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Nrf2-dependent redox regulation protects myoblasts from polystyrene nanoplastic-induced premature senescence. nrf2依赖的氧化还原调控保护成肌细胞免受聚苯乙烯纳米塑料诱导的过早衰老。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1007/s13258-026-01744-0
Chae Rin Jung, EunJin Bang, Gi-Young Kim, JaeHun Cheong, Yung Hyun Choi
{"title":"Nrf2-dependent redox regulation protects myoblasts from polystyrene nanoplastic-induced premature senescence.","authors":"Chae Rin Jung, EunJin Bang, Gi-Young Kim, JaeHun Cheong, Yung Hyun Choi","doi":"10.1007/s13258-026-01744-0","DOIUrl":"10.1007/s13258-026-01744-0","url":null,"abstract":"<p><strong>Background: </strong>Nanoplastics (NPs) have emerged as environmental contaminants posing potential risks to human health. Recently, skeletal muscle has been recognized as a target tissue affected by NP exposure, where NPs trigger premature cellular senescence.</p><p><strong>Objective: </strong>This study aimed to determine whether senescence induced by polystyrene NPs (PS-NPs) in pre-differentiated C2C12 myoblasts is regulated by nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor.</p><p><strong>Methods: </strong>After confirming that PS-NPs induce cellular senescence in C2C12 myoblasts, we examined whether sulforaphane, an Nrf2 activator, attenuates this process by enhancing antioxidant defense and maintaining mitochondrial homeostasis. Additionally, we investigated the effects of Nrf2 knockdown on PS-NP-mediated cellular senescence.</p><p><strong>Results: </strong>PS-NP exposure downregulated and dephosphorylated Nrf2, whereas sulforaphane treatment restored its expression and phosphorylation, concomitant with the upregulation of heme oxygenase-1 activity. Sulforaphane significantly attenuated PS-NP-induced premature cellular senescence, as evidenced by reduced β-galactosidase activity and senescence-associated marker levels and suppressed senescence-associated secretory phenotypes. Moreover, sulforaphane preserved mitochondrial integrity and decreased both intracellular and mitochondrial reactive oxygen species levels, indicating that its anti-senescence effects were mediated via activation of the Nrf2/heme oxygenase-1 pathway. Conversely, Nrf2 knockdown markedly exacerbated PS-NP-induced cellular senescence.</p><p><strong>Conclusions: </strong>Overall, these findings suggest that sulforaphane-mediated activation of Nrf2 mitigates PS-NP-induced premature myoblast senescence through redox regulation, underscoring the essential role of antioxidant defense pathways in protecting skeletal muscle cells from nanoplastic-induced cellular senescence.</p>","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":"647-658"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The control of Plexin A-mediated axon guidance by the Src family kinase Src64B in Drosophila. 果蝇Src家族激酶Src64B对丛蛋白a介导的轴突引导的控制。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-05-01 Epub Date: 2026-03-13 DOI: 10.1007/s13258-026-01750-2
Van Minh Nguyen, Bongsu Kang, Seungchan Kook, Sangyun Jeong
{"title":"The control of Plexin A-mediated axon guidance by the Src family kinase Src64B in Drosophila.","authors":"Van Minh Nguyen, Bongsu Kang, Seungchan Kook, Sangyun Jeong","doi":"10.1007/s13258-026-01750-2","DOIUrl":"10.1007/s13258-026-01750-2","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":"733-746"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ZNF468 stabilization by RNF4 enhances apoptosis resistance and carboplatin resistance in breast cancer via transcription activation of XIAP. 通过XIAP的转录激活，RNF4稳定ZNF468增强乳腺癌细胞凋亡抵抗和卡铂耐药。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-29 DOI: 10.1007/s13258-026-01760-0
Juan Hu, Guo Tian, Peizhi Tang, Sheng Yuan, Bingjian Jiang
{"title":"ZNF468 stabilization by RNF4 enhances apoptosis resistance and carboplatin resistance in breast cancer via transcription activation of XIAP.","authors":"Juan Hu, Guo Tian, Peizhi Tang, Sheng Yuan, Bingjian Jiang","doi":"10.1007/s13258-026-01760-0","DOIUrl":"https://doi.org/10.1007/s13258-026-01760-0","url":null,"abstract":"<p><strong>Background: </strong>Carboplatin is a commonly utilized chemotherapy agent for breast cancer treatment, yet resistance to this drug remains a significant clinical challenge OBJECTIVE: The objective of this study was to investigate the role and regulatory mechanism of zinc finger protein 468 (ZNF468) in carboplatin resistance in breast cancer.</p><p><strong>Methods: </strong>To establish carboplatin-resistant cells, SK-BR-3 and MDA-MB-231 cells were exposed to increasing concentrations of carboplatin. ZNF468 expression was analyzed in clinical samples (carboplatin-resistant vs. sensitive patients, n=40) and carboplatin-resistant cells. Functional assays, including Cell Counting Kit-8 (CCK-8), EDU staining, flow cytometry, and colony formation assays, were conducted to evaluate cell viability and apoptosis. The interactions and underlying mechanisms were further explored using Chromatin immunoprecipitation (ChIP), luciferase reporter assays, co-immunoprecipitation (Co-IP), and cycloheximide chase assays.</p><p><strong>Results: </strong>ZNF468 was significantly elevated in carboplatin-resistant cells and tissues. Knockdown of ZNF468 reduced the growth of cells and increased apoptosis in drug-resistant cells. ZNF468 was found to transcriptionally activate X-linked inhibitor of apoptosis protein (XIAP), which contributed to enhanced resistance to apoptosis and carboplatin. In addition, RING Finger Protein 4 (RNF4) was shown to stabilize ZNF468 by promoting its phosphorylation, and this stabilization further aggravated the resistance to apoptosis and carboplatin treatment in breast cancer cells.</p><p><strong>Conclusion: </strong>RNF4 stabilized ZNF468, which transcriptionally activates XIAP, enhancing resistance to apoptosis and promoting carboplatin resistance in breast cancer. This study highlights the critical role of ZNF468 in carboplatin resistance, providing potential therapeutic targets for overcoming drug resistance in breast cancer treatment.</p>","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone mark remodeling in cancer: an enhancer-centered perspective. 组蛋白标记在癌症中的重塑：以增强子为中心的视角。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-28 DOI: 10.1007/s13258-026-01768-6
Jiyoon Park, Jinha Jeon, Sujeong Gim, Chan Chung
{"title":"Histone mark remodeling in cancer: an enhancer-centered perspective.","authors":"Jiyoon Park, Jinha Jeon, Sujeong Gim, Chan Chung","doi":"10.1007/s13258-026-01768-6","DOIUrl":"https://doi.org/10.1007/s13258-026-01768-6","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platform-dependent performance of P2A and IRES linkers in multicistronic gene expression. P2A和IRES连接子在多顺子基因表达中的平台依赖性表现。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-27 DOI: 10.1007/s13258-026-01771-x
Mingyu Ju, Jinju Han
{"title":"Platform-dependent performance of P2A and IRES linkers in multicistronic gene expression.","authors":"Mingyu Ju, Jinju Han","doi":"10.1007/s13258-026-01771-x","DOIUrl":"https://doi.org/10.1007/s13258-026-01771-x","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptomic analysis reveals functional compartmentalization of the digestive tract in Urechis unicinctus. 转录组学分析揭示了unicuctus消化道的功能区隔化。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-21 DOI: 10.1007/s13258-026-01767-7
Kyoung-Bin Ryu, Geon Woo Lee, Chan-Jun Lee, Min-Ji Song, Sung-Jin Cho
{"title":"Transcriptomic analysis reveals functional compartmentalization of the digestive tract in Urechis unicinctus.","authors":"Kyoung-Bin Ryu, Geon Woo Lee, Chan-Jun Lee, Min-Ji Song, Sung-Jin Cho","doi":"10.1007/s13258-026-01767-7","DOIUrl":"https://doi.org/10.1007/s13258-026-01767-7","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction. 单细胞转录组学和机器学习鉴定RNF144B和C5AR1是心肌梗死的免疫相关分子特征和治疗靶点。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-15 DOI: 10.1007/s13258-026-01753-z
Yuxin Hu, Lu Chen, Jianmei Sha, Caihong Shao, Junli Gao, Jianhua Yao
{"title":"Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction.","authors":"Yuxin Hu, Lu Chen, Jianmei Sha, Caihong Shao, Junli Gao, Jianhua Yao","doi":"10.1007/s13258-026-01753-z","DOIUrl":"https://doi.org/10.1007/s13258-026-01753-z","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner. 5-氨基咪唑-4-羧酰胺核苷，一种AMPK激活剂，以p38 mapk依赖的方式增强trail介导的人膀胱癌细胞凋亡。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-15 DOI: 10.1007/s13258-026-01764-w
Cheol Park, Hyun Hwangbo, Su Hyun Hong, Hyeon Ji Jeong, Seok Joong Yun, Jeong Sook Noh, Sung-Kwon Moon, Wun-Jae Kim, Gi-Young Kim, Yung Hyun Choi
{"title":"5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner.","authors":"Cheol Park, Hyun Hwangbo, Su Hyun Hong, Hyeon Ji Jeong, Seok Joong Yun, Jeong Sook Noh, Sung-Kwon Moon, Wun-Jae Kim, Gi-Young Kim, Yung Hyun Choi","doi":"10.1007/s13258-026-01764-w","DOIUrl":"https://doi.org/10.1007/s13258-026-01764-w","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of Lcn2 and neuroinflammation in a scopolamine-induced cognitive impairment animal model: implication of the NLRP3 inflammasome pathway. Lcn2和神经炎症在东莨菪碱诱导的认知障碍动物模型中的作用：NLRP3炎症小体途径的含义
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-09 DOI: 10.1007/s13258-026-01765-9
Min Yeong Lee, Nicole Bon Campomayor, Bernabe Apare, Ra Eun Park, Doyun Kim, Hee Jin Kim, Mikyung Kim
{"title":"Roles of Lcn2 and neuroinflammation in a scopolamine-induced cognitive impairment animal model: implication of the NLRP3 inflammasome pathway.","authors":"Min Yeong Lee, Nicole Bon Campomayor, Bernabe Apare, Ra Eun Park, Doyun Kim, Hee Jin Kim, Mikyung Kim","doi":"10.1007/s13258-026-01765-9","DOIUrl":"https://doi.org/10.1007/s13258-026-01765-9","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SEMA4A promotes acute myeloid leukemia progression through inhibiting apoptosis. SEMA4A通过抑制细胞凋亡促进急性髓系白血病进展。
IF 1.7 4区 生物学
Genes & genomics Pub Date : 2026-04-09 DOI: 10.1007/s13258-026-01763-x
Xinyu Li, Binyu Yao, Meiling Sun, Wangshi Li, Xingzhi Lv, Keyang Luo, Yue Wu, Ruolin Xiu, Yuzhu Ma, Fukai Liu, Yanhong Zhao, Shengjin Fan, Linqing Tang, Huitao Fan
{"title":"SEMA4A promotes acute myeloid leukemia progression through inhibiting apoptosis.","authors":"Xinyu Li, Binyu Yao, Meiling Sun, Wangshi Li, Xingzhi Lv, Keyang Luo, Yue Wu, Ruolin Xiu, Yuzhu Ma, Fukai Liu, Yanhong Zhao, Shengjin Fan, Linqing Tang, Huitao Fan","doi":"10.1007/s13258-026-01763-x","DOIUrl":"https://doi.org/10.1007/s13258-026-01763-x","url":null,"abstract":"","PeriodicalId":12675,"journal":{"name":"Genes & genomics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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