Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_11_21

J. Robledo-Arias, Veronica Arango-Machado, Michael Ortega-Sierra, Ivan Lozada-Martinez

引用次数: 0

Application and prospect of radiomics in spinal cord and spine system diseases: A narrative review 放射组学在脊髓和脊柱系统疾病中的应用与展望

Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_14_21

Chao Ma, Guihuai Wang

引用次数: 0

Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review 多发性髓圆锥胶质母细胞瘤伴小脑膜播散表现为颅内高压:1例报告并文献复习

Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_15_21

Yu Hu, Wumeng Yin, Jun-peng Ma, Jia-gang Liu, Si-qing Huang, Haifeng Chen

{"title":"Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review","authors":"Yu Hu, Wumeng Yin, Jun-peng Ma, Jia-gang Liu, Si-qing Huang, Haifeng Chen","doi":"10.4103/glioma.glioma_15_21","DOIUrl":"https://doi.org/10.4103/glioma.glioma_15_21","url":null,"abstract":"Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a unique case of GBM in the conus medullaris with leptomeningeal dissemination that initially presented with increased intracranial pressure without hydrocephalus. The patient was first diagnosed with tuberculous meningitis and received antituberculosis therapy, but the symptoms did not resolve and even worsened. Subsequent radiological imaging clearly disclosed an intramedullary lesion at the T12 level with the progression of leptomeningeal enhancement. Subtotal resection of the intramedullary lesion was performed, and pathological examination revealed the presence of GBM. To our knowledge, our case was the first with holocordal and intracranial leptomeningeal dissemination that initially presented with intracranial hypertension in the absence of hydrocephalus. Awareness of this unusually lethal condition is significant for proper diagnosis, timely treatment, and consideration of clinical prognosis.","PeriodicalId":12731,"journal":{"name":"Glioma","volume":"4 1","pages":"57 - 61"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43558093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric high-grade astrocytoma with piloid features of the spinal cord: A report of two cases and literature review 具有脊髓毛状特征的儿童高级别星形细胞瘤：2例报告和文献复习

Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_10_21

Beibei Yu, Yang Lu, L. Jing, Guihuai Wang

引用次数: 0

Diagnostic challenges in epithelioid glioblastoma of the cerebellum: A case report 小脑上皮样胶质母细胞瘤的诊断挑战：一例报告

Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_13_21

P. Aggarwal, D. Chatterjee, V. Gupta, Rekha Gupt

引用次数: 0

Establishment and evaluation of a Sprague-Dawley rat model of intramedullary spinal cord glioma Sprague-Dawley大鼠脊髓髓内神经胶质瘤模型的建立及评价

Glioma Pub Date : 2021-07-01 DOI: 10.4103/glioma.glioma_16_21

Dong-kang Liu, Guo-qing Yi, J. Wang, Guihuai Wang

{"title":"Establishment and evaluation of a Sprague-Dawley rat model of intramedullary spinal cord glioma","authors":"Dong-kang Liu, Guo-qing Yi, J. Wang, Guihuai Wang","doi":"10.4103/glioma.glioma_16_21","DOIUrl":"https://doi.org/10.4103/glioma.glioma_16_21","url":null,"abstract":"Background and Aim: Intramedullary spinal cord glioma has no evident boundary with normal spinal cord tissue. The rate of successful surgical resection of intramedullary spinal cord glioma is low. Well-established animal models for intramedullary spinal cord glioma can help promote translation from related basic therapy research to clinical applications. In this study, we established a rat model of intramedullary spinal cord glioma. Materials and Methods: A total of 23 male Sprague-Dawley (SD) rats were randomized into blank control (n = 3) and experimental (n = 20) groups. The blank control group received intramedullary injection of Dulbecco's modified Eagle medium (DMEM) and the experimental group was injected with DMEM containing C6 glioma cells. The neurological states of these rats were evaluated using the Basso, Beattie, and Bresnahan scale (BBB). Tumor sizes were measured by magnetic resonance imaging. The histopathological analysis was performed to observe the growth of infiltrating tumors. All procedures involving animals were approved by the Ethics Committee of the Laboratory Animal Facility Biomedical Analysis Center, Tsinghua University (Beijing, China; approval No. 17-WGH1). Results: On postoperative 7 days, the experimental group presented with a significant progressive decrease in motor function (mean BBB score 15.00 ± 1.20) compared with the blank control group (20.67 ± 0.47, P < 0.01). All rats in the experimental group showed exponential tumor growth and had an average survival of up to 5 weeks after tumor cell implantation. The tumor sizes were 3.18 ± 0.21 mm3, 68.55 ± 3.38 mm3, and 345.28 ± 22.57 mm3 on postoperative 7, 14, and 28 days. The histopathological analysis illustrated that the growth of infiltrating tumors followed the longitudinal axis of the spinal cord. Conclusions: Thus, we have established a SD rat model of intramedullary spinal cord glioma, and we found that our findings are reproducible and homogeneous. These positive results provide solid bases for further studies of intramedullary spinal cord glioma.","PeriodicalId":12731,"journal":{"name":"Glioma","volume":"4 1","pages":"42 - 48"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47514672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unexpected upper limb compartment syndrome due to venous thrombosis in frontal glioma surgery: A case report 额神经胶质瘤手术中静脉血栓形成引起的意外上肢隔室综合征1例

Glioma Pub Date : 2021-04-01 DOI: 10.4103/glioma.glioma_4_20

A. Dalvi, A. Shetty, G. Gangakhedkar, Pallavi V. Waghalkar

{"title":"Unexpected upper limb compartment syndrome due to venous thrombosis in frontal glioma surgery: A case report","authors":"A. Dalvi, A. Shetty, G. Gangakhedkar, Pallavi V. Waghalkar","doi":"10.4103/glioma.glioma_4_20","DOIUrl":"https://doi.org/10.4103/glioma.glioma_4_20","url":null,"abstract":"Although it is well known that 49% cases of upper limb deep-vein thrombosis are due to malignancies and the likelihood of venous thromboembolism is increased in patients with high grade gliomas due to the heightened prothrombotic milieu, requisite preoperative laboratory coagulation studies are not performed routinely in these patients to decide whether appropriate antithrombotic medications are required preoperatively. In addition, it is controversial whether antithrombotic therapy should be initiated before neurosurgery in view of the risk of intraoperative bleeding. Here, we have described the case of a 29-year-old female with high grade frontal malignant astrocytoma who developed the extremely rare complication of upper limb compartment syndrome postoperatively. The patient had no history of thrombotic events, and her basic laboratory parameters were not deranged in the pre-operative period. This rare case, supported with a literature review, suggested that the risk of thrombosis is increased in high grade and large gliomas, making us rethink the overall battery of investigations and perioperative medical management of such cases. We strongly recommend peri-operative coagulation studies and appropriate antithrombotic measures along with vigilant perioperative monitoring to avoid thrombotic complication in this subset of patients.","PeriodicalId":12731,"journal":{"name":"Glioma","volume":"4 1","pages":"34 - 36"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47191729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CpG2 hypermethylation in the CD95L promoter is associated with survival in patients with glioblastoma: An observational study CD95L启动子CpG2高甲基化与胶质母细胞瘤患者的生存相关:一项观察性研究

Glioma Pub Date : 2021-04-01 DOI: 10.4103/glioma.glioma_8_21

N. F. Farrukh Hameed, Yuyao Zhou, Lei Jin, Ying Xu, J Zhang, Hong Chen, James R. Xue, Jinsong Wu

{"title":"CpG2 hypermethylation in the CD95L promoter is associated with survival in patients with glioblastoma: An observational study","authors":"N. F. Farrukh Hameed, Yuyao Zhou, Lei Jin, Ying Xu, J Zhang, Hong Chen, James R. Xue, Jinsong Wu","doi":"10.4103/glioma.glioma_8_21","DOIUrl":"https://doi.org/10.4103/glioma.glioma_8_21","url":null,"abstract":"Background and Aim: Blockade of CD95/CD95 ligand (CD95 L) signaling is a promising therapeutic approach for the treatment of glioblastoma (GBM), while methylation of a single cytosine-phosphate-guanine site (CpG2) upstream of the CD95 L promoter has been identified as a prognostic biomarker for GBM. Here, we conducted the first investigation of CD95 L expression and CpG2 methylation levels in the CD95 L promoter in GBM patients. Materials and Methods: In this observational study, tissue samples were collected from 69 patients with a primary diagnosis of World Health Organization Grade IV GBM treated at the Department of Glioma Surgery, Huashan Hospital, Shanghai Medical College, Fudan University and tested for CD95 L expression using immunohistochemistry (IHC). The CpG2 methylation status of the samples was also evaluated, and its impact on overall survival (OS) was assessed by univariate analysis. The study was approved by the Hospital Institutional Review Board (approval No. 220) on July 7, 2015. Results: The IHC results showed a CD95 L detection rate of at least 43.5% for tissue samples with IHC scores of 2+ or 3+ and 78.3% for those with IHC scores of 1+, 2+, or 3+. Patients with high CpG2 methylation levels (≥52% higher than the median value; n = 32) had significantly longer median survival compared with those with low CpG2 methylation levels (n = 29) (22.95 vs. 14.5 months; P = 0.0084). GBM patients who underwent gross total tumor resection (n = 57) showed similar results. Those in the high CpG2 methylation group had longer median OS compared with that of patients in the low CpG2 methylation group (23.5 vs. 18.0 months; P = 0.0141). Conclusions: Our results showed a significant prevalence of CD95 L expression in GBM patients, whereas CpG2 hypermethylation within the CD95 L promoter was positively associated with survival. These findings support that CD95/CD95 L signaling blockade has potential as a therapeutic strategy targeting treatment-resistant GBM.","PeriodicalId":12731,"journal":{"name":"Glioma","volume":"4 1","pages":"22 - 26"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44832000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibition of histone deacetylase 6 by tubastatin A as an experimental therapeutic strategy against glioblastoma tubastatin A抑制组蛋白去乙酰化酶6对胶质母细胞瘤的实验性治疗策略

Glioma Pub Date : 2021-04-01 DOI: 10.4103/glioma.glioma_5_21

Alejandro Urdiciain, P. Bermudez-Lekerika, B. Meléndez, Juan Rey, M. Idoate, Natalia A. Riobo-Del Galdo, J. Castresana

引用次数: 0

Progress on glioma surgery and multimodal treatments 神经胶质瘤手术及多模式治疗进展

Glioma Pub Date : 2021-04-01 DOI: 10.4103/glioma.glioma_9_21

M. Berger

引用次数: 0

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