Global Spine Journal最新文献

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Sexual Dysfunction in Cervical Spondylomyelopathy and Its Prognosis Following Surgical Decompression: A Systematic Review. 脊髓型颈椎病的性功能障碍及其手术减压后的预后:一项系统综述。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-21 DOI: 10.1177/21925682251316484
Vibhu Krishnan Viswanathan, Sathish Muthu
{"title":"Sexual Dysfunction in Cervical Spondylomyelopathy and Its Prognosis Following Surgical Decompression: A Systematic Review.","authors":"Vibhu Krishnan Viswanathan, Sathish Muthu","doi":"10.1177/21925682251316484","DOIUrl":"10.1177/21925682251316484","url":null,"abstract":"<p><strong>Study design: </strong>Systematic review.</p><p><strong>Objective: </strong>While the occurrence of sexual dysfunction in patients sustaining traumatic cervical or thoracic injuries is well acknowledged, the evidence regarding its prevalence and outcome in individuals with degenerative cervical myelopathy (DCM) is still limited. The current systematic review was planned to comprehensively evaluate the existing literature regarding the prevalence, patterns, presentation, and outcome of sexual dysfunction in patients presenting with DCM.</p><p><strong>Methods: </strong>A thorough search of the literature was performed on October 15, 2024, using 5 different databases (Google Scholar, Embase, PubMed, Web of Science and Cochrane Library). Studies on sexual dysfunction in DCM published until 2024 were scrutinized. Narrative or systematic reviews, opinions, letters to the editor, and manuscripts published in non-English languages were excluded.</p><p><strong>Results: </strong>Overall, the literature search yielded a total of 384 articles of which 7 articles with 910 patients were included in the analysis. The overall prevalence of erectile dysfunction (ED) in CSM ranges between 3 and 6%. 82% of patients with preoperative ED had an abnormal psychogenic erection while the remaining had an abnormal reflexogenic erectile function. The erectile function was reported to improve substantially following decompressive surgery (68% recovery rate; <i>P</i> = 0.05). The presence of preoperative sexual dysfunction has been associated with poorer neurological outcomes (50% recovery rate; including poorer gait recovery). The data regarding ejaculatory disturbances and female sexual dysfunction in DCM patients are still limited.</p><p><strong>Conclusion: </strong>ED occurs in 3 to 6% of patients with DCM, with a majority of patients suffering from ED from psychogenic origin. Surgical decompression can significantly improve the sexual recovery in these patients. Patients with ED have overall poorer neurological recovery.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251316484"},"PeriodicalIF":2.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Risk Assessment for Lumbar Fusion in Patients With Diabetes: Data-Driven Stratification of HbA1c and Same Day Glucose Levels that Predict 90-Day Complication Rates. 糖尿病患者腰椎融合术的术前风险评估:预测90天并发症发生率的HbA1c和当日血糖水平数据驱动分层
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-20 DOI: 10.1177/21925682251315098
Chloe Farnham, Ivan Z Liu, Amil R Agarwal, Philip Parel, Theodore Quan, Wesley M Durand, Michael Raad, Amit Jain
{"title":"Preoperative Risk Assessment for Lumbar Fusion in Patients With Diabetes: Data-Driven Stratification of HbA1c and Same Day Glucose Levels that Predict 90-Day Complication Rates.","authors":"Chloe Farnham, Ivan Z Liu, Amil R Agarwal, Philip Parel, Theodore Quan, Wesley M Durand, Michael Raad, Amit Jain","doi":"10.1177/21925682251315098","DOIUrl":"10.1177/21925682251315098","url":null,"abstract":"<p><strong>Study designs: </strong>Retrospective Database Analysis.</p><p><strong>Objectives: </strong>Pre-operative glycemic control in diabetic patients undergoing lumbar fusion (LF) is essential for evaluating complication risk. However, current thresholds for preoperative HbA1c and same-day-glucose (SDG) are either non-specific or have low predictive power. This study uses HbA1c and SDG to provide data-driven risk stratification for 90-day major and wound complications in LF patients.</p><p><strong>Methods: </strong>Using a national database, patients undergoing LF from 2013-2022 with a recorded preoperative HbA1c and SDG level were included for analysis. Multiple HbA1c and SDG strata were identified using stratum specific likelihood ratio analysis (SSLR). Each stratum was then propensity-score matched to the lowest strata and compared using risk ratios. Significance level was set at a <i>P</i>-value <0.05.</p><p><strong>Results: </strong>12,026 patients met inclusion criteria. For 90-day major complications, SSLR identified 3 predictive HbA1c (4.5-5.4, 5.5-7.9, and 8.0+) and SDG strata (60-159, 160-239, and 240+). Following propensity-matching, the 90-day major complication risk sequentially increased for HbA1c: 5.5-7.9 (1.69; <i>P</i> = 0.001; 95% CI 1.24-2.30), 8.0+(2.31; <i>P</i> < 0.001; 95% CI 1.56-3.43). Following propensity-matching, the SDG strata similarly demonstrated sequentially increasing 90-day major complication risk: 160-239 (1.34; <i>P</i> < 0.001; 95% CI 1.18-1.54), 240+ (1.64; <i>P</i> < 0.001; 95% CI 1.31-2.05). Matched analysis demonstrated a higher relative-risk of 90-day wound complications for the 8.0+ HbA1c strata (2.23; <i>P</i> = 0.001; 95% CI 1.37-3.63) compared to the HbA1c 4.5-5.4 strata. No other strata were identified that predicted differences in 90-day wound complications.</p><p><strong>Conclusions: </strong>This study identified data-driven HbA1c and SDG strata that better risk-stratify 90-day major complications following LF. Instead of current single-value thresholds, these multiple strata may be utilized for better preoperative guidance.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251315098"},"PeriodicalIF":2.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Efficacy and Safety of Halo-Femoral Traction and Halo-Gravity Traction Techniques in Severe Kyphoscoliosis With Spinal Cord Risk Classification (SCRC) Type 3 Over the Apex. 评价halo -股骨牵引和halo -重力牵引技术在脊髓危险分级(SCRC) 3型超过尖端的严重后凸性脊柱侧凸中的疗效和安全性。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-16 DOI: 10.1177/21925682251314382
Yuan-Shun Lo, Erh-Ti Ernest Lin, Chen-Wei Yeh, Michael Jian-Wen Chen, Cheng-Hung Chiang, Chun-Hao Tsai, Yi-Chin Fong, Pao-Lung Chang, Yen-Jen Chen, Hsien-Te Chen, Yong Qiu
{"title":"Evaluating the Efficacy and Safety of Halo-Femoral Traction and Halo-Gravity Traction Techniques in Severe Kyphoscoliosis With Spinal Cord Risk Classification (SCRC) Type 3 Over the Apex.","authors":"Yuan-Shun Lo, Erh-Ti Ernest Lin, Chen-Wei Yeh, Michael Jian-Wen Chen, Cheng-Hung Chiang, Chun-Hao Tsai, Yi-Chin Fong, Pao-Lung Chang, Yen-Jen Chen, Hsien-Te Chen, Yong Qiu","doi":"10.1177/21925682251314382","DOIUrl":"10.1177/21925682251314382","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Objective: </strong>To analyze the efficacy and safety of Halo-femoral traction (HFT) following spinal release, and preoperative Halo-gravity traction (HGT) in patients with severe spinal kyphoscoliosis and spinal cord risk classification (SCRC) type 3 at the apex.</p><p><strong>Methods: </strong>A total of 73 patients (24 males, 49 females, mean age 22.4 ± 6.4 years) and 56 patients (15 males, 41 females, mean age 22.9 ± 10.4 years) were included in the HFT and HGT group, respectively. Radiographic parameters were measured at the initial assessment, post-traction, post-final surgery, and during each follow-up. Neurologic function was assessed using the Frankel score system. IONM alerts and all complications were documented. Quality-of-life was evaluated using the SF-36 questionnaire.</p><p><strong>Results: </strong>In the HFT vs HGT group, the total correction rates were 39.9 ± 7.2% v.s. 41.3 ± 6.8% for the major Cobb and 36.6 ± 9.3% v.s. 44.4 ± 9.2% for global kyphosis (GK) after final surgery, respectively. The traction contributions were 57.6 ± 11.1% v.s. 52.3 ± 9.3% for major Cobb and 70.1 ± 10.5% v.s. 63.9 ± 11.1% for global kyphosis (GK), respectively. More than half of the total correction can be achieved gradually and safely through preoperative traction with patients in an awake state. No deterioration in neurological function was found post-final surgery. During the last follow-up, SF-36 questionnaire scores improved significantly in both groups (<i>P</i> < .05).</p><p><strong>Conclusions: </strong>Significant outcomes can be expected in patients with severe kyphoscoliosis, even with spinal cord risk classification (SCRC) type 3 at the apex undergoing HFT and HGT.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251314382"},"PeriodicalIF":2.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Outcomes of a New Foot-Worn Non-Invasive Biomechanical Intervention Compared to Traditional Physical Therapy in Patients With Chronic Low Back Pain. A Randomized Clinical Trial. 新型足部无创生物力学干预与传统物理治疗对慢性腰痛患者的临床效果比较一项随机临床试验。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-15 DOI: 10.1177/21925682251314823
Ratnakar Veeramachaneni, Andrew Gitkind, Sandeep Yerra, Michael Hagan, Asude N Hasanoglu, Natnael Akile, Hannah Kareff, Derek Ho, Matthew N Bartels
{"title":"Clinical Outcomes of a New Foot-Worn Non-Invasive Biomechanical Intervention Compared to Traditional Physical Therapy in Patients With Chronic Low Back Pain. A Randomized Clinical Trial.","authors":"Ratnakar Veeramachaneni, Andrew Gitkind, Sandeep Yerra, Michael Hagan, Asude N Hasanoglu, Natnael Akile, Hannah Kareff, Derek Ho, Matthew N Bartels","doi":"10.1177/21925682251314823","DOIUrl":"10.1177/21925682251314823","url":null,"abstract":"<p><strong>Study design: </strong>Randomized Controlled Trial.</p><p><strong>Objective: </strong>Chronic low back pain (CLBP) is a major public health concern that will continue to grow with the expected aging of the population. The purpose of this study was to examine the clinical effect of a personalized, home-based biomechanical intervention compared to traditional physical therapy in patients with CLBP.</p><p><strong>Methods: </strong>This was a randomized controlled trial. One-hundred and sixty-two patients were randomized in a 2:1 ratio to a home-based biomechanical intervention (HBBI, AposHealth) or traditional physical therapy (TPT), respectively. Patients were assessed at baseline and after 12 weeks and 52 weeks. The primary outcome measure was pain at 52 weeks, using a standard Numeric Rating Scale (NRS). Secondary outcomes included pain and function metrics, quality of life and objective spatio-temporal gait test. A Linear Mixed Model assessed changes over time across all study visits.</p><p><strong>Results: </strong>A significant reduction in NRS was found after 52 weeks with a superiority effect of the HBBI arm compared to TPT (F = 13.82, <i>P</i> < 0.001). Patients in the HBBI arm demonstrated a marginal mean reduction of 3.5 points, from 6.2 to 2.7 (a 56% reduction), while patients in the TPT arm reported a mean decrease of 1.8 points from 6.9 to 5.1 (a 26% reduction).</p><p><strong>Conclusions: </strong>A new foot-worn, home-based, biomechanical intervention for patients with chronic non-specific back pain was found to be clinically effective. Given the lack of non-surgical, non-pharmacological interventions for this populations, this treatment might serve as an adjunct to the current standard of care.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251314823"},"PeriodicalIF":2.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre- and Intraoperative Factors Associated With Improvement of Neck Pain After Laminoplasty for the Treatment of Cervical Myelopathy. 颈椎病椎板成形术后颈部疼痛改善的术前和术中相关因素。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-15 DOI: 10.1177/21925682251314490
Dong-Ho Lee, Arnold Joseph P Cagulada, Chang Ju Hwang, Jae Hwan Cho, Sehan Park
{"title":"Pre- and Intraoperative Factors Associated With Improvement of Neck Pain After Laminoplasty for the Treatment of Cervical Myelopathy.","authors":"Dong-Ho Lee, Arnold Joseph P Cagulada, Chang Ju Hwang, Jae Hwan Cho, Sehan Park","doi":"10.1177/21925682251314490","DOIUrl":"10.1177/21925682251314490","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Objective: </strong>To (1) determine whether preoperative neck pain improves after laminoplasty for cervical myelopathy and identify factors that could predict improvements in neck pain.</p><p><strong>Methods: </strong>A total of 88 patients with preoperative neck pain visual analogue scale (VAS) of ≥4, who underwent laminoplasty for cervical myelopathy, and were followed-up for >2 years were retrospectively reviewed. Patients demonstrating ≥50% improvement in VAS scores for neck pain 2 years postoperatively compared toㅇ preoperative assessment were included in neck pain improved (NP-improved) group. The remaining patients were assigned to neck pain unimproved (NP-unimproved) group.</p><p><strong>Results: </strong>Overall, 54 patients (61.4%) were included in NP-improved group and 34 patients (38.6%) were included in NP-unimproved group. NP-unimproved group more frequently underwent C3 laminectomy (<i>P</i> = 0.026) and had lesser degree of preoperative C2-C7 lordosis (<i>P</i> = 0.006) in the extension position compared to that in the NP-improved group. Furthermore, undergoing C3 laminectomy was associated with lower probability of achieving a ≥50% improvement in neck pain VAS scores (<i>P</i> = 0.018), while greater preoperative C2-C7 lordosis in the extension position was associated with a higher possibility of neck pain improvement (<i>P</i> = 0.048). A cut-off value of 20.5° for C2-C7 lordosis in the extension position predicted a ≥50% improvement in neck pain.</p><p><strong>Conclusion: </strong>Preoperative neck pain should not be considered contraindication for laminoplasty as 61.4% of patients experienced ≥50% improvement in neck pain post-operatively. C3 laminectomy decreases the probability of neck pain improvement after laminoplasty, while greater C2-C7 lordosis in the extension position is associated with neck pain improvement.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251314490"},"PeriodicalIF":2.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence for Cervical Spine Fracture Detection: A Systematic Review of Diagnostic Performance and Clinical Potential. 人工智能用于颈椎骨折检测:诊断性能和临床潜力的系统综述。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-12 DOI: 10.1177/21925682251314379
Wongthawat Liawrungrueang, Watcharaporn Cholamjiak, Arunee Promsri, Khanathip Jitpakdee, Sompoom Sunpaweravong, Vit Kotheeranurak, Peem Sarasombath
{"title":"Artificial Intelligence for Cervical Spine Fracture Detection: A Systematic Review of Diagnostic Performance and Clinical Potential.","authors":"Wongthawat Liawrungrueang, Watcharaporn Cholamjiak, Arunee Promsri, Khanathip Jitpakdee, Sompoom Sunpaweravong, Vit Kotheeranurak, Peem Sarasombath","doi":"10.1177/21925682251314379","DOIUrl":"10.1177/21925682251314379","url":null,"abstract":"<p><strong>Study design: </strong>Systematic review.</p><p><strong>Objective: </strong>Artificial intelligence (AI) and deep learning (DL) models have recently emerged as tools to improve fracture detection, mainly through imaging modalities such as computed tomography (CT) and radiographs. This systematic review evaluates the diagnostic performance of AI and DL models in detecting cervical spine fractures and assesses their potential role in clinical practice.</p><p><strong>Methods: </strong>A systematic search of PubMed/Medline, Embase, Scopus, and Web of Science was conducted for studies published between January 2000 and July 2024. Studies that evaluated AI models for cervical spine fracture detection were included. Diagnostic performance metrics were extracted and included sensitivity, specificity, accuracy, and area under the curve. The PROBAST tool assessed bias, and PRISMA criteria were used for study selection and reporting.</p><p><strong>Results: </strong>Eleven studies published between 2021 and 2024 were included in the review. AI models demonstrated variable performance, with sensitivity ranging from 54.9% to 100% and specificity from 72% to 98.6%. Models applied to CT imaging generally outperformed those applied to radiographs, with convolutional neural networks (CNN) and advanced architectures such as MobileNetV2 and Vision Transformer (ViT) achieving the highest accuracy. However, most studies lacked external validation, raising concerns about the generalizability of their findings.</p><p><strong>Conclusions: </strong>AI and DL models show significant potential in improving fracture detection, particularly in CT imaging. While these models offer high diagnostic accuracy, further validation and refinement are necessary before they can be widely integrated into clinical practice. AI should complement, rather than replace, human expertise in diagnostic workflows.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251314379"},"PeriodicalIF":2.6,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supine Traction vs Fulcrum Bending Radiographs in Preoperative Imaging of Scoliosis Patients Treated With Magnetically Controlled Growing Rods (MCGR) - which Technique is Better to Predict Surgical Correction of the Main Curve? 仰卧牵引与支点弯曲x线片在磁控生长棒(MCGR)治疗脊柱侧凸患者的术前成像——哪种技术更能预测主曲线的手术矫正?
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-10 DOI: 10.1177/21925682241299339
Stefan Hemmer, Raphael Trefzer, Tobias Renkawitz, Wojciech Pepke
{"title":"Supine Traction vs Fulcrum Bending Radiographs in Preoperative Imaging of Scoliosis Patients Treated With Magnetically Controlled Growing Rods (MCGR) - which Technique is Better to Predict Surgical Correction of the Main Curve?","authors":"Stefan Hemmer, Raphael Trefzer, Tobias Renkawitz, Wojciech Pepke","doi":"10.1177/21925682241299339","DOIUrl":"10.1177/21925682241299339","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective Cohort Study.</p><p><strong>Objectives: </strong>Flexibility radiographs such as traction or bending radiographs are essential in preoperative imaging to assess for curve flexibility and to estimate the amount of operative correction in order to determine the type and length of instrumentation in growth-accompanying scoliosis treatment. Both traction and bending radiographs are controversially discussed in the literature. The predictability of flexibility radiographs of postoperative main curve correction specifically in patients treated with magnetically controlled growing rods (MCGR) has not yet been studied.</p><p><strong>Methods: </strong>Juvenile patients with idiopathic or neuromuscular scoliosis that were surgically treated with a primary MCGR implant with pedicle screw fixation between 2018-2022 were retrospectively registered. Patients that underwent prior spine surgery, with supine lying-down radiograph and patients with missing traction or bending radiographs available were excluded. Image analysis was conducted using Surgimap® software. For statistical analysis, <i>t</i> test and ANOVA analysis were used to compare the means between groups with a significance level set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>A total of 50 patients, 34 diagnosed with idiopathic scoliosis (IS) and 16 diagnosed with neuromuscular scoliosis (NMS), were included. Globally, main curve Cobb angles were significantly higher in supine traction compared to fulcrum bending images (44.8° vs 39.6°; <i>P</i> < 0.001) and in the IS subgroup (42.4° vs 37.3°; <i>P</i> < 0.001). Compared to postoperative images, significant differences of supine traction but not fulcrum bending radiographs were detected in total (<i>P</i> < 0.001; <i>P</i> = 0.20) as well as IS (<i>P</i> < 0.001; <i>P</i> = 0.32) and NMS (<i>P</i> < 0.001; <i>P</i> = 0.44) subgroups. Fulcrum bending images displayed significantly higher flexibility rates (FR) and flexibility index (FI) compared to traction images in total (FR: 42.9 vs 35.2, <i>P</i> < 0.001; FI: 1.08 vs 1.58, <i>P</i> = 0.024) and the IS subgroup (FR: 44.2 vs 35.8, <i>P</i> < 0.001; FI: 1.19 vs 1.43, <i>P</i> = 0.033).</p><p><strong>Conclusions: </strong>Fulcrum bending radiographs showed better flexibility and prediction of operative main curve correction compared to supine traction radiographs in total and IS subgroup. Fulcrum bending might be more precise for predicting the postoperative main curve correction potential of primary MCGR surgery in IS patients.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682241299339"},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Denosumab on Pain and Radiological Improvement in Giant Cell Tumours of the Spine in the Acute Setting. Denosumab对急性脊柱巨细胞肿瘤疼痛和影像学改善的影响。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-09 DOI: 10.1177/21925682251314378
Nicolas Beresford-Cleary, Charlotte Dandurand, Gerard Mawhinney, Radek Kaiser, Musab Alageel, Jeremy Reynolds
{"title":"The Effect of Denosumab on Pain and Radiological Improvement in Giant Cell Tumours of the Spine in the Acute Setting.","authors":"Nicolas Beresford-Cleary, Charlotte Dandurand, Gerard Mawhinney, Radek Kaiser, Musab Alageel, Jeremy Reynolds","doi":"10.1177/21925682251314378","DOIUrl":"10.1177/21925682251314378","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective Cohort Study.</p><p><strong>Objectives: </strong>The current recommended treatment for Giant Cell Tumour (GCT) of the spine is en bloc excision. Denosumab is a monoclonal antibody reducing osteoclast activity that shows promising results when used as a neo - adjuvant treatment. However, the current literature remains limited. The purpose of this study was to assess the effect of denosumab on tumour characteristics and symptom relief in the acute phase of treatment of spinal GCT.</p><p><strong>Methods: </strong>We performed a retrospective review of 16 patients treated with denosumab as neo-adjuvant and stand - alone treatment. MRI and PET tumour characteristics were taken before and after treatment and patients were interviewed for subjective pain responses.</p><p><strong>Results: </strong>Following treatment, all patients showed improvement of pain, of which 68.7% of patients were pain free with 43.75% noting improvement within 48 hours. Mean relative volumetric reduction in tumour volume was 37.3% (<i>P</i> < .001). Eight patients showed high grade of Bilsky classification (Epidural spinal cord compression scale - ESCC) with seven of them showing significant improvement to low grade of ESCC (<i>P</i> = .016). Median baseline PET Standardised Uptake Value (SUV)max was 14.57 and post treatment was 4.8 (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>This study provides necessary insight to the limited literature on the use of denosumab for spinal GCT in the acute phase. The clinical and radiographic responses observed demonstrate the critical role that neo-adjuvant denosumab has by reducing the tumour burden around critical adjacent neurovascular structures before eventual resection, significant pain improvement even with presence of fractured vertebra.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251314378"},"PeriodicalIF":2.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor Concerning 'Does Early Treatment With Teriparatide Prevent the Need for Surgical Intervention in Osteoporotic Vertebral Compression Fractures'. 致编辑的关于“早期使用特立帕肽治疗是否可以预防骨质疏松性椎体压缩性骨折的手术干预”的信。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-04 DOI: 10.1177/21925682241279239
Yulu Rao, Lin Han, Jingzhi Wang
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引用次数: 0
Letter to the Editor: 'Short-Term Comparison Between Unilateral Versus Bilateral Percutaneous Pedicle Screw Fixation in Short-Level Lateral Lumbar Interbody Fusion-A Prospective Randomized Study' by Akihiko Hiyama et al. 致编辑的信:Akihiko Hiyama等人的“单侧与双侧经皮椎弓根螺钉固定在短水平侧腰椎体间融合中的短期比较——一项前瞻性随机研究”。
IF 2.6 3区 医学
Global Spine Journal Pub Date : 2025-01-03 DOI: 10.1177/21925682241311261
Shashank Chaurasia, Vishal Kumar, Aditya Gupta
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引用次数: 0
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