Hepatobiliary surgery and nutrition最新文献

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Alternatives to left lateral segment for pediatric liver transplantation, or required surgeon toolkit? 小儿肝脏移植手术左外侧切片的替代方案,还是外科医生的必备工具包?
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-20 DOI: 10.21037/hbsn-23-671
Paola A Vargas, Nicolas Goldaracena
{"title":"Alternatives to left lateral segment for pediatric liver transplantation, or required surgeon toolkit?","authors":"Paola A Vargas, Nicolas Goldaracena","doi":"10.21037/hbsn-23-671","DOIUrl":"https://doi.org/10.21037/hbsn-23-671","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"376-378"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-related liver disease. 酒精相关肝病。
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-27 DOI: 10.21037/hbsn-24-16
Gianni Testino, Fabio Caputo
{"title":"Alcohol-related liver disease.","authors":"Gianni Testino, Fabio Caputo","doi":"10.21037/hbsn-24-16","DOIUrl":"https://doi.org/10.21037/hbsn-24-16","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"347-351"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice. 下丘脑室旁核的谷氨酸能神经元参与调节胰腺癌诱发的小鼠内脏疼痛
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-01-24 DOI: 10.21037/hbsn-23-442
Ning-Ning Ji, Shuang Cao, Xing-Lei Song, Bei Pei, Chen-Yu Jin, Bi-Fa Fan, Hong Jiang, Ming Xia
{"title":"Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice.","authors":"Ning-Ning Ji, Shuang Cao, Xing-Lei Song, Bei Pei, Chen-Yu Jin, Bi-Fa Fan, Hong Jiang, Ming Xia","doi":"10.21037/hbsn-23-442","DOIUrl":"https://doi.org/10.21037/hbsn-23-442","url":null,"abstract":"<p><strong>Background: </strong>Visceral pain induced by pancreatic cancer seriously affects patients' quality of life, and there is no effective treatment, because the mechanism of its neural circuit is unknown. Therefore, the aim of this study is to explore the main neural circuit mechanism regulating visceral pain induced by pancreatic cancer in mice.</p><p><strong>Methods: </strong>The mouse model of pancreatic cancer visceral pain was established on C57BL/6N mice by pancreatic injection of mPAKPC-luc cells. Abdominal mechanical hyperalgesia and hunch score were performed to assess visceral pain; the pseudorabies virus (PRV) was used to identify the brain regions innervating the pancreas; the c-fos co-labeling method was used to ascertain the types of activated neurons; <i>in vitro</i> electrophysiological patch-clamp technique was used to record the electrophysiological activity of specific neurons; the calcium imaging technique was used to determine the calcium activity of specific neurons; specific neuron destruction and chemogenetics methods were used to explore whether specific neurons were involved in visceral pain induced by pancreatic cancer.</p><p><strong>Results: </strong>The PRV injected into the pancreas was detected in the paraventricular nucleus of the hypothalamus (PVN). Immunofluorescence staining showed that the majority of c-fos were co-labeled with glutamatergic neurons in the PVN. <i>In vitro</i> electrophysiological results showed that the firing frequency of glutamatergic neurons in the PVN was increased. The calcium imaging results showed that the calcium activity of glutamatergic neurons in the PVN was enhanced. Both specific destruction of glutamatergic neurons and chemogenetics inhibition of glutamatergic neurons in the PVN alleviated visceral pain induced by pancreatic cancer.</p><p><strong>Conclusions: </strong>Glutamatergic neurons in the PVN participate in the regulation of visceral pain induced by pancreatic cancer in mice, providing new insights for the discovery of effective targets for the treatment of pancreatic cancer visceral pain.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"258-272"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study. 肝移植候选患者体育锻炼减少并影响术后效果--一项前瞻性队列研究。
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-02-02 DOI: 10.21037/hbsn-23-399
Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz
{"title":"Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.","authors":"Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz","doi":"10.21037/hbsn-23-399","DOIUrl":"https://doi.org/10.21037/hbsn-23-399","url":null,"abstract":"<p><strong>Background: </strong>Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical morbidity and mortality. We investigated physical activity (PA) in patients awaiting LT in a country with long waiting times.</p><p><strong>Methods: </strong>Prospective, single center, longitudinal study in Bern, Switzerland between June 2019 and February 2020 (halted due to SARS-CoV-2 pandemic), with follow-up data up to six months post-transplant. Patients were instructed to use a wrist tracker (FitBit) to monitor PA, which was assessed using mixed-effects generalized linear models. The study was approved by the local ethics committee (BASEC ID 2019-00606).</p><p><strong>Results: </strong>Thirty-five patients were included [71% male, median 59 years, body mass index (BMI) 28 kg/m<sup>2</sup>, lab Model End-Stage Liver Disease (MELD) 11], 17 (49%) pre-frail and 5 (14%) frail according to the Liver Frailty Index (LFI). Twenty-eight patients underwent transplantation with 0 ninety-day mortality and 15 (53.6%) composite adverse clinical outcome. Median daily steps were 4,661 [interquartile range (IQR), 1,685-8,609] and weekly moderate PA (MPA) was 41 min (IQR, 0-127 min). Longitudinal analysis showed that female patients and patients on nutritional support had an increase in MPA between weeks 20 and 40. A significant decrease was seen in MPA after week 40, whilst no significant association was seen with age, Child-Pugh Score, LFI or quality of life at time of inclusion. MPA was significantly associated with the occurrence of the composite clinical endpoint after week 30 of waiting time (odds ratio 0.882, P=0.026). World Health Organization (WHO)-recommended MPA was significantly associated with less adverse composite clinical outcomes (P<0.001).</p><p><strong>Conclusions: </strong>In patients listed for LT, MPA decreased over time, showing a significant association with adverse outcome, specifically after week 30 on the waiting list. Our data support the implementation of routine pre-habilitation in patients awaiting LT.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"229-240"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic impact of tumor marker kinetics and normalization during neoadjuvant chemotherapy for pancreatic cancer. 胰腺癌新辅助化疗期间肿瘤标志物动力学和正常化对预后的影响。
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-20 DOI: 10.21037/hbsn-23-662
Hiromitsu Hayashi, Zhao Liu, Yuxuan Sun, Daisuke Ogawa, Hideo Baba
{"title":"Prognostic impact of tumor marker kinetics and normalization during neoadjuvant chemotherapy for pancreatic cancer.","authors":"Hiromitsu Hayashi, Zhao Liu, Yuxuan Sun, Daisuke Ogawa, Hideo Baba","doi":"10.21037/hbsn-23-662","DOIUrl":"https://doi.org/10.21037/hbsn-23-662","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"317-320"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18F-fluorodeoxyglucose positron emission tomography/computed tomography in intrahepatic cholangiocarcinoma: could it be a new paradigm? 18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在肝内胆管癌中的应用:它能成为一种新范例吗?
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-25 DOI: 10.21037/hbsn-23-675
Masakatsu Tsurusaki, Ryohei Kozuki, Atsushi Urase
{"title":"<sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography in intrahepatic cholangiocarcinoma: could it be a new paradigm?","authors":"Masakatsu Tsurusaki, Ryohei Kozuki, Atsushi Urase","doi":"10.21037/hbsn-23-675","DOIUrl":"https://doi.org/10.21037/hbsn-23-675","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"379-381"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of preoperative imaging in living-donor hepatectomy. 活体肝切除术术前成像的重要性。
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-20 DOI: 10.21037/hbsn-24-29
Michel Rayar, Giovanni Battista Levi Sandri
{"title":"The importance of preoperative imaging in living-donor hepatectomy.","authors":"Michel Rayar, Giovanni Battista Levi Sandri","doi":"10.21037/hbsn-24-29","DOIUrl":"https://doi.org/10.21037/hbsn-24-29","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"356-358"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymph node ratio in resected pancreatic head cancers: time for a broader clinical implementation? 胰头癌切除术中的淋巴结比值:是时候进行更广泛的临床应用了吗?
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2024-04-03 Epub Date: 2024-03-20 DOI: 10.21037/hbsn-23-670
Ernesto Sparrelid, Poya Ghorbani, Marcus Holmberg
{"title":"Lymph node ratio in resected pancreatic head cancers: time for a broader clinical implementation?","authors":"Ernesto Sparrelid, Poya Ghorbani, Marcus Holmberg","doi":"10.21037/hbsn-23-670","DOIUrl":"https://doi.org/10.21037/hbsn-23-670","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"374-375"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is tenofovir disoproxil fumarate superior to entecavir for prevention of hepatocellular carcinoma in patients with chronic hepatitis B? 在预防慢性乙型肝炎患者肝细胞癌方面,富马酸替诺福韦酯是否优于恩替卡韦?
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2023-12-01 DOI: 10.21037/hbsn-23-472
Lisa M. van Velsen, M. Sonneveld, K. J. van Erpecum
{"title":"Is tenofovir disoproxil fumarate superior to entecavir for prevention of hepatocellular carcinoma in patients with chronic hepatitis B?","authors":"Lisa M. van Velsen, M. Sonneveld, K. J. van Erpecum","doi":"10.21037/hbsn-23-472","DOIUrl":"https://doi.org/10.21037/hbsn-23-472","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":" 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic dysfunction-associated fatty liver disease and hepatocellular carcinoma: present and future 代谢功能障碍相关性脂肪肝和肝细胞癌:现状与未来
IF 8 2区 医学
Hepatobiliary surgery and nutrition Pub Date : 2023-12-01 DOI: 10.21037/hbsn-23-539
Feng Gao, Gang Chen, Christopher D. Byrne, G. Targher, Tan To Cheung, M. Zheng
{"title":"Metabolic dysfunction-associated fatty liver disease and hepatocellular carcinoma: present and future","authors":"Feng Gao, Gang Chen, Christopher D. Byrne, G. Targher, Tan To Cheung, M. Zheng","doi":"10.21037/hbsn-23-539","DOIUrl":"https://doi.org/10.21037/hbsn-23-539","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":" 14","pages":""},"PeriodicalIF":8.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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