endoscopic treatment for SETs are expected to improve, thereby enhancing patients' quality of life.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":"151-160"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors. 胃神经内分泌肿瘤的临床特点及远期预后。
IF 3.4 3区 医学
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2025-01-03 DOI: 10.5009/gnl240272
Quanxin Zheng, Ji Yoon Kim, Soo-Jeong Cho, Sang Gyun Kim, Hyunsoo Chung
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