Gynecologic oncology最新文献

{"title":"Phase II study of cadonilimab monotherapy for recurrent small cell neuroendocrine carcinoma of the cervix","authors":"Helen Clark, Kelly Rangel, Zhouxuan Li, Ying Yuan, Shannon Westin, Amir Jazaeri, Travis Sims","doi":"10.1016/j.ygyno.2026.01.203","DOIUrl":"10.1016/j.ygyno.2026.01.203","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S14-S15"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOREWORD — SGO Winter Meeting","authors":"","doi":"10.1016/j.ygyno.2026.01.184","DOIUrl":"10.1016/j.ygyno.2026.01.184","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S1"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substratification of mismatch repair deficient endometrial cancers based on mechanism of MMR loss can provide prognostic and predictive refinement","authors":"Amy Jamieson ,&nbsp;Sila Rogan ,&nbsp;Allen W. Zhang ,&nbsp;Spencer D. Martin ,&nbsp;Samuel Leung ,&nbsp;Derek Chiu ,&nbsp;Kathryn McRae ,&nbsp;Sarah J. Mah ,&nbsp;Stefan Kommoss ,&nbsp;Aline Talhouk ,&nbsp;David G. Huntsman ,&nbsp;C. Blake Gilks ,&nbsp;Jessica N. McAlpine","doi":"10.1016/j.ygyno.2026.01.233","DOIUrl":"10.1016/j.ygyno.2026.01.233","url":null,"abstract":"<div><h3>Background</h3><div>Mismatch repair deficient (MMRd) endometrial carcinomas (EC) encompass 25–30% of ECs. Identifying MMRd directs Lynch Syndrome testing and immune checkpoint inhibitor (ICI) therapy. Our aim was to characterize the clinicopathologic and molecular features of MMRd ECs treated in the pre-ICI era.</div></div><div><h3>Methods</h3><div>MMRd ECs were identified retrospectively and tumors underwent selective immunohistochemistry and hotspot panel sequencing.</div></div><div><h3>Results</h3><div>MMRd ECs (<em>n</em> = 899) were predominantly FIGO 2009 stage I (77%), endometrioid histotype (92%), with 14% lymph node metastases (LNM). Lymphovascular invasion and myoinvasion were prognostic in MMRd ECs, but grade and histotype were not. Patients with MLH1 loss (80%) were older with higher BMI, had more deeply invasive tumors and more LNM compared to patients with MSH2/MSH6/isolated PMS2 loss (20%). Worse outcomes were observed with MLH1 loss; 18% of patients recurred and 10% died of disease compared to 7% and 4% with MSH2/MSH6/isolated PMS2 loss. MLH1 loss tumors had lower CD8+ tumor infiltrating lymphocyte densities, which were associated with worse prognosis. ER, PR, L1CAM and <em>CTNNB1</em> were not associated with outcomes in MMRd ECs. There was no difference in outcomes between patients with MMRd-p53abn (<em>N</em> = 150, multiple classifiers) and MMRd ECs with wildtype p53 expression. Outcomes were identical for chemoradiation vs radiation alone for ESMO high risk or high/advanced/metastatic risk groups combined.</div></div><div><h3>Conclusion</h3><div>MLH1 loss identifies a subset of MMRd ECs with worse outcomes and lower CD8+ densities supporting substratification of this molecular subtype. Grade, histotype, ER, PR, L1CAM, <em>CTNNB1</em> and p53 status do not add prognostic refinement within MMRd EC.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages 105-112"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146062532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood deprivation & oncologic outcomes in cervical cancer at a large, urban, tertiary care and NCI referral center","authors":"Megan Teramoto,&nbsp;Sarah Ackroyd,&nbsp;Nita Lee,&nbsp;Sandra Tilmon,&nbsp;Gini Fleming,&nbsp;Seiko Yamada","doi":"10.1016/j.ygyno.2026.01.226","DOIUrl":"10.1016/j.ygyno.2026.01.226","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S28"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving treatment of radiation-induced premature ovarian insufficiency after cervical cancer: A practice quality improvement initiative","authors":"Emily Smith ,&nbsp;Neil Taunk ,&nbsp;Jonathan Heintz ,&nbsp;Arina Chesnokova","doi":"10.1016/j.ygyno.2026.01.224","DOIUrl":"10.1016/j.ygyno.2026.01.224","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S27"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial differences in endometrial stripe thickness among uterine cancer patients","authors":"Simone Sasse ,&nbsp;Sarah Lawson ,&nbsp;Sydney Williams ,&nbsp;Arslan Kasimov ,&nbsp;Danielle Blemur ,&nbsp;Brooke Howitt","doi":"10.1016/j.ygyno.2026.01.223","DOIUrl":"10.1016/j.ygyno.2026.01.223","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S26-S27"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A second chance for the second look: Feasibility of laparoscopic HIPEC at the conclusion of upfront treatment for epithelial ovarian cancer","authors":"Ana Kouri ,&nbsp;Anya Menzies ,&nbsp;Kristen Stearns ,&nbsp;Christine McGough ,&nbsp;Fang-Chi Hsu ,&nbsp;Janelle Darby ,&nbsp;Michael Kelly ,&nbsp;Samuel Lentz ,&nbsp;Laurel Berry","doi":"10.1016/j.ygyno.2026.01.213","DOIUrl":"10.1016/j.ygyno.2026.01.213","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S20-S21"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit and cost: Early PARP inhibitor exposure shortens times to subsequent recurrences","authors":"Floor Backes ,&nbsp;Anna Gonzalez ,&nbsp;Reed O'Connor ,&nbsp;Julia Chalif ,&nbsp;Paulina Haight ,&nbsp;Monica Levine ,&nbsp;Robert Neff ,&nbsp;Christa Nagel ,&nbsp;Casey Cosgrove ,&nbsp;Laura Chambers ,&nbsp;David Cohn ,&nbsp;Larry Copeland ,&nbsp;David O'Malley","doi":"10.1016/j.ygyno.2026.01.210","DOIUrl":"10.1016/j.ygyno.2026.01.210","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Pages S18-S19"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missed opportunities for ovarian cancer prevention with salpingectomy","authors":"Laureen Gbordzoe,&nbsp;Mehrnaz Siavoshi,&nbsp;Christine Garcia,&nbsp;Allison Kay","doi":"10.1016/j.ygyno.2026.01.209","DOIUrl":"10.1016/j.ygyno.2026.01.209","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S18"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV clade classification is associated with response to chemoradiation in locally advanced cervical cancer","authors":"Shae Jansen Aref ,&nbsp;D'Shaunique Walters ,&nbsp;Matthew Wong ,&nbsp;Molly El Alam ,&nbsp;David Lo ,&nbsp;Timothy Harris ,&nbsp;Jhoan Sebastian Gonzalez Diaz ,&nbsp;Travis Sims ,&nbsp;Nadim Ajami ,&nbsp;Lauren Colbert","doi":"10.1016/j.ygyno.2026.01.194","DOIUrl":"10.1016/j.ygyno.2026.01.194","url":null,"abstract":"","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"205 ","pages":"Page S8"},"PeriodicalIF":4.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}