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Progressing Aspects in Pediatrics and Neonatology最新文献

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Neuroprotective Effects Of D-Penicillamine In The Neonatal Period: Case Reports d -青霉胺在新生儿期的神经保护作用:病例报告
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-10-30 DOI: 10.9734/ijmpcr/2015/17239
L. Lakatos
{"title":"Neuroprotective Effects Of D-Penicillamine In The Neonatal Period: Case Reports","authors":"L. Lakatos","doi":"10.9734/ijmpcr/2015/17239","DOIUrl":"https://doi.org/10.9734/ijmpcr/2015/17239","url":null,"abstract":"“fetal copper is ….with Abstract D-penicillamine (D-PA) was first used as a potential benefit for neonatal hyperbilirubinemia (NHBI) caused by hemolytic diseases of the newborn infant or immaturity of UDP-glucuronyltransferase enzyme. In this time there was a remarkedly low incidence of retinopathy of prematurity (ROP) in the infants treated with D-PA. Later, our studies were replicated in other institutes in Hungary, Poland, the USA, India and Mexico. It is important to note that there was no intolerance or short- or long-term toxicity of the medication, in spite of the fact that D-PA was used 10-20 times higher doses in the newborn period, than those in adult age. To our concept, the bilirubin-induced neurologic dysfunction (BIND), ROP and Autism Spectrum Disorders (ASD) are neurodegenerative and neurodevelopmental diseases (NDs) of immature brain caused by accumulation of free metals, unconjugated bilirubin (UCB), and UCB-Cu complex (as prooxidant), respectively, in the basal ganglia (BG) and other relevant parts of the central nervous system (CNS). The main cause is the hemolysis of neonatal red blood cells producing a great amount of heavy metals (mainly iron and copper) which are inducing reactive oxygen species (ROS). These elements can be find in the bloodstream, and pass through the immature blood-brain-barrier (BBB). In addition, ROS contribute to increased BBB permeability creating a dangerous vitious circle in the neonatal brain.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129668689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Detecting Ehlers-Danlos Syndrome Early in Life Is an Urgent Priority 在生命早期发现埃勒-丹洛斯综合征是当务之急
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-08-19 DOI: 10.32474/papn.2019.02.000139
H. C.
{"title":"Detecting Ehlers-Danlos Syndrome Early in Life Is an Urgent Priority","authors":"H. C.","doi":"10.32474/papn.2019.02.000139","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000139","url":null,"abstract":"Ehlers-Danlos syndrome is a frequent hereditary disease that affects all the connective tissue and is transmitted to all the children of an affected person. A diagnosis is possible, from birth, or shortly thereafter, when observing a clubfoot, hip dislocation, intestinal intussusception, acute umbilical or inguinal parietal hernia, hemorrhages [cutaneous, oral, gastric, intestinal, nasal], persistent constipation, regurgitation and vomiting during bottle-feeding, or false roads. These symptoms are often the cause of false allegations of abuse with children withdrawal and wrongful parents or false accusations of Munchausen disease “by delegation” in a parent, the mother most often.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130807650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Presentation of Myasthenia Gravis 重症肌无力的不寻常表现
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-04-05 DOI: 10.32474/PAPN.2019.02.000135
J. Rawal, O. Davies, Shatha Al-ani
{"title":"Unusual Presentation of Myasthenia Gravis","authors":"J. Rawal, O. Davies, Shatha Al-ani","doi":"10.32474/PAPN.2019.02.000135","DOIUrl":"https://doi.org/10.32474/PAPN.2019.02.000135","url":null,"abstract":"A 12 year old, previously fit & well girl, presented to A&E with\u0000h/o worsening Cough for 3 days and difficulty in breathing for 24\u0000hours. She needed 15 litres of oxygen to maintain saturations of\u000094%.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126795124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ifosfamide Encephalopathy in A 4yr Old with Ewing’s Sarcoma 4岁儿童尤因氏肉瘤异环磷酰胺性脑病
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-02-08 DOI: 10.32474/papn.2019.02.000133
E. Dias, A. Dias
{"title":"Ifosfamide Encephalopathy in A 4yr Old with Ewing’s Sarcoma","authors":"E. Dias, A. Dias","doi":"10.32474/papn.2019.02.000133","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000133","url":null,"abstract":"","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128644485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Health Risks in Children and Adolescents in Pediatric Care: Let’s Not Forget Social Determinants of Health 评估儿童和青少年的健康风险:让我们不要忘记健康的社会决定因素
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-02-05 DOI: 10.32474/papn.2019.02.000131
Jeanne Cartier
{"title":"Assessing Health Risks in Children and Adolescents in Pediatric Care: Let’s Not Forget Social Determinants of Health","authors":"Jeanne Cartier","doi":"10.32474/papn.2019.02.000131","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000131","url":null,"abstract":"Within the practice of pediatric medicine, a family and social history has historically been a part of the assessment of children. However, the scope of said history was usually limited to understanding the family composition, family health history and developmental behavior and activities of the child. Ongoing advances in basic and clinical sciences have increased knowledge of underlying disease etiology, including the role of genetics and genomics, brain physiology and immune functioning in disease origins and development, have led to the discovery of new and effective pharmacological agents and have informed the development of evidenced based treatment protocols. These advances have clearly improved treatment of existing diseases and conditions. There has also been advances in understanding the role of social factors as contributors to both immediate and long term health outcomes for patients throughout childhood and reaching into adulthood. Medical care as well as genetics, social circumstances, behavior, environmental and physical influences have been defined as the major determinants of health [1]. While access to medical care and clinical care contribute to health outcomes, more than 80% of the health outcomes are attributable to health behaviors as well as social and environmental factors [2]. Pediatrics is well situated to take the lead for including a broader and more robust social history to deepen our understanding, assessment and treatment of these risk factors.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122764982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Early Amino Acids Supplementation on Serum Glucose and Calcium of Very Low Birth Weight Premature Infants 早期补充氨基酸对极低出生体重早产儿血清葡萄糖和钙的影响
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-02-05 DOI: 10.32474/papn.2019.02.000132
Ghassan S. A. Salama
{"title":"Effect of Early Amino Acids Supplementation on Serum Glucose and Calcium of Very Low Birth Weight Premature Infants","authors":"Ghassan S. A. Salama","doi":"10.32474/papn.2019.02.000132","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000132","url":null,"abstract":"","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130185106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use Judiciously, or I Will Be Useless” A Clinical Audit on Use of Antibiotics Within First 72 hrs of Life in Symptomatic Term Babies With no Maternal Risk for Infection 明智地使用，否则我将是无用的“一项对无母亲感染风险的有症状的足月婴儿在生命最初72小时内使用抗生素的临床审计
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-02-01 DOI: 10.32474/papn.2019.02.000128
K. Salameh, Abedal khalik Ahmad Khedr, R. Valappil, A. Tomerak
{"title":"Use Judiciously, or I Will Be Useless” A Clinical Audit on Use of Antibiotics Within First 72 hrs of Life in Symptomatic Term Babies With no Maternal Risk for Infection","authors":"K. Salameh, Abedal khalik Ahmad Khedr, R. Valappil, A. Tomerak","doi":"10.32474/papn.2019.02.000128","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000128","url":null,"abstract":"Over use of antibiotics lead to resistance and unwanted sideeffects in newborns. Since 1992, professional societies or public health agencies have issued several generations of recommendations for prevention or management of early-onset neonatal sepsis (EOS) [1-5]. Despite these efforts, recommendations remain inconsistent, clarifications are necessary, local adaptations are common, and compliance rates are low [6-7]. It is common clinical practice to discontinue antibiotic treatment of asymptomatic babies if the blood cultures are negative at 48 hours [8-10]. But it is very common to have prolonged antibiotic courses for more than 48 hours due to delayed release of blood culture, high CRP, abnormal CBC or delayed decision by the Physician to stop antibiotics. In a previous study, McDonald et al. [11] found this as a common occurrence in neonatal intensive care units. The purpose of this audit is to rationalize the use of antibiotics in symptomatic term babies, with no risk for infection.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128689435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical Analysis of Euphorbia Hirta and Cytotoxic Activity on Ma104 大戟的植物化学分析及对Ma104的细胞毒活性
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-02-01 DOI: 10.32474/papn.2019.02.000130
P. Arun, Kaveri Krishnasamic, Palani Gunasekeranc, V. Padmanabhan
{"title":"Phytochemical Analysis of Euphorbia Hirta and Cytotoxic Activity on Ma104","authors":"P. Arun, Kaveri Krishnasamic, Palani Gunasekeranc, V. Padmanabhan","doi":"10.32474/papn.2019.02.000130","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000130","url":null,"abstract":"","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134271979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Greig Syndrome: A Rare Disease - Case Report 格里格综合征:一种罕见疾病病例报告
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2019-01-25 DOI: 10.32474/papn.2019.02.000129
A. Mithwani, Muhammad Ziad Shama, Assem Ahmad Kadrey, Abdullah AlomarAlmeshrif, Amerullah Malik
{"title":"Greig Syndrome: A Rare Disease - Case Report","authors":"A. Mithwani, Muhammad Ziad Shama, Assem Ahmad Kadrey, Abdullah AlomarAlmeshrif, Amerullah Malik","doi":"10.32474/papn.2019.02.000129","DOIUrl":"https://doi.org/10.32474/papn.2019.02.000129","url":null,"abstract":"","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114606816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Juvenile Myasthenia Gravis: A Short Review 青少年重症肌无力:简要回顾
Progressing Aspects in Pediatrics and Neonatology Pub Date : 2018-11-29 DOI: 10.32474/PAPN.2018.02.000127
Shubhankar Mishra
{"title":"Juvenile Myasthenia Gravis: A Short Review","authors":"Shubhankar Mishra","doi":"10.32474/PAPN.2018.02.000127","DOIUrl":"https://doi.org/10.32474/PAPN.2018.02.000127","url":null,"abstract":"Juvenile myasthenia gravis (JMG) is an autoimmune disorder of neuromuscular transmission caused by production of antibodies against components of the postsynaptic membrane of the neuromuscular junction. The patients present with a wide range of symptoms-from isolated intermittent ocular symptoms to general muscle weakness with or without respiratory insufficiency. Prepubertal children in particular have a higher prevalence of isolated ocular symptoms, lower frequency of acetylcholine receptor antibodies, and a higher probability of achieving remission. It must be differentiated from congenital myasthenia which is a channelopathy rather than autoimmune disease. Treatment commonly includes anticholinesterases, corticosteroids with or without steroid-sparing agents, and newer immune modulating agents. Plasma exchange and intravenous immunoglobulin (IVIG) are effective in preparation for surgery and in treatment of myasthenic crisis.","PeriodicalId":127942,"journal":{"name":"Progressing Aspects in Pediatrics and Neonatology","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122946569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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