GSC Biological and Pharmaceutical Sciences最新文献_第3页

Integrating pharmacogenomic testing into personalized medicine practices in the USA: Implications for medication quality control and therapeutic efficacy 美国将药物基因组学检测纳入个性化医疗实践：对药物质量控制和疗效的影响

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0081

James Tabat Bature, Michael Alurame Eruaga, Esther Oleiye Itua

{"title":"Integrating pharmacogenomic testing into personalized medicine practices in the USA: Implications for medication quality control and therapeutic efficacy","authors":"James Tabat Bature, Michael Alurame Eruaga, Esther Oleiye Itua","doi":"10.30574/gscbps.2024.26.3.0081","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0081","url":null,"abstract":"This concept paper explores the integration of pharmacogenomic testing into personalized medicine practices in the USA and its implications for medication quality control and therapeutic efficacy. By leveraging genetic information to optimize medication selection and dosing, this paper aims to improve patient outcomes and minimize adverse drug reactions, thereby enhancing medication safety and efficacy in clinical practice. Integrating pharmacogenomic testing into personalized medicine practices has the potential to revolutionize healthcare by improving medication quality control and therapeutic efficacy. This concept paper explores the implications of pharmacogenomic testing for personalized medicine practices in the USA. The paper begins by discussing the current landscape of personalized medicine and the role of pharmacogenomic testing in optimizing medication selection and dosing. It then examines the benefits of integrating pharmacogenomic testing into clinical practice, including improved medication safety, efficacy, and cost-effectiveness. Key considerations for implementing pharmacogenomic testing in personalized medicine practices are discussed, including regulatory considerations, reimbursement challenges, and ethical considerations. The paper also highlights the importance of healthcare provider education and patient engagement in the successful implementation of pharmacogenomic testing. Through a comprehensive analysis, this concept paper aims to provide insights into the implications of integrating pharmacogenomic testing into personalized medicine practices in the USA. By leveraging pharmacogenomic testing, healthcare providers can personalize medication selection and dosing, leading to improved medication quality control and therapeutic efficacy for patients.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"26 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracted Dilapan-s in a multiparous woman at term on induction of labour 一名临产多产妇在引产时发生子宫颈后缩

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0091

Ali Nakash, Olusegun Agunbiade, Olufemi Abidoye, Emma Clark

引用次数: 0

Enhancing the nutritional quality of fufu with a starter culture 用启动培养基提高豆腐的营养质量

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0082

Olufemi Gabriel Abimbola, Kausarat Omowunmi Oyetunji, Blessing Ademidun Adedoyin, Basirat Olaide Lamidi, Emmanuel Ayotunde Folagboye, Kehinde Oluwaseyi Abimbola, Omotade Richard Ogunremi, Stella Mojisola Adeyemo

{"title":"Enhancing the nutritional quality of fufu with a starter culture","authors":"Olufemi Gabriel Abimbola, Kausarat Omowunmi Oyetunji, Blessing Ademidun Adedoyin, Basirat Olaide Lamidi, Emmanuel Ayotunde Folagboye, Kehinde Oluwaseyi Abimbola, Omotade Richard Ogunremi, Stella Mojisola Adeyemo","doi":"10.30574/gscbps.2024.26.3.0082","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0082","url":null,"abstract":"This study investigates the nutritional enrichment of fufu, a staple African food, by controlling the fermentation of cassava root tuber using a starter culture. Lactic acid bacteria (LAB) were isolated from fermented cassava and analyzed for their technological properties. The physicochemical parameters, proximate and antinutrient content of the fufu samples were determined by standard analytical methods. Twelve LAB were identified as Lactobacilli plantarum (42%), L. acidophilus (25%), L. fermentum (17%), L. brevis (8%), and L. mesenteroides (8%). The LAB isolates produced lactic acid, diacetyl, and hydrogen peroxide ranging from 1.90-2.90, 1.30-2.10, and 1.10 -2.90 mg/mL respectively. Lactobacillus plantarum (FF8) was selected as a starter culture due to its exceptional ability to produce antimicrobial substances, leading to higher yields of lactic acid, diacetyl, and hydrogen peroxide, reducing the fermenting medium's pH. The pH changes in starter-induced fermented fufu (SIFF) and spontaneous fermented fufu (SFF) samples from 0 to 96 hours were 7.10 - 2.60 and 7.10 - 3.30, respectively, while the Total Titratable Acidity (TTA) increased from 0.71-1.79 and 0.28-0.51, respectively. Starter-induced fermented fufu (SIFF) has higher protein, fat, sodium, potassium, iron, zinc, phosphorus, and Vit. C, B1, and A content of 2.93, 0.23 (%) 596.4, 270.9, 8.93, 1.67, 296.67, 5.28, 0.24, and 0.31 (mg/100g) respectively, compared to spontaneous fermented fufu and a significant decrease in antinutrient content, such as cyanide, saponin, and phytates of 0.05, 0.16, and 0.06 (mg/100g), respectively. The study found that L. plantarum FF8 used as a starter culture, improves the nutritional value of fufu and reduces anti-nutrients, suggesting potential health benefits for consumers.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Medicago sativa ethanol leaf extract for antidiarrheal activity in Wistar rats 在 Wistar 大鼠体内评估草本植物乙醇叶提取物的止泻活性

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0085

Anele Donatus Onyebuchi, Akuodor Godwin Christian, Okoroama Casmir Emeka, Unaeze Bright Chukwuebuka, Ajegi Innocent Fountain, Iganga Ogbonnaya Nnabuike, Nwokike Matthew Onyemaechi

{"title":"Evaluation of Medicago sativa ethanol leaf extract for antidiarrheal activity in Wistar rats","authors":"Anele Donatus Onyebuchi, Akuodor Godwin Christian, Okoroama Casmir Emeka, Unaeze Bright Chukwuebuka, Ajegi Innocent Fountain, Iganga Ogbonnaya Nnabuike, Nwokike Matthew Onyemaechi","doi":"10.30574/gscbps.2024.26.3.0085","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0085","url":null,"abstract":"Aim: Medicago sativa leaf is traditionally used for the treatment of gastrointestinal disorders in Nigeria. This research investigates the in vivo antidiarrheal activity of M. sativa (Alfalfa) leaf extract in Wistar rats. Method: The study employed three models: castor oil-induced diarrhea, gastrointestinal motility (charcoal meal), and castor oil-induced intestinal fluid accumulation. The phytochemical analysis as well acute toxicity tests were carried out in the leaf extract. Results: The results demonstrate a dose-dependent and significant antidiarrheal effect of M. sativa leaf extract. In the castor oil-induced diarrhea model, the extract reduced fecal frequency, delayed onset, and lowered severity, with the highest effect at 600 mg/kg compared to a positive control (Loperamide). Gastrointestinal motility was inhibited by the extract in a dose-dependent manner, achieving maximum effect at 600 mg/kg, comparable to atropine sulfate. The castor oil-induced intestinal fluid accumulation model revealed a significant decrease in fluid volume at 600 mg/kg, exhibiting a potent inhibitory effect. The oral LD50 values obtained were greater than 5000 mg/kg in rats Conclusion: This study provides compelling evidence of Medicago sativa leaf extract's potential as an antidiarrheal agent in Wistar rats. Further investigations could explore its mechanism of action and safety profile, contributing valuable insights to the development of novel antidiarrheal therapies.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"49 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a bio-industry-need hemisection of spinal cord rat model 建立生物产业需要的脊髓半切大鼠模型

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0086

Yu-Hsing Lin, Pi-Hsin Chen, Ya-Ling Cyue, Ya-Peng Wang, Yu-Ying Fang, Tsung-Han Wu, Shih-Yi Guo, Yan-Zhong Wu, Chien-Chao Chiu, Keng-Chia Hsu, Chia-Ying Lin, Yu-Wen Hung, Shao-Wen Hung

引用次数: 0

Antibacterial activities of honey bee against gram-positive bacteria isolated from urine 蜜蜂对从尿液中分离出来的革兰氏阳性细菌的抗菌活性

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0092

H. Eze, Euphemia Afoma Ikegwuonu, Okonkwo OBASI CJ, Ngozi Nonyelum, U. O. Okoli

{"title":"Antibacterial activities of honey bee against gram-positive bacteria isolated from urine","authors":"H. Eze, Euphemia Afoma Ikegwuonu, Okonkwo OBASI CJ, Ngozi Nonyelum, U. O. Okoli","doi":"10.30574/gscbps.2024.26.3.0092","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0092","url":null,"abstract":"The medicinal benefits of honey have long been recorded in ancient days as a solution for various ailments and infections. This study x-rayed the effects of honey on common gram-positive bacteria isolated from urine. The study evaluated the in vitro susceptibility of two gram positive bacteria strains, isolated from urine of students of Nnamdi Azikiwe University, Awka Anambra state, Nigeria. The end point was achieved via macroscopic, microscopic methods and biochemical examinations which includes: gram staining, urease, catalase, coagulase testing to a hsoney sample. The evaluation of the antibacterial activity was ascertained by the agar diffusion well method. The results obtained in this study proved that the honey sample exhibited potent antibacterial activity against the tested strains, the zone of inhibition was at a mean value of 20.5 mm and 29.5 mm respectively at 100% concentration of honey. Staphylococcus epidermidis was found to be less susceptible than Enterococcus faecalis with a mean inhibition zones being 29.5 mm. This contribution has provided a broad overview of the antibacterial activity of honey and shown that honey bee has great potential for therapeutic use as an alternative therapy for infections caused by the isolates.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"25 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Momordica dioica: A medicinal plant, its benefits and pharmacological activity Momordica dioica：一种药用植物、它的益处和药理活性

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0079

Ankita P. Jatale, Gayatri B. Jaiswal, Payal G. Kabra, Chhaya V. Mahajan, Swati P. Deshmukh

{"title":"Momordica dioica: A medicinal plant, its benefits and pharmacological activity","authors":"Ankita P. Jatale, Gayatri B. Jaiswal, Payal G. Kabra, Chhaya V. Mahajan, Swati P. Deshmukh","doi":"10.30574/gscbps.2024.26.3.0079","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0079","url":null,"abstract":"Momordica dioica is a cucurbitaceous climbing creeper (commonly known as kakrol, spiny gourd or teasle gourd). It is native to Asia with widely distributed in India and Bangladesh also. It is used as preventive and curative agent for various diseases. It has also significant nutritional value as vegetable over thousands of years. This review aims to take an attempt to evaluate the pharmacological properties and benefits of Momordica dioica according to the view of traditional medicinal plant based on treatment including. Momordica dioica is considered as an underutilized vegetable, although having significant presence of certain compounds containing higher nutritional value than many frequently consumed vegetables. Different plant parts of Momordica dioica provide a numbers of phyto-constituents like alkaloids, glycosides, steroids, triterpenoids, flavonoids, ursolic acid, vitamins, minerals and rich in fibre. They have potential to cure asthma, excessive salivation and inflammation caused by lizards, snake bite, elephantiasis, fever, mental and digestive disorders. It is used to maintain skin health.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of density and specific gravity tests of some selected Ayurvedic medicinal plants 一些选定的阿育吠陀药用植物的密度和比重测试评估

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0076

Umakant N. Rabb

{"title":"Assessment of density and specific gravity tests of some selected Ayurvedic medicinal plants","authors":"Umakant N. Rabb","doi":"10.30574/gscbps.2024.26.3.0076","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0076","url":null,"abstract":"The Guna(Static properties) in common terms known as properties or qualities. There are 41 Gunas in Ayurvedc classics. Among them the Gurvadi Gunas and Paradi Gunas are used in the various treatment measures. The Guru is known as heaviness. Gurutwa is correlated with Gravity in modern science. Parthiva and Apya Mahabhuta are responsible for this Guru Guna. The Guru drugs act as Brumhana(Nourishing as well as help to increase the mass of the tissues), Anuloman(Mild laxative). The exact opposite action of Guru drug is seen in Laghu Dravya. The Laghu drugs give Lightness to the body, as it is light in nature. The Akashiya, Vayavya, Agneya, Laghu Gunas are predominant in this drugs. These drugs act as Agnideepan(Appetizer), Strotoshodhan(Cleanses the channels). The more Parthiva Dravya, more the Guru can be considered. Less Parthiva Dravya more the Laghu can be considered. To assess the Parthivatwa by its correlation with Density and Specific gravity. Same can be considered for Jaliyatwa and Vayaviyatwa. Assessment of objective Parametric measures of Guru and Laghu Guna can be done by Density(Bulk), Specific Gravity(Liquid and solid). The Specific gravity, more formally known as relative density, is a measure of the density of a substance in comparison to the density of water. In this present research work there are 16 drugs for specific gravity for solids, 12 drugs for specific gravity for liquids, 20 drugs for Bulk density and the same 20 drugs for True density drugs have been selected.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"24 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on method development and validation for different pharmaceutical dosage form 不同药物剂型的方法开发与验证综述

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0070

Vaishnawi R. Bhagwat, Chetan M. Jain, Nitin I. Kochar, Krutika S. Sonar

{"title":"Review on method development and validation for different pharmaceutical dosage form","authors":"Vaishnawi R. Bhagwat, Chetan M. Jain, Nitin I. Kochar, Krutika S. Sonar","doi":"10.30574/gscbps.2024.26.3.0070","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0070","url":null,"abstract":"Pharmaceutical analysis is crucial for bulk and formulation quality control. Due to global medication manufacturing and pharmaceutical sector expansion, innovative analytical methods are in demand. Developing analytical procedures is now the most significant part of analysis. Improvements in analytical instruments have led to new analytical methods. The improvement of analytical methodologies and technologies has reduced analysis time, increased precision and accuracy, and decreased analysis costs. As a consequence, the majority of pharmaceutical businesses are investing heavily in specialist analysis labs. Analytical techniques for active pharmaceutical ingredients (API), excipients, drug products, degradation products and related substances, residual solvents, and other chemicals are created and verified. As a consequence, it has become an essential component of the regulating organization's standards. Development of analytical methodologies leads to official test methods. Quality control labs utilize these methods to verify drug identity, purity, safety, effectiveness, and performance. Production analytical methods are becoming relevant to regulators. Regulatory agencies expect applicants to demonstrate control of the drug development process using established analytical methodologies.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"22 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico genomic analysis of heat shock protein 70 in poultry under tropical conditions 热带条件下家禽热休克蛋白 70 的硅基因组分析

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-03-30 DOI: 10.30574/gscbps.2024.26.3.0032

Abayomi Jude Agbana, Adebayo Omowaye Ete, Roseline Ruth Fanwo, Emmanuel Umakwu Simon, Babatunde Aderemi Yusuf

{"title":"In silico genomic analysis of heat shock protein 70 in poultry under tropical conditions","authors":"Abayomi Jude Agbana, Adebayo Omowaye Ete, Roseline Ruth Fanwo, Emmanuel Umakwu Simon, Babatunde Aderemi Yusuf","doi":"10.30574/gscbps.2024.26.3.0032","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.3.0032","url":null,"abstract":"The negative effect of climate change predisposes farm animals under tropical conditions to heat stress, which limit their productivity. This has necessitated the search for livestock with suitable adaptive genotype. Limited records exist for livestock with high genetic adaptability hence, selection for the most suitable breeding stock remain difficult. This study attempt to use genomic characteristics of heat shock protein 70 (HSP70) in common meat type birds as biomarker for selecting breeding stock of high genetic merit for tolerance. In silico expasy translate tool analysis revealed that heat shock protein 70 gene in chicken (Gallus gallus) and Japanese quail (Cortinux japonica) are on chromosome 30 and contain 2 and 3 exons linked to 67 and 45 introns, respectively while, in turkey (Meleagris gallopavo) and guinea fowl (Numida meleagris), HSP70 gene is located on chromosome 24 and 28, respectively. They also contain 2 and 4 exons interspersed by 41 and 38 introns, respectively. The variations in chromosomal locations validates differences observed in the adaptation and geographical spread of studied animals. It may also provide new insight into cellular response to heat stress and adaptive mechanism which is necessary in selection. Functional properties and physiological structures resisting thermal stress needs further investigation.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"49 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0