MOJ Biology and Medicine最新文献_第5页

Artery of percheron stroke: a case report 脑卒中动脉1例

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.06.00132

Marcelo Zalli, Victor Cubas Schulz, Henrique Orefice Farah, Matheus Soares Flor

引用次数: 0

Ginger as a commercial product in China 生姜在中国是一种商业产品

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/MOJBM.2019.04.00115

Shuangsheng Yan, Rasheed Abdulwase, A. Abbas

引用次数: 3

A brief note on the scope of RNA interference(RNAi) therapy in mitigating COVID-19 简要介绍RNA干扰(RNAi)治疗在缓解COVID-19中的范围

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.06.00138

Sanzida Islam Bristi

{"title":"A brief note on the scope of RNA interference(RNAi) therapy in mitigating COVID-19","authors":"Sanzida Islam Bristi","doi":"10.15406/mojbm.2021.06.00138","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00138","url":null,"abstract":"Together with the use of number of repurposed/ repositioned antiviral drugs and immunomodulatory agents against the severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, currently several vaccines are under human trials to mitigate the COVID-19 worldwide. Although the drugs and vaccines appear to be effective in maximum cases or trials; however, the associated side effects, the required induction of the long-lasting immunity, and finally, the safety concerns are of significance in terms of their consistent application/ administration. A vast research on the SARS-CoV-2 genomics and on its similarities with SARS-CoV-1 and with the Middle East Respiratory Syndrome coronavirus (MERS-CoV) have unraveled the viral avoidance of the host immunity which creates a challenge in course of effective vaccine development although several COVID-19 vaccines are currently being used commercially worldwide. Such an unsteady circumstance led the scientists also to think on a new remedial approach i.e., the RNA interference (RNAi) therapy to inhibit the SARS-CoV-2 proliferation by degrading the viral RNAs. Present review discussed such strategy and its effectiveness during the ongoing COVID-19 pandemic.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132880200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunomodulation by helmintos: Possible use as therapy for autoimmune diseases 蠕虫的免疫调节作用:可能用于自身免疫性疾病的治疗

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.06.00139

Juan Farak Gomez

{"title":"Immunomodulation by helmintos: Possible use as therapy for autoimmune diseases","authors":"Juan Farak Gomez","doi":"10.15406/mojbm.2021.06.00139","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00139","url":null,"abstract":"Context: The incidence of autoimmune diseases and allergies has increased markedly in the last half of the 20th century, especially in more developed countries, with an increase in urbanization and hygiene that has led to the elimination of many parasitic infections. Objective: To analyze through scientific bibliographic sources the effects of the parasite load, especially helminthiasis, on the appearance of autoimmune and allergic diseases. Methodology: The documentary analysis of different scientific sources that refer to the theory of immunomodulation by helminths was used. Results: They suggest that the treatment of autoimmune diseases with helminths or products derived from them can have protective and therapeutic effects in these patients. Conclusions: It could be concluded that the immunodulation mechanisms carried out by helminths prevent patients from eliminating the parasites, but have beneficial effects on the course of some autoimmune diseases. Although the causal relationship is not fully proven, studies in animal models and clinical trials carried out in patients with autoimmune diseases suggest that their treatment with helminths or products derived from them may have protective and therapeutic effects in these patients.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131601663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of melancholy in swat valley, Pakistan 巴基斯坦斯瓦特山谷忧郁的流行

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.06.00148

{"title":"Prevalence of melancholy in swat valley, Pakistan","authors":"","doi":"10.15406/mojbm.2021.06.00148","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00148","url":null,"abstract":"Melancholy is major mental challenges that is characterize by sadness, sleep disorder, decrease energy, etc. It also have a great social and mental consequences, it is well know that depression will be the second largest cause of disability globally till 2020. The risk are even higher in developed countries. According to world health organization globally it effect more than 121 million people. Depression is a complex and multi-dimensional anarchy according to it has many faces and cannot be describing by one simple formula because it originate from numerous complex mechanism. Multi-faced nature of depression makes it difficult to find out its etiology. The purpose of this study is to find out the prevalence of melancholy in different age groups and genders in district Swat. Overall 300 samples were collected randomly across different age groups and genders in which we found the prevalence of melancholy were 48.3% in which male depressed individual were 27.6% while female depressed were 20.6%. The number of depressed individual were maximum in age group vary from 10-20 which is 15%. To conclude depression is easily manageable but it need understanding that how to control your feeling and thought and think new and positively.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124696237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidants properties of some spices with their chemistry and mechanism of action 几种香料的抗氧化性能及其化学成分和作用机理

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/MOJBM.2021.06.00126

Sunita Singh

{"title":"Antioxidants properties of some spices with their chemistry and mechanism of action","authors":"Sunita Singh","doi":"10.15406/MOJBM.2021.06.00126","DOIUrl":"https://doi.org/10.15406/MOJBM.2021.06.00126","url":null,"abstract":"Herbs and spices are the very best way to add flavor and dimension to a dish without adding fat, salt or calories. In fact, some herbs and spices already include a little something extra, like antioxidants. Antioxidants are substances that slow or prevent the oxidative process in which cells are damaged by free radicals, which can lead to cell dysfunction. These powerful nutrients have been linked to the prevention of heart disease and diabetes, improving immune function and lowering the risk of infection and even some cancers. The bioactive compounds present in spices having antioxidant properties mainly consists of flavonoids, phenolic compounds, sulfur-containing compounds, tannins, alkaloids, phenolic diterpenes, and vitamins. While we hear a lot about the antioxidants found in dark chocolate and red wine, spices like ground cloves, oregano leaves, ginger, cinnamon, turmeric and yellow mustard seed are the real antioxidant stars – delivering a higher concentration of antioxidants per 100g than dark chocolate, wine, even blueberries and whole grain cereal. Plus, they have none of the calories found in chocolate or the drawbacks associated with alcohol consumption.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124441182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antioxidant and phytochemical analysis of volatile oil and extracts of Pinus wallichiana 油松挥发油及提取物的抗氧化及植物化学分析

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2019.04.00111

Pooja Sharma, Sahil Gupta, N. Bhatt, Shajaat Hussain Ahanger, D. Gupta, P. Singh, R. Lochan, M. Bhagat

{"title":"Antioxidant and phytochemical analysis of volatile oil and extracts of Pinus wallichiana","authors":"Pooja Sharma, Sahil Gupta, N. Bhatt, Shajaat Hussain Ahanger, D. Gupta, P. Singh, R. Lochan, M. Bhagat","doi":"10.15406/mojbm.2019.04.00111","DOIUrl":"https://doi.org/10.15406/mojbm.2019.04.00111","url":null,"abstract":"The present study aims to explore the chemical constituents and antioxidant potential of Pinus wallichiana essential oil and extracts. Chemical composition of the essential oil was analyzed by GC-MS and result showed that the oil contain three major monoterpene compounds viz. α-pinene (48.6%), β-pinene (45.6%) and limonene (5.6%). Antioxidant potential of Pinus wallichiana was analyzed by three basic methods; DPPH radical scavenging method, FRAP assay and Fe2+ ion chelating activity. Among leaf and bark extracts, best radical scavenging, activity was determined by aqueous extract (IC50 values 20.83±0.8µg/ml) of bark followed by its methanol extract (IC50 value 25.9±1.6µg/ml). The aqueous extract of bark also exhibited better reducing and chelating activity than leaf extracts. Essential oil showed moderate radical scavenging and chelating activity but negligible reducing activity. Phytochemical analysis of extracts determined that the aqueous and methanol extracts of bark contain rich amount of poly phenol and flavonoids, in comparison to the leaf extracts. A significant correlation between the antioxidant activity and these phytoconstituents of the extracts has been observed. The results of the present study concluded that the bark of Pinus wallichiana is a potential source of active antioxidant constituents that could be further explored and exploited for numerous commercial applications.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122254404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

ACE Gene I/D polymorphism and systemic arterial hypertension in different classes of hypertensive individuals 不同类型高血压患者的 ACE 基因 I/D 多态性与全身性动脉高血压

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2019.04.00108

Rubia Caldas Umburanas, Priscila Costa Estabile, Rogério Pincela Mateus, Mara Cristina de Almeida, Roberto Ferreira Artoni

{"title":"ACE Gene I/D polymorphism and systemic arterial hypertension in different classes of hypertensive individuals","authors":"Rubia Caldas Umburanas, Priscila Costa Estabile, Rogério Pincela Mateus, Mara Cristina de Almeida, Roberto Ferreira Artoni","doi":"10.15406/mojbm.2019.04.00108","DOIUrl":"https://doi.org/10.15406/mojbm.2019.04.00108","url":null,"abstract":"Systemic arterial hypertension (SAH) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP). Some studies have reported that variants of the angiotensin-converting enzyme (ace) gene increase the risk of hypertension. The aim of this study was to verify the existence of the relationship between the insertion/deletion (I/D) polymorphism in the ACE gene and its genotypic variants with BP in four distinct groups of hypertensive individuals and also to genetically and epidemiologically characterize the investigated samples. The study was formed of 112 individuals arranged into the following groups: normotensive (control); hypertensive and non-obese; hypertensive and obese; and, hypertensive and with type 2 diabetes mellitus (T2DM). Epidemiological data and peripheral blood were collected from participants for DNA extraction and amplification by PCR (polymerase chain reaction). The allele (D=0.5446; I=0.4554) and genotype (DD =0.2411, ID =0.6071; II =0.1518) frequencies showed low genetic differentiation (Fst<0.05) and were outside the Hardy-Weinberg equilibrium (p<0.05). There was no significant difference between the groups (chi-square=4.4335; p=0.6174). There was no association of the D allele with SAH, reinforcing the hypothesis that environmental interferences are prevalent in the evolution of SAH.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127923498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open and closed treatment of chest injuries: mortality, hospitalization, trauma indices and physiological data 胸部损伤的开合治疗:死亡率、住院率、创伤指标和生理数据

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.05.00119

J. M. Pereira de Godoy, Francisco de Assis Cury, Maria de Fatima Guerreiro Godoy OT, Fatima Guerreiro Godoy OT

{"title":"Open and closed treatment of chest injuries: mortality, hospitalization, trauma indices and physiological data","authors":"J. M. Pereira de Godoy, Francisco de Assis Cury, Maria de Fatima Guerreiro Godoy OT, Fatima Guerreiro Godoy OT","doi":"10.15406/mojbm.2021.05.00119","DOIUrl":"https://doi.org/10.15406/mojbm.2021.05.00119","url":null,"abstract":"Background: In more than half of cases of chest trauma, patients also have head injuries, abdominal injuries or polytrauma. Aim: The aim of the present study was to compare open and closed treatment for chest injuries according to mortality, hospitalization, trauma indices and physiological data. Method: Three hundred sixty-seven patients (293 males and 74 females) with an Anatomic Injury Scale (AIS) score of 2 or more for thoracic trauma were evaluated. The following aspects were evaluated associations between treatment (open and closed) for chest injury, discharge from hospital, hospitalization and death, Trauma indices Revised Trauma Score (RTS), Injury Severity Score (ISS) and TRISS, Blood pressure, diastolic pressure, respiratory rate and pulse. Results: No significant associations were found between the type of treatment (open or closed procedure) and discharge from hospital, hospitalization or death (p = 0.3).No significant associations were found between the type of treatment (open or closed procedure) and the trauma indices, blood pressure, pulse or respiratory rate.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116632239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the complex interplay in the regulation of cardiac pathophysiological functions by protein kinases and phosphatases 探讨蛋白激酶和磷酸酶在心脏病理生理功能调节中的复杂相互作用

MOJ Biology and Medicine Pub Date : 1900-01-01 DOI: 10.15406/mojbm.2021.06.00151

Dr Chrysanthus Chukwuma Sr

{"title":"Exploring the complex interplay in the regulation of cardiac pathophysiological functions by protein kinases and phosphatases","authors":"Dr Chrysanthus Chukwuma Sr","doi":"10.15406/mojbm.2021.06.00151","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00151","url":null,"abstract":"Cardiovascular disease manifests as an intricately complex entity presenting as a derangement of the cardiovascular system. Cardiac or heart failure connotes the pathophysiological state in which deficient cardiac output compromises the body burden and requirements. Protein kinases regulate several pathophysiological processes and are emerging targets for drug lead or discovery. The protein kinases are family members of the serine/threonine phosphatases. Protein kinases and phosphatases are pivotal in the regulatory mechanisms in the reversible phosphorylation of diverse effectors whereby discrete signaling molecules regulate cardiac excitation and contraction. Protein phosphorylation is critical for the sustenance of cardiac functionalities. The two major contributory ingredients to progressive myocardium derangement are dysregulation of Ca2+processes and contemporaneous elevated concentrations of reactive oxygen species, ROS. Certain cardiac abnormalities include cardiac myopathy or hypertrophy due to response in untoward haemodynamic demand with concomitant progressive heart failure. The homeostasis or equilibrium between protein kinases and phosphatases influence cardiac morphology and excitability during pathological and physiological processes of the cardiovascular system.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132196331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2