{"title":"Alternatives to left lateral segment for pediatric liver transplantation, or required surgeon toolkit?","authors":"Paola A Vargas, Nicolas Goldaracena","doi":"10.21037/hbsn-23-671","DOIUrl":"https://doi.org/10.21037/hbsn-23-671","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"376-378"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ning-Ning Ji, Shuang Cao, Xing-Lei Song, Bei Pei, Chen-Yu Jin, Bi-Fa Fan, Hong Jiang, Ming Xia
{"title":"Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice.","authors":"Ning-Ning Ji, Shuang Cao, Xing-Lei Song, Bei Pei, Chen-Yu Jin, Bi-Fa Fan, Hong Jiang, Ming Xia","doi":"10.21037/hbsn-23-442","DOIUrl":"https://doi.org/10.21037/hbsn-23-442","url":null,"abstract":"<p><strong>Background: </strong>Visceral pain induced by pancreatic cancer seriously affects patients' quality of life, and there is no effective treatment, because the mechanism of its neural circuit is unknown. Therefore, the aim of this study is to explore the main neural circuit mechanism regulating visceral pain induced by pancreatic cancer in mice.</p><p><strong>Methods: </strong>The mouse model of pancreatic cancer visceral pain was established on C57BL/6N mice by pancreatic injection of mPAKPC-luc cells. Abdominal mechanical hyperalgesia and hunch score were performed to assess visceral pain; the pseudorabies virus (PRV) was used to identify the brain regions innervating the pancreas; the c-fos co-labeling method was used to ascertain the types of activated neurons; <i>in vitro</i> electrophysiological patch-clamp technique was used to record the electrophysiological activity of specific neurons; the calcium imaging technique was used to determine the calcium activity of specific neurons; specific neuron destruction and chemogenetics methods were used to explore whether specific neurons were involved in visceral pain induced by pancreatic cancer.</p><p><strong>Results: </strong>The PRV injected into the pancreas was detected in the paraventricular nucleus of the hypothalamus (PVN). Immunofluorescence staining showed that the majority of c-fos were co-labeled with glutamatergic neurons in the PVN. <i>In vitro</i> electrophysiological results showed that the firing frequency of glutamatergic neurons in the PVN was increased. The calcium imaging results showed that the calcium activity of glutamatergic neurons in the PVN was enhanced. Both specific destruction of glutamatergic neurons and chemogenetics inhibition of glutamatergic neurons in the PVN alleviated visceral pain induced by pancreatic cancer.</p><p><strong>Conclusions: </strong>Glutamatergic neurons in the PVN participate in the regulation of visceral pain induced by pancreatic cancer in mice, providing new insights for the discovery of effective targets for the treatment of pancreatic cancer visceral pain.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"258-272"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz
{"title":"Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.","authors":"Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz","doi":"10.21037/hbsn-23-399","DOIUrl":"https://doi.org/10.21037/hbsn-23-399","url":null,"abstract":"<p><strong>Background: </strong>Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical morbidity and mortality. We investigated physical activity (PA) in patients awaiting LT in a country with long waiting times.</p><p><strong>Methods: </strong>Prospective, single center, longitudinal study in Bern, Switzerland between June 2019 and February 2020 (halted due to SARS-CoV-2 pandemic), with follow-up data up to six months post-transplant. Patients were instructed to use a wrist tracker (FitBit) to monitor PA, which was assessed using mixed-effects generalized linear models. The study was approved by the local ethics committee (BASEC ID 2019-00606).</p><p><strong>Results: </strong>Thirty-five patients were included [71% male, median 59 years, body mass index (BMI) 28 kg/m<sup>2</sup>, lab Model End-Stage Liver Disease (MELD) 11], 17 (49%) pre-frail and 5 (14%) frail according to the Liver Frailty Index (LFI). Twenty-eight patients underwent transplantation with 0 ninety-day mortality and 15 (53.6%) composite adverse clinical outcome. Median daily steps were 4,661 [interquartile range (IQR), 1,685-8,609] and weekly moderate PA (MPA) was 41 min (IQR, 0-127 min). Longitudinal analysis showed that female patients and patients on nutritional support had an increase in MPA between weeks 20 and 40. A significant decrease was seen in MPA after week 40, whilst no significant association was seen with age, Child-Pugh Score, LFI or quality of life at time of inclusion. MPA was significantly associated with the occurrence of the composite clinical endpoint after week 30 of waiting time (odds ratio 0.882, P=0.026). World Health Organization (WHO)-recommended MPA was significantly associated with less adverse composite clinical outcomes (P<0.001).</p><p><strong>Conclusions: </strong>In patients listed for LT, MPA decreased over time, showing a significant association with adverse outcome, specifically after week 30 on the waiting list. Our data support the implementation of routine pre-habilitation in patients awaiting LT.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"229-240"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiromitsu Hayashi, Zhao Liu, Yuxuan Sun, Daisuke Ogawa, Hideo Baba
{"title":"Prognostic impact of tumor marker kinetics and normalization during neoadjuvant chemotherapy for pancreatic cancer.","authors":"Hiromitsu Hayashi, Zhao Liu, Yuxuan Sun, Daisuke Ogawa, Hideo Baba","doi":"10.21037/hbsn-23-662","DOIUrl":"https://doi.org/10.21037/hbsn-23-662","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"317-320"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography in intrahepatic cholangiocarcinoma: could it be a new paradigm?","authors":"Masakatsu Tsurusaki, Ryohei Kozuki, Atsushi Urase","doi":"10.21037/hbsn-23-675","DOIUrl":"https://doi.org/10.21037/hbsn-23-675","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"379-381"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The importance of preoperative imaging in living-donor hepatectomy.","authors":"Michel Rayar, Giovanni Battista Levi Sandri","doi":"10.21037/hbsn-24-29","DOIUrl":"https://doi.org/10.21037/hbsn-24-29","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"356-358"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lymph node ratio in resected pancreatic head cancers: time for a broader clinical implementation?","authors":"Ernesto Sparrelid, Poya Ghorbani, Marcus Holmberg","doi":"10.21037/hbsn-23-670","DOIUrl":"https://doi.org/10.21037/hbsn-23-670","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"13 2","pages":"374-375"},"PeriodicalIF":8.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa M. van Velsen, M. Sonneveld, K. J. van Erpecum
{"title":"Is tenofovir disoproxil fumarate superior to entecavir for prevention of hepatocellular carcinoma in patients with chronic hepatitis B?","authors":"Lisa M. van Velsen, M. Sonneveld, K. J. van Erpecum","doi":"10.21037/hbsn-23-472","DOIUrl":"https://doi.org/10.21037/hbsn-23-472","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":" 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Feng Gao, Gang Chen, Christopher D. Byrne, G. Targher, Tan To Cheung, M. Zheng
{"title":"Metabolic dysfunction-associated fatty liver disease and hepatocellular carcinoma: present and future","authors":"Feng Gao, Gang Chen, Christopher D. Byrne, G. Targher, Tan To Cheung, M. Zheng","doi":"10.21037/hbsn-23-539","DOIUrl":"https://doi.org/10.21037/hbsn-23-539","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":" 14","pages":""},"PeriodicalIF":8.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}