Central India Journal of Medical Research最新文献

{"title":"Giant Cell Fibroblastoma of Hand in an Adult: An Uncommon Presentation","authors":"Akshay Surana, S. Nandedkar, Virendra K. Mehta","doi":"10.58999/cijmr.v2i02.23","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.23","url":null,"abstract":"Giant cell fibroblastoma is a rare intermediate grade fibrohistiocytic tumour of childhood and even rarer in adults. It is seen in first decade of life. It is known for its recurrence, but its metastasis has never been reported. Giant cell fibroblastoma requires attention as it was previously misdiagnosed as sarcoma.  So histology  is mandatory and remains the gold standard for its diagnosis. We present a case of 21 year old female who presented with complains of painless lesion over the dorsal aspect of left hand.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement and Clinical Usefulness of Delta Bilirubin in Liver Disease","authors":"Anurag Kesarwani, Prashant Nichat, Nikhil Rajak, G. G. Potey","doi":"10.58999/cijmr.v2i02.116","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.116","url":null,"abstract":"Delta bilirubin is albumin bound conjugated bilirubin that can be calculated by formula [Total bilirubin - (conjugated + unconjugated bilirubin)]. Newer technology like dry chemistry provide conjugated and unconjugated bilirubin fraction which is more specific and informative than direct and indirect bilirubin by conventional method in which only approximate values of conjugated bilirubin can be measured. In cholestasis conjugated bilirubin combines with albumin non enzymatically and form delta bilirubin in circulation and remains for long duration. The present review describes the usefulness of delta bilirubin in cholestasis, chronicity of liver diseases, in pediatric jaundice, transplant rejection and other jaundice condition.clinical correlation of delta bilirubin in all conditions have been summarized and their future perspectives are discussed.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the Major Research Methodology Steps under a Clinical Study?","authors":"S. N. Dwivedi","doi":"10.58999/cijmr.v2i02.120","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.120","url":null,"abstract":"Keeping in view of the need of quality evidence for public health care/ clinical practice, along with focus on adopting a culture of strong morality at every level of a research work, it is needed to follow each of the major steps required under research methodology for a clinical study. Accordingly the aim of the present write-up is to briefly list major steps under research methodology so that a reader can easily be aware about them at a glance, and choose and follow all relevant/ applicable steps in their clinical study. If feasible, except two steps (sample size & scales of measurements) which are already published in earlier issues of this journal, each of the remaining major steps may be elaborated separately and published in the ensuing issues of the journal.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Mucormycosis in a Diabetic Patient and an Approach to its Management in a Tertiary Care Centre of Central India","authors":"Manoj Gupta, S. Vaidya","doi":"10.58999/cijmr.v2i02.80","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.80","url":null,"abstract":"Background: Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infection which  usually begins in the nose and paranasal sinuses following inhalation of fungal spores. Case details:This is a case report of a 65 year old male ,admitted in our hospital with long history of Type 2 diabetes  with pain and swelling on right side of nose  and signs and symptoms indicating Rhino-Orbital-Cerebral-mucormycosis.  Methodology:The level of involvement like nasal cavity, septum, turbinates, sinuses, palate, orbit involvement was noted and the protocol of medical and surgical management was decided in accordance to that. Post surgery KOH mount and HPE report after every debridement,CT and MRI findings were the mainstay. Conclusion : We here report a case of mucormycosis in diabetic patient shows aggressive and alarming mortality,which can be reduced by rapid diagnosis, surgical debridment and administration of drugs like amphotericin B.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mullerian Duct Anomaly: Two Patients in Adolescent Age in C. R. Gardi Hospital","authors":"Aditi Vashistha, Suchika Agrawal, Surbhi Patidar, P. K. Roy, Case Reports","doi":"10.58999/cijmr.v2i02.66","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.66","url":null,"abstract":"Clinical manifestations of Mullerian duct abnormalities vary greatly and can range from isolated abnormalities of a single reproductive organ to multiorgan aplasia. An early and precise diagnosis is essential because untreated symptoms may result in pelvic endometriosis, retrograde tubal reflux, and infertility. MRI and ultrasonography are the imaging modality that accurately helps in the diagnosis of mullerian duct anomalies. Two interesting cases came to C. R. Gardi OPD with Mullerian duct anomalies. The first case came with dysmenorrhea and a lower abdominal palpable mass upto 14 wk size was present, which was diagnosed to be bicornuate uterus, obstructed hemivagina. It is a diagnostic dilemma because menses were regular. Another case came with severe cyclic dysmenorrhea and was found to be a hematometra in the non-communicating rudimentary horn on the left side.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug – Alcohol (Ethyl Alcohol) Interactions","authors":"S. P. Dhaneria","doi":"10.58999/cijmr.v2i02.115","DOIUrl":"https://doi.org/10.58999/cijmr.v2i02.115","url":null,"abstract":"Alcohol is the oldest recreational substance, and its consumption is increasing all over the world as it produces a pleasurable effect and also it allows people to relax and unwind. A large number of over the counter and prescription medicine interacts with Alcohol by Pharmacokinetic and/or Pharmacodynamic mechanisms. Alcohol consumption with drugs having CNS depressant property may lead to marked impairment in psychomotor performance and making the person’s injury prone. Alcohol consumption increases the systemic toxicity and organ dysfunction caused by certain drugs. Alcohol consumption may cause unpleasant manifestations with a few drugs/substances (didisulfiram-likeeaction). Alcohol may reduce the therapeutic effect of a few drugs. Awareness about the various interactions of Alcohol with drugs/medicines/food/herbals/occupational agents will ensure the safety of the people consuming Alcohol and may help the physician in clinical decision-making.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and Correlation of Laboratory Investigation Values and Disease Outcome among COVID-19 Patients in a Tertiary Care Medical College in India","authors":"A. Tripathi, Ashish Sharma, V. Patidar, Babu Lal Bamboriya, Amit Dubey, Ajay Adhikari, H. Jain, Tejaswini Dwivedi","doi":"10.58999/cijmr.v1i03.45","DOIUrl":"https://doi.org/10.58999/cijmr.v1i03.45","url":null,"abstract":"Background- COVID-19 and post-COVID sequel are a persistent challenge in India. We as tertiary careinstitute, managed much of the COVID-19 cases. We have studied associations between COVID-19disease outcomes and common lab investigation values to ascertain their association by analyzing 467 RTPCR confirmed COVID-19 cases.Methods- Records of 467 RTPCR confirmed COVID-19 admitted in ICU were analyzed. Descriptivedata about routine investigation taking all admitted patients as a single cohort were analyzed. Further, patients were divided into 2 groups, those requiring ventilatory support and those not requiring ventilatory support, independent sample t-test was applied to ascertain differences in mean values of investigation in these groups. Pts were also divided according to the severity in chest X-ray films by using RALES score as criteria. A hierarchical regression analysis study was done and model was developed.Results- The descriptive data of investigation values mean median mode and CI was calculated forall admitted patients as single cohort. Among cohort of patients requiring ventilatory support vs notrequiring ventilatory support, an independent t-sample test indicated significant differences of meanvalues (2-tailed p-value < 0.05) among these groups, differences in pulse, SpO2, total leucocyte count, neutrophil%, lymphocyte%, neutrophil to lymphocyte ratio (NLR), serum sodium (S.Na), serumpotassium (S.K), serum urea, serum creatinine, serum ferritin, serum lactate dehydrogenase (S LDH),d-dimer, C reactive protein (CRP), serum glutamic oxaloacetic transaminase (SGOT), chest X-rayradiographic assessment of lung edema (RALE) score. Among the cohort divided on chest X-ray severity on RALES score, we applied hierarchical regression analysis, further 5 tests values were found to pedict adverse RALES outcome more closely, those were SpO2, CRP, LDH, ferritin, RBS on admission with p-values and beta coefficient significant.Conclusion- There is significant association with specific laboratory investigations and adverse disease outcome on COVID-19 pneumonia.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125487839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post COVID-19 Vaccine-associated Complications","authors":"A. Tripathi, Ashish Sharma, Dr Himanshu Jain, Chandrakant Salve, Dr Aayush Malik, Tejaswini Dwivedi","doi":"10.58999/cijmr.v1i03.35","DOIUrl":"https://doi.org/10.58999/cijmr.v1i03.35","url":null,"abstract":"The COVID-19 pandemic is being fought against worldwide; the major weapon against this pandemichas been the vaccine against it. There are reports of neurological complications and sequelae afterCOVID-19 vaccinations, some cases with ChAdOx1 nCov-19 is adenovirus vector-based vaccines. InIndia vaccination program against covid19 is using this vaccine by this vaccine. Reports of vaccineassociated side effects have emerged, which are rare but serious. This case series presents a few such cases reported in our hospitals:- RD Gardi Medical college (CR Gardi Hospital, Ujjain) and Charitable trust Hospital, Ujjain.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114101619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Cell Neuroendocrine Carcinoma of Cervix: A Rare Case Report","authors":"Kavita Jain, P. K. Roy","doi":"10.58999/cijmr.v1i03.73","DOIUrl":"https://doi.org/10.58999/cijmr.v1i03.73","url":null,"abstract":"Neuroendocrine neoplasms (NEN) are derived from endocrine cells and are very rarely seen in gynecological practice. Here we report a case of small cell neuroendocrine carcinoma (SCNEC) of cervix in a 45 year old married female who presented with history of menorrhagia. On gynecological examination, she had bulky uterus with a palpable non tender, hard nodule on posterior wall of cervix. Ultrasonogram of pelvis was reported as bulky ? adenomyotic uterus with 2.7x2.4x1.0cm well defined collection in fundal region of endometrium. She underwent total abdominal hysterectomy for abnormal uterine bleeding. Histopathology with immunohistochemical markers was reported as small cell neuroendocrine carcinoma (SCNEC) of cervix. This case is reported here for its rarity.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124456044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Deal with Sample Size Exploration and its reporting in Clinical Research?","authors":"S. Dwivedi","doi":"10.58999/cijmr.v1i03.65","DOIUrl":"https://doi.org/10.58999/cijmr.v1i03.65","url":null,"abstract":"The minimum sample size required to answer a specific research question is unavoidable regardlessof study designs, more pertinent in case of randomized controlled trials. Sample size exploration isnot required in many situations, including a pilot study; it is simply decided as feasible or a rule ofthumb. However, in situations, including a conclusive study like the third and final phase of drugdevelopment, it becomes mandatory to ensure optimal power as well as level of confidence to thestudy. The present write-up aims to address various issues related to sample size considerations forclinical studies in a non-statistical language, focusing on making it easily understandable by medicalresearchers.","PeriodicalId":127536,"journal":{"name":"Central India Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127402190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}